Published in Proc Natl Acad Sci U S A on September 30, 1997
Caveolins, liquid-ordered domains, and signal transduction. Mol Cell Biol (1999) 4.70
The caveolin proteins. Genome Biol (2004) 2.23
A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance. J Cell Biol (2001) 1.92
Cholesterol and fatty acids regulate dynamic caveolin trafficking through the Golgi complex and between the cell surface and lipid bodies. Mol Biol Cell (2005) 1.86
Plasma membrane microdomains: organization, function and trafficking. Mol Membr Biol (2004) 1.48
Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase. J Clin Invest (1999) 1.42
Caveolin, cholesterol, and lipid droplets? J Cell Biol (2001) 1.38
Caveolin-1: an ambiguous partner in cell signalling and cancer. J Cell Mol Med (2008) 1.31
Molecular characterization of caveolin association with the Golgi complex: identification of a cis-Golgi targeting domain in the caveolin molecule. J Cell Biol (1999) 1.26
Role of NF-kappaB-dependent caveolin-1 expression in the mechanism of increased endothelial permeability induced by lipopolysaccharide. J Biol Chem (2007) 1.25
Loss of caveolin-1 accelerates neurodegeneration and aging. PLoS One (2010) 1.23
Caveolin-1: a critical regulator of lung injury. Am J Physiol Lung Cell Mol Physiol (2010) 1.17
Stage-specific expression and targeting of cyst wall protein-green fluorescent protein chimeras in Giardia. Mol Biol Cell (2000) 1.13
Specificity of intramembrane protein-lipid interactions. Cold Spring Harb Perspect Biol (2011) 1.12
Proinflammatory phenotype and increased caveolin-1 in alveolar macrophages with silenced CFTR mRNA. PLoS One (2010) 1.05
Lipid rafts and caveolae and their role in compartmentation of redox signaling. Antioxid Redox Signal (2009) 1.02
Direct control of caveolin-1 expression by FOXO transcription factors. Biochem J (2005) 1.02
Transit of hormonal and EGF receptor-dependent signals through cholesterol-rich membranes. Steroids (2006) 1.00
Regulation of intracellular cholesterol distribution by Na/K-ATPase. J Biol Chem (2009) 0.99
Changes in lipid and protein constituents of rafts and caveolae in multidrug resistant cancer cells and their functional consequences. Glycoconj J (2001) 0.95
Apolipoprotein A-I stimulates the transport of intracellular cholesterol to cell-surface cholesterol-rich domains (caveolae). Biochem J (2001) 0.95
Mechanism for endogenously expressed ApoE modulation of adipocyte very low density lipoprotein metabolism: role in endocytic and lipase-mediated metabolic pathways. J Biol Chem (2009) 0.92
Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis. Int J Cancer (2013) 0.92
Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells. Respir Res (2009) 0.91
Increased PEA3/E1AF and decreased Net/Elk-3, both ETS proteins, characterize human NSCLC progression and regulate caveolin-1 transcription in Calu-1 and NCI-H23 NSCLC cell lines. Carcinogenesis (2009) 0.91
Pulmonary lipid phosphate phosphohydrolase in plasma membrane signalling platforms. Biochem J (2001) 0.90
A pathway approach to investigate the function and regulation of SREBPs. Genes Nutr (2013) 0.89
Caveolin-1 upregulation contributes to c-Myc-induced high-grade prostatic intraepithelial neoplasia and prostate cancer. Mol Cancer Res (2011) 0.88
Mitochondrial cholesterol: a connection between caveolin, metabolism, and disease. Traffic (2011) 0.87
Transcriptional repression of Caveolin-1 (CAV1) gene expression by GATA-6 in bladder smooth muscle hypertrophy in mice and human beings. Am J Pathol (2011) 0.85
HIV infection upregulates caveolin 1 expression to restrict virus production. J Virol (2010) 0.84
Caveolin-1 protects B6129 mice against Helicobacter pylori gastritis. PLoS Pathog (2013) 0.84
