GPI-anchored influenza hemagglutinin induces hemifusion to both red blood cell and planar bilayer membranes.

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Published in J Cell Biol on November 01, 1995

Authors

G B Melikyan1, J M White, F S Cohen

Author Affiliations

1: Department of Molecular Biophysics and Physiology, Rush Medical College, Chicago, Illinois 60612, USA.

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Intracellular aspects of the process of protein synthesis. Science (1975) 25.21

Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution. Nature (1981) 24.17

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The structure and function of the hemagglutinin membrane glycoprotein of influenza virus. Annu Rev Biochem (1987) 11.99

A fluorescent complex between ethidium bromide and nucleic acids. Physical-chemical characterization. J Mol Biol (1967) 10.36

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Membrane fusion. Science (1992) 5.91

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Potocytosis: sequestration and transport of small molecules by caveolae. Science (1992) 4.94

Patch-clamp techniques for time-resolved capacitance measurements in single cells. Pflugers Arch (1988) 4.88

Sequestration of GPI-anchored proteins in caveolae triggered by cross-linking. Science (1994) 4.36

Membrane fusion activity of the influenza virus hemagglutinin. The low pH-induced conformational change. J Biol Chem (1985) 4.32

Energetics of intermediates in membrane fusion: comparison of stalk and inverted micellar intermediate mechanisms. Biophys J (1993) 3.82

Anti-peptide antibodies detect steps in a protein conformational change: low-pH activation of the influenza virus hemagglutinin. J Cell Biol (1987) 3.52

Activity-dependent fluorescent staining and destaining of living vertebrate motor nerve terminals. J Neurosci (1992) 3.45

Intermediates in influenza induced membrane fusion. EMBO J (1990) 3.24

Biomembrane fusion: a new concept derived from model studies using two interacting planar lipid bilayers. Biochim Biophys Acta (1987) 2.91

Restricted movement of lipid and aqueous dyes through pores formed by influenza hemagglutinin during cell fusion. J Cell Biol (1994) 2.87

Patch clamp studies of single cell-fusion events mediated by a viral fusion protein. Nature (1989) 2.83

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The hemifusion intermediate and its conversion to complete fusion: regulation by membrane composition. Biophys J (1995) 2.55

H+- and Ca2+-induced fusion and destabilization of liposomes. Biochemistry (1985) 2.44

Exocytosis. Annu Rev Physiol (1990) 2.42

Membrane fusion during secretion. A hypothesis based on electron microscope observation of Phytophthora Palmivora zoospores during encystment. J Cell Biol (1977) 2.32

Membrane flux through the pore formed by a fusogenic viral envelope protein during cell fusion. J Cell Biol (1993) 2.24

Proton pumps populate the contractile vacuoles of Dictyostelium amoebae. J Cell Biol (1993) 2.18

The HA2 subunit of influenza hemagglutinin inserts into the target membrane prior to fusion. J Biol Chem (1991) 2.07

Stalk mechanism of vesicle fusion. Intermixing of aqueous contents. Eur Biophys J (1989) 2.03

The influenza virus hemagglutinin cytoplasmic tail is not essential for virus assembly or infectivity. EMBO J (1994) 2.01

The exocytotic fusion pore modeled as a lipidic pore. Biophys J (1992) 1.99

Hydrophobic binding of the ectodomain of influenza hemagglutinin to membranes occurs through the "fusion peptide". J Biol Chem (1989) 1.96

GPI- and transmembrane-anchored influenza hemagglutinin differ in structure and receptor binding activity. J Cell Biol (1993) 1.78

Electron microscopy of antibody complexes of influenza virus haemagglutinin in the fusion pH conformation. EMBO J (1995) 1.74

Alterations to influenza virus hemagglutinin cytoplasmic tail modulate virus infectivity. J Virol (1992) 1.74

Kinetics of ultrastructural changes during electrically induced fusion of human erythrocytes. J Membr Biol (1986) 1.66

Membrane events involved in myoblast fusion. J Cell Biol (1979) 1.59

Role of hydrophobic forces in bilayer adhesion and fusion. Biochemistry (1992) 1.58

Permeability properties of phospholipid membranes: effect of cholesterol and temperature. Biochim Biophys Acta (1972) 1.56

Evidence for H(+)-induced insertion of influenza hemagglutinin HA2 N-terminal segment into viral membrane. J Biol Chem (1994) 1.44

Characteristics of self-quenching of the fluorescence of lipid-conjugated rhodamine in membranes. J Biol Chem (1990) 1.43

An architecture for the fusion site of influenza hemagglutinin. FEBS Lett (1990) 1.38

Tensions and free energies of formation of "solventless" lipid bilayers. Measurement of high contact angles. Biophys J (1983) 1.32

Delivery of macromolecules into cells expressing a viral membrane fusion protein. Methods Cell Biol (1989) 1.31

Influenza hemagglutinin-mediated fusion pores connecting cells to planar membranes: flickering to final expansion. J Gen Physiol (1993) 1.31

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Influenza virus hemagglutinin-induced cell-planar bilayer fusion: quantitative dissection of fusion pore kinetics into stages. J Gen Physiol (1993) 1.16

How to make a glycoinositol phospholipid anchor. Trends Biochem Sci (1992) 1.10

Asymmetric membranes resulting from the fusion of two black lipid bilayers. Biochim Biophys Acta (1974) 1.06

Divalent cation induced fusion and lipid lateral segregation in phosphatidylcholine-phosphatidic acid vesicles. Biochemistry (1986) 1.05

An osmotic model for the fusion of biological membranes. FEBS Lett (1986) 1.03

Movements of fluorescent probes in the mechanism of cell fusion induced by poly(ethylene glycol). J Cell Sci (1987) 0.99

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