Published in Proc Natl Acad Sci U S A on September 26, 1995
Inflammation and Alzheimer's disease. Neurobiol Aging (2000) 12.56
Pathways towards and away from Alzheimer's disease. Nature (2004) 8.72
Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH. Nature (2013) 3.22
Signal transduction of stress via ceramide. Biochem J (1998) 2.86
NF-kappaB in neuronal plasticity and neurodegenerative disorders. J Clin Invest (2001) 2.78
The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res Rev (2008) 2.39
Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. Proc Natl Acad Sci U S A (2000) 2.20
Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury. Proc Natl Acad Sci U S A (1999) 1.91
Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice. J Cell Biol (2007) 1.90
Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc Natl Acad Sci U S A (1997) 1.77
Up-regulation of BDNF in astrocytes by TNF-alpha: a case for the neuroprotective role of cytokine. J Neuroimmune Pharmacol (2006) 1.77
Neuroinflammatory processes in Alzheimer's disease. J Neural Transm (Vienna) (2010) 1.73
NF-kappaB in the nervous system. Cold Spring Harb Perspect Biol (2009) 1.70
Intracerebral production of tumor necrosis factor-alpha, a local neuroprotective agent, in Alzheimer disease and vascular dementia. J Clin Immunol (1999) 1.68
Intrathecal inflammation precedes development of Alzheimer's disease. J Neurol Neurosurg Psychiatry (2003) 1.62
Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy. Am J Pathol (1998) 1.62
Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity. Proc Natl Acad Sci U S A (1997) 1.55
Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism. Proc Natl Acad Sci U S A (1998) 1.48
Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat. J Neuroinflammation (2016) 1.38
Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction. Cell Signal (2010) 1.34
Tumor necrosis factor-alpha at the crossroads of neuronal life and death during HIV-associated dementia. J Neurochem (2003) 1.31
Features of microglia and neuroinflammation relevant to environmental exposure and neurotoxicity. Int J Environ Res Public Health (2011) 1.27
Targeting TNF-α to elucidate and ameliorate neuroinflammation in neurodegenerative diseases. CNS Neurol Disord Drug Targets (2011) 1.16
Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha. J Cell Biol (2001) 1.16
TNF-alpha preconditioning protects neurons via neuron-specific up-regulation of CREB-binding protein. J Immunol (2009) 1.12
BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer's disease. Mol Neurodegener (2012) 1.11
Delayed dominant-negative TNF gene therapy halts progressive loss of nigral dopaminergic neurons in a rat model of Parkinson's disease. Mol Ther (2010) 1.10
Central role of TRAF-interacting protein in a new model of brain sexual differentiation. Proc Natl Acad Sci U S A (2009) 1.07
Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines. J Exp Med (2002) 1.06
Increased intrathecal inflammatory activity in frontotemporal dementia: pathophysiological implications. J Neurol Neurosurg Psychiatry (2004) 1.04
Suppression of steady-state, but not stimulus-induced NF-kappaB activity inhibits alphavirus-induced apoptosis. J Cell Biol (1998) 1.02
S100beta induction of the proinflammatory cytokine interleukin-6 in neurons. J Neurochem (2000) 1.02
Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain. Am J Pathol (2011) 1.02
Obesity and dementia: adipokines interact with the brain. Eur Neuropsychopharmacol (2014) 1.00
Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease. Ann Transl Med (2015) 0.99
Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation. Proc Natl Acad Sci U S A (1999) 0.98
Role of inflammation and its mediators in acute ischemic stroke. J Cardiovasc Transl Res (2013) 0.97
Targeting TNF-alpha receptors for neurotherapeutics. Trends Neurosci (2008) 0.97
NF-kappaB mediated enhancement of potassium currents by the chemokine CXCL1/growth related oncogene in small diameter rat sensory neurons. Mol Pain (2009) 0.97
Cyclooxygenase-2 is a neuronal target gene of NF-kappaB. BMC Mol Biol (2002) 0.97
Tumor necrosis factor alpha stimulates NMDA receptor activity in mouse cortical neurons resulting in ERK-dependent death. J Neurochem (2007) 0.96
