Published in Science on November 05, 1999
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev (2000) 11.49
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol (2001) 7.26
p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J Cell Biol (2000) 7.26
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Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function. Genes Dev (2001) 1.40
Spontaneous chromosome loss in Saccharomyces cerevisiae is suppressed by DNA damage checkpoint functions. Genetics (2001) 1.38
Direct kinase-to-kinase signaling mediated by the FHA phosphoprotein recognition domain of the Dun1 DNA damage checkpoint kinase. Mol Cell Biol (2003) 1.37
Roles of Chk1 in cell biology and cancer therapy. Int J Cancer (2013) 1.37
Mec1 and Rad53 inhibit formation of single-stranded DNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants. Genetics (2004) 1.36
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Chromatin assembly factors Asf1 and CAF-1 have overlapping roles in deactivating the DNA damage checkpoint when DNA repair is complete. Proc Natl Acad Sci U S A (2009) 1.25
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The F-box protein Dia2 regulates DNA replication. Mol Biol Cell (2006) 1.21
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Mitotic CDKs control the metaphase-anaphase transition and trigger spindle elongation. Genes Dev (2008) 1.16
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Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage. Mol Biol Cell (2005) 1.11
DNA damage checkpoints inhibit mitotic exit by two different mechanisms. Mol Cell Biol (2007) 1.10
Condensin function at centromere chromatin facilitates proper kinetochore tension and ensures correct mitotic segregation of sister chromatids. Genes Cells (2007) 1.09
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Functions of the DNA damage response pathway target Ho endonuclease of yeast for degradation via the ubiquitin-26S proteasome system. Proc Natl Acad Sci U S A (2000) 1.05
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Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1. DNA Repair (Amst) (2007) 1.02
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