Published in Proc Natl Acad Sci U S A on April 25, 1995
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science (1988) 35.59
Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol (1991) 15.04
Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation. Cell (1987) 6.91
Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors. J Virol (1987) 6.88
Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src. Cell (1987) 5.84
Autophosphorylation sites on the epidermal growth factor receptor. Nature (1984) 5.11
Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain. Cell (1987) 4.63
Cell transformation by the viral src oncogene. Annu Rev Cell Biol (1987) 4.18
SH2 and SH3 domains. Curr Biol (1993) 4.17
Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src. Nature (1991) 3.97
Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions. J Biol Chem (1991) 3.93
Isolation and characterization of chicken DNA homologous to the two putative oncogenes of avian erythroblastosis virus. Cell (1982) 3.53
Activation of the cellular oncogene c-erbB by LTR insertion: molecular basis for induction of erythroblastosis by avian leukosis virus. Cell (1983) 3.45
The when and how of Src regulation. Cell (1993) 3.07
Genetics of src: structure and functional organization of a protein tyrosine kinase. Curr Top Microbiol Immunol (1989) 3.03
c-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor. Cell (1985) 3.00
Ligand-induced transformation by a noninternalizing epidermal growth factor receptor. Science (1990) 2.92
Amino acid substitutions sufficient to convert the nontransforming p60c-src protein to a transforming protein. Mol Cell Biol (1986) 2.84
All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor. J Biol Chem (1989) 2.46
Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substrates. J Biol Chem (1990) 2.13
Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src. Mol Cell Biol (1992) 2.06
Linker insertion-deletion mutagenesis of the v-src gene: isolation of host- and temperature-dependent mutants. J Virol (1989) 1.95
A new avian erythroblastosis virus, AEV-H, carries erbB gene responsible for the induction of both erythroblastosis and sarcomas. Cell (1983) 1.95
Membrane association of a 36,000-dalton substrate for tyrosine phosphorylation in chicken embryo fibroblasts transformed by avian sarcoma viruses. J Cell Biol (1983) 1.65
c-erbB activation in avian leukosis virus-induced erythroblastosis: clustered integration sites and the arrangement of provirus in the c-erbB alleles. Proc Natl Acad Sci U S A (1985) 1.62
v-erbA cooperates with sarcoma oncogenes in leukemic cell transformation. Cell (1986) 1.56
Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stability. J Virol (1989) 1.53
Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity. Proc Natl Acad Sci U S A (1994) 1.51
Mutations in src homology regions 2 and 3 of activated chicken c-src that result in preferential transformation of mouse or chicken cells. Proc Natl Acad Sci U S A (1990) 1.50
Deletions in the SH2 domain of p60v-src prevent association with the detergent-insoluble cellular matrix. Mol Cell Biol (1991) 1.46
Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein. Mol Cell Biol (1991) 1.42
Hematopoietic cell transformation by a murine recombinant retrovirus containing the src gene of Rous sarcoma virus. Proc Natl Acad Sci U S A (1984) 1.34
Requirement of phosphatidylinositol-3 kinase modification for its association with p60src. Mol Cell Biol (1991) 1.33
Receptor tyrosine kinase substrates: src homology domains and signal transduction. FASEB J (1992) 1.30
Closing in on SH2 specificity. Science (1993) 1.25
Deletions within the amino-terminal half of the c-src gene product that alter the functional activity of the protein. Mol Cell Biol (1989) 1.25
Induction of angiosarcoma by a c-erbB transducing virus. J Virol (1985) 1.22
A complete description of the EGF-receptor exon structure: implication in oncogenic activation and domain evolution. Oncogene (1993) 1.20
Transmembrane signaling by epidermal growth factor receptors lacking autophosphorylation sites. J Biol Chem (1993) 1.13
Effect of src infection on long-term marrow cultures: increased self-renewal of hemopoietic progenitor cells without leukemia. Cell (1984) 1.11
Proviral-activated c-erbB is leukemogenic but not sarcomagenic: characterization of a replication-competent retrovirus containing the activated c-erbB. J Virol (1988) 1.07
Tissue-specific transformation by epidermal growth factor receptor: a single point mutation within the ATP-binding pocket of the erbB product increases its intrinsic kinase activity and activates its sarcomagenic potential. Proc Natl Acad Sci U S A (1990) 1.04
Most of the substrates of oncogenic viral tyrosine protein kinases can be phosphorylated by cellular tyrosine protein kinases in normal cells. Oncogene Res (1988) 1.00
Host range mutants of v-src: alterations in kinase activity and substrate interactions. J Virol (1992) 0.92
Dissecting the activating mutations in v-erbB of avian erythroblastosis virus strain R. J Virol (1991) 0.92
