Published in Proc Natl Acad Sci U S A on August 29, 1995
Role of ventral tegmental area glial cell line-derived neurotrophic factor in incubation of cocaine craving. Biol Psychiatry (2009) 1.48
Excessive alcohol consumption is blocked by glial cell line-derived neurotrophic factor. Alcohol (2009) 1.39
Role of BDNF and GDNF in drug reward and relapse: a review. Neurosci Biobehav Rev (2009) 1.31
Parkinson's disease therapeutics: new developments and challenges since the introduction of levodopa. Neuropsychopharmacology (2011) 1.21
Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease. Proc Natl Acad Sci U S A (1997) 1.14
GDNF--a potential target to treat addiction. Pharmacol Ther (2008) 1.07
GDNF is an endogenous negative regulator of ethanol-mediated reward and of ethanol consumption after a period of abstinence. Alcohol Clin Exp Res (2009) 1.02
TRPV1 induction in airway vagal low-threshold mechanosensory neurons by allergen challenge and neurotrophic factors. Am J Physiol Lung Cell Mol Physiol (2012) 1.02
Endogenous GDNF in ventral tegmental area and nucleus accumbens does not play a role in the incubation of heroin craving. Addict Biol (2010) 1.00
Effects of cerebral ischemia in mice deficient in Persephin. Proc Natl Acad Sci U S A (2002) 0.98
A next step in adeno-associated virus-mediated gene therapy for neurological diseases: regulation and targeting. Br J Clin Pharmacol (2013) 0.97
Synaptogenesis in the CNS: an odyssey from wiring together to firing together. J Physiol (2003) 0.93
Glial-derived neurotrophic factor gene transfer for Parkinson's disease: anterograde distribution of AAV2 vectors in the primate brain. Neurobiol Dis (2011) 0.93
Nucleus accumbens-derived glial cell line-derived neurotrophic factor is a retrograde enhancer of dopaminergic tone in the mesocorticolimbic system. J Neurosci (2010) 0.91
Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease. Brain Behav (2013) 0.91
GDNF-based therapies, GDNF-producing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson's disease. Front Neuroanat (2015) 0.87
Positive autoregulation of GDNF levels in the ventral tegmental area mediates long-lasting inhibition of excessive alcohol consumption. Transl Psychiatry (2011) 0.87
Nigral GFRα1 infusion in aged rats increases locomotor activity, nigral tyrosine hydroxylase, and dopamine content in synchronicity. Mol Neurobiol (2013) 0.85
Characterization of trans-neuronal trafficking of Cbln1. Mol Cell Neurosci (2009) 0.85
Neuroprotective potential of pleiotrophin overexpression in the striatonigral pathway compared with overexpression in both the striatonigral and nigrostriatal pathways. Gene Ther (2014) 0.83
Transgenic expression of human glial cell line-derived neurotrophic factor from integration-deficient lentiviral vectors is neuroprotective in a rodent model of Parkinson's disease. Hum Gene Ther (2014) 0.82
Glial cell line-derived neurotrophic factor is crucial for long-term maintenance of the nigrostriatal system. Neuroscience (2010) 0.81
Prenatal LPS increases inflammation in the substantia nigra of Gdnf heterozygous mice. Brain Pathol (2010) 0.81
GDNF reduces oxidative stress in a 6-hydroxydopamine model of Parkinson's disease. Neurosci Lett (2006) 0.81
Anatomical basis of glial cell line-derived neurotrophic factor expression in the striatum and related basal ganglia during postnatal development of the rat. J Comp Neurol (2005) 0.81
The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior. Eur J Neurosci (2008) 0.80
Behavioural Effects of Adult Vitamin D Deficiency in BALB/c Mice Are not Associated with Proliferation or Survival of Neurons in the Adult Hippocampus. PLoS One (2016) 0.80
Effects of glial cell line-derived neurotrophic factor deletion on ventral mesencephalic organotypic tissue cultures. Brain Res (2006) 0.78
Autologous transplantation of GDNF-expressing mesenchymal stem cells protects against MPTP-induced damage in cynomolgus monkeys. Sci Rep (2013) 0.77
Glial cell line-derived neurotrophic factor partially ameliorates motor symptoms without slowing neurodegeneration in mice with respiratory chain-deficient dopamine neurons. Cell Transplant (2012) 0.76
Sigma-1 Receptors and Neurodegenerative Diseases: Towards a Hypothesis of Sigma-1 Receptors as Amplifiers of Neurodegeneration and Neuroprotection. Adv Exp Med Biol (2017) 0.76
