Published in Proc Natl Acad Sci U S A on December 01, 1993
Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J Clin Invest (2006) 2.09
Overexpression of Glut4 protein in muscle increases basal and insulin-stimulated whole body glucose disposal in conscious mice. J Clin Invest (1995) 1.65
An ATP-dependent As(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae. Proc Natl Acad Sci U S A (1996) 1.44
Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4). J Clin Invest (1995) 1.35
Insulin resistance, diabetes, and the insulin-regulated trafficking of GLUT-4. J Cell Biol (1994) 1.24
Insulin unmasks a COOH-terminal Glut4 epitope and increases glucose transport across T-tubules in skeletal muscle. J Cell Biol (1996) 1.20
Improved insulin sensitivity by GLUT12 overexpression in mice. Diabetes (2011) 1.17
Acute inhibition of fatty acid import inhibits GLUT4 transcription in adipose tissue, but not skeletal or cardiac muscle tissue, partly through liver X receptor (LXR) signaling. Diabetes (2010) 1.05
Insulin-sensitive targeting of the GLUT4 glucose transporter in L6 myoblasts is conferred by its COOH-terminal cytoplasmic tail. J Cell Biol (1995) 1.05
Control of muscle glucose uptake: test of the rate-limiting step paradigm in conscious, unrestrained mice. J Physiol (2004) 1.03
Glucose transport and GLUT4 protein distribution in skeletal muscle of GLUT4 transgenic mice. Biochem J (1996) 0.98
Degradation of IRS1 leads to impaired glucose uptake in adipose tissue of the type 2 diabetes mouse model TALLYHO/Jng. J Endocrinol (2009) 0.96
Moderate GLUT4 overexpression improves insulin sensitivity and fasting triglyceridemia in high-fat diet-fed transgenic mice. Diabetes (2013) 0.95
Enhanced energy expenditure, glucose utilization, and insulin sensitivity in VAMP8 null mice. Diabetes (2010) 0.93
Separation of insulin signaling into distinct GLUT4 translocation and activation steps. Mol Cell Biol (2004) 0.92
Expression of an insulin-responsive glucose transporter (GLUT4) minigene in transgenic mice: effect of exercise and role in glucose homeostasis. Proc Natl Acad Sci U S A (1995) 0.86
Prevention of diabetic alterations in transgenic mice overexpressing Myc in the liver. Proc Natl Acad Sci U S A (1996) 0.86
Regulation of cell surface GLUT4 in skeletal muscle of transgenic mice. Biochem J (1997) 0.86
Enhanced fasting glucose turnover in mice with disrupted action of TUG protein in skeletal muscle. J Biol Chem (2013) 0.84
Insulin-sensitive regulation of glucose transport and GLUT4 translocation in skeletal muscle of GLUT1 transgenic mice. Biochem J (1999) 0.82
Regulation of endogenous glucose production in glucose transporter 4 over-expressing mice. PLoS One (2012) 0.78
A MED13-dependent skeletal muscle gene program controls systemic glucose homeostasis and hepatic metabolism. Genes Dev (2016) 0.77
Regulation of GLUT4 and Insulin-Dependent Glucose Flux. ISRN Mol Biol (2012) 0.76
Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism. Diabetes (2016) 0.75
METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS. J Biol Chem (1964) 21.04
Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat. J Cell Biol (1991) 8.67
Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med (1990) 4.87
Translocation of the glucose transporter GLUT4 in cardiac myocytes of the rat. Proc Natl Acad Sci U S A (1991) 2.91
Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: characterization of subcellular fractions. Biochim Biophys Acta (1983) 2.88
Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester. J Biol Chem (1990) 2.84
Preparation and characterization of a plasma membrane fraction from isolated fat cells. J Cell Biol (1970) 2.53
Insulin-regulated glucose uptake in rat adipocytes is mediated by two transporter isoforms present in at least two vesicle populations. J Biol Chem (1989) 2.39
