Published in Protein Eng on January 01, 1993
Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block. J Virol (1993) 4.76
A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity. Proc Natl Acad Sci U S A (1997) 4.03
Influenza A virus M2 ion channel protein: a structure-function analysis. J Virol (1994) 3.02
Backbone structure of the amantadine-blocked trans-membrane domain M2 proton channel from Influenza A virus. Biophys J (2007) 2.68
Structure of amantadine-bound M2 transmembrane peptide of influenza A in lipid bilayers from magic-angle-spinning solid-state NMR: the role of Ser31 in amantadine binding. J Mol Biol (2008) 2.15
Amantadine-induced conformational and dynamical changes of the influenza M2 transmembrane proton channel. Proc Natl Acad Sci U S A (2008) 2.07
The Vpu protein of human immunodeficiency virus type 1 forms cation-selective ion channels. J Virol (1996) 2.01
A secondary gate as a mechanism for inhibition of the M2 proton channel by amantadine. J Phys Chem B (2008) 1.97
Conformational heterogeneity of the M2 proton channel and a structural model for channel activation. Proc Natl Acad Sci U S A (2009) 1.94
Influenza A virus can undergo multiple cycles of replication without M2 ion channel activity. J Virol (2001) 1.63
The dielectric properties of water within model transbilayer pores. Biophys J (1997) 1.55
Parallel helix bundles and ion channels: molecular modeling via simulated annealing and restrained molecular dynamics. Biophys J (1994) 1.41
Sequence determinants of the energetics of folding of a transmembrane four-helix-bundle protein. Proc Natl Acad Sci U S A (2002) 1.39
Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy. J Am Chem Soc (2011) 1.30
Growth impairment resulting from expression of influenza virus M2 protein in Saccharomyces cerevisiae: identification of a novel inhibitor of influenza virus. Antimicrob Agents Chemother (1995) 1.08
Binding hot spots and amantadine orientation in the influenza a virus M2 proton channel. Biophys J (2009) 1.05
Flu channel drug resistance: a tale of two sites. Protein Cell (2010) 1.01
Calculation of rigid-body conformational changes using restraint-driven Cartesian transformations. Biophys J (2001) 0.95
Conformational analysis of the full-length M2 protein of the influenza A virus using solid-state NMR. Protein Sci (2013) 0.94
Modeling the membrane environment has implications for membrane protein structure and function: influenza A M2 protein. Protein Sci (2013) 0.92
Distribution and dynamics of adamantanes in a lipid bilayer. Biophys J (2008) 0.88
Free-energy profiles for ions in the influenza M2-TMD channel. Proteins (2009) 0.85
WebProAnalyst: an interactive tool for analysis of quantitative structure-activity relationships in protein families. Nucleic Acids Res (2005) 0.81
In silico investigations of possible routes of assembly of ORF 3a from SARS-CoV. J Mol Model (2011) 0.81
Computational studies of gramicidin permeation: an entry way sulfonate enhances cation occupancy at entry sites. Biochim Biophys Acta (2009) 0.75
Why bound amantadine fails to inhibit proton conductance according to simulations of the drug-resistant influenza A M2 (S31N). J Phys Chem B (2014) 0.75
Investigation of the free energy profiles of amantadine and rimantadine in the AM2 binding pocket. Eur Biophys J (2015) 0.75
A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: identification of duplicated repeats and potential active site residues. Protein Sci (1996) 3.34
The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol (2013) 2.48
The influenza A virus M2 channel: a molecular modeling and simulation study. Virology (1997) 1.94
Molecular dynamics simulations of water within models of ion channels. Biophys J (1996) 1.72
Water in channel-like cavities: structure and dynamics. Biophys J (1996) 1.66
Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle. EMBO J (2001) 1.54
Alamethicin and related peptaibols--model ion channels. Eur Biophys J (1993) 1.49
Two approaches to discovering and developing new drugs for Chagas disease. Mem Inst Oswaldo Cruz (2009) 1.41
Transbilayer pores formed by beta-barrels: molecular modeling of pore structures and properties. Biophys J (1995) 1.16
Alamethicin channels - modelling via restrained molecular dynamics simulations. Biochim Biophys Acta (1997) 1.15
Modelling membrane proteins using structural restraints. Nat Struct Biol (1995) 1.12
Ion channels formed by HIV-1 Vpu: a modelling and simulation study. FEBS Lett (1997) 1.09
Ion-channel gating. Twist to open. Curr Biol (1995) 1.02
The alpha-5 segment of Bacillus thuringiensis delta-endotoxin: in vitro activity, ion channel formation and molecular modelling. Biochem J (1994) 1.01
Multiple drugbinding sites on the R482G isoform of the ABCG2 transporter. Br J Pharmacol (2006) 0.94
Seven-helix bundles: molecular modeling via restrained molecular dynamics. Biophys J (1995) 0.94
Ion channels formed by amphipathic helical peptides. A molecular modelling study. Eur Biophys J (1991) 0.94
Packing interactions of Aib-containing helices: molecular modeling of parallel dimers of simple hydrophobic helices and of alamethicin. Biopolymers (1995) 0.89
Protein-water-ion interactions in a model of the pore domain of a potassium channel: a simulation study. Biochim Biophys Acta (1998) 0.87
A structural perspective on the enzymes that convert dTDP-d-glucose into dTDP-l-rhamnose. Biochem Soc Trans (2003) 0.87
Cation selectivity in ion channels. Nature (1995) 0.85
The roles of serine and threonine sidechains in ion channels: a modelling study. Eur Biophys J (1992) 0.85
Studies of the pore-forming domain of a voltage-gated potassium channel protein. Protein Eng (1994) 0.84
Alamethicin pyromellitate: an ion-activated channel-forming peptide. Biochemistry (1994) 0.84
Ion channel formation by zervamicin-IIB. A molecular modelling study. Eur Biophys J (1993) 0.84
Ion channel stability and hydrogen bonding. Molecular modelling of channels formed by synthetic alamethicin analogues. Biochim Biophys Acta (1997) 0.83
Structure-based interpretation of the mutagenesis database for the nucleotide binding domains of P-glycoprotein. Biochim Biophys Acta (2007) 0.83
Principles of proteomics and its applications in cancer. Surgeon (2007) 0.82
Ion channels: a first view of K+ channels in atomic glory. Curr Biol (1998) 0.82
A selective biotinylated probe for V1a vasopressin receptors. Mol Cell Endocrinol (1991) 0.78
Water dynamics in model transbilayer pores. Biochem Soc Trans (1996) 0.78
Ferrocenoyl derivatives of alamethicin: redox-sensitive ion channels. Biochemistry (1997) 0.77
Simulation studies on bacteriorhodopsin bundle of transmembrane alpha segments. Eur Biophys J (2000) 0.76
Modelling the packing of transmembrane helices: application to aquaporin-1. Biochem Soc Trans (1998) 0.76
Molecular dynamics of ion/channel interactions. Biochem Soc Trans (1998) 0.75
A scientific paradox--explosives that are safe for use in flammable atmospheres. Sci Prog (1990) 0.75
Secondary structure of an isolated P-region from the voltage-gated sodium channel: a molecular modelling/dynamics study. Biophys Chem (1997) 0.75