Published in Infect Immun on February 01, 1993
Interferon gamma receptor deficient mice are resistant to endotoxic shock. J Exp Med (1994) 1.95
Lipopolysaccharide-binding protein as a major plasma protein responsible for endotoxemic shock. Proc Natl Acad Sci U S A (1993) 1.31
Immunoreactivity and bioactivity of lipopolysaccharide-binding protein in normal and heat-inactivated sera. Infect Immun (1995) 1.12
Lipopolysaccharide (LPS)-binding protein and soluble CD14 function as accessory molecules for LPS-induced changes in endothelial barrier function, in vitro. J Clin Invest (1994) 1.05
Fish oil attenuates omega-6 polyunsaturated fatty acid-induced dysbiosis and infectious colitis but impairs LPS dephosphorylation activity causing sepsis. PLoS One (2013) 1.03
Pathogenesis of paralytic ileus: intestinal manipulation opens a transient pathway between the intestinal lumen and the leukocytic infiltrate of the jejunal muscularis. Ann Surg (2002) 0.99
Mode of action of anti-lipopolysaccharide-binding protein antibodies for prevention of endotoxemic shock in mice. Proc Natl Acad Sci U S A (1994) 0.97
Role of plasma, lipopolysaccharide-binding protein, and CD14 in response of mouse peritoneal exudate macrophages to endotoxin. Infect Immun (2001) 0.94
Potent CD14-mediated signalling of human leukocytes by Escherichia coli can be mediated by interaction of whole bacteria and host cells without extensive prior release of endotoxin. Infect Immun (1996) 0.92
CD14 and tissue factor expression by bacterial lipopolysaccharide-stimulated bovine alveolar macrophages in vitro. Infect Immun (1995) 0.81
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A (1979) 365.71
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science (1990) 17.86
Secretory products of macrophages. J Clin Invest (1987) 10.33
A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes. J Immunol Methods (1986) 8.88
Structure and function of lipopolysaccharide binding protein. Science (1990) 7.76
Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum. J Exp Med (1986) 3.84
Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin. Infect Immun (1986) 3.42
Cachectin/tumor necrosis factor exerts endocrine, paracrine, and autocrine control of inflammatory responses. J Cell Biol (1988) 2.66
Expression of myeloid differentiation antigens on normal and malignant myeloid cells. J Clin Invest (1981) 2.34
Cloning of the cDNA of a human neutrophil bactericidal protein. Structural and functional correlations. J Biol Chem (1989) 2.29
Control of lipopolysaccharide (LPS) binding and LPS-induced tumor necrosis factor secretion in human peripheral blood monocytes. J Immunol (1992) 1.82
A family of lipopolysaccharide binding proteins involved in responses to gram-negative sepsis. J Biol Chem (1988) 1.79
The role of cytokine mediators in septic shock. Adv Surg (1990) 1.40
Binding sites for endotoxins (lipopolysaccharides) on human monocytes. J Immunol (1991) 1.39
Identification of individual tumor necrosis factor/cachectin-producing cells after lipopolysaccharide induction. Eur J Immunol (1988) 1.19
Enhancement of murine macrophage binding of and response to bacterial lipopolysaccharide (LPS) by LPS-binding protein. J Leukoc Biol (1992) 1.16
The optimal application of forward and ninety-degree light scatter in flow cytometry for the gating of mononuclear cells. Cytometry (1985) 0.97
Nucleotide sequence of the bovine bactericidal permeability increasing protein (BPI). Nucleic Acids Res (1990) 0.83
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science (1990) 17.86
Toll-like receptors in the induction of the innate immune response. Nature (2000) 12.23
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science (1994) 10.99
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem (1995) 9.56
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science (1995) 7.87
Structure and function of lipopolysaccharide binding protein. Science (1990) 7.76
Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu Rev Immunol (1995) 6.99
The effects of bacterial endotoxins on host mediation systems. A review. Am J Pathol (1978) 6.03
V beta-specific stimulation of human T cells by staphylococcal toxins. Science (1989) 5.34
Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits. J Clin Invest (1988) 4.76
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature (1997) 4.59
BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. EMBO J (1997) 4.51
Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J Biol Chem (1995) 4.36
Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc Natl Acad Sci U S A (1993) 4.35
Treatment of gram-negative bacteremia and shock with human antiserum to a mutant Escherichia coli. N Engl J Med (1982) 4.28
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. Nat Immunol (2001) 4.13
Septic shock: pathogenesis. Lancet (1991) 3.99
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway. Nat Immunol (2000) 3.96
Protection from septic shock by neutralization of macrophage migration inhibitory factor. Nat Med (2000) 3.89
Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum. J Exp Med (1986) 3.84
CD14 is a pattern recognition receptor. Immunity (1994) 3.79
Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J Biol Chem (1996) 3.63
CD14: cell surface receptor and differentiation marker. Immunol Today (1993) 3.47
Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J (1991) 3.41
Atherogenic dyslipidemia in HIV-infected individuals treated with protease inhibitors. The Swiss HIV Cohort Study. Circulation (1999) 3.16
MIF regulates innate immune responses through modulation of Toll-like receptor 4. Nature (2002) 3.10
The clearance, tissue distribution, and cellular localization of intravenously injected lipopolysaccharide in rabbits. J Immunol (1979) 3.09
Regulation of the MEF2 family of transcription factors by p38. Mol Cell Biol (1999) 3.02
Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2. J Biol Chem (2001) 2.94
