Published in J Biol Chem on January 05, 1993
Regulation of the human GLUT4 gene promoter: interaction between a transcriptional activator and myocyte enhancer factor 2A. Proc Natl Acad Sci U S A (2003) 1.17
Acute inhibition of fatty acid import inhibits GLUT4 transcription in adipose tissue, but not skeletal or cardiac muscle tissue, partly through liver X receptor (LXR) signaling. Diabetes (2010) 1.05
Class II histone deacetylases downregulate GLUT4 transcription in response to increased cAMP signaling in cultured adipocytes and fasting mice. Diabetes (2012) 0.93
Culture of isolated human adipocytes and isolated adipose tissue. Methods Mol Biol (2012) 0.92
Regulation of GLUT4 gene expression by SREBP-1c in adipocytes. Biochem J (2006) 0.91
Class II histone deacetylases limit GLUT4 gene expression during adipocyte differentiation. J Biol Chem (2010) 0.90
Expression of an insulin-responsive glucose transporter (GLUT4) minigene in transgenic mice: effect of exercise and role in glucose homeostasis. Proc Natl Acad Sci U S A (1995) 0.86
Regulated expression of an insulin-responsive glucose transporter (GLUT4) minigene in 3T3-L1 adipocytes and transgenic mice. Proc Natl Acad Sci U S A (1993) 0.85
Mechanisms regulating GLUT4 transcription in skeletal muscle cells are highly conserved across vertebrates. PLoS One (2013) 0.83
Comparison of in vitro and in situ methods for studying lipolysis. ISRN Endocrinol (2013) 0.83
Regulation of GLUT4 and Insulin-Dependent Glucose Flux. ISRN Mol Biol (2012) 0.76
Adipocyte dysfunction in rats with streptozotocin-nicotinamide-induced diabetes. Int J Exp Pathol (2014) 0.75
CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature (2000) 4.10
Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. Nature (2001) 2.77
Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes. Mol Cell (1999) 2.22
Regulation of insulin-stimulated GLUT4 translocation by Munc18c in 3T3L1 adipocytes. J Biol Chem (1998) 2.11
Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals. Proc Natl Acad Sci U S A (2007) 2.04
Regulation of glucose transporter messenger RNA in insulin-deficient states. Nature (1989) 2.02
Dynamin is required for recombinant adeno-associated virus type 2 infection. J Virol (1999) 1.99
Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin. J Biol Chem (1995) 1.97
Insulin-stimulated GLUT4 translocation in adipocytes is dependent upon cortical actin remodeling. J Biol Chem (2001) 1.94
Structure, function, and regulation of the mammalian facilitative glucose transporter gene family. Annu Rev Nutr (1996) 1.91
Syntaxin 4, VAMP2, and/or VAMP3/cellubrevin are functional target membrane and vesicle SNAP receptors for insulin-stimulated GLUT4 translocation in adipocytes. Mol Cell Biol (1997) 1.85
Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways. Mol Cell Biol (1998) 1.68
Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events. Virology (1992) 1.67
Expression of a dominant interfering dynamin mutant in 3T3L1 adipocytes inhibits GLUT4 endocytosis without affecting insulin signaling. J Biol Chem (1998) 1.60
Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling. Proc Natl Acad Sci U S A (1995) 1.55
Skeletal muscle glucose transport and metabolism are enhanced in transgenic mice overexpressing the Glut4 glucose transporter. J Biol Chem (1995) 1.52
Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways. Diabetologia (2002) 1.50
Budding of Rous sarcoma virus and vesicular stomatitis virus from localized lipid regions in the plasma membrane of chicken embryo fibroblasts. J Biol Chem (1980) 1.50
SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways. J Biol Chem (1996) 1.48
Myocyte enhancer factor 2 (MEF2)-binding site is required for GLUT4 gene expression in transgenic mice. Regulation of MEF2 DNA binding activity in insulin-deficient diabetes. J Biol Chem (1998) 1.47
Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation. J Cell Biol (2001) 1.46
Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance. J Clin Invest (2001) 1.45
Photoaffinity labeling of the human erythrocyte D-glucose transporter. J Biol Chem (1982) 1.43
Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex. J Biol Chem (1995) 1.42
Phorbol ester induces desensitization of adenylate cyclase and phosphorylation of the beta-adrenergic receptor in turkey erythrocytes. Proc Natl Acad Sci U S A (1984) 1.39
Prevention and therapy of serous otitis media by oral decongestant: a double-blind study in pediatric practice. Pediatrics (1978) 1.39
Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits. Mol Cell Biol (1994) 1.38