Caveolin-1 suppresses human immunodeficiency virus-1 replication by inhibiting acetylation of NF-κB. Virology (2012) 0.83
Distinct dedifferentiation processes affect caveolin-1 expression in hepatocytes. Cell Commun Signal (2013) 0.82
In vitro evolution of ligands to the membrane protein caveolin. J Am Chem Soc (2011) 0.81
Alterations in membrane caveolae and BKCa channel activity in skin fibroblasts in Smith-Lemli-Opitz syndrome. Mol Genet Metab (2011) 0.80
Effect of Daxx on cholesterol accumulation in hepatic cells. World J Gastroenterol (2008) 0.79
Myocardin Family Members Drive Formation of Caveolae. PLoS One (2015) 0.79
Expression of Caveolin 1 is enhanced by DNA demethylation during adipocyte differentiation. status of insulin signaling. PLoS One (2014) 0.79
Perilipin-5 is regulated by statins and controls triglyceride contents in the hepatocyte. J Hepatol (2014) 0.78
The Niemann-Pick C1 and caveolin-1 proteins interact to modulate efflux of low density lipoprotein-derived cholesterol from late endocytic compartments. J Mol Biochem (2014) 0.76
Ezetimibe suppresses cholesterol accumulation in lipid-loaded vascular smooth muscle cells in vitro via MAPK signaling. Acta Pharmacol Sin (2014) 0.76
Caveolin contributes to the modulation of basal and β-adrenoceptor stimulated function of the adult rat ventricular myocyte by simvastatin: a novel pleiotropic effect. PLoS One (2014) 0.76
Versatile Functions of Caveolin-1 in Aging-related Diseases. Chonnam Med J (2017) 0.75
Oligodendroglial process formation is differentially affected by modulating the intra- and extracellular cholesterol content. J Mol Neurosci (2012) 0.75
Simvastatin Promotes Cardiac Myocyte Relaxation in Association with Phosphorylation of Troponin I. Front Pharmacol (2017) 0.75
Caveolin1 protects against diet induced hepatic lipid accumulation in mice. PLoS One (2017) 0.75
Is There a Potential Therapeutic Role for Caveolin-1 in Fibrosis? Front Pharmacol (2017) 0.75
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res (1989) 22.73
Regulation of the mevalonate pathway. Nature (1990) 18.25
SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell (1994) 7.10
ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol Cell Biol (1993) 5.34
Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc Natl Acad Sci U S A (1995) 4.40
Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell (1996) 4.12
De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin. Proc Natl Acad Sci U S A (1995) 3.73
Detergent-insoluble glycolipid microdomains in lymphocytes in the absence of caveolae. J Biol Chem (1994) 3.67
Minimally modified low density lipoprotein stimulates monocyte endothelial interactions. J Clin Invest (1990) 3.40
Reduction of caveolin and caveolae in oncogenically transformed cells. Proc Natl Acad Sci U S A (1995) 3.03
Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation. J Cell Biol (1994) 3.03
Digging into caveolae. Science (1995) 2.38
Caveolin isoforms differ in their N-terminal protein sequence and subcellular distribution. Identification and epitope mapping of an isoform-specific monoclonal antibody probe. J Biol Chem (1995) 2.25
Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1. J Biol Chem (1988) 2.00
Intracellular cholesterol transport. J Lipid Res (1997) 1.86
The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles. FEBS Lett (1992) 1.85
A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene. J Biol Chem (1996) 1.80
Plasma membrane caveolae mediate the efflux of cellular free cholesterol. Biochemistry (1995) 1.67
Molecular cloning and functional analysis of the promoter of the human squalene synthase gene. J Biol Chem (1995) 1.30
Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers. Proc Natl Acad Sci U S A (1997) 1.14
