Published in J Exp Med on May 01, 1995
Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease. Proc Natl Acad Sci U S A (2004) 2.33
Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice. J Exp Med (2008) 2.17
Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein. J Exp Med (1998) 1.94
A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis. J Exp Med (2013) 1.69
Melanoma cells present a MAGE-3 epitope to CD4(+) cytotoxic T cells in association with histocompatibility leukocyte antigen DR11. J Exp Med (1999) 1.58
Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: a mechanism for MHC-linked susceptibility to human autoimmune diseases. J Exp Med (1995) 1.46
Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice. Proc Natl Acad Sci U S A (1998) 1.38
MHC haplotype-dependent regulation of MOG-induced EAE in rats. J Clin Invest (1998) 1.33
T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin. Proc Natl Acad Sci U S A (1998) 1.28
HLA DPA1, DPB1 alleles and haplotypes contribute to the risk associated with type 1 diabetes: analysis of the type 1 diabetes genetics consortium families. Diabetes (2010) 1.26
Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris. Proc Natl Acad Sci U S A (1995) 1.24
MHC Class II Polymorphisms, Autoreactive T-Cells, and Autoimmunity. Front Immunol (2013) 1.22
HLA class II DR-DQ amino acids and insulin-dependent diabetes mellitus: application of the haplotype method. Am J Hum Genet (1997) 1.19
Melan-A/MART-1(51-73) represents an immunogenic HLA-DR4-restricted epitope recognized by melanoma-reactive CD4(+) T cells. Proc Natl Acad Sci U S A (2000) 1.19
Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection. EMBO J (2011) 1.17
HLA-A2 subtypes are functionally distinct in peptide binding and presentation. J Exp Med (1995) 1.14
Desmoglein-1-specific T lymphocytes from patients with endemic pemphigus foliaceus (fogo selvagem). J Clin Invest (2000) 1.12
T cell receptor recognition of self and foreign antigens in the induction of autoimmunity. Semin Immunol (2011) 1.11
Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60 T cell epitope in rats suppresses both adjuvant arthritis and nonmicrobially induced experimental arthritis. Proc Natl Acad Sci U S A (1997) 1.10
A peptide-binding motif for I-A(g7), the class II major histocompatibility complex (MHC) molecule of NOD and Biozzi AB/H mice. J Exp Med (1997) 1.09
Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire. J Clin Invest (1997) 1.03
Plasmodium vivax promiscuous T-helper epitopes defined and evaluated as linear peptide chimera immunogens. Infect Immun (2002) 1.00
Arginine at positions 13 or 70-71 in pocket 4 of HLA-DRB1 alleles is associated with susceptibility to tuberculoid leprosy. J Exp Med (1996) 0.97
Employing a recombinant HLA-DR3 expression system to dissect major histocompatibility complex II-thyroglobulin peptide dynamism: a genetic, biochemical, and reverse immunological perspective. J Biol Chem (2009) 0.94
Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides. Proc Natl Acad Sci U S A (1998) 0.94
An integrated peptide-antigen microarray on plasmonic gold films for sensitive human antibody profiling. PLoS One (2013) 0.92
Do MHCII-presented neoantigens drive type 1 diabetes and other autoimmune diseases? Cold Spring Harb Perspect Med (2012) 0.92
Association of MHC and rheumatoid arthritis. HLA-DR4 and rheumatoid arthritis: studies in mice and men. Arthritis Res (2000) 0.92
Associations of human leukocyte antigens with autoimmune diseases: challenges in identifying the mechanism. J Hum Genet (2015) 0.91
The role and clinical implications of G6PI in experimental models of rheumatoid arthritis. Arthritis Res Ther (2004) 0.90
Further investigation of the role of HLA-DPB1 in adult Hodgkin's disease (HD) suggests an influence on susceptibility to different HD subtypes. Br J Cancer (1999) 0.90
Modeling the ternary complex TCR-Vbeta/CollagenII(261-273)/HLA-DR4 associated with rheumatoid arthritis. PLoS One (2010) 0.89