New function for high density lipoproteins. Their participation in intravascular reactions of bacterial lipopolysaccharides. J Clin Invest (1979) 2.93
Gram-positive cell walls stimulate synthesis of tumor necrosis factor alpha and interleukin-6 by human monocytes. Infect Immun (1994) 2.92
Recognition of gram-negative bacteria and endotoxin by the innate immune system. Curr Opin Immunol (1999) 2.85
How we detect microbes and respond to them: the Toll-like receptors and their transducers. J Leukoc Biol (2003) 2.83
Natural history of aortic valve endocarditis in rats. Infect Immun (1982) 2.74
Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. J Exp Med (1989) 2.72
Lipopolysaccharide (LPS) partial structures inhibit responses to LPS in a human macrophage cell line without inhibiting LPS uptake by a CD14-mediated pathway. J Exp Med (1992) 2.71
Identification of a lipid A binding site in the acute phase reactant lipopolysaccharide binding protein. J Biol Chem (1989) 2.69
Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. Nature (1998) 2.62
Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase. J Biol Chem (1996) 2.51
Tumor localization of radiolabeled antibodies against carcinoembryonic antigen in patients with carcinoma: a critical evaluation. N Engl J Med (1980) 2.50
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta. J Biol Chem (1997) 2.47
The modification of biophysical and endotoxic properties of bacterial lipopolysaccharides by serum. J Clin Invest (1978) 2.37
Prognostic values of tumor necrosis factor/cachectin, interleukin-1, interferon-alpha, and interferon-gamma in the serum of patients with septic shock. Swiss-Dutch J5 Immunoglobulin Study Group. J Infect Dis (1990) 2.36
Successful single-dose amoxicillin prophylaxis against experimental streptococcal endocarditis: evidence for two mechanisms of protection. J Infect Dis (1983) 2.35
Fluconazole prophylaxis prevents intra-abdominal candidiasis in high-risk surgical patients. Crit Care Med (1999) 2.35
Correlation between in vitro susceptibility of Candida albicans and fluconazole-resistant oropharyngeal candidiasis in HIV-infected patients. Eur J Clin Microbiol Infect Dis (1993) 2.35
Potent synergism of the combination of fluconazole and cyclosporine in Candida albicans. Antimicrob Agents Chemother (2000) 2.27
Isolation of cDNA clones encoding HLA-DR alpha chains. Proc Natl Acad Sci U S A (1982) 2.17
Toll-like receptor 4, but not toll-like receptor 2, is a signaling receptor for Escherichia and Salmonella lipopolysaccharides. J Immunol (2000) 2.16
Primary structure of BMK1: a new mammalian map kinase. Biochem Biophys Res Commun (1995) 2.15
Adaptation to bacterial lipopolysaccharide controls lipopolysaccharide-induced tumor necrosis factor production in rabbit macrophages. J Clin Invest (1990) 2.12
Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur Cytokine Netw (2000) 2.11
Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. Biochim Biophys Acta (2001) 2.09
New function for high density lipoproteins. Isolation and characterization of a bacterial lipopolysaccharide-high density lipoprotein complex formed in rabbit plasma. J Clin Invest (1981) 2.08
Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein. J Exp Med (1992) 2.05
Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b. Immunity (1997) 2.04
Characterization of receptors for alpha-melanocyte-stimulating hormone on human melanoma cells. Cancer Res (1989) 2.03
Lipopolysaccharide binding protein-mediated complexation of lipopolysaccharide with soluble CD14. J Biol Chem (1995) 2.02
Lipopolysaccharide induces hyporesponsiveness to its own action in RAW 264.7 cells. J Biol Chem (1989) 2.00
The primary structure of p38 gamma: a new member of p38 group of MAP kinases. Biochem Biophys Res Commun (1996) 1.99
Purification and molecular cloning of an inducible gram-negative bacteria-binding protein from the silkworm, Bombyx mori. Proc Natl Acad Sci U S A (1996) 1.97
Binding of bacterial peptidoglycan to CD14. J Biol Chem (1998) 1.97
In vivo localisation of radiolabelled antibodies to carcinoembryonic antigen in human colon carcinoma grafted into nude mice. Nature (1974) 1.96
The preparation and characterization of a radioiodinated bacterial lipopolysaccharide. Immunochemistry (1978) 1.95
Interferon gamma receptor deficient mice are resistant to endotoxic shock. J Exp Med (1994) 1.95
Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14. J Biol Chem (1993) 1.93
Mediation systems in bacterial lipopolysaccharide-induced hypotension and disseminated intravascular coagulation. I. The role of complement. J Exp Med (1975) 1.91
MD-2 binds to bacterial lipopolysaccharide. J Biol Chem (2001) 1.91
Distinct forms of both alpha and beta subunits are present in the human Ia molecular pool. Proc Natl Acad Sci U S A (1981) 1.91
Regulation of an essential innate immune response by the p50 subunit of NF-kappaB. J Clin Invest (1998) 1.89
BAL9141, a novel extended-spectrum cephalosporin active against methicillin-resistant Staphylococcus aureus in treatment of experimental endocarditis. Antimicrob Agents Chemother (2002) 1.88
Subsets of human Ia-like molecules defined by monoclonal antibodies. Mol Immunol (1981) 1.87
TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide. J Leukoc Biol (2000) 1.85
The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. Proc Natl Acad Sci U S A (1997) 1.83
Control of lipopolysaccharide (LPS) binding and LPS-induced tumor necrosis factor secretion in human peripheral blood monocytes. J Immunol (1992) 1.82
Escherichia coli resistant to fluoroquinolones in patients with cancer and neutropenia. N Engl J Med (1994) 1.81
Expression of MAGE genes in primary and metastatic cutaneous melanoma. Int J Cancer (1995) 1.81
A family of lipopolysaccharide binding proteins involved in responses to gram-negative sepsis. J Biol Chem (1988) 1.79
Isolation of distinct cDNA clones encoding HLA-DR beta chains by use of an expression assay. Proc Natl Acad Sci U S A (1982) 1.77