Letter: Enzymatic determination of cholesterol in high-density lipoprotein fractions prepared by polyanion precipitation. Clin Chem (1976) 1.12
Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte-derived macrophages. J Clin Invest (1996) 1.02
Intracellular transport of low density lipoprotein derived free cholesterol begins at clathrin-coated pits and terminates at cell surface caveolae. Biochemistry (1996) 0.93
Mechanism of transfer of LDL-derived free cholesterol to HDL subfractions in human plasma. Biochemistry (1990) 0.92
An apo-E-free very low density lipoprotein enriched in phosphatidylethanolamine in human plasma. J Biol Chem (1986) 0.91
Identification of a 6-base pair element involved in the sterol-mediated transcriptional regulation of farnesyl diphosphate synthase. J Biol Chem (1994) 0.88
Molecular physiology of reverse cholesterol transport. J Lipid Res (1995) 3.66
A protein cofactor of lecithin:cholesterol acyltransferase. Biochem Biophys Res Commun (1972) 2.37
Discoidal bilayer structure of nascent high density lipoproteins from perfused rat liver. J Clin Invest (1976) 2.14
Early incorporation of cell-derived cholesterol into pre-beta-migrating high-density lipoprotein. Biochemistry (1988) 1.97
Intracellular cholesterol transport. J Lipid Res (1997) 1.86
Cofactor activity of protein components of human very low density lipoproteins in the hydrolysis of triglycerides by lipoproteins lipase from different sources. Biochemistry (1973) 1.68
Plasma membrane caveolae mediate the efflux of cellular free cholesterol. Biochemistry (1995) 1.67
Human plasma lecithin-cholesterol acyltransferase. Characterization of cofactor-dependent phospholipase activity. J Biol Chem (1978) 1.55
Cholesterol and caveolae: structural and functional relationships. Biochim Biophys Acta (2000) 1.52
Role of contact inhibition in the regulation of receptor-mediated uptake of low density lipoprotein in cultured vascular endothelial cells. Proc Natl Acad Sci U S A (1978) 1.36
A cholesteryl ester transfer complex in human plasma. Proc Natl Acad Sci U S A (1980) 1.34
Isolation and characterization of a human serum cholesteryl ester transfer protein. Proc Natl Acad Sci U S A (1978) 1.30
Evidence for a lipoprotein carrier in human plasma catalyzing sterol efflux from cultured fibroblasts and its relationship to lecithin:cholesterol acyltransferase. Proc Natl Acad Sci U S A (1981) 1.27
Cellular cholesterol efflux. Biochim Biophys Acta (2001) 1.27
Cholesterol net transport, esterification, and transfer in human hyperlipidemic plasma. J Clin Invest (1983) 1.25
The ABCs of cholesterol efflux. Nat Genet (1999) 1.25
Lecithin: cholesterol acyltransferase: effects of substrate composition upon enzyme activity. Biochim Biophys Acta (1972) 1.24
Cholesterol transport between cells and body fluids. Role of plasma lipoproteins and the plasma cholesterol esterification system. Med Clin North Am (1982) 1.18
Validation of a procedure for exogenous isotopic labeling of lipoprotein triglyceride with radioactive triolein. Biochim Biophys Acta (1979) 1.17
A two-step mechanism for free cholesterol and phospholipid efflux from human vascular cells to apolipoprotein A-1. Biochemistry (2000) 1.14
Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers. Proc Natl Acad Sci U S A (1997) 1.14
p53 regulates caveolin gene transcription, cell cholesterol, and growth by a novel mechanism. Biochemistry (2000) 1.12
Effect of contact inhibition on the regulation of cholesterol metabolism in cultured vascular endothelial cells. J Biol Chem (1979) 1.11
The relation between breakdown of superinfecting virus deoxyribonucleic acid and temporal exclusion induced by T4 and T5 bacteriophages. J Gen Virol (1970) 1.10