Nuclear factor kappaB signaling in opioid functions and receptor gene expression. J Neuroimmune Pharmacol (2006) 0.95
NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review. Front Mol Neurosci (2015) 0.94
Use of cell permeable NBD peptides for suppression of inflammation. Ann Rheum Dis (2006) 0.94
Apoptotic death of neurons exhibiting peripherin aggregates is mediated by the proinflammatory cytokine tumor necrosis factor-alpha. J Cell Biol (2001) 0.92
Microglial cell dysregulation in brain aging and neurodegeneration. Front Aging Neurosci (2015) 0.92
Transcriptional control of maladaptive and protective responses in alcoholics: a role of the NF-κB system. Brain Behav Immun (2010) 0.90
Neuroinflammation in the aging down syndrome brain; lessons from Alzheimer's disease. Curr Gerontol Geriatr Res (2012) 0.90
The characteristic long-term upregulation of hippocampal NF-κB complex in PTSD-like behavioral stress response is normalized by high-dose corticosterone and pyrrolidine dithiocarbamate administered immediately after exposure. Neuropsychopharmacology (2011) 0.88
Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system. Pharmacol Rev (2014) 0.87
Growing old with nuclear factor-kappaB. Cell Stress Chaperones (2002) 0.87
Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries. Bioorg Med Chem (2012) 0.87
Cocaine induces cell death and activates the transcription nuclear factor kappa-B in PC12 cells. Mol Brain (2009) 0.86
Tumor necrosis factor-alpha potentiates intraneuronal Ca2+ signaling via regulation of the inositol 1,4,5-trisphosphate receptor. J Biol Chem (2008) 0.86
FKBP51 protects 661w cell culture from staurosporine-induced apoptosis. Mol Vis (2011) 0.86
Inflammation and clinical presentation in neurodegenerative disease: a volatile relationship. Neurocase (2012) 0.86
Secret talk between adipose tissue and central nervous system via secreted factors-an emerging frontier in the neurodegenerative research. J Neuroinflammation (2016) 0.86
Strain dependent effects of prenatal stress on gene expression in the rat hippocampus. Physiol Behav (2011) 0.85
Vascular consequences of passive Abeta immunization for Alzheimer's disease. Is avoidance of "malactivation" of microglia enough? J Neuroinflammation (2005) 0.85
Reduced basal and lipopolysaccharide-stimulated adenosine A1 receptor expression in the brain of nuclear factor-kappaB p50-/- mice. Neuroscience (2007) 0.85
Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death. Cell Death Dis (2015) 0.85
The emergence of proteinase-activated receptor-2 as a novel target for the treatment of inflammation-related CNS disorders. J Physiol (2007) 0.84
HIV Associated Neurocognitive Disorders. Infect Dis Rep (2013) 0.84
Ischemic preconditioning mediates cyclooxygenase-2 expression via nuclear factor-kappa B activation in mixed cortical neuronal cultures. Transl Stroke Res (2010) 0.84
Help-me signaling: Non-cell autonomous mechanisms of neuroprotection and neurorecovery. Prog Neurobiol (2016) 0.83
Alteration of NF-kappaB activity leads to mitochondrial apoptosis after infection with pathological prion protein. Cell Microbiol (2007) 0.83
Anti-inflammatory Activity of 1-docosanoyl Cafferate Isolated from Rhus verniciflua in LPS-stimulated BV2 Microglial Cells. Korean J Physiol Pharmacol (2011) 0.83
3,6'-dithiothalidomide improves experimental stroke outcome by suppressing neuroinflammation. J Neurosci Res (2013) 0.83
Chronic neuron- and age-selective down-regulation of TNF receptor expression in triple-transgenic Alzheimer disease mice leads to significant modulation of amyloid- and Tau-related pathologies. Am J Pathol (2013) 0.82
Effect of activation of canonical Wnt signaling by the Wnt-3a protein on the susceptibility of PC12 cells to oxidative and apoptotic insults. Braz J Med Biol Res (2011) 0.81
Trophic factors and stem cells for promoting recovery in stroke. J Vasc Interv Neurol (2010) 0.81
TNF-α/NF-κB signaling in the CNS: possible connection to EPHB2. J Neuroimmune Pharmacol (2013) 0.81
Acetylcholineestarase-inhibiting alkaloids from Lycoris radiata delay paralysis of amyloid beta-expressing transgenic C. elegans CL4176. PLoS One (2013) 0.80
RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-κB signaling in dopaminergic cells. Neurobiol Dis (2013) 0.80
Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus. BMC Genomics (2013) 0.79
Glimepiride reduces CD14 expression and cytokine secretion from macrophages. J Neuroinflammation (2014) 0.79
Increased expression of the homologue of enhancer-of-split 1 protects neurons from beta amyloid neurotoxicity and hints at an alternative role for transforming growth factor beta1 as a neuroprotector. Alzheimers Res Ther (2012) 0.78
NF-κB protects human neuroblastoma cells from nitric oxide-induced apoptosis through upregulating biglycan. Am J Transl Res (2015) 0.78
Alzheimer's disease and brain development: common molecular pathways. Front Biosci (1998) 0.78
Changes in TNFα, NFκB and MnSOD protein in the vestibular nuclei after unilateral vestibular deafferentation. J Neuroinflammation (2010) 0.77
Nuclear factor-kappaB to the rescue of cytokine-induced neuronal survival. J Cell Biol (2000) 0.77
Cerebrospinal fluid levels of inflammation, oxidative stress and NAD+ are linked to differences in plasma carotenoid concentrations. J Neuroinflammation (2014) 0.77
Metaflammasome components in the human brain: a role in dementia with alzheimer's pathology? Brain Pathol (2016) 0.76
CX3CL1/CX3CR1 in Alzheimer's Disease: A Target for Neuroprotection. Biomed Res Int (2016) 0.75
Attenuation of microglial activation in a mouse model of Alzheimer's disease via NFAT inhibition. J Neuroinflammation (2015) 0.75
Cytokine/neurotrophin interaction in the aged central nervous system. J Anat (2000) 0.75
Heparan sulfate proteoglycan induces the production of NO and TNF-alpha by murine microglia. Immun Ageing (2005) 0.75
Amyloid Beta, TNFα and FAIM-L; Approaching New Therapeutic Strategies for AD. Front Neurol (2014) 0.75
Astrocyte mediated MMP-9 activation in the synapse dysfunction: An implication in Alzheimer disease. Ther Targets Neurol Dis (2015) 0.75
Influence of the dopaminergic system, CREB, and transcription factor-κB on cocaine neurotoxicity. Braz J Med Biol Res (2013) 0.75
Neurodegeneration and neuroinflammation: two processes, one target. Neural Regen Res (2015) 0.75
Cytokines and Cytokine Receptors Involved in the Pathogenesis of Alzheimer's Disease. J Clin Cell Immunol (2016) 0.75
The Effects of Melilotus officinalis Extract on Expression of Daxx, Nfkb and Vegf Genes in the Streptozotocin-Induced Rat Model of Sporadic Alzheimer's Disease. Avicenna J Med Biotechnol (2017) 0.75
Streptococcal infection and immune response in children with Tourette's syndrome. Childs Nerv Syst (2015) 0.75
The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell (1994) 9.25
Oxidative stress, glutamate, and neurodegenerative disorders. Science (1993) 7.96
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci U S A (1989) 5.97
Hydrogen peroxide mediates amyloid beta protein toxicity. Cell (1994) 5.19
Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radic Res Commun (1992) 4.45
Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature (1995) 4.18
beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci (1992) 4.10
The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell (1994) 3.91
Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc Natl Acad Sci U S A (1991) 3.76
Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia (1993) 2.51
Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. Proc Natl Acad Sci U S A (1989) 2.48
A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. Proc Natl Acad Sci U S A (1994) 2.39
Tumor necrosis factor-alpha expression in ischemic neurons. Stroke (1994) 2.37
Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res (1990) 2.26
Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis. Neuron (1994) 2.09
The I kappa B proteins: members of a multifunctional family. Trends Genet (1993) 1.96
Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF. Brain Res (1993) 1.74
Elevated circulating tumor necrosis factor levels in Alzheimer's disease. Neurosci Lett (1991) 1.63
Calcium, free radicals, and excitotoxic neuronal death in primary cell culture. Methods Cell Biol (1995) 1.61