Transcription factor Six2 mediates the protection of GDNF on 6-OHDA lesioned dopaminergic neurons by regulating Smurf1 expression. Cell Death Dis (2016) 0.75
Striatal GDNF Production Is Independent to Circulating Estradiol Level Despite Pan-Neuronal Activation in the Female Mouse. PLoS One (2016) 0.75
Update of neurotrophic factors in neurobiology of addiction and future directions. Neurobiol Dis (2016) 0.75
Simultaneous Detection of Both GDNF and GFRα1 Expression Patterns in the Mouse Central Nervous System. Front Neuroanat (2016) 0.75
Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra. eNeuro (2017) 0.75
GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science (1993) 6.73
GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science (1994) 3.63
Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature (1995) 2.69
The neostriatal mosaic: compartmental distribution of calcium-binding protein and parvalbumin in the basal ganglia of the rat and monkey. Proc Natl Acad Sci U S A (1985) 1.83
Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF. Nature (1995) 1.81
Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature (1995) 1.79
In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons. Nature (1995) 1.75
Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo. Neurosci Lett (1994) 1.40
Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo. Brain Res Bull (1995) 1.29
Subdivisions of the dopamine-containing A8-A9-A10 complex identified by their differential mesostriatal innervation of striosomes and extrastriosomal matrix. Neuroscience (1987) 1.27
Heterogeneity of striatal and limbic dopamine innervation: highly fluorescent islands in developing and adult rats. Brain Res (1972) 1.26
GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo. Brain Res (1995) 1.25
Glial cell line-derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopamine neurons in vivo. Exp Neurol (1993) 1.19
Regional and cell-specific expression of GDNF in rat brain. Exp Neurol (1993) 1.18
Expression of GDNF mRNA in rat and human nervous tissue. Exp Neurol (1994) 1.05
Correspondence between the dopamine islands and striosomes of the mammalian striatum. Neuroscience (1984) 1.04
Brain-derived neurotrophic factor: subcellular compartmentalization and interneuronal transfer as visualized with anti-peptide antibodies. Proc Natl Acad Sci U S A (1991) 0.94
Late prenatal ontogeny of central monoamine neurons in the rat: Fluorescence histochemical observations. Z Anat Entwicklungsgesch (1973) 0.93
Neurons of the hippocampal formation express glial cell line-derived neurotrophic factor messenger RNA in response to kainate-induced excitation. Neuroscience (1994) 0.93
Intraputaminal infusion of nerve growth factor to support adrenal medullary autografts in Parkinson's disease. One-year follow-up of first clinical trial. Arch Neurol (1991) 0.91
Glial cell line-derived neurotrophic factor stimulates fiber formation and survival in cultured neurons from peripheral autonomic ganglia. J Neurosci Res (1995) 0.91
GDNF is expressed in two forms in many tissues outside the CNS. Neuroreport (1994) 0.90
Glial cell-line derived neurotrophic factor (GDNF) mRNA upregulation in striatum and cortical areas after pilocarpine-induced status epilepticus in rats. Brain Res Mol Brain Res (1994) 0.88
Direct demonstration of a correspondence between the dopamine islands and acetylcholinesterase patches in the developing striatum. Proc Natl Acad Sci U S A (1981) 0.88
Glial cell line-derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneurones. Neuroreport (1994) 0.86
Compartmental organization of the mammalian striatum. Prog Brain Res (1983) 0.83
5'-nucleotidase: a new marker for striosomal organization in the rat caudoputamen. J Comp Neurol (1992) 0.81
A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell (1983) 20.32
Dopamine neuron agenesis in Nurr1-deficient mice. Science (1997) 5.40
T-cell co-stimulation through B7RP-1 and ICOS. Nature (1999) 4.20
Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proc Natl Acad Sci U S A (2002) 4.03
Transcriptional 'enhancers' from SV40 and polyoma virus show a cell type preference. Nucleic Acids Res (1982) 3.94
Defects in enteric innervation and kidney development in mice lacking GDNF. Nature (1996) 3.82
Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo. Proc Natl Acad Sci U S A (1992) 3.61