Facilitative glucose transporters: regulatory mechanisms and dysregulation in diabetes. J Clin Invest (1992) 2.37
Members of the VAMP family of synaptic vesicle proteins are components of glucose transporter-containing vesicles from rat adipocytes. J Biol Chem (1992) 2.33
Mammalian facilitative glucose transporter family: structure and molecular regulation. Annu Rev Physiol (1992) 2.05
Regulation of glucose transporter messenger RNA in insulin-deficient states. Nature (1989) 2.02
Insulin-induced translocation of glucose transporters in rat hindlimb muscles. FEBS Lett (1987) 2.00
Pretranslational suppression of an insulin-responsive glucose transporter in rats with diabetes mellitus. Science (1989) 1.97
Differential regulation of two glucose transporters in adipose cells from diabetic and insulin-treated diabetic rats. J Clin Invest (1989) 1.89
Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting. Nature (1989) 1.88
The efficient intracellular sequestration of the insulin-regulatable glucose transporter (GLUT-4) is conferred by the NH2 terminus. J Cell Biol (1992) 1.86
Kinetics of glucose disposal in whole body and across the forearm in man. J Clin Invest (1987) 1.83
Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med (1992) 1.82
Identification of an intracellular pool of glucose transporters from basal and insulin-stimulated rat skeletal muscle. J Biol Chem (1990) 1.77
Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity. J Clin Invest (1991) 1.76
Membrane transport: its relation to cellular metabolic rates. Science (1975) 1.74
Structure-function relationships in the adipose cell. I. Ultrastructure of the isolated adipose cell. J Cell Biol (1970) 1.58
Immunocytochemical and biochemical studies of GLUT4 in rat skeletal muscle. J Biol Chem (1992) 1.53
Effect of insulin on the distribution and disposition of glucose in man. J Clin Invest (1985) 1.49
Insulin and nonhydrolyzable GTP analogs induce translocation of GLUT 4 to the plasma membrane in alpha-toxin-permeabilized rat adipose cells. J Biol Chem (1991) 1.48
Glucose transport is rate limiting for skeletal muscle glucose metabolism in normal and STZ-induced diabetic rats. Diabetes (1988) 1.43
Decreased expression of glucose transporter in muscle from insulin-resistant patients. Am J Physiol (1991) 1.36
Immunolocalization of glucose transporter GLUT4 within human skeletal muscle. Diabetes (1991) 1.31
Isoform-specific subcellular targeting of glucose transporters in mouse fibroblasts. J Cell Biol (1992) 1.30
Decreased in vivo glucose uptake but normal expression of GLUT1 and GLUT4 in skeletal muscle of diabetic rats. J Clin Invest (1991) 1.30
Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression. J Clin Invest (1991) 1.28
Rate-limiting steps for insulin-mediated glucose uptake into perfused rat hindlimb. Am J Physiol (1986) 1.25
Hormonal/metabolic regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice. J Biol Chem (1993) 1.24
Domains responsible for the differential targeting of glucose transporter isoforms. J Biol Chem (1992) 1.21
Purification of insulin-dependent exocytic vesicles containing the glucose transporter. J Biol Chem (1987) 1.14
A reliable photomicrographic method to determining fat cell size and number: application to dietary obesity. Proc Soc Exp Biol Med (1977) 1.04
Regulation of glucose transporter-specific mRNA levels in rat adipose cells with fasting and refeeding. Implications for in vivo control of glucose transporter number. J Clin Invest (1989) 0.99
Analysis of the glucose transporter content of islet cell lines: implications for glucose-stimulated insulin release. Cell Signal (1992) 0.98
Differential regulation of glucose transporter activity and expression in red and white skeletal muscle. J Biol Chem (1991) 0.96