S100 beta protein expression in Alzheimer disease: potential role in the pathogenesis of neuritic plaques. J Neurosci Res (1994) 1.52
Closed head injury triggers early production of TNF alpha and IL-6 by brain tissue. J Cereb Blood Flow Metab (1994) 1.49
A serine/threonine kinase activity is closely associated with a 65-kDa phosphoprotein specifically recognized by the kappa B enhancer element. J Biol Chem (1991) 1.46
Increased S100 beta neurotrophic activity in Alzheimer's disease temporal lobe. Neurobiol Aging (1992) 1.39
Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury. Exp Neurol (1994) 1.38
Nordihydroguaiaretic acid protects hippocampal neurons against amyloid beta-peptide toxicity, and attenuates free radical and calcium accumulation. Brain Res (1994) 1.31
Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1. Neuron (1995) 1.28
Neuroprotective role of IL-4 against activated microglia. J Immunol (1993) 1.26
Transforming growth factor-beta 1 prevents glutamate neurotoxicity in rat neocortical cultures and protects mouse neocortex from ischemic injury in vivo. J Cereb Blood Flow Metab (1993) 1.20
Inflammatory mechanisms in Alzheimer's disease: implications for therapy. Am J Psychiatry (1994) 1.19
Beta-amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease. Brain Res (1992) 1.16
Neurotoxic effects of tumor necrosis factor alpha in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: implications for AIDS neuropathogenesis. Dev Neurosci (1993) 1.10
Localization of TNF alpha and IL-1 alpha immunoreactivities in striatal neurons after surgical injury to the hippocampus. Neuron (1993) 1.00
Tumor necrosis factor facilitates regeneration of injured central nervous system axons. Brain Res (1991) 0.99
Correlation of cytokine secretion by mononuclear cells of Alzheimer patients and their disease stage. J Neuroimmunol (1994) 0.93
Protein oxidation in aging brain. Ann N Y Acad Sci (1992) 0.91
The Rel family of proteins in oncogenesis and differentiation. Semin Cancer Biol (1994) 0.89
Induction of manganese superoxide dismutase by cytokines and lipopolysaccharide in cultured mouse astrocytes. J Neurochem (1994) 0.87
Effect of chlorine substitution on the bacterial metabolism of various polychlorinated biphenyls. Appl Environ Microbiol (1979) 6.33
Cloning of a gene cluster encoding biphenyl and chlorobiphenyl degradation in Pseudomonas pseudoalcaligenes. J Bacteriol (1986) 4.35
Analysis of bph operon from the polychlorinated biphenyl-degrading strain of Pseudomonas pseudoalcaligenes KF707. J Biol Chem (1992) 3.96
Involvement of plasmids in total degradation of chlorinated biphenyls. Appl Environ Microbiol (1982) 3.51
Genetic transformation of the extreme thermophile Thermus thermophilus and of other Thermus spp. J Bacteriol (1986) 3.16
Microbial metabolism of polychlorinated biphenyls. Studies on the relative degradability of polychlorinated biphenyl components by Alkaligenes sp. J Agric Food Chem (1976) 2.88
Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med (1996) 2.74
Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J Neurosci (1998) 2.65
A hierarchical neural-network model for control and learning of voluntary movement. Biol Cybern (1987) 2.52
AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation. J Mol Neurosci (2001) 2.51
Common induction and regulation of biphenyl, xylene/toluene, and salicylate catabolism in Pseudomonas paucimobilis. J Bacteriol (1983) 2.46
Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults. Ann Neurol (1999) 2.42
A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. Proc Natl Acad Sci U S A (1994) 2.39
Cloning and nucleotide sequence of the 2,3-dihydroxybiphenyl dioxygenase gene from the PCB-degrading strain of Pseudomonas paucimobilis Q1. Biochemistry (1988) 2.34
Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease. Nat Med (1998) 2.30
Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice. J Cell Biol (2000) 2.26
Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nat Med (1999) 2.25
Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci (2000) 2.21
HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress. Exp Neurol (1998) 2.14
