A cellular gene encodes scrapie PrP 27-30 protein.

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Published in Cell on April 01, 1985

Authors

B Oesch, D Westaway, M Wälchli, M P McKinley, S B Kent, R Aebersold, R A Barry, P Tempst, D B Teplow, L E Hood

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Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. Proc Natl Acad Sci U S A (1993) 10.36

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Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins. J Virol (1987) 7.05

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Regional mapping of prion proteins in brain. Proc Natl Acad Sci U S A (1992) 3.68

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Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells. J Cell Biol (1990) 3.46

Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins. J Virol (1988) 3.37

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Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid. Proc Natl Acad Sci U S A (1992) 2.64

Purified prion proteins and scrapie infectivity copartition into liposomes. Proc Natl Acad Sci U S A (1987) 2.61

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Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells. J Cell Biol (1990) 2.42

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The major polypeptide of scrapie-associated fibrils (SAF) has the same size, charge distribution and N-terminal protein sequence as predicted for the normal brain protein (PrP). EMBO J (1986) 2.19

High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene. Mol Med (1994) 2.18

The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein. EMBO J (2001) 2.16

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Prion protein biosynthesis in scrapie-infected and uninfected neuroblastoma cells. J Virol (1989) 2.08

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Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains. J Virol (1986) 1.95

Molecular cloning and complete sequence of prion protein cDNA from mouse brain infected with the scrapie agent. Proc Natl Acad Sci U S A (1986) 1.92

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A single hamster PrP amino acid blocks conversion to protease-resistant PrP in scrapie-infected mouse neuroblastoma cells. J Virol (1995) 1.87

Conversion of truncated and elongated prion proteins into the scrapie isoform in cultured cells. Proc Natl Acad Sci U S A (1993) 1.87

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Heterologous PrP molecules interfere with accumulation of protease-resistant PrP in scrapie-infected murine neuroblastoma cells. J Virol (1994) 1.85

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Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain. EMBO J (2001) 1.85

Two alleles of a neural protein gene linked to scrapie in sheep. Proc Natl Acad Sci U S A (1990) 1.84

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Chemical chaperones interfere with the formation of scrapie prion protein. EMBO J (1996) 1.81

Isolation of a cDNA clone encoding the leader peptide of prion protein and expression of the homologous gene in various tissues. Proc Natl Acad Sci U S A (1986) 1.75

Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58. EMBO J (1991) 1.74

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Synthetic peptides homologous to prion protein residues 106-147 form amyloid-like fibrils in vitro. Proc Natl Acad Sci U S A (1993) 1.68

Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein. EMBO J (2001) 1.68

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Three scrapie prion isolates exhibit different accumulation patterns of the prion protein scrapie isoform. Proc Natl Acad Sci U S A (1993) 1.65

Evidence suggesting that PrP is not the infectious agent in Creutzfeldt-Jakob disease. EMBO J (1987) 1.64

Specific binding of normal prion protein to the scrapie form via a localized domain initiates its conversion to the protease-resistant state. EMBO J (1999) 1.64

Synthetic prions generated in vitro are similar to a newly identified subpopulation of PrPSc from sporadic Creutzfeldt-Jakob Disease. Protein Sci (2005) 1.62

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Congo red inhibition of scrapie agent replication. J Virol (1993) 1.60

Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation. Proc Natl Acad Sci U S A (1990) 1.59

Copper binding to octarepeat peptides of the prion protein monitored by mass spectrometry. Protein Sci (2000) 1.57

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Trafficking of prion proteins through a caveolae-mediated endosomal pathway. J Cell Biol (2003) 1.51

Endogenous proteolytic cleavage of normal and disease-associated isoforms of the human prion protein in neural and non-neural tissues. Am J Pathol (1998) 1.48

Differences in proteinase K resistance and neuronal deposition of abnormal prion proteins characterize bovine spongiform encephalopathy (BSE) and scrapie strains. Mol Med (1999) 1.47

Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain. Proc Natl Acad Sci U S A (1988) 1.45

Accumulation of proteinase K-resistant prion protein (PrP) is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob disease agent. J Virol (1995) 1.45

Purified scrapie prions resist inactivation by UV irradiation. J Virol (1987) 1.43

Congo red prolongs the incubation period in scrapie-infected hamsters. J Virol (1995) 1.42

Prion filament networks in [URE3] cells of Saccharomyces cerevisiae. J Cell Biol (2001) 1.41

Prion hypothesis: the end of the controversy? Trends Biochem Sci (2010) 1.40

Biogenesis and transmembrane orientation of the cellular isoform of the scrapie prion protein [published errratum appears in Mol Cell Biol 1987 May;7(5):2035]. Mol Cell Biol (1987) 1.39

Molecular cloning of a candidate chicken prion protein. Proc Natl Acad Sci U S A (1992) 1.38

Molecular mass, biochemical composition, and physicochemical behavior of the infectious form of the scrapie precursor protein monomer. Proc Natl Acad Sci U S A (1990) 1.38

Physical properties of the Creutzfeldt-Jakob disease agent. J Virol (1989) 1.36

Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie. EMBO J (1997) 1.36

Transmission of prions. Proc Natl Acad Sci U S A (2002) 1.36

Propagation of prion strains through specific conformers of the prion protein. J Virol (1997) 1.35

Proposed three-dimensional structure for the cellular prion protein. Proc Natl Acad Sci U S A (1994) 1.35

Antisera to scrapie-associated fibril protein and prion protein decorate scrapie-associated fibrils. J Virol (1987) 1.35

Etiology and pathogenesis of prion diseases. Am J Pathol (1995) 1.35

Prion protein NMR structures of chickens, turtles, and frogs. Proc Natl Acad Sci U S A (2005) 1.34

Assignment of the human and mouse prion protein genes to homologous chromosomes. Proc Natl Acad Sci U S A (1986) 1.33

Mechanism of inhibition of Psi+ prion determinant propagation by a mutation of the N-terminus of the yeast Sup35 protein. EMBO J (1998) 1.31

Conservation of a portion of the S. cerevisiae Ure2p prion domain that interacts with the full-length protein. Proc Natl Acad Sci U S A (2002) 1.30

Genomic structure of the human prion protein gene. Am J Hum Genet (1991) 1.29

Parallel in-register intermolecular β-sheet architectures for prion-seeded prion protein (PrP) amyloids. J Biol Chem (2014) 1.27

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