Published in Hepatology on July 01, 1995
High-throughput real-time reverse transcription-PCR quantitation of hepatitis C virus RNA. J Clin Microbiol (1999) 3.88
Early changes in hepatitis C viral quasispecies during interferon therapy predict the therapeutic outcome. Proc Natl Acad Sci U S A (2002) 2.04
Viral determinants of resistance to treatment in patients with hepatitis C. Clin Microbiol Rev (2007) 1.65
Quasispecies heterogeneity within the E1/E2 region as a pretreatment variable during pegylated interferon therapy of chronic hepatitis C virus infection. J Virol (2005) 1.29
Nucleotide and amino acid complexity of hepatitis C virus quasispecies in serum and liver. J Virol (2000) 1.23
Evidence of recombination in intrapatient populations of hepatitis C virus. PLoS One (2008) 1.16
The quasispecies nature and biological implications of the hepatitis C virus. Infect Genet Evol (2009) 1.14
Genetic heterogeneity of hypervariable region 1 of the hepatitis C virus (HCV) genome and sensitivity of HCV to alpha interferon therapy. J Virol (2000) 1.14
Structure of replicating hepatitis C virus (HCV) quasispecies in the liver may not be reflected by analysis of circulating HCV virions. J Virol (1997) 1.11
How Escherichia coli can bias the results of molecular cloning: preferential selection of defective genomes of hepatitis C virus during the cloning procedure. Proc Natl Acad Sci U S A (1997) 0.95
Progression of fibrosis during chronic hepatitis C is associated with rapid virus evolution. J Virol (2007) 0.94
Hepatitis C virus envelope glycoprotein co-evolutionary dynamics during chronic hepatitis C. Virology (2008) 0.89
High diversity of hepatitis C viral quasispecies is associated with early virological response in patients undergoing antiviral therapy. Hepatology (2009) 0.89
Longitudinal evaluation of the structure of replicating and circulating hepatitis C virus quasispecies in nonprogressive chronic hepatitis C patients. J Virol (2001) 0.83
Significance of pretreatment analysis of hepatitis C virus genotype 1b hypervariable region 1 sequences to predict antiviral outcome. J Clin Microbiol (2003) 0.82
Hepatitis C virus: molecular biology and genetic variability. Dig Dis Sci (1996) 0.81
Comparison of quasispecies diversity of HCV between chronic hepatitis c and hepatocellular carcinoma by Ultradeep pyrosequencing. Biomed Res Int (2014) 0.79
Quasispecies as predictive response factors for antiviral treatment in patients with chronic hepatitis C. Dig Dis Sci (2006) 0.78
Duration of HCV infection as a predictor of nonresponse to interferon. Dig Dis Sci (1996) 0.75
Applications of polymerase chain reaction-single stranded conformational polymorphism to microbiology. Clin Mol Pathol (1996) 0.75
Predictors of response to interferon therapy. Dig Dis Sci (1996) 0.75
Cloning and expression of apical membrane water channel of rat kidney collecting tubule. Nature (1993) 4.99
Prediction of acute left main coronary artery obstruction by 12-lead electrocardiography. ST segment elevation in lead aVR with less ST segment elevation in lead V(1). J Am Coll Cardiol (2001) 4.81
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68
Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. N Engl J Med (1996) 4.61
Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis). Cytometry (1997) 3.90
Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor. EMBO J (1997) 3.74
A recombination hotspot responsible for two inherited peripheral neuropathies is located near a mariner transposon-like element. Nat Genet (1996) 3.45
Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos. Development (1996) 3.30
Efficient promoter cassettes for enhanced expression of foreign genes in dicotyledonous and monocotyledonous plants. Plant Cell Physiol (1996) 3.30
Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J Clin Invest (1995) 3.19
Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus. Exp Cell Res (1986) 3.17
Phosphorylation of serine 256 is required for cAMP-dependent regulatory exocytosis of the aquaporin-2 water channel. J Biol Chem (1997) 2.65
Purification and characterization of the human interleukin-18 receptor. J Biol Chem (1997) 2.58