Diastolic paradoxic jet flow in patients with hypertrophic cardiomyopathy: evidence of concealed apical asynergy with cavity obliteration. J Am Coll Cardiol (1992) 2.12
Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system. Proc Natl Acad Sci U S A (1996) 2.10
Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis. Neuron (1994) 2.09
Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons. J Neurochem (1996) 2.06
Stent placement for recurrent vasospastic angina resistant to medical treatment. Cathet Cardiovasc Diagn (1997) 2.05
Nucleotide sequence of the 2,3-dihydroxybiphenyl dioxygenase gene of Pseudomonas pseudoalcaligenes. J Bacteriol (1987) 1.99
Pseudomonas putida KF715 bphABCD operon encoding biphenyl and polychlorinated biphenyl degradation: cloning, analysis, and expression in soil bacteria. J Bacteriol (1990) 1.97
The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis. Exp Neurol (1999) 1.95
Nucleotide sequence of the tetracycline resistance gene of pTHT15, a thermophilic Bacillus plasmid: comparison with staphylococcal TcR controls. Gene (1985) 1.95
Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. J Neurosci Res (1999) 1.94
Stem cells and aging: expanding the possibilities. Mech Ageing Dev (2001) 1.89
Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation. Science (1999) 1.88
Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells. J Neurosci Res (1998) 1.82
Evidence for the involvement of TNF and NF-kappaB in hippocampal synaptic plasticity. Synapse (2000) 1.82
Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J Neurosci (1997) 1.81
Metabolic breakdown of Kaneclors (polychlorobiphenyls) and their products by Acinetobacter sp. Appl Environ Microbiol (1983) 1.81
Caspase and calpain substrates: roles in synaptic plasticity and cell death. J Neurosci Res (1999) 1.80
Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals. J Neurosci (1997) 1.80
Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons. J Biol Chem (2000) 1.79
Energetics of RNA cleavage: implications for the mechanism of action of ribozymes. Protein Eng (1990) 1.79
Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation. J Neurosci (1997) 1.79
A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide. J Neurochem (1997) 1.79
Enhanced degradation of polychlorinated biphenyls by directed evolution of biphenyl dioxygenase. Nat Biotechnol (1998) 1.71
Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: evidence for a preconditioning mechanism. J Neurosci Res (1999) 1.70
Calcium regulation of the neuronal growth cone. Trends Neurosci (1988) 1.67
Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain. J Neurochem (1996) 1.66
Dysregulation of sphingolipid and sterol metabolism by ApoE4 in HIV dementia. Neurology (2004) 1.66
Cloning and nucleotide sequences of histidase and regulatory genes in the Bacillus subtilis hut operon and positive regulation of the operon. J Bacteriol (1988) 1.66
HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity. J Neurochem (2001) 1.64
Associative and predictive biomarkers of dementia in HIV-1-infected patients. Neurology (2007) 1.62
Prognostic factors after hepatectomy for hepatocellular carcinomas. A univariate and multivariate analysis. Cancer (1990) 1.61
The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women. Int J Obes (Lond) (2010) 1.61
Expression and function of the leucine zipper protein Par-4 in apoptosis. Mol Cell Biol (1997) 1.59
Paroxysmal nocturnal haemoglobinuria clones in patients with myelodysplastic syndromes. Br J Haematol (1998) 1.58
Functional analyses of a variety of chimeric dioxygenases constructed from two biphenyl dioxygenases that are similar structurally but different functionally. J Bacteriol (1997) 1.58
A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. J Neurochem (2001) 1.58
Exacerbation of damage and altered NF-kappaB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury. J Neurosci (1999) 1.55
Recent trends in the incidence and lifetime risk of hip fracture in Tottori, Japan. Osteoporos Int (2008) 1.55
Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway. Oncogene (2000) 1.54