Spinal cord repair in adult paraplegic rats: partial restoration of hind limb function. Science (1996) 2.83
Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature (1995) 2.69
Functional analysis of putative restriction-modification system genes in the Helicobacter pylori J99 genome. Nucleic Acids Res (2000) 2.48
Organ donation in three major American cities with large Latino and black populations. Transplantation (1988) 2.41
Enzyme evolution: generation of a bifunctional enzyme by fusion of adjacent genes. Nature (1970) 2.35
Functional recovery in parkinsonian monkeys treated with GDNF. Nature (1996) 2.35
Prevalence and specificity of LKB1 genetic alterations in lung cancers. Oncogene (2007) 2.27
Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family. Neuron (1990) 2.22
Hereditary breast/ovarian and colorectal cancer genetics knowledge in a national sample of US physicians. J Med Genet (2005) 2.13
Meta- and pooled analysis of GSTT1 and lung cancer: a HuGE-GSEC review. Am J Epidemiol (2006) 2.02
Analysis of the transcriptional enhancer effect. Cold Spring Harb Symp Quant Biol (1983) 1.99
Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain. Proc Natl Acad Sci U S A (1990) 1.94
Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA. J Cell Biol (1992) 1.87
Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice. J Neurosci (2001) 1.81
Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF. Nature (1995) 1.81
Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors. Oncogene (2011) 1.78
Exposure to acute stress induces brain interleukin-1beta protein in the rat. J Neurosci (1998) 1.78
Adenine nucleotides and synaptic transmission in the in vitro rat hippocampus. Br J Pharmacol (1980) 1.78
US physicians' attitudes toward genetic testing for cancer susceptibility. Am J Med Genet A (2003) 1.77
Transplantation of adrenal medullary tissue to striatum in parkinsonism. First clinical trials. J Neurosurg (1985) 1.75
Long-term follow-up studies of open-door expansive laminoplasty for cervical stenotic myelopathy. Spine (Phila Pa 1976) (1994) 1.74
Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system. Science (1979) 1.74
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau. Proc Natl Acad Sci U S A (1998) 1.71
Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system. Brain Res Mol Brain Res (1996) 1.70
Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage. Oncogene (1997) 1.69
Molecular recognition of the identity-determinant set of isoleucine transfer RNA from Escherichia coli. J Mol Biol (1994) 1.68
Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product. Cell (1992) 1.62
Expression of calf prochymosin in Saccharomyces cerevisiae. Gene (1984) 1.61
Dental pulp cells produce neurotrophic factors, interact with trigeminal neurons in vitro, and rescue motoneurons after spinal cord injury. Dev Biol (2001) 1.61
Development and regional expression of beta nerve growth factor messenger RNA and protein in the rat central nervous system. Proc Natl Acad Sci U S A (1986) 1.56
Activation of the pathway from locus coeruleus to rat cerebellar Purkinje neurons: pharmacological evidence of noradrenergic central inhibition. J Pharmacol Exp Ther (1973) 1.55
Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease. Dement Geriatr Cogn Disord (1998) 1.55
Studies on norepinephrine-containing afferents to Purkinje cells of rat cerebellum. II. Sensitivity of Purkinje cells to norepinephrine and related substances administered by microiontophoresis. Brain Res (1971) 1.55
Comparison of benefits provided by different hearing aid technologies. J Am Acad Audiol (2001) 1.53
Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases. J Biol Chem (1997) 1.52
Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice. Exp Cell Res (1999) 1.51
Neurotrophic factors and receptors in the immature and adult spinal cord after mechanical injury or kainic acid. J Neurosci (2001) 1.50
Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis. Genes Dev (2001) 1.50
Activation of a central noradrenergic projection to cerebellum. Nature (1971) 1.48
Sorsby fundus dystrophy without a mutation in the TIMP-3 gene. Br J Ophthalmol (2000) 1.48
Subretinal neovascularization in the rat induced by IRBP synthetic peptides. Exp Eye Res (1994) 1.48
Glial cell line-derived neurotrophic factor protects against ischemia-induced injury in the cerebral cortex. J Neurosci (1997) 1.48