Recovery of maximal insulin responsiveness and insulin sensitivity after induction of insulin resistance in primary cultured adipocytes. J Biol Chem (1989) 0.85
Lectin and immunolabeling of microvascular endothelia. J Electron Microsc Tech (1991) 0.84
Characterization of GTP-binding proteins in Golgi-associated membrane vesicles from rat adipocytes. Biochem J (1992) 0.80
CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature (2000) 4.10
Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. Nature (2001) 2.77
Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes. Mol Cell (1999) 2.22
Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice. Am J Physiol Endocrinol Metab (2000) 2.17
Regulation of insulin-stimulated GLUT4 translocation by Munc18c in 3T3L1 adipocytes. J Biol Chem (1998) 2.11
Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals. Proc Natl Acad Sci U S A (2007) 2.04
Regulation of glucose transporter messenger RNA in insulin-deficient states. Nature (1989) 2.02
Dynamin is required for recombinant adeno-associated virus type 2 infection. J Virol (1999) 1.99
Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin. J Biol Chem (1995) 1.97
Insulin-stimulated GLUT4 translocation in adipocytes is dependent upon cortical actin remodeling. J Biol Chem (2001) 1.94
Structure, function, and regulation of the mammalian facilitative glucose transporter gene family. Annu Rev Nutr (1996) 1.91
Leukotriene B4 plays a critical role in the progression of collagen-induced arthritis. Proc Natl Acad Sci U S A (1995) 1.85
Syntaxin 4, VAMP2, and/or VAMP3/cellubrevin are functional target membrane and vesicle SNAP receptors for insulin-stimulated GLUT4 translocation in adipocytes. Mol Cell Biol (1997) 1.85
Insulin-induced translocation of glucose transporters from post-Golgi compartments to the plasma membrane of 3T3-L1 adipocytes. J Cell Biol (1988) 1.78
Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways. Mol Cell Biol (1998) 1.68
Expression of a dominant interfering dynamin mutant in 3T3L1 adipocytes inhibits GLUT4 endocytosis without affecting insulin signaling. J Biol Chem (1998) 1.60
Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling. Proc Natl Acad Sci U S A (1995) 1.55
Skeletal muscle glucose transport and metabolism are enhanced in transgenic mice overexpressing the Glut4 glucose transporter. J Biol Chem (1995) 1.52
Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways. Diabetologia (2002) 1.50
Budding of Rous sarcoma virus and vesicular stomatitis virus from localized lipid regions in the plasma membrane of chicken embryo fibroblasts. J Biol Chem (1980) 1.50
SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways. J Biol Chem (1996) 1.48
Myocyte enhancer factor 2 (MEF2)-binding site is required for GLUT4 gene expression in transgenic mice. Regulation of MEF2 DNA binding activity in insulin-deficient diabetes. J Biol Chem (1998) 1.47
Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation. J Cell Biol (2001) 1.46
Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance. J Clin Invest (2001) 1.45
Photoaffinity labeling of the human erythrocyte D-glucose transporter. J Biol Chem (1982) 1.43
Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex. J Biol Chem (1995) 1.42
Phorbol ester induces desensitization of adenylate cyclase and phosphorylation of the beta-adrenergic receptor in turkey erythrocytes. Proc Natl Acad Sci U S A (1984) 1.39
Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits. Mol Cell Biol (1994) 1.38
In vivo quantification of subcutaneous and visceral adiposity by micro-computed tomography in a small animal model. Med Eng Phys (2008) 1.38
The glucose transporter in 3T3-L1 adipocytes is phosphorylated in response to phorbol ester but not in response to insulin. J Biol Chem (1986) 1.38
Abundance, localization, and insulin-induced translocation of glucose transporters in red and white muscle. Am J Physiol (1992) 1.36