Cross-reactivity between the rheumatoid arthritis-associated motif EQKRAA and structurally related sequences found in Proteus mirabilis. Infect Immun (1999) 0.88
Molecular mimicry and T cell-mediated autoimmune disease. J Exp Med (1997) 0.86
HLA-DR alleles determine responsiveness to Borrelia burgdorferi antigens in a mouse model of self-perpetuating arthritis. Arthritis Rheum (2009) 0.85
Structure-based design of altered MHC class II-restricted peptide ligands with heterogeneous immunogenicity. J Immunol (2013) 0.85
Second-generation peptidomimetic inhibitors of antigen presentation effectively treat autoimmune diseases in HLA-DR-transgenic mouse models. J Autoimmun (2006) 0.84
Amino acid polymorphism at residue 71 in HLA-DR beta chain plays a critical role in susceptibility to ulcerative colitis. Dig Dis Sci (1999) 0.83
Association of MHC and rheumatoid arthritis. Regulatory role of HLA class II molecules in animal models of RA: studies on transgenic/knockout mice. Arthritis Res (2000) 0.83
The presence of glutamic acid at positions 71 or 74 in pocket 4 of the HLA-DRbeta1 chain is associated with the clinical course of multiple sclerosis. J Neurol Neurosurg Psychiatry (2005) 0.82
Synthetic amino acid copolymers that bind to HLA-DR proteins and inhibit type II collagen-reactive T cell clones. Proc Natl Acad Sci U S A (1998) 0.81
A computational assay to design an epitope-based Peptide vaccine against saint louis encephalitis virus. Bioinform Biol Insights (2013) 0.81
VitAL: Viterbi algorithm for de novo peptide design. PLoS One (2010) 0.80
ATPase4A Autoreactivity and Its Association With Autoimmune Phenotypes in the Type 1 Diabetes Genetics Consortium Study. Diabetes Care (2015) 0.80
Ligand design by a combinatorial approach based on modeling and experiment: application to HLA-DR4. J Comput Aided Mol Des (2007) 0.80
Human papillomavirus type 33 E7 peptides presented by HLA-DR*0402 to tumor-infiltrating T cells in cervical cancer. J Virol (2000) 0.79
An autoantibody targeting glycated IgG is associated with elevated serum immune complexes in rheumatoid arthritis (RA). Clin Exp Immunol (2000) 0.78
Peptide motif for the rat MHC class II molecule RT1.Da: similarities to the multiple sclerosis-associated HLA-DRB1*1501 molecule. Immunogenetics (2005) 0.78
Immunoinformatics prediction of linear epitopes from Taenia solium TSOL18. Bioinformation (2011) 0.78
Absence of peripheral blood T cell responses to "shared epitope' containing peptides in recent onset rheumatoid arthritis. Ann Rheum Dis (1997) 0.77
Variation in positively selected major histocompatibility complex class I loci in rufous-collared sparrows (Zonotrichia capensis). Immunogenetics (2014) 0.77
Molecular analysis of thymopentin binding to HLA-DR molecules. PLoS One (2007) 0.77
Design of peptide immunotherapies for MHC Class-II-associated autoimmune disorders. Clin Dev Immunol (2013) 0.76
An automated framework for understanding structural variations in the binding grooves of MHC class II molecules. BMC Bioinformatics (2010) 0.75
The association of HLA-class I and class II with Hodgkin's lymphoma in Iranian patients. Biomed Res Int (2014) 0.75
Joint-specific and systemic autoreactivity in the development of inflammatory arthritis. Arthritis Res (1999) 0.75
Bifunctional Peptide Inhibitors Suppress Interleukin-6 Proliferation and Ameliorates Murine Collagen-Induced Arthritis. J Clin Cell Immunol (2014) 0.75
A reciprocal HLA-Disease Association in Rheumatoid Arthritis and Pemphigus Vulgaris. Front Biosci (Landmark Ed) (2017) 0.75
The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum (1987) 14.21
T cell tolerance by clonal elimination in the thymus. Cell (1987) 13.83
Autoimmunity to type II collagen an experimental model of arthritis. J Exp Med (1977) 10.09
Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature (1994) 7.13
Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature (1988) 5.22
MHC class-II molecules and autoimmunity. Annu Rev Immunol (1991) 3.41
