Published in J Biol Chem on May 02, 2001
The sphingolipid salvage pathway in ceramide metabolism and signaling. Cell Signal (2007) 2.16
Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. FASEB J (2008) 1.56
Roles of bioactive sphingolipids in cancer biology and therapeutics. Subcell Biochem (2008) 1.49
Ceramide starves cells to death by downregulating nutrient transporter proteins. Proc Natl Acad Sci U S A (2008) 1.46
Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK. PLoS One (2009) 1.42
Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. J Biol Chem (2007) 1.38
Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling. Mol Cancer (2010) 1.21
Ceramide accumulation precedes caspase-3 activation during apoptosis of A549 human lung adenocarcinoma cells. Am J Physiol Lung Cell Mol Physiol (2003) 1.20
A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis. PLoS One (2009) 1.11
Evolving concepts in cancer therapy through targeting sphingolipid metabolism. Biochim Biophys Acta (2013) 1.04
Sphingolipids and expression regulation of genes in cancer. Prog Lipid Res (2010) 1.02
Direct binding of glyceraldehyde 3-phosphate dehydrogenase to telomeric DNA protects telomeres against chemotherapy-induced rapid degradation. J Mol Biol (2009) 1.01
Glucosylceramide synthase, a factor in modulating drug resistance, is overexpressed in metastatic breast carcinoma. Int J Oncol (2011) 0.99
Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance. Adv Cancer Res (2013) 0.99
Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer. J Cancer Res Clin Oncol (2008) 0.96
Resveratrol antagonizes EGFR-dependent Erk1/2 activation in human androgen-independent prostate cancer cells with associated isozyme-selective PKC alpha inhibition. Invest New Drugs (2004) 0.95
Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells. J Biol Chem (2008) 0.95
Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation. J Cancer Res Clin Oncol (2011) 0.93
Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation. Biochim Biophys Acta (2009) 0.93
Ceramide signaling in cancer and stem cells. Future Lipidol (2008) 0.92
Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK. Cell Cycle (2008) 0.91
Ceramide induced mitophagy and tumor suppression. Biochim Biophys Acta (2015) 0.84
Senescent vs. non-senescent cells in the human annulus in vivo: cell harvest with laser capture microdissection and gene expression studies with microarray analysis. BMC Biotechnol (2010) 0.83
Rapid upregulation of telomerase activity in human leukemia HL-60 cells treated with clinical doses of the DNA-damaging drug etoposide. Leukemia (2002) 0.82
Lung cancer and lung injury: the dual role of ceramide. Handb Exp Pharmacol (2013) 0.81
C-6 Ceramide Induces p53 Dependent Apoptosis in Human Astrocytoma Grade4 (Glioblastoma Multiforme) Cells. J Cancer Sci Ther (2012) 0.76
Cancer risks from arsenic in drinking water. Environ Health Perspect (1992) 6.98
Programmed cell death induced by ceramide. Science (1993) 5.43
Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J Biol Chem (1986) 3.05
Ceramide in the eukaryotic stress response. Trends Cell Biol (2000) 2.98
Screening for tuberculosis in adults with advanced HIV infection prior to preventive therapy. Int J Tuberc Lung Dis (2004) 2.81
Ceramide activates heterotrimeric protein phosphatase 2A. J Biol Chem (1993) 2.77
An association between HIV-1 subtypes and mode of transmission in Cape Town, South Africa. AIDS (1997) 2.74
Chest radiograph reading and recording system: evaluation for tuberculosis screening in patients with advanced HIV. Int J Tuberc Lung Dis (2010) 2.60
Why is mortality higher in Scotland than in England and Wales? Decreasing influence of socioeconomic deprivation between 1981 and 2001 supports the existence of a 'Scottish Effect'. J Public Health (Oxf) (2005) 2.58
Role of phospholipase in generating lipid second messengers in signal transduction. FASEB J (1991) 2.56
Association between tuberculosis and HIV disease progression in a high tuberculosis prevalence area. Int J Tuberc Lung Dis (2001) 2.51
Biological activity of paramyxovirus fusion proteins: factors influencing formation of syncytia. J Virol (1992) 2.47
Earlier HIV diagnosis--are mobile services the answer? S Afr Med J (2010) 2.46
Enzymes of sphingolipid metabolism: from modular to integrative signaling. Biochemistry (2001) 2.39
Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J Biol Chem (1989) 2.32
Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. Science (1987) 2.29
Ceramide: an intracellular signal for apoptosis. Trends Biochem Sci (1995) 2.28
Ceramide and apoptosis. Trends Biochem Sci (1999) 2.19
Tuberculosis in HIV programmes in lower-income countries: practices and risk factors. Int J Tuberc Lung Dis (2011) 2.15
Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine. J Biol Chem (1985) 2.11
Teenage mothers and the health of their children. Popul Trends (1998) 2.01
Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem (1990) 1.99
Presurgical columellar elongation and primary retrograde nasal reconstruction in one-stage bilateral cleft lip and nose repair. Plast Reconstr Surg (1998) 1.97
Back pain in young athletes. Significant differences from adults in causes and patterns. Arch Pediatr Adolesc Med (1995) 1.91
Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J Biol Chem (1997) 1.88
Rehabilitation after severe brain injury: a follow-up study of a behaviour modification approach. J Neurol Neurosurg Psychiatry (1985) 1.85
Independent epidemics of heterosexual and homosexual HIV infection in South Africa--survival differences. QJM (1997) 1.84
Role for ceramide in cell cycle arrest. J Biol Chem (1995) 1.83
