Published in Immunol Today on June 01, 1995
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Role for ceramide in cell cycle arrest. J Biol Chem (1995) 1.83
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Role of ceramide in cellular senescence. J Biol Chem (1995) 1.74
Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J Biol Chem (2000) 1.73
Ceramide stimulates a cytosolic protein phosphatase. J Biol Chem (1992) 1.72
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Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid. J Biol Chem (1999) 1.63
Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. J Biol Chem (1993) 1.63
FADD is required for multiple signaling events downstream of the receptor Fas. Cell Growth Differ (1999) 1.62
Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc Natl Acad Sci U S A (1995) 1.62
The role of ceramide in cell signaling. Biochim Biophys Acta (1998) 1.59
Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha. J Biol Chem (1994) 1.55
Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proc Natl Acad Sci U S A (1996) 1.53
Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. Am J Pathol (1997) 1.52
Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. J Biol Chem (1998) 1.52
Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity. J Biol Chem (2000) 1.52
Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2. J Biol Chem (1997) 1.49
Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. J Biol Chem (1996) 1.49
Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. FASEB J (2001) 1.45
Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae. J Biol Chem (1993) 1.43
Quantitative determination of ceramide using diglyceride kinase. Methods Enzymol (2000) 1.41
Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem (1994) 1.40
Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide. J Biol Chem (2000) 1.39
Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. J Biol Chem (2001) 1.39
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Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C. Cell Signal (1995) 1.34
Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. J Biol Chem (1997) 1.33
Ceramide activates the stress-activated protein kinases. J Biol Chem (1995) 1.33
FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1. J Biol Chem (2001) 1.29
Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione. J Biol Chem (1997) 1.29
Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis. J Biol Chem (1997) 1.29
The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. Biochem J (1999) 1.27
Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B. J Biol Chem (1993) 1.27
Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. J Biol Chem (2000) 1.26
Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae. J Biol Chem (2000) 1.25
Regulation of protein kinase C and role in cancer biology. Cancer Metastasis Rev (1994) 1.25
Modulation of ceramide metabolism enhances viral protein apoptin's cytotoxicity in prostate cancer. Mol Ther (2006) 1.24
Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc Natl Acad Sci U S A (1995) 1.24
Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. J Biol Chem (2001) 1.24
Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha. J Biol Chem (1993) 1.23
Determination of ceramides and diglycerides by the diglyceride kinase assay. Anal Biochem (2001) 1.23
(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase. J Biol Chem (1996) 1.23
Protein kinase C activation in mixed micelles. Mechanistic implications of phospholipid, diacylglycerol, and calcium interdependencies. J Biol Chem (1986) 1.23
Ceramide: a stress signal and mediator of growth suppression and apoptosis. J Cell Biochem (1995) 1.23
The use of diglyceride kinase for quantifying ceramide. Trends Biochem Sci (1999) 1.20
Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. J Biol Chem (2001) 1.19
Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line. J Biol Chem (2001) 1.17
Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds. Biochemistry (1989) 1.16
Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle. J Biol Chem (1994) 1.16
Ceramide inactivates cellular protein kinase Calpha. J Biol Chem (1996) 1.16
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Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway. J Exp Med (1997) 1.15
Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors. J Biol Chem (1995) 1.14
Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae. J Biol Chem (2001) 1.12
Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem (1993) 1.12
Ceramide generation by two distinct pathways in tumor necrosis factor alpha-induced cell death. FEBS Lett (2001) 1.12
Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C. J Biol Chem (1999) 1.12
p53-dependent ceramide response to genotoxic stress. J Clin Invest (1998) 1.11
Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses. J Biol Chem (1999) 1.11
Inhibition of caspases inhibits the release of apoptotic bodies: Bcl-2 inhibits the initiation of formation of apoptotic bodies in chemotherapeutic agent-induced apoptosis. J Cell Biol (1999) 1.10
Role of ceramide in mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma cells. J Biol Chem (2001) 1.10