Promiscuous and allele-specific anchors in HLA-DR-binding peptides. Cell (1993) 3.41
The cytokeratin filament-aggregating protein filaggrin is the target of the so-called "antikeratin antibodies," autoantibodies specific for rheumatoid arthritis. J Clin Invest (1993) 2.37
HLA genes associated with rheumatoid arthritis. Identification of susceptibility alleles using specific oligonucleotide probes. Arthritis Rheum (1989) 2.28
Association of HLA-Aw31 and HLA-DR1 with adult rheumatoid arthritis. Ann Rheum Dis (1982) 1.99
Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning. J Exp Med (1994) 1.81
Identification of a motif for HLA-DR1 binding peptides using M13 display libraries. J Exp Med (1992) 1.78
High-affinity binding of short peptides to major histocompatibility complex class II molecules by anchor combinations. Proc Natl Acad Sci U S A (1994) 1.69
Immunity to cartilage proteoglycans in BALB/c mice with progressive polyarthritis and ankylosing spondylitis induced by injection of human cartilage proteoglycan. Arthritis Rheum (1987) 1.66
Recognition of a mycobacteria-specific epitope in the 65-kD heat-shock protein by synovial fluid-derived T cell clones. J Exp Med (1990) 1.57
Selection of T cell epitopes and vaccine engineering. Methods Enzymol (1991) 1.50
Murine MHC polymorphism and T cell specificities. Science (1989) 1.34
Pocket 4 of the HLA-DR(alpha,beta 1*0401) molecule is a major determinant of T cells recognition of peptide. J Exp Med (1995) 1.28
Structural requirements for recognition of the HLA-Dw14 class II epitope: a key HLA determinant associated with rheumatoid arthritis. Proc Natl Acad Sci U S A (1990) 1.03
Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med (1998) 8.56
Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. J Exp Med (2001) 5.56
Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices. Nat Biotechnol (1999) 5.13
Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science (1998) 3.68
Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J Exp Med (1997) 3.57
Promiscuous and allele-specific anchors in HLA-DR-binding peptides. Cell (1993) 3.41
Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor). J Immunol (1991) 3.40
Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: effect of HIV sequence variation and a mechanism for CD4+ cell depletion. Cell (1988) 3.25
The traditional and a new version of the mouse H-2 complex. Nature (1981) 3.12
Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J Immunol (1995) 3.06
DNA polymerase I gene of Saccharomyces cerevisiae: nucleotide sequence, mapping of a temperature-sensitive mutation, and protein homology with other DNA polymerases. Proc Natl Acad Sci U S A (1988) 2.97
Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. J Immunol (1998) 2.84
Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. J Clin Invest (1998) 2.78
Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. Proc Natl Acad Sci U S A (1996) 2.71
Transcript imaging of the development of human T helper cells using oligonucleotide arrays. Nat Genet (2000) 2.71
The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells. J Immunol (1998) 2.32
Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone. J Exp Med (1996) 2.28
Why peptides? Their possible role in the evolution of MHC-restricted T-cell recognition. Immunol Today (1989) 2.23
Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses. J Clin Invest (2001) 2.10
The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J Clin Invest (2001) 2.05
HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis. J Exp Med (1996) 1.99
Identification of a CD4 binding site on the beta 2 domain of HLA-DR molecules. Nature (1992) 1.98
Beta2-agonists prevent Th1 development by selective inhibition of interleukin 12. J Clin Invest (1997) 1.94
T lymphocytes from healthy individuals with specificity to self-epitopes shared by the mycobacterial and human 65-kilodalton heat shock protein. J Immunol (1989) 1.94
