Published in J Biol Chem on September 15, 1995
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest (1996) 7.93
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J Clin Invest (1997) 6.16
Hypocholesterolemic effect of Nostoc commune var. sphaeroides Kützing, an edible blue-green alga. Eur J Nutr (2009) 1.50
Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol. Proc Natl Acad Sci U S A (1997) 1.46
Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins. Proc Natl Acad Sci U S A (1997) 1.28
Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines. Proc Natl Acad Sci U S A (1996) 1.15
Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites. Proc Natl Acad Sci U S A (2000) 1.08
A novel amplicon at 8p22-23 results in overexpression of cathepsin B in esophageal adenocarcinoma. Proc Natl Acad Sci U S A (1998) 1.03
Regulation of squalene synthase, a key enzyme of sterol biosynthesis, in tobacco. Plant Physiol (2002) 0.89
Regulation of cholesterol biosynthetic pathway in patients with the Smith-Lemli-Opitz syndrome. J Inherit Metab Dis (2000) 0.82
Molecular Analysis of a Recurrent Sarcoma Identifies a Mutation in FAF1. Sarcoma (2015) 0.81
Lipid deprivation increases surfactant phosphatidylcholine synthesis via a sterol-sensitive regulatory element within the CTP:phosphocholine cytidylyltransferase promoter. Biochem J (2002) 0.80
Effects of Long-Term Supplementation of Blue-Green Algae on Lipid Metabolism in C57BL/6J mice. J Nutrit Health Food Sci (2015) 0.77
Cloning and characterization of farnesyl diphosphate synthase gene involved in triterpenoids biosynthesis from Poria cocos. Int J Mol Sci (2014) 0.76
Hypolipidemic Effect of a Blue-Green Alga (Nostoc commune) Is Attributed to Its Nonlipid Fraction by Decreasing Intestinal Cholesterol Absorption in C57BL/6J Mice. J Med Food (2015) 0.75
PCR detection of human papillomavirus: comparison between MY09/MY11 and GP5+/GP6+ primer systems. J Clin Microbiol (1997) 5.76
Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages. Proc Natl Acad Sci U S A (1980) 4.66
A novel human opsin in the inner retina. J Neurosci (2000) 4.30
Melanopsin: An opsin in melanophores, brain, and eye. Proc Natl Acad Sci U S A (1998) 3.85
Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ (2001) 2.85
Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase. Mol Cell Biol (2001) 2.24
Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility. Nat Genet (2000) 2.18
The metabolism of native and malondialdehyde-altered low density lipoproteins by human monocyte-macrophages. J Lipid Res (1981) 1.97
Biosynthesis of gibberellins. IV. Biosynthesis of cyclic diterpenes from trans-geranylgeranyl pyrophosphate. J Biol Chem (1969) 1.80
Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia. Diabetologia (2006) 1.74
Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice. Oncogene (2009) 1.66
Competitive quantitative PCR analysis of herpes simplex virus type 1 DNA and latency-associated transcript RNA in latently infected cells of the rat brain. J Virol (1994) 1.51
Galectin-1 prolongs survival of mouse liver allografts from Flt3L-pretreated donors. Am J Transplant (2013) 1.44
Multiple sequence elements are involved in the transcriptional regulation of the human squalene synthase gene. J Biol Chem (1997) 1.43
Five unique compounds: xyloketals from mangrove fungus Xylaria sp. from the South China Sea coast. J Org Chem (2001) 1.37
Comparison between Biosynthesis of ent-Kaurene in Germinating Tomato Seeds and Cell Suspension Cultures of Tomato and Tobacco. Plant Physiol (1975) 1.36
Properties of purified rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and regulation of enzyme activity. J Biol Chem (1980) 1.35
Identification of vertebral fractures: an update. Osteoporos Int (2005) 1.34
Dipeptidyl peptidase-4 inhibitors administered in combination with metformin result in an additive increase in the plasma concentration of active GLP-1. Clin Pharmacol Ther (2010) 1.30
Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res (1996) 1.29
Molecular cloning, localization and circadian expression of chicken melanopsin (Opn4): differential regulation of expression in pineal and retinal cell types. J Neurochem (2005) 1.28
An expressed sequence tag SSR map of tetraploid alfalfa (Medicago sativa L.). Theor Appl Genet (2005) 1.27
Rapid, accurate determination of multidrug resistance in M. tuberculosis isolates and sputum using a biochip system. Int J Tuberc Lung Dis (2009) 1.27
Dissemination and characterization of NDM-1-producing Acinetobacter pittii in an intensive care unit in China. Clin Microbiol Infect (2012) 1.26
Solubilization and purification of trans-farnesyl pyrophosphate-squalene synthetase. J Biol Chem (1971) 1.25