The biological activity of the human epidermal growth factor receptor is positively regulated by its C-terminal tyrosines. Oncogene (1991) 0.92
The amino-terminal 14 amino acids of v-src can functionally replace the extracellular and transmembrane domains of v-erbB. Mol Cell Biol (1991) 0.88
Control of src kinase activity by activators, inhibitors, and substrate chaperones. Proc Natl Acad Sci U S A (1990) 0.87
Characterization of an angiosarcoma-inducing mutation in the erbB oncogene. Oncogene (1992) 0.87
Analysis of the role of the Shc and Grb2 proteins in signal transduction by the v-ErbB protein. Mol Cell Biol (1994) 0.87
Modulation of erbB kinase activity and oncogenic potential by single point mutations in the glycine loop of the catalytic domain. Mol Cell Biol (1994) 0.86
Mutational analysis of the role of the carboxy-terminal region of the v-erbB protein in erythroid cell transformation. Oncogene (1993) 0.83
Purification and characterization of a pp60c-src-related tyrosine kinase that effectively phosphorylates a synthetic peptide derived from p34cdc2. J Biol Chem (1991) 0.81
Induction of renal adenocarcinoma by a nonmutated erbB oncogene. J Virol (1993) 0.80
Mapping unintegrated avian sarcoma virus DNA: termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA. Cell (1978) 13.33
Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites. Cell (1978) 7.46
Covalently closed circular DNA of avian sarcoma virus: purification from nuclei of infected quail tumor cells and measurement by electron microscopy and gel electrophoresis. J Mol Biol (1976) 4.65
Kinetics of synthesis, structure and purification of avian sarcoma virus-specific DNA made in the cytoplasm of acutely infected cells. J Mol Biol (1978) 4.04
Activation of the cellular oncogene c-erbB by LTR insertion: molecular basis for induction of erythroblastosis by avian leukosis virus. Cell (1983) 3.45
On the mechanism of retrovirus-induced avian lymphoid leukosis: deletion and integration of the proviruses. Proc Natl Acad Sci U S A (1981) 3.30
RD-114, baboon, and woolly monkey viral RNA's compared in size and structure. Cell (1976) 3.20
Interaction between retroviral U5 RNA and the T psi C loop of the tRNA(Trp) primer is required for efficient initiation of reverse transcription. J Virol (1992) 3.06
c-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor. Cell (1985) 3.00
An electron microscope study of Sindbis virus RNA. Cold Spring Harb Symp Quant Biol (1974) 2.99
Structure, subunit composition, and molecular weight of RD-114 RNA. J Virol (1975) 2.66
Electron microscope studies of tumor virus RNA. Cold Spring Harb Symp Quant Biol (1975) 2.30
Kaposi's sarcoma-associated herpesvirus encodes a bZIP protein with homology to BZLF1 of Epstein-Barr virus. J Virol (1999) 2.24
Characterization of DNA complementary to nucleotide sequences adjacent to poly(A) at the 3'-terminus of the avian sarcoma virus genome. Virology (1977) 2.18
CWR22: the first human prostate cancer xenograft with strongly androgen-dependent and relapsed strains both in vivo and in soft agar. Cancer Res (1996) 2.18
Characterization of DNA complementary to nucleotide sequences at the 5'-terminus of the avian sarcoma virus genome. Virology (1977) 2.16
Specific integration of REV proviruses in avian bursal lymphomas. Nature (1981) 2.11
Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells. Nature (1998) 2.08
Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation. Proc Natl Acad Sci U S A (1990) 1.95
Evidence of independent origin of multiple tumors from patients with prostate cancer. J Natl Cancer Inst (1998) 1.81
Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors. Proc Natl Acad Sci U S A (1992) 1.78
CWR22: androgen-dependent xenograft model derived from a primary human prostatic carcinoma. Cancer Res (1994) 1.77
Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII). Biochem J (1997) 1.72
Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells. Proc Natl Acad Sci U S A (1998) 1.70
Altered expression of RET proto-oncogene product in prostatic intraepithelial neoplasia and prostate cancer. J Natl Cancer Inst (1998) 1.68
Synthesis of plus strands of retroviral DNA in cells infected with avian sarcoma virus and mouse mammary tumor virus. J Virol (1981) 1.67
A tyrosine kinase profile of prostate carcinoma. Proc Natl Acad Sci U S A (1996) 1.67
Gamma knife radiosurgery for malignant melanoma brain metastases. Cancer J Sci Am (1998) 1.63
c-erbB activation in avian leukosis virus-induced erythroblastosis: clustered integration sites and the arrangement of provirus in the c-erbB alleles. Proc Natl Acad Sci U S A (1985) 1.62
Signaling network of the Btk family kinases. Oncogene (2000) 1.58
The complete unique long sequence and the overall genomic organization of the GA strain of Marek's disease virus. Proc Natl Acad Sci U S A (2000) 1.55
Tumor induction by direct injection of cloned v-src DNA into chickens. Proc Natl Acad Sci U S A (1983) 1.53
Hierarchical cleavage of focal adhesion kinase by caspases alters signal transduction during apoptosis of intestinal epithelial cells. Gastroenterology (2001) 1.52