The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway. J Biol Chem (1997) 1.35
Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4). J Clin Invest (1995) 1.35
Phosphatidylinositol 3-kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcription. J Biol Chem (1993) 1.32
The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism. J Biol Chem (1999) 1.32
Germline manipulation of glucose homeostasis via alteration of glucose transporter levels in skeletal muscle. J Biol Chem (1993) 1.32
Collagen-induced arthritis is reduced in 5-lipoxygenase-activating protein-deficient mice. J Exp Med (1997) 1.29
Intracellular organization of insulin signaling and GLUT4 translocation. Recent Prog Horm Res (2001) 1.28
Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo. Proc Natl Acad Sci U S A (1998) 1.27
Insulin-stimulated translocation of the HepG2/erythrocyte-type glucose transporter expressed in 3T3-L1 adipocytes. J Biol Chem (1989) 1.26
beta-Adrenergic regulation of insulin and epidermal growth factor receptors in rat adipocytes. J Biol Chem (1983) 1.25
Hormonal/metabolic regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice. J Biol Chem (1993) 1.24
The MEF2A isoform is required for striated muscle-specific expression of the insulin-responsive GLUT4 glucose transporter. J Biol Chem (2000) 1.24
Exercise protects against articular cartilage degeneration in the hamster. Arthritis Rheum (1998) 1.23
Munc18c function is required for insulin-stimulated plasma membrane fusion of GLUT4 and insulin-responsive amino peptidase storage vesicles. Mol Cell Biol (2000) 1.23
Insulin stimulates fluid-phase endocytosis and exocytosis in 3T3-L1 adipocytes. J Biol Chem (1986) 1.22
Transdominant inhibition of tyrosine kinase activity in mutant insulin/insulin-like growth factor I hybrid receptors. Proc Natl Acad Sci U S A (1991) 1.21
Osmotic shock stimulates GLUT4 translocation in 3T3L1 adipocytes by a novel tyrosine kinase pathway. J Biol Chem (1997) 1.21
Functional expression of insulin receptor substrate-1 is required for insulin-stimulated mitogenic signaling. J Biol Chem (1993) 1.20
(+)-1-(3S,4R)-[3-(4-phenylbenzyl)-4-hydroxychroman-7-yl]cyclopentane carboxylic acid, a highly potent, selective leukotriene B4 antagonist with oral activity in the murine collagen-induced arthritis model. J Med Chem (1994) 1.19
VAMP3 null mice display normal constitutive, insulin- and exercise-regulated vesicle trafficking. Mol Cell Biol (2001) 1.18
Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contraction- and phosphatidylinositol-3-kinase-independent pathway. Diabetes (1997) 1.18
Enhanced peripheral glucose utilization in transgenic mice expressing the human GLUT4 gene. J Biol Chem (1994) 1.17
Functional cooperation of two independent targeting domains in syntaxin 6 is required for its efficient localization in the trans-golgi network of 3T3L1 adipocytes. J Biol Chem (2000) 1.17
Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes. EMBO J (1998) 1.16
Surface densities of diaphragmed fenestrae and transendothelial channels in different murine capillary beds. Circ Res (1985) 1.16
Subcellular compartmentalization and trafficking of the insulin-responsive glucose transporter, GLUT4. Exp Cell Res (2001) 1.16
Insulin receptor substrate-1 (IRS1) and Shc compete for a limited pool of Grb2 in mediating insulin downstream signaling. J Biol Chem (1994) 1.15
Aldolase mediates the association of F-actin with the insulin-responsive glucose transporter GLUT4. J Biol Chem (1999) 1.13
Glucose transport activity in L6 muscle cells is regulated by the coordinate control of subcellular glucose transporter distribution, biosynthesis, and mRNA transcription. J Biol Chem (1990) 1.12
Insulin-stimulated disassociation of the SOS-Grb2 complex. Mol Cell Biol (1995) 1.11