Analysis of protein dimerization and ligand binding of orphan receptor HNF4alpha. J Mol Biol (2000) 1.21
High-level erythroid-specific gene expression in primary human and murine hematopoietic cells with self-inactivating lentiviral vectors. Blood (2001) 1.19
DNA methyltransferase 3B mutations linked to the ICF syndrome cause dysregulation of lymphogenesis genes. Hum Mol Genet (2001) 1.19
Enhancement of bone growth by sustained delivery of recombinant human bone morphogenetic protein-2 in a polymeric matrix. Pharm Res (2001) 1.16
Accuracy of height loss during prospective monitoring for detection of incident vertebral fractures. Osteoporos Int (2004) 1.15
Acetamide--a metabolite of metronidazole formed by the intestinal flora. Biochem Pharmacol (1979) 1.15
Is short vertebral height always an osteoporotic fracture? The Osteoporosis and Ultrasound Study (OPUS). Bone (2007) 1.15
Metronidazole metabolism in cultures of Entamoeba histolytica and Trichomonas vaginalis. Antimicrob Agents Chemother (1981) 1.15
Function-structure studies and identification of three enzyme domains involved in the catalytic activity in rat hepatic squalene synthase. J Biol Chem (1998) 1.14
Preparation and characterization of a composite PLGA and poly(acryloyl hydroxyethyl starch) microsphere system for protein delivery. Pharm Res (2001) 1.13
Relationship between metronidazole metabolism and bactericidal activity. Antimicrob Agents Chemother (1980) 1.13
Piperlongumine induces autophagy by targeting p38 signaling. Cell Death Dis (2013) 1.13
Inhibition of angiogenesis and breast cancer xenograft tumor growth by VEGI, a novel cytokine of the TNF superfamily. Int J Cancer (1999) 1.11
kdgREcc negatively regulates genes for pectinases, cellulase, protease, HarpinEcc, and a global RNA regulator in Erwinia carotovora subsp. carotovora. J Bacteriol (1999) 1.09
Chronic treatment with a glucagon receptor antagonist lowers glucose and moderately raises circulating glucagon and glucagon-like peptide 1 without severe alpha cell hypertrophy in diet-induced obese mice. Diabetologia (2011) 1.08
The anaerobic metabolism of metronidazole forms N-(2-hydroxyethyl)-oxamic acid. J Pharmacol Exp Ther (1979) 1.06
Subcellular localization of squalene synthase in rat hepatic cells. Biochemical and immunochemical evidence. J Biol Chem (1993) 1.02
Influence of baseline deformity definition on subsequent vertebral fracture risk in postmenopausal women. Osteoporos Int (2006) 1.02
Genetic characterization of the human papillomavirus (HPV) 18 E2 gene in clinical specimens suggests the presence of a subtype with decreased oncogenic potential. Int J Cancer (1995) 1.01
Dimerization of receptor protein-tyrosine phosphatase alpha in living cells. BMC Cell Biol (2001) 1.01
The woodchuck hepatitis virus post-transcriptional regulatory element reduces readthrough transcription from retroviral vectors. Gene Ther (2007) 1.00
Endotoxin, tumor necrosis factor, and interleukin-1 decrease hepatic squalene synthase activity, protein, and mRNA levels in Syrian hamsters. J Lipid Res (1997) 1.00
New metabolically stabilized analogues of lysophosphatidic acid: agonists, antagonists and enzyme inhibitors. Biochem Soc Trans (2005) 1.00
PD-1/B7-H1 interaction contribute to the spontaneous acceptance of mouse liver allograft. Am J Transplant (2009) 1.00
Regulation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase. Evidence for thiol-dependent allosteric modulation of enzyme activity. J Biol Chem (1984) 1.00
Lung autotransplantation technique for treating central lung cancer of upper lobe. Zhonghua Wai Ke Za Zhi (2000) 1.00
Comparative properties of 2,3-oxidosqualene-lanosterol cyclase from yeast and liver. Biochim Biophys Acta (1970) 1.00
Gonadotropin-releasing hormone antagonists: novel members of the azaline B family. J Med Chem (1995) 0.99
O6-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomas. Cell Death Dis (2013) 0.98
Characterization of apolipoprotein B mRNA editing from rabbit intestine. Arterioscler Thromb (1992) 0.98
Squalene synthase: structure and regulation. Prog Nucleic Acid Res Mol Biol (2001) 0.97
Seasonal changes of reproductive behavior and fecal steroid concentrations in Père David's deer. Horm Behav (2001) 0.97
Chitosan-coated liposomes: characterization and interaction with leuprolide. Int J Pharm (2003) 0.95
Structure and regulation of mammalian squalene synthase. Biochim Biophys Acta (2000) 0.94
Differential transcriptional regulation of the human squalene synthase gene by sterol regulatory element-binding proteins (SREBP) 1a and 2 and involvement of 5' DNA sequence elements in the regulation. J Biol Chem (1998) 0.93
Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase. J Biol Chem (1993) 0.93