In vivo quantification of subcutaneous and visceral adiposity by micro-computed tomography in a small animal model. Med Eng Phys (2008) 1.38
Abundance, localization, and insulin-induced translocation of glucose transporters in red and white muscle. Am J Physiol (1992) 1.36
The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway. J Biol Chem (1997) 1.35
Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4). J Clin Invest (1995) 1.35
Phosphatidylinositol 3-kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcription. J Biol Chem (1993) 1.32
Transgenic mice expressing the human GLUT4/muscle-fat facilitative glucose transporter protein exhibit efficient glycemic control. Proc Natl Acad Sci U S A (1993) 1.32
The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism. J Biol Chem (1999) 1.32
Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase. J Appl Physiol (1985) (2001) 1.29
Intracellular organization of insulin signaling and GLUT4 translocation. Recent Prog Horm Res (2001) 1.28
beta-Adrenergic regulation of insulin and epidermal growth factor receptors in rat adipocytes. J Biol Chem (1983) 1.25
Hormonal/metabolic regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice. J Biol Chem (1993) 1.24
The MEF2A isoform is required for striated muscle-specific expression of the insulin-responsive GLUT4 glucose transporter. J Biol Chem (2000) 1.24
Munc18c function is required for insulin-stimulated plasma membrane fusion of GLUT4 and insulin-responsive amino peptidase storage vesicles. Mol Cell Biol (2000) 1.23
Transdominant inhibition of tyrosine kinase activity in mutant insulin/insulin-like growth factor I hybrid receptors. Proc Natl Acad Sci U S A (1991) 1.21
Osmotic shock stimulates GLUT4 translocation in 3T3L1 adipocytes by a novel tyrosine kinase pathway. J Biol Chem (1997) 1.21
Functional expression of insulin receptor substrate-1 is required for insulin-stimulated mitogenic signaling. J Biol Chem (1993) 1.20
VAMP3 null mice display normal constitutive, insulin- and exercise-regulated vesicle trafficking. Mol Cell Biol (2001) 1.18
Enhanced peripheral glucose utilization in transgenic mice expressing the human GLUT4 gene. J Biol Chem (1994) 1.17
Functional cooperation of two independent targeting domains in syntaxin 6 is required for its efficient localization in the trans-golgi network of 3T3L1 adipocytes. J Biol Chem (2000) 1.17
Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes. EMBO J (1998) 1.16
Subcellular compartmentalization and trafficking of the insulin-responsive glucose transporter, GLUT4. Exp Cell Res (2001) 1.16
Insulin receptor substrate-1 (IRS1) and Shc compete for a limited pool of Grb2 in mediating insulin downstream signaling. J Biol Chem (1994) 1.15
Identification of a 30-base pair regulatory element and novel DNA binding protein that regulates the human GLUT4 promoter in transgenic mice. J Biol Chem (2000) 1.14
Aldolase mediates the association of F-actin with the insulin-responsive glucose transporter GLUT4. J Biol Chem (1999) 1.13
GLUT4 gene regulation and manipulation. J Biol Chem (1999) 1.13
Glucose transport activity in L6 muscle cells is regulated by the coordinate control of subcellular glucose transporter distribution, biosynthesis, and mRNA transcription. J Biol Chem (1990) 1.12
Insulin-stimulated disassociation of the SOS-Grb2 complex. Mol Cell Biol (1995) 1.11
Insulin stimulates actin comet tails on intracellular GLUT4-containing compartments in differentiated 3T3L1 adipocytes. J Biol Chem (2001) 1.10
Insulin stimulation of a MEK-dependent but ERK-independent SOS protein kinase. Mol Cell Biol (1996) 1.09
Myocyte enhancer factor 2 (MEF2) binding site is essential for C2C12 myotube-specific expression of the rat GLUT4/muscle-adipose facilitative glucose transporter gene. J Biol Chem (1994) 1.09
Insulin stimulates the phosphorylation of the 66- and 52-kilodalton Shc isoforms by distinct pathways. Endocrinology (1997) 1.08
Mammalian glucose transporters: structure and molecular regulation. Recent Prog Horm Res (1991) 1.08
Isolation of functional alpha beta heterodimers from the purified human placental alpha 2 beta 2 heterotetrameric insulin receptor complex. A structural basis for insulin binding heterogeneity. J Biol Chem (1987) 1.07
Identification of a skeletal muscle-specific regulatory domain in the rat GLUT4/muscle-fat gene. J Biol Chem (1993) 1.07
Pulmonary fibrosis is associated with an elevated risk of thromboembolic disease. Eur Respir J (2011) 1.07
Insulin action rapidly modulates the apparent affinity of the insulin-like growth factor II receptor. J Biol Chem (1983) 1.06