Regulation of human plasma lecithin:cholesterol acyltransferase activity by lipoprotein acceptor cholesteryl ester content. J Biol Chem (1981) 1.09
Caveolae and intracellular trafficking of cholesterol. Adv Drug Deliv Rev (2001) 1.08
Lipoprotein lipase. Arch Pathol Lab Med (1977) 1.07
Intracellular cholesterol transport in synchronized human skin fibroblasts. Biochemistry (1999) 1.01
Human lipoprotein lipase. I. Purification and substrate specificity. Biochim Biophys Acta (1970) 0.99
Metabolism of cholesterol-rich chylomicroms. Mechanism of binding and uptake of cholesteryl esters by the vascular bed of the perfused rat heart. J Clin Invest (1978) 0.99
Lipoprotein lipase: comparative properties of the membrane-supported and solubilized enzyme species. Biochemistry (1974) 0.97
Increased free cholesterol in plasma low and very low density lipoproteins in non-insulin-dependent diabetes mellitus: its role in the inhibition of cholesteryl ester transfer. Proc Natl Acad Sci U S A (1984) 0.96
Lipoprotein lipase. Mechanism of formation of triglyceride-rich remnant particles from very low density lipoproteins and chylomicrons. Biochemistry (1975) 0.96
Parameters of cholesterol metabolism in the human hepatoma cell line, Hep-G2. J Lipid Res (1986) 0.95
Endotoxin and TNF lead to reduced plasma LCAT activity and decreased hepatic LCAT mRNA levels in Syrian hamsters. J Lipid Res (1995) 0.95
Prebeta-migrating high density lipoprotein: quantitation in normal and hyperlipidemic plasma by solid phase radioimmunoassay following electrophoretic transfer. J Lipid Res (1987) 0.94
Further characterisation of lipoprotein lipase and hepatic post-heparin lipase from rat plasma. Biochim Biophys Acta (1972) 0.94
Membrane cholesterol and the regulation of signal transduction. Biochem Soc Trans (2004) 0.94
Synthesis and secretion of wild-type and mutant human plasma cholesteryl ester transfer protein in baculovirus-transfected insect cells: the carboxyl-terminal region is required for both lipoprotein binding and catalysis of transfer. Proc Natl Acad Sci U S A (1992) 0.94
Expression of human lecithin-cholesterol acyltransferase in transgenic mice. Effect of human apolipoprotein AI and human apolipoprotein all on plasma lipoprotein cholesterol metabolism. J Clin Invest (1995) 0.93
Intracellular transport of low density lipoprotein derived free cholesterol begins at clathrin-coated pits and terminates at cell surface caveolae. Biochemistry (1996) 0.93
Effects of postprandial lipemia on plasma cholesterol metabolism. J Clin Invest (1985) 0.93
Cutaneous xanthoma in association with paraproteinemia in the absence of hyperlipidemia. J Clin Invest (1989) 0.92
Mechanism of transfer of LDL-derived free cholesterol to HDL subfractions in human plasma. Biochemistry (1990) 0.92
The origin and properties of free cholesterol potential gradients in plasma, and their relation to atherogenesis. J Lipid Res (1984) 0.91
Characteristics of chylomicron binding and lipid uptake by endothelial cells in culture. J Biol Chem (1979) 0.91
A protein component of serum high density lipoprotein with CO-factor activity against purified lipoprotein lipase. Biochem Biophys Res Commun (1970) 0.91
Quantitation of pre beta-HDL-dependent and nonspecific components of the total efflux of cellular cholesterol and phospholipid. Biochemistry (1993) 0.91
Sterol efflux to apolipoprotein A-I originates from caveolin-rich microdomains and potentiates PDGF-dependent protein kinase activity. Biochemistry (2002) 0.91
An apo-E-free very low density lipoprotein enriched in phosphatidylethanolamine in human plasma. J Biol Chem (1986) 0.91
