Published in Int J Environ Res Public Health on July 20, 2011
Inflammation in neurodegenerative diseases--an update. Immunology (2014) 1.30
Microglia in the developing brain: a potential target with lifetime effects. Neurotoxicology (2012) 1.07
The role of MAC1 in diesel exhaust particle-induced microglial activation and loss of dopaminergic neuron function. J Neurochem (2013) 0.99
Chronic exposure to corticosterone enhances the neuroinflammatory and neurotoxic responses to methamphetamine. J Neurochem (2012) 0.98
Oxidative stress and microglial cells in Parkinson's disease. Mediators Inflamm (2012) 0.96
Neurotoxicants are in the air: convergence of human, animal, and in vitro studies on the effects of air pollution on the brain. Biomed Res Int (2014) 0.95
Conditional Tat protein expression in the GT-tg bigenic mouse brain induces gray matter density reductions. Prog Neuropsychopharmacol Biol Psychiatry (2012) 0.89
Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus. J Neuroinflammation (2012) 0.89
HIV-1 Tat C-mediated regulation of tumor necrosis factor receptor-associated factor-3 by microRNA 32 in human microglia. J Neuroinflammation (2012) 0.89
JNK and NADPH oxidase involved in fluoride-induced oxidative stress in BV-2 microglia cells. Mediators Inflamm (2013) 0.86
Neuronal cellular responses to extremely low frequency electromagnetic field exposure: implications regarding oxidative stress and neurodegeneration. PLoS One (2014) 0.85
Adenosine A2A receptor deficiency up-regulates cystatin F expression in white matter lesions induced by chronic cerebral hypoperfusion. PLoS One (2012) 0.84
CX3CL1 (fractalkine) protein expression in normal and degenerating mouse retina: in vivo studies. PLoS One (2014) 0.84
Intrastriatal convection-enhanced delivery results in widespread perivascular distribution in a pre-clinical model. Fluids Barriers CNS (2012) 0.83
Microglial disruption in young mice with early chronic lead exposure. Toxicol Lett (2013) 0.82
Coordinated gene expression of neuroinflammatory and cell signaling markers in dorsolateral prefrontal cortex during human brain development and aging. PLoS One (2014) 0.81
Neuroprotective effects of cuscutae semen in a mouse model of Parkinson's disease. Evid Based Complement Alternat Med (2014) 0.80
Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction. Mediators Inflamm (2015) 0.80
Nanoscale Particulate Matter from Urban Traffic Rapidly Induces Oxidative Stress and Inflammation in Olfactory Epithelium with Concomitant Effects on Brain. Environ Health Perspect (2016) 0.79
Hydroxysafflor Yellow A Attenuates Neuron Damage by Suppressing the Lipopolysaccharide-Induced TLR4 Pathway in Activated Microglial Cells. Cell Mol Neurobiol (2016) 0.79
Dynamic microglial modulation of spatial learning and social behavior. Brain Behav Immun (2015) 0.79
Gene expression profiling as a tool to investigate the molecular machinery activated during hippocampal neurodegeneration induced by trimethyltin (TMT) administration. Int J Mol Sci (2013) 0.79
Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure. J Neuroinflammation (2015) 0.78
Microglia mediate diesel exhaust particle-induced cerebellar neuronal toxicity through neuroinflammatory mechanisms. Neurotoxicology (2016) 0.76
Delayed administration of alpha-difluoromethylornithine prevents hippocampus-dependent cognitive impairment after single and combined injury in mice. Radiat Res (2014) 0.76
Glial cell response to 3,4-(+/-)-methylenedioxymethamphetamine and its metabolites. Toxicol Sci (2013) 0.76
Autism, Mitochondria and Polybrominated Diphenyl Ether Exposure. CNS Neurol Disord Drug Targets (2016) 0.76
Culturing microglia from the neonatal and adult central nervous system. J Vis Exp (2013) 0.76
Bee venom phospholipase A2 ameliorates motor dysfunction and modulates microglia activation in Parkinson's disease alpha-synuclein transgenic mice. Exp Mol Med (2016) 0.75
Hijacking microglial glutathione by inorganic arsenic impels bystander death of immature neurons through extracellular cystine/glutamate imbalance. Sci Rep (2016) 0.75
Antibacterial, Anti-Inflammatory, Antioxidant, and Antiproliferative Properties of Essential Oils from Hairy and Normal Roots of Leonurus sibiricus L. and Their Chemical Composition. Oxid Med Cell Longev (2017) 0.75
Perinatal asphyxia leads to PARP-1 overactivity, p65 translocation, IL-1β and TNF-α overexpression, and apoptotic-like cell death in mesencephalon of neonatal rats: prevention by systemic neonatal nicotinamide administration. Neurotox Res (2015) 0.75