Guanosine 5'-O-(3-thiotriphosphate) (GTPgammaS) stimulation of GLUT4 translocation is tyrosine kinase-dependent. J Biol Chem (1998) 1.06
Assembly of insulin/insulin-like growth factor-1 hybrid receptors in vitro. J Biol Chem (1989) 1.05
Transcriptional regulation of the human GLUT4 gene promoter in diabetic transgenic mice. J Biol Chem (1995) 1.05
Transmembrane domain length determines intracellular membrane compartment localization of syntaxins 3, 4, and 5. Am J Physiol Cell Physiol (2001) 1.04
Munc18c regulates insulin-stimulated glut4 translocation to the transverse tubules in skeletal muscle. J Biol Chem (2000) 1.04
In vivo association of Grb2 with pp116, a substrate of the T cell antigen receptor-activated protein tyrosine kinase. J Biol Chem (1994) 1.03
Shc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors. J Biol Chem (1995) 1.02
Osmotic shock inhibits insulin signaling by maintaining Akt/protein kinase B in an inactive dephosphorylated state. Mol Cell Biol (1999) 1.02
Molecular machinery involved in the insulin-regulated fusion of GLUT4-containing vesicles with the plasma membrane (review). Mol Membr Biol (2002) 1.01
Identification of the spinal cord as a major site of persistence during chronic infection with a murine coronavirus. Virology (1990) 1.01
Polylysine specifically activates the insulin-dependent insulin receptor protein kinase. J Biol Chem (1989) 1.01
Identification of the stereospecific hexose transporter from starved and fed chicken embryo fibroblasts. Proc Natl Acad Sci U S A (1982) 0.99
Insulin and glucose-dependent regulation of the glucose transport system in the rat L6 skeletal muscle cell line. J Biol Chem (1989) 0.99
Relationship between alpha subunit ligand occupancy and beta subunit autophosphorylation in insulin/insulin-like growth factor-1 hybrid receptors. J Biol Chem (1993) 0.99
CD40 ligation results in protein kinase C-independent activation of ERK and JNK in resting murine splenic B cells. J Immunol (1996) 0.99
Transmembrane signaling by the human insulin receptor kinase. Relationship between intramolecular beta subunit trans- and cis-autophosphorylation and substrate kinase activation. J Biol Chem (1992) 0.98
Glucose-dependent regulation of glucose transport activity, protein, and mRNA in primary cultures of rat brain glial cells. J Biol Chem (1988) 0.98
Divergent insulin and platelet-derived growth factor regulation of focal adhesion kinase (pp125FAK) tyrosine phosphorylation, and rearrangement of actin stress fibers. J Biol Chem (1995) 0.98
Insulin-dependent intermolecular subunit communication between isolated alpha beta heterodimeric insulin receptor complexes. J Biol Chem (1987) 0.97
Temporal separation of insulin-stimulated GLUT4/IRAP vesicle plasma membrane docking and fusion in 3T3L1 adipocytes. J Biol Chem (1999) 0.97
Differential regulation of glucose transporter activity and expression in red and white skeletal muscle. J Biol Chem (1991) 0.96
Insulin-dependent covalent reassociation of isolated alpha beta heterodimeric insulin receptors into an alpha 2 beta 2 heterotetrameric disulfide-linked complex. J Biol Chem (1988) 0.96
Signal transducer and activator of transcription-3 serine phosphorylation by insulin is mediated by a Ras/Raf/MEK-dependent pathway. Endocrinology (1997) 0.96
Calmodulin antagonists inhibit insulin-stimulated GLUT4 (glucose transporter 4) translocation by preventing the formation of phosphatidylinositol 3,4,5-trisphosphate in 3T3L1 adipocytes. Mol Endocrinol (2000) 0.95
Insulin stimulates the serine phosphorylation of the signal transducer and activator of transcription (STAT3) isoform. J Biol Chem (1996) 0.95
A community-based randomized trial encouraging sun protection for children. Pediatrics (1998) 0.95
Evidence supporting a passive role for the insulin receptor transmembrane domain in insulin-dependent signal transduction. J Biol Chem (1991) 0.94
Expression and regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice. J Biol Chem (1992) 0.94
Regulation of glucose transporter messenger RNA levels in rat adipose tissue by insulin. Mol Endocrinol (1990) 0.94
Insulin and epidermal growth factor receptors regulate distinct pools of Grb2-SOS in the control of Ras activation. J Biol Chem (1996) 0.94
Carnitine status of lactoovovegetarians and strict vegetarian adults and children. Am J Clin Nutr (1989) 0.93
Alteration of intramolecular disulfides in insulin receptor/kinase by insulin and dithiothreitol: insulin potentiates the apparent dithiothreitol-dependent subunit reduction of insulin receptor. Biochemistry (1986) 0.93