Antithyroid drug-induced agranulocytosis. The usefulness of routine white blood cell count monitoring. Arch Intern Med (1990) 2.39
Site-specific phosphorylation induces disassembly of vimentin filaments in vitro. Nature (1987) 2.33
Natural history of polypoid lesions in the gall bladder. Gut (1996) 2.33
Urinary excretion of aquaporin-2 in patients with diabetes insipidus. N Engl J Med (1995) 2.33
Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes. Circ Res (1994) 2.29
Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i) Nature (1999) 2.23
Human immunodeficiency virus type 1 N-terminal capsid mutants that exhibit aberrant core morphology and are blocked in initiation of reverse transcription in infected cells. J Virol (2001) 2.17
BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells. Immunity (1999) 2.11
Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells. J Biol Chem (1998) 2.10
Aeromonas sobria infection with severe muscle degeneration in a patient with alcoholic liver cirrhosis. Am J Gastroenterol (1995) 2.09
Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla. J Biol Chem (1993) 2.01
Diffusion-weighted single-shot echoplanar MR imaging for liver disease. AJR Am J Roentgenol (1999) 2.00
Interstitial lung diseases associated with amyopathic dermatomyositis. Eur Respir J (2006) 1.92
Substitution at codon 269 (glutamine --> proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat. Biochem Biophys Res Commun (1996) 1.89
Cloning and expression of a protein kinase C-regulated chloride channel abundantly expressed in rat brain neuronal cells. Neuron (1994) 1.89
Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney. J Am Soc Nephrol (2001) 1.88
PCR localization of angiotensin II receptor and angiotensinogen mRNAs in rat kidney. Kidney Int (1993) 1.86
Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population. Br J Dermatol (2003) 1.86
Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel. Nat Genet (1999) 1.83
Early cancer of the stomach. World J Surg (1979) 1.82
A founder mutation in presenilin 1 causing early-onset Alzheimer disease in unrelated Caribbean Hispanic families. JAMA (2001) 1.82
Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells. J Clin Invest (1993) 1.80
Raised plasma endothelin in aneurysmal subarachnoid haemorrhage. Lancet (1989) 1.79
cAMP-dependent phosphorylation stimulates water permeability of aquaporin-collecting duct water channel protein expressed in Xenopus oocytes. J Biol Chem (1995) 1.77
Molecular identification of a eukaryotic, stretch-activated nonselective cation channel. Science (1999) 1.77
Pathway of chymotrypsin evolution suggested by the structure of the FMN-binding protein from Desulfovibrio vulgaris (Miyazaki F) Nat Struct Biol (1997) 1.75
Typing of hepatitis C virus genomes by restriction fragment length polymorphism. J Gen Virol (1991) 1.74
Intracellular Ca2+-dependent protease (calpain) and its high-molecular-weight endogenous inhibitor (calpastatin). Adv Enzyme Regul (1980) 1.74
Expression of vascular permeability factor/vascular endothelial growth factor in human hepatocellular carcinoma. Cancer Res (1996) 1.74
Epidermal growth factor receptor overexpression and genetic aberrations in metastatic squamous-cell carcinoma of the skin. Dermatology (2001) 1.72
Heterogeneity within a large kindred with frontotemporal dementia: a novel progranulin mutation. Neurology (2007) 1.71
Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes. Circ Res (1991) 1.71
Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea. J Biol Chem (1997) 1.68
Ultrasonographic characteristics of thyroid nodules: prediction of malignancy. Arch Surg (2001) 1.65
Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations. Neurology (2001) 1.64
Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft. Am J Transplant (2007) 1.64
Changes in oropharyngeal airway and respiratory function during sleep after orthognathic surgery in patients with mandibular prognathism. Int J Oral Maxillofac Surg (2011) 1.64
Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes. Diabetologia (2011) 1.63