Insulin stimulates actin comet tails on intracellular GLUT4-containing compartments in differentiated 3T3L1 adipocytes. J Biol Chem (2001) 1.10
GLUT4 overexpression in db/db mice dose-dependently ameliorates diabetes but is not a lifelong cure. Diabetes (2001) 1.09
Insulin stimulation of a MEK-dependent but ERK-independent SOS protein kinase. Mol Cell Biol (1996) 1.09
Myocyte enhancer factor 2 (MEF2) binding site is essential for C2C12 myotube-specific expression of the rat GLUT4/muscle-adipose facilitative glucose transporter gene. J Biol Chem (1994) 1.09
Insulin stimulates the phosphorylation of the 66- and 52-kilodalton Shc isoforms by distinct pathways. Endocrinology (1997) 1.08
Detection of collagenase-induced damage of collagen by 9A4, a monoclonal C-terminal neoepitope antibody. Matrix Biol (1999) 1.08
Mammalian glucose transporters: structure and molecular regulation. Recent Prog Horm Res (1991) 1.08
Isolation of functional alpha beta heterodimers from the purified human placental alpha 2 beta 2 heterotetrameric insulin receptor complex. A structural basis for insulin binding heterogeneity. J Biol Chem (1987) 1.07
Identification of a skeletal muscle-specific regulatory domain in the rat GLUT4/muscle-fat gene. J Biol Chem (1993) 1.07
Insulin action rapidly modulates the apparent affinity of the insulin-like growth factor II receptor. J Biol Chem (1983) 1.06
Guanosine 5'-O-(3-thiotriphosphate) (GTPgammaS) stimulation of GLUT4 translocation is tyrosine kinase-dependent. J Biol Chem (1998) 1.06
Assembly of insulin/insulin-like growth factor-1 hybrid receptors in vitro. J Biol Chem (1989) 1.05
Transcriptional regulation of the human GLUT4 gene promoter in diabetic transgenic mice. J Biol Chem (1995) 1.05
Transmembrane domain length determines intracellular membrane compartment localization of syntaxins 3, 4, and 5. Am J Physiol Cell Physiol (2001) 1.04
Munc18c regulates insulin-stimulated glut4 translocation to the transverse tubules in skeletal muscle. J Biol Chem (2000) 1.04
Differential binding of the lectins Griffonia simplicifolia I and Lycopersicon esculentum to microvascular endothelium: organ-specific localization and partial glycoprotein characterization. Eur J Cell Biol (1990) 1.03
Purification, visualization, and biophysical characterization of Kv1.3 tetramers. J Biol Chem (1997) 1.03
Shc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors. J Biol Chem (1995) 1.02
Osmotic shock inhibits insulin signaling by maintaining Akt/protein kinase B in an inactive dephosphorylated state. Mol Cell Biol (1999) 1.02
Molecular machinery involved in the insulin-regulated fusion of GLUT4-containing vesicles with the plasma membrane (review). Mol Membr Biol (2002) 1.01
The formation of fenestrations and channels by capillary endothelium in vitro. Proc Natl Acad Sci U S A (1985) 1.01
Polylysine specifically activates the insulin-dependent insulin receptor protein kinase. J Biol Chem (1989) 1.01
Regulation of the GLUT4/muscle-fat glucose transporter mRNA in adipose tissue of insulin-deficient diabetic rats. J Biol Chem (1993) 1.00
Expression of the brain-type glucose transporter is restricted to brain and neuronal cells in mice. Diabetologia (1992) 0.99
Identification of the stereospecific hexose transporter from starved and fed chicken embryo fibroblasts. Proc Natl Acad Sci U S A (1982) 0.99
Insulin and glucose-dependent regulation of the glucose transport system in the rat L6 skeletal muscle cell line. J Biol Chem (1989) 0.99
Inhibition of leukotriene B4-receptor interaction suppresses eosinophil infiltration and disease pathology in a murine model of experimental allergic encephalomyelitis. J Exp Med (1996) 0.99
Relationship between alpha subunit ligand occupancy and beta subunit autophosphorylation in insulin/insulin-like growth factor-1 hybrid receptors. J Biol Chem (1993) 0.99