Purification and properties of 2,3-dihydroxybiphenyl dioxygenase from polychlorinated biphenyl-degrading Pseudomonas pseudoalcaligenes and Pseudomonas aeruginosa carrying the cloned bphC gene. J Bacteriol (1987) 1.54
Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. J Neurosci Res (1997) 1.54
Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats. J Mol Neurosci (2000) 1.54
Anti-apoptotic role of telomerase in pheochromocytoma cells. J Biol Chem (1999) 1.53
A tombstone in Alzheimer's? Nature (1995) 1.52
Neuroprotective effects of Ginkgo biloba extract. Cell Mol Life Sci (2003) 1.52
Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal. J Neurochem (1997) 1.51
Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons. J Neurochem (1995) 1.51
Growth retardation and early death of beta-1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells. EMBO J (1997) 1.50
Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo. J Neurosci Res (1998) 1.50
Effect of intravenous omega-6 and omega-3 fat emulsions on nitrogen retention and protein kinetics in burned rats. Nutrition (1999) 1.50
Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide. Neuroreport (1996) 1.48
Coronary endothelial damage during off-pump CABG related to coronary-clamping and gas insufflation. Eur J Cardiothorac Surg (2001) 1.48
Dynamics of normal and injured human liver regeneration after hepatectomy as assessed on the basis of computed tomography and liver function. Hepatology (1993) 1.48
Regulation of the cardiac ryanodine receptor by protein kinase-dependent phosphorylation. J Biochem (1991) 1.48
Ischemic and excitotoxic brain injury is enhanced in mice lacking the p55 tumor necrosis factor receptor. J Cereb Blood Flow Metab (1998) 1.47
Difference in direct charge-parity violation between charged and neutral B meson decays. Nature (2008) 1.46
A 90-kilobase conjugative chromosomal element coding for biphenyl and salicylate catabolism in Pseudomonas putida KF715. J Bacteriol (2000) 1.45
Antiinflammatory effects of estrogen on microglial activation. Endocrinology (2000) 1.44
Construction of hybrid biphenyl (bph) and toluene (tod) genes for functional analysis of aromatic ring dioxygenases. Gene (1994) 1.42
Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death. J Neurosci (1995) 1.40
Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice. J Neurochem (1999) 1.39
Estrogen protects against the synergistic toxicity by HIV proteins, methamphetamine and cocaine. BMC Neurosci (2001) 1.39
The transcription factor NF-kappaB mediates increases in calcium currents and decreases in NMDA- and AMPA/kainate-induced currents induced by tumor necrosis factor-alpha in hippocampal neurons. J Neurochem (1998) 1.38
Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury. Exp Neurol (1994) 1.38
Neuroprotective effects of gelsolin during murine stroke. J Clin Invest (1999) 1.38
Analysis of the transcriptional activity of the hut promoter in Bacillus subtilis and identification of a cis-acting regulatory region associated with catabolite repression downstream from the site of transcription. Mol Microbiol (1992) 1.37
Antecedent infections in Fisher syndrome: a common pathogenesis of molecular mimicry. Neurology (2005) 1.37
Expression of Lewisa, Lewisb, X, and Y blood group antigens in human colonic tumors and normal tissue and in human tumor-derived cell lines. Cancer Res (1986) 1.36
Impaired mitochondrial function, oxidative stress and altered antioxidant enzyme activities following traumatic spinal cord injury. Brain Res (1997) 1.35
Vasodilating actions of 2-nicotinamidoethyl nitrate on porcine and guinea-pig coronary arteries. J Pharmacol Exp Ther (1981) 1.35
Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function. Proc Natl Acad Sci U S A (1998) 1.34
Effects of 2-nicotinamidoethyl nitrate on smooth muscle cells and on adrenergic transmission in the guinea-pig and porcine mesenteric arteries. J Pharmacol Exp Ther (1981) 1.32
Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein. Nature (1996) 1.32
Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody. Proc Natl Acad Sci U S A (1994) 1.32
Astrocytic gap junctional communication decreases neuronal vulnerability to oxidative stress-induced disruption of Ca2+ homeostasis and cell death. J Neurochem (1998) 1.32