Mechanisms influencing the immunodominance of T cell determinants. J Exp Med (1988) 1.91
Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning. J Exp Med (1994) 1.81
Identification of a motif for HLA-DR1 binding peptides using M13 display libraries. J Exp Med (1992) 1.78
Single amino acid changes in DR and antigen define residues critical for peptide-MHC binding and T cell recognition. J Immunol (1991) 1.75
High-affinity binding of short peptides to major histocompatibility complex class II molecules by anchor combinations. Proc Natl Acad Sci U S A (1994) 1.69
Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes. J Exp Med (1995) 1.67
In vivo competition between self peptides and foreign antigens in T-cell activation. Nature (1988) 1.66
The role of Stat4 in species-specific regulation of Th cell development by type I IFNs. J Immunol (1998) 1.65
Genetics of the major histocompatibility complex: the final act. Annu Rev Immunol (1983) 1.65
Isolation and characterization of Ni-specific T cell clones from patients with Ni-contact dermatitis. J Immunol (1985) 1.59
Melanoma cells present a MAGE-3 epitope to CD4(+) cytotoxic T cells in association with histocompatibility leukocyte antigen DR11. J Exp Med (1999) 1.58
Analysis of the molecular specificities of anti-class II monoclonal antibodies by using L cell transfectants expressing HLA class II molecules. J Immunol (1988) 1.54
Interaction of an immunodominant epitope with Ia molecules in T-cell activation. Proc Natl Acad Sci U S A (1988) 1.51
Selection of T cell epitopes and vaccine engineering. Methods Enzymol (1991) 1.50
Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains. J Exp Med (1981) 1.49
Protection against malaria in Aotus monkeys immunized with a recombinant blood-stage antigen fused to a universal T-cell epitope: correlation of serum gamma interferon levels with protection. Infect Immun (1992) 1.45
The viral chemokine macrophage inflammatory protein-II is a selective Th2 chemoattractant. Blood (1998) 1.42
Ia antigens as restriction molecules in Ir-gene controlled T-cell proliferation. Immunol Rev (1981) 1.42
Association of HLA-DRw4 with rheumatoid arthritis in black and white patients. Arthritis Rheum (1980) 1.42
Characterization of a conserved T cell epitope in HIV-1 gp41 recognized by vaccine-induced human cytolytic T cells. J Immunol (1991) 1.38
Polypeptide structure of DNA primase from a yeast DNA polymerase-primase complex. J Biol Chem (1985) 1.36
Induction of regulatory T-lymphocyte responses by liposomes carrying major histocompatibility complex molecules and foreign antigen. Nature (1985) 1.34
Molecular relationships of the human B cell alloantigens, MT2, MB3, MT4, and DR5. J Immunol (1982) 1.34
Chemokines and their receptors guiding T lymphocyte recruitment in lung inflammation. Am J Respir Crit Care Med (2001) 1.32
Assessment in humans of a synthetic peptide-based vaccine against the sporozoite stage of the human malaria parasite, Plasmodium falciparum. J Immunol (1988) 1.28
Relationship between peptide selectivities of human transporters associated with antigen processing and HLA class I molecules. J Immunol (1998) 1.28
Pocket 4 of the HLA-DR(alpha,beta 1*0401) molecule is a major determinant of T cells recognition of peptide. J Exp Med (1995) 1.28
Genetic control of T-cell proliferative responses to poly(glu40ala60) and poly(glu51lys34tyr15): subregion-specific inhibition of the responses with monoclonal Ia antibodies. Immunogenetics (1980) 1.27
Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig. J Clin Invest (1995) 1.27
Competition for antigen presentation in living cells involves exchange of peptides bound by class II MHC molecules. Nature (1989) 1.26
Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation. J Clin Invest (1995) 1.24
Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris. Proc Natl Acad Sci U S A (1995) 1.24
H-2-controlled suppression of T cell response to lactate dehydrogenase B. Characterization of the lactate dehydrogenase B suppressor pathway. J Exp Med (1982) 1.22
