Human immunodeficiency virus type 1 N-terminal capsid mutants that exhibit aberrant core morphology and are blocked in initiation of reverse transcription in infected cells.

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Published in J Virol on October 01, 2001

Authors

S Tang1, T Murakami, B E Agresta, S Campbell, E O Freed, J G Levin

Author Affiliations

1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

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Nonresponse bias and early versus all responders in mail and telephone surveys. Am J Epidemiol (1984) 2.04

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Identification and synthesis of a recognition signal for the attachment of glycosaminoglycans to proteins. Proc Natl Acad Sci U S A (1987) 2.00

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Translational suppression in retroviral gene expression. Adv Virus Res (1992) 1.93

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Follow-up study of small-for-dates babies. Br Med J (1976) 1.86

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Membrane-associated replication complex in arbovirus infection. J Virol (1972) 1.83

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Early cancer of the stomach. World J Surg (1979) 1.82

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The present place of routine ultrasound screening. Clin Obstet Gynaecol (1983) 1.82

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Effect of diagnostic ultrasound on maternal and fetal chromosomes. Lancet (1971) 1.76

Functional characteristics of Peyer's patch lymphoid cells. I. Induction of humoral antibody and cell-mediated allograft reactions. J Exp Med (1974) 1.76

Pathway of chymotrypsin evolution suggested by the structure of the FMN-binding protein from Desulfovibrio vulgaris (Miyazaki F) Nat Struct Biol (1997) 1.75

Intracellular Ca2+-dependent protease (calpain) and its high-molecular-weight endogenous inhibitor (calpastatin). Adv Enzyme Regul (1980) 1.74

Sampling pure fetal blood by fetoscopy in second trimester of pregnancy. Br Med J (1978) 1.73

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Oestrogens, arterial status, and postmenopausal women. Lancet (1990) 1.70

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