Published in Bioessays on June 01, 1995
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DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science (2000) 7.85
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BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev (2000) 7.29
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Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science (1999) 6.93
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Mrc1 transduces signals of DNA replication stress to activate Rad53. Nat Cell Biol (2001) 5.05
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Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1. Science (1999) 4.65
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Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Nature (2000) 4.52
Inhibition of cyclin-dependent kinases by p21. Mol Biol Cell (1995) 4.48
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Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature (1996) 4.05
DUN1 encodes a protein kinase that controls the DNA damage response in yeast. Cell (1993) 3.90
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev (2000) 3.86
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A family of mammalian F-box proteins. Curr Biol (1999) 3.68
How the cyclin became a cyclin: regulated proteolysis in the cell cycle. Cell (1999) 3.34
SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. Mol Cell (1999) 3.19
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Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme. Proc Natl Acad Sci U S A (1994) 3.03
p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step. Genes Dev (1999) 2.58
Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination. Nat Genet (2000) 2.53
RAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae. Genes Dev (1996) 2.53
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Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae. Mol Cell Biol (1997) 2.46
Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development. Genes Dev (1998) 2.39
Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints. Cell (2001) 2.33
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Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15. Proc Natl Acad Sci U S A (1996) 2.17
Asf1 links Rad53 to control of chromatin assembly. Genes Dev (2001) 2.16
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PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system. J Cell Biol (1995) 2.05
Finding prospective partners in the library: the two-hybrid system and phage display find a match. Trends Biochem Sci (1995) 2.04
DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1999) 2.00
Hepatitis B virus X protein interacts with a probable cellular DNA repair protein. J Virol (1995) 1.95
Direct DNA binding by Brca1. Proc Natl Acad Sci U S A (2001) 1.94
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Isolation of crt mutants constitutive for transcription of the DNA damage inducible gene RNR3 in Saccharomyces cerevisiae. Genetics (1992) 1.84
The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing. J Cell Biol (1994) 1.80
New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res (1999) 1.68
The muc genes of pKM101 are induced by DNA damage. J Bacteriol (1983) 1.68
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Gene identification using the yeast two-hybrid system. Methods Enzymol (1997) 1.53
Oppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome. Genes Dev (1999) 1.51
Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53. FEBS Lett (1995) 1.49
Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function. Genes Dev (2001) 1.40
Human cyclin F. EMBO J (1994) 1.39
The Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit. Curr Biol (2000) 1.36
The role of Cdk7 in CAK function, a retro-retrospective. Genes Dev (1998) 1.34
G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts. Curr Biol (1998) 1.28
Gene targeting at the human CD4 locus by epitope addition. Genes Dev (1990) 1.27
The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment. J Bacteriol (1996) 1.27
Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells. Genetics (1997) 1.25
Ran-binding protein-1 is an essential component of the Ran/RCC1 molecular switch system in budding yeast. J Biol Chem (1995) 1.23
Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. Mol Cell Biol (1998) 1.22
Multiple genetic loci within 11p15 defined by Beckwith-Wiedemann syndrome rearrangement breakpoints and subchromosomal transferable fragments. Proc Natl Acad Sci U S A (1995) 1.19
Isolation of temperature-sensitive diphtheria toxins in yeast and their effects on Drosophila cells. Development (1992) 1.17
p53 sends nucleotides to repair DNA. Nature (2000) 1.16
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Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5. Oncogene (1996) 1.13
Interactions among vertebrate helix-loop-helix proteins in yeast using the two-hybrid system. J Biol Chem (1993) 1.11
A family of vectors that facilitate transposon and insertional mutagenesis of cloned genes in yeast. Yeast (1994) 1.08
PAT1, an evolutionarily conserved acetyltransferase homologue, is required for multiple steps in the cell cycle. Genes Cells (1996) 1.07
In vivo gene therapy with p53 or p21 adenovirus for prostate cancer. Cancer Res (1995) 1.04
Amplification of cyclin genes in colorectal carcinomas. Cancer Res (1993) 1.04
Rapid construction of recombinant DNA by the univector plasmid-fusion system. Methods Enzymol (2000) 1.03
Mitotic treasures in the nucleolus. Nature (1999) 0.99
Analysis of budding yeast kinases controlled by DNA damage. Methods Enzymol (1997) 0.95
The cellular chamber of doom. Sci Am (2001) 0.92
Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli. FEBS Lett (1994) 0.91
Purification and analysis of CIP/KIP proteins. Methods Enzymol (1997) 0.90