Endothelin is a potent mitogen for rat vascular smooth muscle cells. Atherosclerosis (1989) 1.63
Effects of injection rates of contrast material on arterial phase hepatic CT. AJR Am J Roentgenol (1998) 1.62
Melanin production in cultured albino melanocytes transfected with mouse tyrosinase cDNA. Jpn J Genet (1989) 1.61
Epstein-Barr virus-associated gastric carcinoma and atrophic gastritis. J Clin Gastroenterol (1999) 1.59
Cyclin A/cdk2 activation is involved in hypoxia-induced apoptosis in cardiomyocytes. Circ Res (2001) 1.57
LRRK2 gene in Parkinson disease: mutation analysis and case control association study. Neurology (2005) 1.56
Loss of constitutional heterozygosity in colon carcinoma from patients with familial polyposis coli. Nature (1988) 1.54
Analysis of genotypes and amino acid residues 2209 to 2248 of the NS5A region of hepatitis C virus in relation to the response to interferon-beta therapy. Hepatology (1997) 1.54
High prevalence of vitamin D deficiency in Japanese female patients with Graves' disease. Endocr J (2001) 1.53
Chronic nonpulsatile blood flow in an alive, awake animal 34-day survival. Trans Am Soc Artif Intern Organs (1980) 1.52
Two sporadic cases of Liddle's syndrome caused by De novo ENaC mutations. Am J Kidney Dis (2001) 1.52
Application of the scanning electron microscope to the study of the fine distribution of the blood vessels. Arch Histol Jpn (1971) 1.52
Epifluorescent microscopic evidence for maternal inheritance of chloroplast DNA. Nature (1982) 1.50
Insulin-like growth factor-I induces hypertrophy with enhanced expression of muscle specific genes in cultured rat cardiomyocytes. Circulation (1993) 1.49
Doppler echocardiographic transmitral peak early velocity does not directly reflect hemodynamic changes in humans: importance of normalization to mitral stroke volume. J Am Coll Cardiol (1991) 1.48
Structural analysis of the titin gene in hypertrophic cardiomyopathy: identification of a novel disease gene. Biochem Biophys Res Commun (1999) 1.48
Bone mineral density of the spine, hip and distal forearm in representative samples of the Japanese female population: Japanese Population-Based Osteoporosis (JPOS) Study. Osteoporos Int (2001) 1.47
Long-term observation after transjugular intrahepatic portosystemic stent-shunt in two patients with hepatocellular carcinoma. J Clin Gastroenterol (2000) 1.47
Analysis of stress-induced or salicylic acid-induced expression of the pathogenesis-related 1a protein gene in transgenic tobacco. Plant Cell (1990) 1.44
Ischemic hepatitis in cirrhosis. clinical features and prognostic implications. J Clin Gastroenterol (1996) 1.44
Synthesis of protegrin-related peptides and their antibacterial and anti-human immunodeficiency virus activity. Chem Pharm Bull (Tokyo) (1995) 1.44
Three cases of malignant hypertension: the roles of endothelin-1 and the renin-angiotensin-aldosterone system. Clin Nephrol (1994) 1.44
Postoperative changes in cerebral metabolites associated with cognitive improvement and impairment after carotid endarterectomy: a 3T proton MR spectroscopy study. AJNR Am J Neuroradiol (2012) 1.44
Nicastrin binds to membrane-tethered Notch. Nat Cell Biol (2001) 1.44
Development of large numbers of mast cells at sites of idiopathic chronic dermatitis in genetically mast cell-deficient WBB6F1-W/Wv mice. Blood (1987) 1.43
Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function. J Biol Chem (1997) 1.43
Two isoforms of a chloride channel predominantly expressed in thick ascending limb of Henle's loop and collecting ducts of rat kidney. J Biol Chem (1994) 1.42
Current status of renal replacement therapy in Japan: results of the annual survey of the Japanese Society for Dialysis Therapy. Nephrol Dial Transplant (1996) 1.41
Survival in long-term haemodialysis patients: results from the annual survey of the Japanese Society for Dialysis Therapy. Nephrol Dial Transplant (1996) 1.41
Vitamin D receptors and hyperparathyroidism. Nat Med (1996) 1.41
Percutaneous transluminal coronary angioplasty improves oxygen uptake kinetics during the onset of exercise in patients with coronary artery disease. Chest (2000) 1.41