Analysis of DR beta and DQ beta chain cDNA clones from a DR7 haplotype. J Immunol (1986) 1.22
Localization of Th-cell subsets in inflammation: differential thresholds for extravasation of Th1 and Th2 cells. Immunol Today (2000) 1.21
Triggering receptor expressed on myeloid cells: role in the diagnosis of lung infections. Eur Respir J (2004) 1.20
The circumsporozoite protein gene from NF54, a Plasmodium falciparum isolate used in malaria vaccine trials. Mol Biochem Parasitol (1989) 1.20
Epitopes recognized by human T cells map within the conserved part of the GP190 of P. falciparum. Science (1988) 1.19
Suppression of cell-mediated lymphocytotoxicity against minor histocompatibility antigens mediated by Lyt-1+Lyt-2+ T cells of stimulator-strain origin. Eur J Immunol (1982) 1.19
All human monocytes have the capability of expressing HLA-DQ and HLA-DP molecules upon stimulation with interferon-gamma. J Immunol (1986) 1.19
HLA polymorphism and T cell recognition of a conserved region of p190, a malaria vaccine candidate. Int Immunol (1991) 1.16
Antibodies to the IL-12 receptor beta 2 chain mark human Th1 but not Th2 cells in vitro and in vivo. J Immunol (1999) 1.15
Plasmodium falciparum-specific human T cell clones: evidence for helper and cytotoxic activities. Eur J Immunol (1987) 1.14
Peptide competition for antigen presentation. Immunol Today (1990) 1.14
Cytotoxic monoclonal antibody specific for the Lyt-1.2 antigen. Immunogenetics (1982) 1.12
Absence of Ir gene control of T cells recognizing foreign antigen in the context of allogenic MHC molecules. Nature (1982) 1.10
Structural identity of human histocompatibility leukocyte antigen-B27 molecules from patients with ankylosing spondylitis and normal individuals. J Clin Invest (1982) 1.10
Residual type 1 immunity in patients genetically deficient for interleukin 12 receptor beta1 (IL-12Rbeta1): evidence for an IL-12Rbeta1-independent pathway of IL-12 responsiveness in human T cells. J Exp Med (2000) 1.09
A peptide-binding motif for I-A(g7), the class II major histocompatibility complex (MHC) molecule of NOD and Biozzi AB/H mice. J Exp Med (1997) 1.09
Structural requirements for the interaction between peptide antigens and I-Ed molecules. J Immunol (1989) 1.09
CD4+ T cell clones obtained from Plasmodium falciparum sporozoite-immunized volunteers recognize polymorphic sequences of the circumsporozoite protein. J Immunol (1993) 1.09
A novel type of T-T cell interaction removes the requirement for I-B region in the H-2 complex. Proc Natl Acad Sci U S A (1981) 1.08
Inhibition by IL-12 and IFN-alpha of I-309 and macrophage-derived chemokine production upon TCR triggering of human Th1 cells. Eur J Immunol (2000) 1.05
Selective interaction of Ni with an MHC-bound peptide. EMBO J (1991) 1.03
HLA class II peptide binding specificity and autoimmunity. Adv Immunol (1997) 1.02
Identification of HLA-DR alpha chain residues critical for binding of the toxic shock syndrome toxin superantigen. J Exp Med (1992) 1.02
Analysis of the permissive association of a malaria T cell epitope with DR molecules. J Immunol (1991) 1.01
Lyt phenotypes of primary cytotoxic T cells generated across the A and E region of the H-2 complex. Eur J Immunol (1981) 1.00
Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures. J Med Chem (2000) 1.00
Platelet activation by von Willebrand factor requires coordinated signaling through thromboxane A2 and Fc gamma IIA receptor. J Biol Chem (2001) 1.00
Pathogenesis and immunotherapy of autoimmune diseases. Immunol Today (1997) 1.00
Upregulation of integrin alpha6/beta1 and chemokine receptor CCR1 by interleukin-12 promotes the migration of human type 1 helper T cells. Blood (1999) 0.99
Selection of H-2 molecules for the context of antigen recognition by T lymphocytes. Immunogenetics (1981) 0.98
Diacylglycerol kinase-alpha phosphorylation by Src on Y335 is required for activation, membrane recruitment and Hgf-induced cell motility. Oncogene (2007) 0.98