Effects of site-directed mutagenesis at residues cysteine-31 and cysteine-184 on lecithin-cholesterol acyltransferase activity. Proc Natl Acad Sci U S A (1991) 0.90
Assay of cholesteryl ester transfer activity and purification of a cholesteryl ester transfer protein. Methods Enzymol (1985) 0.90
Human lipoprotein lipase. II. Inhibition of enzyme activity by plasma low density lipoproteins. Biochim Biophys Acta (1970) 0.90
Mechanism of salt-mediated inhibition of lipoprotein lipase. J Lipid Res (1976) 0.90
Analysis of hABC1 gene 5' end: additional peptide sequence, promoter region, and four polymorphisms. Biochem Biophys Res Commun (2000) 0.90
Cholesteryl ester transfer protein: friend or foe? J Clin Invest (1996) 0.89
Evidence for the distribution of apolipoprotein E between lipoprotein classes in human normocholesterolemic plasma and for the origin of unassociated apolipoprotein E (Lp-E). J Lipid Res (1984) 0.89
Interaction of lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in the transport of cholesteryl ester into sphingomyelin liposomes. Biochemistry (1980) 0.89
Effects of inhibitors of N-linked oligosaccharide processing on the secretion, stability, and activity of lecithin:cholesterol acyltransferase. Biochemistry (1991) 0.88
Regulation of the concentration of pre beta high-density lipoprotein in normal plasma by cell membranes and lecithin-cholesterol acyltransferase activity. Biochemistry (1992) 0.88
Phospholipid substrate specificity of purified human plasma lecithin:cholesterol acyltransferase. Scand J Clin Lab Invest Suppl (1974) 0.88
Plasma cholesterol metabolism in end-stage renal disease. Difference between treatment by hemodialysis or peritoneal dialysis. J Clin Invest (1986) 0.88
Monoglyceride hydrolase activities of rat plasma and platelets. Their properties and roles in the activity of lipoprotein lipase. J Biol Chem (1981) 0.88
Human noninsulin-dependent diabetes: identification of a defect in plasma cholesterol transport normalized in vivo by insulin and in vitro by selective immunoadsorption of apolipoprotein E. Proc Natl Acad Sci U S A (1982) 0.88
Chylomicron protein content and the rate of lipoprotein lipase activity. J Lipid Res (1976) 0.88
Promotion of sterol efflux and net transport by apolipoprotein E in lecithin:cholesterol acyltransferase deficiency. Metabolism (1982) 0.87
Structure-function relationships in human lecithin:cholesterol acyltransferase. Site-directed mutagenesis at serine residues 181 and 216. Biochemistry (1991) 0.87
Liver X receptor inhibits the synthesis and secretion of apolipoprotein A1 by human liver-derived cells. Biochemistry (2006) 0.87
Unique epitope of apolipoprotein A-I expressed in pre-beta-1 high-density lipoprotein and its role in the catalyzed efflux of cellular cholesterol. Biochemistry (1994) 0.86
Lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity from the isolated perfused rabbit liver. J Lipid Res (1984) 0.85
Site-directed mutagenesis and structure-function analysis of the human apolipoprotein A-I. Relation between lecithin-cholesterol acyltransferase activation and lipid binding. J Biol Chem (1992) 0.85
Two-dimensional nondenaturing electrophoresis of lipoproteins: applications to high-density lipoprotein speciation. Methods Enzymol (1996) 0.85
Abnormal lecithin:cholesterol acyltransferase activation by a human apolipoprotein A-I variant in which a single lysine residue is deleted. J Biol Chem (1984) 0.84
LPS and cytokines regulate extra hepatic mRNA levels of apolipoproteins during the acute phase response in Syrian hamsters. Biochim Biophys Acta (1997) 0.83
Purification of lipoprotein lipase from rat post-heparin plasma. Biochim Biophys Acta (1969) 0.83
Lipoprotein lipase: evidence for high- and low-affinity enzyme sites. Biochemistry (1976) 0.83