Published in J Biol Chem on October 06, 1995
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J (2000) 6.55
Involvement of 14-3-3 proteins in nuclear localization of telomerase. EMBO J (2000) 2.05
14-3-3 proteins regulate intracellular localization of the bZIP transcriptional activator RSG. Plant Cell (2001) 1.94
The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site. Proc Natl Acad Sci U S A (1996) 1.54
Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding. Mol Cell Biol (2003) 1.53
Significance of 14-3-3 self-dimerization for phosphorylation-dependent target binding. Mol Biol Cell (2003) 1.42
14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J (2006) 1.40
An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ. Mol Cell Biol (1997) 1.37
Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1. Mol Cell Biol (2002) 1.26
14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation. Biochem J (2000) 1.22
Specific interactions with TBP and TFIIB in vitro suggest that 14-3-3 proteins may participate in the regulation of transcription when part of a DNA binding complex. Plant Cell (1999) 1.19
Glucocorticoid-induced leucine zipper (GILZ)/NF-kappaB interaction: role of GILZ homo-dimerization and C-terminal domain. Nucleic Acids Res (2006) 1.15
14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo. Mol Cell Biol (1998) 1.10
Molecular organization and tissue-specific expression of an Arabidopsis 14-3-3 gene. Plant Cell (1996) 1.07
In vivo functional specificity and homeostasis of Drosophila 14-3-3 proteins. Genetics (2007) 0.96
Dimerization is essential for 14-3-3zeta stability and function in vivo. J Biol Chem (2009) 0.92
14-3-3 gamma associates with muscle specific kinase and regulates synaptic gene transcription at vertebrate neuromuscular synapse. Proc Natl Acad Sci U S A (2004) 0.92
Glial cell type-specific subcellular localization of 14-3-3 zeta: an implication for JCV tropism. Glia (2009) 0.90
Binding and transcriptional regulation by 14-3-3 (Bmh) proteins requires residues outside of the canonical motif. Eukaryot Cell (2013) 0.79
Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner. Stem Cells (2015) 0.78
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev (2001) 13.15
The stress-activated protein kinase subfamily of c-Jun kinases. Nature (1994) 11.45
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem (1998) 9.37
Phosphorylation of c-jun mediated by MAP kinases. Nature (1991) 8.07
Raf-1 activates MAP kinase-kinase. Nature (1992) 7.05
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature (1995) 6.20
Preparation and properties of plasma membrane and endoplasmic reticulum fragments from isolated rat fat cells. Biochim Biophys Acta (1971) 5.74
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr Biol (1998) 5.04
Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science (1992) 5.00
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature (1993) 4.88
Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase. Nature (2001) 4.73
Sounding the alarm: protein kinase cascades activated by stress and inflammation. J Biol Chem (1996) 4.49
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO J (1994) 4.37
Protein kinase cascades activated by stress and inflammatory cytokines. Bioessays (1996) 3.96
Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor. Cancer Res (1997) 3.55
Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. Proc Natl Acad Sci U S A (1988) 3.52
Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK. J Biol Chem (1998) 3.29
Linkage of faulty major histocompatibility complex class I to autoimmune diabetes. Science (1991) 2.99
A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity. Nature (1998) 2.89
Raf meets Ras: completing the framework of a signal transduction pathway. Trends Biochem Sci (1994) 2.75
Regulation of eIF-4E BP1 phosphorylation by mTOR. J Biol Chem (1997) 2.73
Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation. Mol Cell Biol (2001) 2.72
Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Curr Biol (2000) 2.70
Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells. J Biol Chem (1999) 2.65
Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro. J Biol Chem (1999) 2.49
Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies. J Biol Chem (1998) 2.46
Purification of a hepatic S6 kinase from cycloheximide-treated Rats. J Biol Chem (1989) 2.44
Multiple independent inputs are required for activation of the p70 S6 kinase. Mol Cell Biol (1995) 2.39
Intracellular signalling: PDK1--a kinase at the hub of things. Curr Biol (1999) 2.31
Oligomerization activates c-Raf-1 through a Ras-dependent mechanism. Nature (1996) 2.29
Insulin-stimulated tyrosine phosphorylation of the insulin receptor in detergent extracts of human placental membranes. Comparison to epidermal growth factor-stimulated phosphorylation. J Biol Chem (1982) 2.21
Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation. Proc Natl Acad Sci U S A (1995) 2.06
The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1. J Biol Chem (1996) 2.06
Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini. Mol Cell Biol (1991) 2.00
Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. Recent Prog Horm Res (2001) 1.87
UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase. EMBO J (1993) 1.86
The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion. J Biol Chem (1994) 1.84
Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase. Curr Biol (2001) 1.82
Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase. Proc Natl Acad Sci U S A (1990) 1.80
An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase. J Biol Chem (1992) 1.79
Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase. Nature (1995) 1.79
Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase. Mol Cell Biol (1997) 1.76
Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation. J Biol Chem (1994) 1.74
Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells. Oncogene (1993) 1.69
Purification and characterisation of the insulin-stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II. Eur J Biochem (1991) 1.69
Identification of Nore1 as a potential Ras effector. J Biol Chem (1998) 1.69
Insulin regulation of protein biosynthesis in differentiated 3T3 adipocytes. Regulation of glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem (1985) 1.68
Immunization of metastatic breast cancer patients with a fully synthetic globo H conjugate: a phase I trial. Proc Natl Acad Sci U S A (2001) 1.63
Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252. J Biol Chem (1999) 1.61
Recombinant fragment of protein kinase inhibitor blocks cyclic AMP-dependent gene transcription. Science (1987) 1.59
FDA approved guidance conduits and wraps for peripheral nerve injury: a review of materials and efficacy. Injury (2011) 1.58
Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues. Mol Cell Biol (1994) 1.56
Repeated administration of cocaine or amphetamine alters neuronal responses to glutamate in the mesoaccumbens dopamine system. J Pharmacol Exp Ther (1995) 1.54
Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo. J Biol Chem (2000) 1.52
Identification of insulin receptor tyrosine residues autophosphorylated in vitro. J Biol Chem (1987) 1.52
Regulation of an epitope-tagged recombinant Rsk-1 S6 kinase by phorbol ester and erk/MAP kinase. Biochemistry (1993) 1.50
Interleukin 2 induces tyrosine phosphorylation and activation of p72-74 Raf-1 kinase in a T-cell line. Proc Natl Acad Sci U S A (1991) 1.49
Magnetic resonance lymphography at 3T: a promising noninvasive approach to characterise inguinal lymphatic vessel leakage. Eur J Vasc Endovasc Surg (2011) 1.48
Effects of epinephrine and insulin on phosphopeptide metabolism in adipocytes. J Biol Chem (1976) 1.47
Combined transplantation of neural stem cells and olfactory ensheathing cells for the repair of spinal cord injuries. Med Hypotheses (2007) 1.43
Circadian variation of heart rate variability in postinfarction patients with and without life-threatening ventricular tachyarrhythmias. J Cardiovasc Electrophysiol (1995) 1.41
Phosphorylation of endogenous substrates by erythrocyte membrane protein kinases. I. A monovalent cation-stimulated reaction. Biochemistry (1974) 1.38
An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ. Mol Cell Biol (1997) 1.37
pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine. J Biol Chem (1990) 1.36
Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells. J Biol Chem (1997) 1.36
Demonstration of a phosphopeptide intermediate in the Mg ++ -dependent, Na + - and K + -stimulated adenosine triphosphatase reaction of the erythrocyte membrane. Proc Natl Acad Sci U S A (1972) 1.34
Stress-activated protein kinases bind directly to the delta domain of c-Jun in resting cells: implications for repression of c-Jun function. Oncogene (1995) 1.34
Purification of a hepatic 123,000-dalton hormone-stimulated 32P-peptide and its identification as ATP-citrate lyase. J Biol Chem (1979) 1.33
RNA-DNA covalent bonds between the RNA primers and the DNA products formed by RNA tumor virus DNA polymerase. J Virol (1973) 1.30
Epidermal growth factor (EGF) stimulates association and kinase activity of Raf-1 with the EGF receptor. Mol Cell Biol (1991) 1.28
Four gel systems for electrophoretic fractionation of membrane proteins using ionic detergents. J Supramol Struct (1972) 1.28
Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase. J Biol Chem (1993) 1.26
Role of insulin-stimulated protein phosphorylation in insulin action. Fed Proc (1982) 1.26
Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases. Mol Endocrinol (1992) 1.26
Identification of the insulin receptor tyrosine residues undergoing insulin-stimulated phosphorylation in intact rat hepatoma cells. J Biol Chem (1988) 1.26
Cystic echinococcosis in semi-nomadic pastoral communities in north-west China. Trans R Soc Trop Med Hyg (2001) 1.23
Insulin-activated protein kinases phosphorylate a pseudosubstrate synthetic peptide inhibitor of the p70 S6 kinase. J Biol Chem (1991) 1.23
MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase. J Biol Chem (1997) 1.22
Interferon-inducible protein 10 and macrophage inflammatory protein-1 alpha inhibit growth factor stimulation of Raf-1 kinase activity and protein synthesis in a human growth factor-dependent hematopoietic cell line. J Biol Chem (1995) 1.20
Insulin and growth factors stimulate the phosphorylation of a Mr-22000 protein in 3T3-L1 adipocytes. Biochem J (1983) 1.20
Enzymatic characteristics of the c-Raf-1 protein kinase. Proc Natl Acad Sci U S A (1994) 1.19
Identification and subcellular distribution of adipocyte peptides and phosphopeptides. J Biol Chem (1976) 1.17
Relationship of site-specific beta subunit tyrosine autophosphorylation to insulin activation of the insulin receptor (tyrosine) protein kinase activity. J Biol Chem (1988) 1.17
Endothelin, vasopressin, and angiotensin II enhance tyrosine phosphorylation by protein kinase C-dependent and -independent pathways in glomerular mesangial cells. J Biol Chem (1991) 1.16
Insulin-stimulated tyrosine protein kinase. Characterization and relation to the insulin receptor. J Biol Chem (1984) 1.16
A formation mechanism for catalytically grown helix-shaped graphite nanotubes. Science (1994) 1.15
Properties and biocompatibility of chitosan films modified by blending with PEG. Biomaterials (2002) 1.14
An S6 kinase activated during liver regeneration is related to the insulin-stimulated S6 kinase in H4 hepatoma cells. J Biol Chem (1988) 1.13
An insulin-stimulated (ribosomal S6) protein kinase from soluble extracts of H4 hepatoma cells. Arch Biochem Biophys (1986) 1.12
Endogenous calcium buffering capacity of substantia nigral dopamine neurons. J Neurophysiol (2009) 1.11
Insulin activates a 70-kDa S6 kinase through serine/threonine-specific phosphorylation of the enzyme polypeptide. Proc Natl Acad Sci U S A (1990) 1.09
pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity. J Biol Chem (1991) 1.08
A second generation synthesis of the MBr1 (globo-H) breast tumor antigen: new application of the n-pentenyl glycoside method for achieving complex carbohydrate protein linkages. Chemistry (2000) 1.06
Preliminary characterization of a heat-stable protein from rat adipose tissue whose phosphorylation is stimulated by insulin. Biochem J (1982) 1.06
Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific. J Immunol (1991) 1.04
Phylogenetic relationships of Anaplasma marginale and 'Ehrlichia platys' to other Ehrlichia species determined by GroEL amino acid sequences. Int J Syst Evol Microbiol (2001) 1.04