Antiretroviral therapy and the control of HIV-associated tuberculosis. Will ART do it? Int J Tuberc Lung Dis (2011) 1.76
Molecular cloning and characterization of a human mitochondrial ceramidase. J Biol Chem (2000) 1.76
Establishing a workplace antiretroviral therapy programme in South Africa. AIDS Care (2007) 1.75
Role of ceramide in cellular senescence. J Biol Chem (1995) 1.74
Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J Biol Chem (2000) 1.73
World-wide variation in HIV-1 phenotypic susceptibility in untreated individuals: biologically relevant values for resistance testing. AIDS (2001) 1.73
Ceramide stimulates a cytosolic protein phosphatase. J Biol Chem (1992) 1.72
Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans. Genes Dev (2001) 1.72
Management of the infected median sternotomy wound with muscle flaps. The Emory 20-year experience. Ann Surg (1997) 1.72
Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science (1994) 1.71
Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res (2001) 1.71
Tissue and cellular distribution of the extended family of protein kinase C isoenzymes. J Cell Biol (1992) 1.69
The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J Biol Chem (1997) 1.69
Diagnostic and prognostic value of serum C-reactive protein for screening for HIV-associated tuberculosis. Int J Tuberc Lung Dis (2013) 1.69
Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae. J Biol Chem (2000) 1.65
Initiating co-trimoxazole prophylaxis in HIV-infected patients in Africa: an evaluation of the provisional WHO/UNAIDS recommendations. AIDS (2001) 1.64
Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols. Proc Natl Acad Sci U S A (1986) 1.63
Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid. J Biol Chem (1999) 1.63
Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. J Biol Chem (1993) 1.63
FADD is required for multiple signaling events downstream of the receptor Fas. Cell Growth Differ (1999) 1.62
Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc Natl Acad Sci U S A (1995) 1.62
Diaphragmatic flutter presenting as inspiratory stridor. Chest (1995) 1.62
The role of ceramide in cell signaling. Biochim Biophys Acta (1998) 1.59
CD4 and total lymphocyte counts as predictors of HIV disease progression. QJM (1996) 1.58
HIV-1 subtypes in different risk groups in South Africa. Lancet (1995) 1.55
Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha. J Biol Chem (1994) 1.55
Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proc Natl Acad Sci U S A (1996) 1.53
Models of job-related stress and personal achievement among consultant doctors. Br J Psychol (1996) 1.53
Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. Am J Pathol (1997) 1.52
Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity. J Biol Chem (2000) 1.52
Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. J Biol Chem (1998) 1.52
Mental health and sexual risk behaviours in a South African township: a community-based cross-sectional study. Public Health (2006) 1.50
MCC, a candidate familial polyposis gene in 5q.21, shows frequent allele loss in colorectal and lung cancer. Oncogene (1991) 1.49
Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2. J Biol Chem (1997) 1.49
Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. J Biol Chem (1996) 1.49
A predominantly HIV type 1 subtype C-restricted epidemic in South African urban populations. AIDS Res Hum Retroviruses (1999) 1.49
When is now? Perception of simultaneity. Proc Biol Sci (2001) 1.46
Skinfold thickness measurements in obese subjects. Am J Clin Nutr (1990) 1.45
Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. FASEB J (2001) 1.45
Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae. J Biol Chem (1993) 1.43
Quantitative determination of ceramide using diglyceride kinase. Methods Enzymol (2000) 1.41
Ceramide: an endogenous regulator of apoptosis and growth suppression. Immunol Today (1995) 1.40
Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem (1994) 1.40
Alkyl and alk-1-enyl ethers of glycerol in lipids from normal and neoplastic human tissues. Cancer Res (1969) 1.39
Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide. J Biol Chem (2000) 1.39
Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. J Biol Chem (2001) 1.39
17-hydroxy progesterone caproate for preterm labor prevention: final blood levels. Am J Obstet Gynecol (2013) 1.38
Effect of perceived controllability and performance standards on self-regulation of complex decision making. J Pers Soc Psychol (1989) 1.38
Alpaca and llama nematodes in Britain. Vet Rec (2008) 1.38
The impact of human immunodeficiency virus (HIV) infection on quality of life in a multiracial South African population. Qual Life Res (1996) 1.37
Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. J Biol Chem (1986) 1.35
Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C. Cell Signal (1995) 1.34
Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. J Biol Chem (1997) 1.33
Outbreak of food poisoning caused by Bacillus cereus. Public Health Rep (1970) 1.33
Ceramide activates the stress-activated protein kinases. J Biol Chem (1995) 1.33
Evidence for distinct cytokine expression in allergic versus nonallergic chronic sinusitis. J Allergy Clin Immunol (1995) 1.33
Pulmonary tuberculosis in HIV infection: radiographic appearance is related to CD4+ T-lymphocyte count. Tuber Lung Dis (1995) 1.32
FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1. J Biol Chem (2001) 1.29
Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis. J Biol Chem (1997) 1.29
Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione. J Biol Chem (1997) 1.29