Fibroblast growth factor receptor 2 (FGFR2): genomic sequence and variations. Cytogenet Cell Genet (2001) 0.92
Solubilization and pharmacokinetic behaviors of sodium cholate/lecithin-mixed micelles containing cyclosporine A. Drug Deliv (2005) 0.92
Visual identification of vertebral fractures in osteoporosis using morphometric X-ray absorptiometry. J Bone Miner Res (2003) 0.92
A simple method for in-field sex determination of the multicolored Asian lady beetle Harmonia axyridis. J Insect Sci (2007) 0.91
Contractile regulation of the Na(+)-K(+)-2Cl(-) cotransporter in vascular smooth muscle. Am J Physiol Cell Physiol (2001) 0.91
Molecular cloning, expression, and characterization of the cDNA for the rat hepatic squalene synthase. J Biol Chem (1992) 0.91
Expression of Endo180 is spatially and temporally regulated during wound healing. Histopathology (2006) 0.91
Toxicity of commonly used insecticides in sweet corn and soybean to multicolored Asian lady beetle (Coleoptera: Coccinellidae). J Econ Entomol (2005) 0.90
Involvement of farnesyl protein transferase (FPTase) in FcarepsilonRI-induced activation of RBL-2H3 mast cells. Arch Biochem Biophys (1999) 0.90
Surgical management of secondary spontaneous pneumothorax in elderly patients with chronic obstructive pulmonary disease: retrospective study of 107 cases. Thorac Cardiovasc Surg (2009) 0.90
B7-H1 expression is upregulated in peripheral blood CD14+ monocytes of patients with chronic hepatitis B virus infection, which correlates with higher serum IL-10 levels. J Viral Hepat (2006) 0.89
Isolation of a kaurene synthetase inhibitor from castor bean seedlings and cell suspension cultures. Plant Physiol (1981) 0.88
Inhibition of Na,K-ATPase activates PI3 kinase and inhibits apoptosis in LLC-PK1 cells. Biochem Biophys Res Commun (2001) 0.88
A modified p53 overcomes mdm2-mediated oncogenic transformation: a potential cancer therapeutic agent. Cancer Res (2000) 0.88
Lysophosphatidic acid-induced platelet shape change revealed through LPA(1-5) receptor-selective probes and albumin. Platelets (2008) 0.87
Room-temperature green upconversion fluorescence of an Er(3+)-doped laser liquid. Opt Lett (1996) 0.87
Computed tomography-guided iodine-125 interstitial implantation as an alternative treatment option for lung cancer. Indian J Cancer (2015) 0.86
Return to fertility after extended chemical castration with a GnRH antagonist. BMC Cancer (2001) 0.86
Lobar torsion after video-assisted thoracoscopic lobectomy: 2 case reports. Thorac Cardiovasc Surg (2011) 0.86
Differential binding of proteins to peroxisomes in rat hepatoma cells: unique association of enzymes involved in isoprenoid metabolism. J Lipid Res (1999) 0.86
Metabolites from the reduction of metronidazole by xanthine oxidase. Mol Pharmacol (1980) 0.86
Identification of vertebral deformities in women: comparison of radiological assessment and quantitative morphometry using morphometric radiography and morphometric X-ray absorptiometry. J Bone Miner Res (2000) 0.86
Farnesyl diphosphate synthase is abundantly expressed and regulated by androgen in rat prostatic epithelial cells. J Steroid Biochem Mol Biol (2001) 0.85
Role of human CYP1A1 and NAT2 in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutagenicity and DNA adducts. Xenobiotica (2009) 0.85
Fatty acyl-coenzyme A elongation in brain of normal and quaking mice. Science (1973) 0.85
Betidamino acids: versatile and constrained scaffolds for drug discovery. Proc Natl Acad Sci U S A (1996) 0.85
Biosynthesis of trans-farnesyl triphosphate in Gibberella fujikuroi. Biochim Biophys Acta (1973) 0.84
Bile-blood fistula: a complication of percutaneous transhepatic cholangiography. Radiology (1969) 0.83
Avoiding false positives in colony PCR. Biotechniques (1998) 0.83
Chromosome landing at the bacterial blight resistance gene Xa4 locus using a deep coverage rice BAC library. Mol Genet Genomics (2001) 0.82
A deficiency of mixed function oxidase activities in the cholesterol biosynthetic pathway of human granulocytes. J Lipid Res (1980) 0.82
Comparing the reduction of nitroimidazoles in bacteria and mammalian tissues and relating it to biological activity. Biochem Pharmacol (1986) 0.82
Identification and recombinant expression of glyceraldehyde-3-phosphate dehydrogenase of Plasmodium falciparum. Gene (2000) 0.82
An efficient method for the synthesis and purification of trans-[14C]geranylgeranyl pyrophosphate. Anal Biochem (1979) 0.82
Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors. Cell Death Dis (2012) 0.81
Serial quantitation of HPV-16 in the smears of women with mild and moderate dyskaryosis. J Med Virol (1995) 0.80
ABL1 promoter methylation can exist independently of BCR-ABL transcription in chronic myeloid leukemia hematopoietic progenitors. Cancer Res (2001) 0.80