Absence of Cytotoxicity towards Microglia of Iron Oxide (α-Fe2O3) Nanorhombohedra. Toxicol Res (Camb) (2016) 0.75
Benfotiamine upregulates antioxidative system in activated BV-2 microglia cells. Front Cell Neurosci (2015) 0.75
The Plant-Derived Chalcone 2,2',5'-Trihydroxychalcone Provides Neuroprotection against Toll-Like Receptor 4 Triggered Inflammation in Microglia. Oxid Med Cell Longev (2015) 0.75
Role of p53, Mitochondrial DNA Deletions, and Paternal Age in Autism: A Case-Control Study. Pediatrics (2016) 0.75
Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain. Toxicology (2016) 0.75
Role of nitric oxide in developmental biology in plants, bacteria, and man. Curr Top Pharmacol (2011) 0.75
Neuropeptide Y protects cerebral cortical neurons by regulating microglial immune function. Neural Regen Res (2014) 0.75
Homocysteine exaggerates microglia activation and neuroinflammation through microglia localized STAT3 overactivation following ischemic stroke. J Neuroinflammation (2017) 0.75
Neuroprotective and Anti-Inflammatory Activities of Allyl Isothiocyanate through Attenuation of JNK/NF-κB/TNF-α Signaling. Int J Mol Sci (2017) 0.75
Fluoride Induces Neuroinflammation and Alters Wnt Signaling Pathway in BV2 Microglial Cells. Inflammation (2017) 0.75
Pathogen recognition and innate immunity. Cell (2006) 44.14
Free radicals in the physiological control of cell function. Physiol Rev (2002) 19.62
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science (2005) 14.43
NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol (2004) 12.93
Inflammation and Alzheimer's disease. Neurobiol Aging (2000) 12.56
Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science (2010) 12.15
Microglia: a sensor for pathological events in the CNS. Trends Neurosci (1996) 12.00
Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J (1991) 11.86
ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci (2005) 11.55
Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci (2007) 11.11
The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol (2008) 10.39
The classical complement cascade mediates CNS synapse elimination. Cell (2007) 9.06
Mechanisms underlying inflammation in neurodegeneration. Cell (2010) 7.66
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci (2007) 7.42
Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature (2008) 6.89
Microglial physiology: unique stimuli, specialized responses. Annu Rev Immunol (2009) 6.79
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions. Nat Neurosci (2007) 6.23
Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat Med (2006) 6.15
Identification of Tim4 as a phosphatidylserine receptor. Nature (2007) 6.06
Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat Med (2007) 5.87
Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J Biol Chem (1992) 5.60
Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science (1988) 5.56
Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proc Natl Acad Sci U S A (2003) 5.11
Neuroinflammation in Parkinson's disease: a target for neuroprotection? Lancet Neurol (2009) 4.88
Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J Neurosci (2009) 4.83
Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation (2005) 4.71
A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell (2009) 4.60
Immune function of microglia. Glia (2001) 4.59
Microglia as a source and target of cytokines. Glia (2002) 4.48
Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nat Med (2005) 4.43
Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science (2000) 4.41
Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci (2002) 4.38
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nat Rev Neurosci (2009) 3.97
Microglia as mediators of inflammatory and degenerative diseases. Annu Rev Neurosci (1999) 3.90
UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Nature (2007) 3.78
Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. J Biol Chem (1992) 3.64
Microglial interactions with synapses are modulated by visual experience. PLoS Biol (2010) 3.59
Regulation of Toll-like receptors in human monocytes and dendritic cells. J Immunol (2001) 3.45
Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J Exp Med (2005) 3.42
Microglia promote the death of developing Purkinje cells. Neuron (2004) 3.42
Regulation of innate immune responses in the brain. Nat Rev Immunol (2009) 3.41
Manganism and idiopathic parkinsonism: similarities and differences. Neurology (1994) 3.34
Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature (2009) 3.33
TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J Neuroinflammation (2008) 3.19
Inflammation, immunoregulation, and inducible nitric oxide synthase. J Leukoc Biol (1993) 3.07
What is immune privilege (not)? Trends Immunol (2006) 3.02
Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proc Natl Acad Sci U S A (2001) 2.95
TLR signaling tailors innate immune responses in human microglia and astrocytes. J Immunol (2005) 2.94
NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. J Biol Chem (2003) 2.92
Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat Neurosci (2009) 2.85
Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat. Neurobiol Dis (2002) 2.83
Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity. Nat Rev Neurosci (2007) 2.77
Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice. J Neurosci (2009) 2.76
Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med (1996) 2.74
CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation. J Neurosci (2009) 2.69
Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations. Am J Physiol Regul Integr Comp Physiol (2004) 2.61
Inflammatory mechanisms after ischemia and stroke. J Neuropathol Exp Neurol (2003) 2.57
NADPH oxidases of the brain: distribution, regulation, and function. Antioxid Redox Signal (2006) 2.56
Neuronal 'On' and 'Off' signals control microglia. Trends Neurosci (2007) 2.55
Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J Immunol (1993) 2.53
Microglia: biology and pathology. Acta Neuropathol (2009) 2.51
CD200 and membrane protein interactions in the control of myeloid cells. Trends Immunol (2002) 2.45
Inflammatory neurodegeneration and mechanisms of microglial killing of neurons. Mol Neurobiol (2010) 2.43
Activation of protein kinase C by tyrosine phosphorylation in response to H2O2. Proc Natl Acad Sci U S A (1997) 2.42
Studies on the pathogenesis of atherosclerosis. I. Adhesion and emigration of mononuclear cells in the aorta of hypercholesterolemic rats. Am J Pathol (1983) 2.41
Air pollution, cognitive deficits and brain abnormalities: a pilot study with children and dogs. Brain Cogn (2008) 2.41
Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity. J Neurosci (2001) 2.40
Preferential expression and function of Toll-like receptor 3 in human astrocytes. J Neuroimmunol (2004) 2.39
Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. J Immunol (2003) 2.38
Toll-like receptors; their physiological role and signal transduction system. Int Immunopharmacol (2001) 2.36
The origin and cell lineage of microglia: new concepts. Brain Res Rev (2006) 2.36
Assessing activation states in microglia. CNS Neurol Disord Drug Targets (2010) 2.29
Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats. Environ Health Perspect (2001) 2.28
Mature microglia resemble immature antigen-presenting cells. Glia (1998) 2.28
Air pollution and brain damage. Toxicol Pathol (2002) 2.27
Particulate matter in polluted air may increase biomarkers of inflammation in mouse brain. Neurotoxicology (2005) 2.25
Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation. Proc Natl Acad Sci U S A (1995) 2.24
The microglial "activation" continuum: from innate to adaptive responses. J Neuroinflammation (2005) 2.23
The role of microglia in amyloid clearance from the AD brain. J Neural Transm (Vienna) (2010) 2.21
Microglial phenotype: is the commitment reversible? Trends Neurosci (2006) 2.18
Manganese: recent advances in understanding its transport and neurotoxicity. Toxicol Appl Pharmacol (2007) 2.17
The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. J Exp Med (2007) 2.16
Localizing central nervous system immune surveillance: meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis. Ann Neurol (2009) 2.15
Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease. Cell Physiol Biochem (2007) 2.12
Microglia potentiate damage to blood-brain barrier constituents: improvement by minocycline in vivo and in vitro. Stroke (2006) 2.11
Inflammation and the degenerative diseases of aging. Ann N Y Acad Sci (2004) 2.11
Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis. Neuron (1994) 2.09
Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis. J Neuroimmunol (2007) 2.08
The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease. J Neurosci (2000) 2.07
The promise of minocycline in neurology. Lancet Neurol (2004) 2.06
Cultured astrocytes express toll-like receptors for bacterial products. Glia (2003) 2.01
Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia. FASEB J (2004) 2.00
Manganese neurotoxicity: a review of clinical features, imaging and pathology. Neurotoxicology (1999) 1.97
A new concept in neurodegeneration: TNFalpha is a silencer of survival signals. Trends Neurosci (2000) 1.93
Microglial senescence: does the brain's immune system have an expiration date? Trends Neurosci (2006) 1.93
Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc Natl Acad Sci U S A (2006) 1.92
The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. J Exp Med (2004) 1.90
P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease. J Biol Chem (2003) 1.87
Rat brain arachidonic acid metabolism is increased by a 6-day intracerebral ventricular infusion of bacterial lipopolysaccharide. J Neurochem (2004) 1.33
IGF-1 and pAKT signaling promote hippocampal CA1 neuronal survival following injury to dentate granule cells. Neurotox Res (2009) 0.98
G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator. J Biol Chem (2008) 0.98
Heterogeneity of microglia and TNF signaling as determinants for neuronal death or survival. Neurotoxicology (2009) 0.98
Retracted Imaging upregulated brain arachidonic acid metabolism in HIV-1 transgenic rats. J Cereb Blood Flow Metab (2010) 0.97
Ontogenetic alterations in molecular and structural correlates of dendritic growth after developmental exposure to polychlorinated biphenyls. Environ Health Perspect (2007) 0.94
Altered cerebellar development in nuclear receptor TAK1/ TR4 null mice is associated with deficits in GLAST(+) glia, alterations in social behavior, motor learning, startle reactivity, and microglia. Cerebellum (2010) 0.91
Isolation of rafts from mouse brain tissue by a detergent-free method. J Lipid Res (2008) 0.90
Lifespan profiles of Alzheimer's disease-associated genes and products in monkeys and mice. J Alzheimers Dis (2009) 0.89
Alterations in cyclin A, B, and D1 in mouse dentate gyrus following TMT-induced hippocampal damage. Neurotox Res (2003) 0.85
Molecular profiles of mRNA levels in laser capture microdissected murine hippocampal regions differentially responsive to TMT-induced cell death. J Neurochem (2005) 0.84
Regional protein levels of cytosolic phospholipase A2 and cyclooxygenase-2 in Rhesus monkey brain as a function of age. Brain Res Bull (2006) 0.83
Carbon monoxide neurotoxicity: transient inhibition of avoidance response and delayed microglia reaction in the absence of neuronal death. Toxicology (2003) 0.83
Co-localization and distribution of cerebral APP and SP1 and its relationship to amyloidogenesis. J Alzheimers Dis (2008) 0.83
Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeks. Toxicol Appl Pharmacol (2004) 0.82
Autotaxin downregulates LPS-induced microglia activation and pro-inflammatory cytokines production. J Cell Biochem (2014) 0.82
Interleukin-6 (IL-6) receptor/IL-6 fusion protein (Hyper IL-6) effects on the neonatal mouse brain: possible role for IL-6 trans-signaling in brain development and functional neurobehavioral outcomes. Brain Behav Immun (2012) 0.82
Injury-induced neurogenesis: consideration of resident microglia as supportive of neural progenitor cells. Neurotox Res (2010) 0.82
When human immunodeficiency virus meets chemokines and microglia: neuroprotection or neurodegeneration? J Neuroimmune Pharmacol (2012) 0.81
Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons. Neurobiol Aging (2011) 0.81
Diffuse white matter injury and neurologic outcomes of infants born very preterm in the 1990s. J Obstet Gynecol Neonatal Nurs (2007) 0.80
SDF-1α and LPA modulate microglia potassium channels through rho gtpases to regulate cell morphology. Glia (2013) 0.78
Lead-induced alterations of apoptosis and neurotrophic factor mRNA in the developing rat cortex, hippocampus, and cerebellum. J Biochem Mol Toxicol (2007) 0.77
Exposure to an organometal compound stimulates adipokine and cytokine expression in white adipose tissue. Cytokine (2010) 0.77
Neurobehavioral assessment of mice after developmental AZT exposure. Neurotoxicol Teratol (2004) 0.76
Bilateral common carotid artery ligation transiently changes brain lipid metabolism in rats. Neurochem Res (2012) 0.76
Environmental, occupational, and genetic risk factors for alpha-1 antitrypsin deficiency. Environ Health Perspect (2003) 0.75
Interdisciplinary neurotoxicity inhalation studies: carbon disulfide and carbonyl sulfide research in F344 rats. Toxicol Appl Pharmacol (2005) 0.75