Eighteen cases exposed to sarin in Matsumoto, Japan. Intern Med (1997) 1.47
Vitamin D(3) attenuates 6-hydroxydopamine-induced neurotoxicity in rats. Brain Res (2001) 1.46
Growth characteristics of adrenergic nerves in the adult rat. Fluorescence histochemical and 3H-noradrenaline uptake studies using tissue transplantations to the anterior chamber of the eye. Acta Physiol Scand Suppl (1970) 1.45
Electrolyte effects on the activity of mutant enzymes in vivo and in vitro. Biochemistry (1979) 1.44
Immunofluorescent studies of fibronectin and laminin in the human eye. Invest Ophthalmol Vis Sci (1987) 1.43
Alpha-bungarotoxin binding to hippocampal interneurons: immunocytochemical characterization and effects on growth factor expression. J Neurosci (1993) 1.42
Correlation of apomorphine- and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats. Brain Res (1993) 1.40
Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo. Neurosci Lett (1994) 1.40
Comparison of hemodynamic, pulmonary, and renal effects of use of three types of fluids after major surgical procedures on the abdominal aorta. Crit Care Med (1979) 1.39
Nerve growth factors in the rat iris. Nature (1980) 1.39
Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits. Mol Cell Biol (1994) 1.38
Role of retinoids in the CNS: differential expression of retinoid binding proteins and receptors and evidence for presence of retinoic acid. Eur J Neurosci (1999) 1.38
Lingual deficits in BDNF and NT3 mutant mice leading to gustatory and somatosensory disturbances, respectively. Development (1997) 1.38
Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization. Exp Neurol (1990) 1.37
Natural history of intrahepatic canine islet cell autografts. J Clin Invest (1986) 1.37
Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury. Neuroscience (2003) 1.36
Studies on norepinephrine-containing afferents to Purkinje cells of rat cerebellum. 3. Evidence for mediation of norepinephrine effects by cyclic 3',5'-adenosine monophosphate. Brain Res (1971) 1.36
Expression of the beta-nerve growth factor gene in hippocampal neurons. Science (1988) 1.35
Ontogenesis of peripheral adrenergic neurons in the rat: pre- and postnatal observations. Acta Physiol Scand (1970) 1.33
The dextro and levorotatory isomers of N-phenylisopropyladenosine: stereospecific effects on cyclic AMP-formation and evoked synaptic responses in brain slices. Life Sci (1979) 1.32
Constitutive activation of the Wnt signaling pathway by CTNNB1 (beta-catenin) mutations in a subset of human lung adenocarcinoma. Genes Chromosomes Cancer (2001) 1.32
Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1. Mol Endocrinol (1996) 1.31
Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor. Proc Natl Acad Sci U S A (1995) 1.31
Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. Genomics (1999) 1.29
On the projections from the locus coeruleus noradrealine neurons: the cerebellar innervation. Brain Res (1971) 1.29
Safe at home? Domestic violence and other homicides among women in New Mexico. Ann Emerg Med (1996) 1.28
Expression of nerve growth factor receptor mRNA is developmentally regulated and increased after axotomy in rat spinal cord motoneurons. Neuron (1989) 1.28
A national survey of the home visiting practice and attitudes of family physicians and internists. Arch Intern Med (1992) 1.28
Cyclic adenosine monophosphate: possible mediator for norepinephrine effects on cerebellar Purkinje cells. Science (1969) 1.26
Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease. Neuroscience (2008) 1.26
Heterogeneity of striatal and limbic dopamine innervation: highly fluorescent islands in developing and adult rats. Brain Res (1972) 1.26
A Salmonella frameshift suppressor that acts at runs of A residues in the messenger RNA. J Mol Biol (1978) 1.25
Chlorhexidine-induced degeneration of adrenergic nerves. Acta Neuropathol (1984) 1.25
Effects of delayed visual information on the rate and amount of prism adaptation in the human. J Neurosci (1995) 1.25
The ability of human Schwann cell grafts to promote regeneration in the transected nude rat spinal cord. Exp Neurol (1997) 1.25
Effect of baseline or changes in adrenergic activity on clinical outcomes in the beta-blocker evaluation of survival trial. Circulation (2004) 1.24
Structures of the extracellular domain of the type I tumor necrosis factor receptor. Structure (1996) 1.24