Neuropeptide-induced androgen independence in prostate cancer cells: roles of nonreceptor tyrosine kinases Etk/Bmx, Src, and focal adhesion kinase. Mol Cell Biol (2001) 1.46
Human cellular src gene: nucleotide sequence and derived amino acid sequence of the region coding for the carboxy-terminal two-thirds of pp60c-src. Mol Cell Biol (1985) 1.46
Size, subunit composition, and secondary structure of the Friend virus genome. J Virol (1976) 1.45
Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. Mol Cell Biol (2000) 1.44
Nucleolar and nuclear localization properties of a herpesvirus bZIP oncoprotein, MEQ. J Virol (1997) 1.43
DNA sequence encoding the amino-terminal region of the human c-src protein: implications of sequence divergence among src-type kinase oncogenes. Mol Cell Biol (1987) 1.41
Transforming potential of the herpesvirus oncoprotein MEQ: morphological transformation, serum-independent growth, and inhibition of apoptosis. J Virol (1998) 1.39
MCF-10A-NeoST: a new cell system for studying cell-ECM and cell-cell interactions in breast cancer. Clin Cancer Res (2001) 1.36
Marek's disease virus (MDV) encodes an interleukin-8 homolog (vIL-8): characterization of the vIL-8 protein and a vIL-8 deletion mutant MDV. J Virol (2001) 1.34
The identification of monoclonality in human aberrant crypt foci. Cancer Res (1999) 1.34
Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. Nat Cell Biol (2001) 1.34
ErbB kinases and NDF signaling in human prostate cancer cells. Oncogene (1997) 1.28
Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells. J Biol Chem (2001) 1.27
Structural analysis and transcriptional mapping of the Marek's disease virus gene encoding pp38, an antigen associated with transformed cells. J Virol (1991) 1.26
Orientation and position of avian leukosis virus DNA relative to the cellular oncogene c-myc in B-lymphoma tumors of highly susceptible 15I5 X 7(2) chickens. J Virol (1982) 1.24
Retrovirus insertion into herpesvirus in vitro and in vivo. Proc Natl Acad Sci U S A (1992) 1.22
MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway. Oncogene (2001) 1.22
Isolation and structural mapping of a human c-src gene homologous to the transforming gene (v-src) of Rous sarcoma virus. J Virol (1985) 1.20
A complete description of the EGF-receptor exon structure: implication in oncogenic activation and domain evolution. Oncogene (1993) 1.20
Transactivation activity of Meq, a Marek's disease herpesvirus bZIP protein persistently expressed in latently infected transformed T cells. J Virol (1995) 1.19
Three-dimensional intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: the University of California-San Francisco experience. Int J Radiat Oncol Biol Phys (2000) 1.18
Origin and prognostic value of circulating KRAS mutations in lung cancer patients. Cancer Lett (2007) 1.17
Rous-associated virus 1-induced erythroleukemic cells exhibit a weakly transformed phenotype in vitro and release c-erbB-containing retroviruses unable to transform fibroblasts. J Virol (1986) 1.16
Use of an Epstein-Barr virus episomal replicon for anti-sense RNA-mediated gene inhibition in a human cytotoxic T-cell clone. Proc Natl Acad Sci U S A (1988) 1.15
Radiosurgery for brain metastases: relationship of dose and pattern of enhancement to local control. Int J Radiat Oncol Biol Phys (1997) 1.14
Glycolipid reanchoring of T-lymphocyte surface antigen CD8 using the 3' end sequence of decay-accelerating factor's mRNA. Proc Natl Acad Sci U S A (1988) 1.13
Mitogenic signals and transforming potential of Nyk, a newly identified neural cell adhesion molecule-related receptor tyrosine kinase. Mol Cell Biol (1995) 1.13
Comparative tyrosine-kinase profiles in colorectal cancers: enhanced arg expression in carcinoma as compared with adenoma and normal mucosa. Int J Cancer (1999) 1.12
Mechanism of c-erbB transduction: newly released transducing viruses retain poly(A) tracts of erbB transcripts and encode C-terminally intact erbB proteins. J Virol (1988) 1.12
Retroviral insertions into a herpesvirus are clustered at the junctions of the short repeat and short unique sequences. Proc Natl Acad Sci U S A (1993) 1.12
Hormonal regulation of the gene for the type C ecotropic retrovirus receptor in rat liver cells. J Virol (1994) 1.08
B-lymphoma induction by reticuloendotheliosis virus: characterization of a mutated chicken syncytial virus provirus involved in c-myc activation. J Virol (1987) 1.07
EGF-R as a hemopoietic growth factor receptor: the c-erbB product is present in chicken erythrocytic progenitors and controls their self-renewal. Cell (1991) 1.07
Proviral-activated c-erbB is leukemogenic but not sarcomagenic: characterization of a replication-competent retrovirus containing the activated c-erbB. J Virol (1988) 1.07
Identification of the major autophosphorylation sites of Nyk/Mer, an NCAM-related receptor tyrosine kinase. J Biol Chem (1996) 1.05
c-erbB activation in avian leukosis virus-induced erythroblastosis: multiple epidermal growth factor receptor mRNAs are generated by alternative RNA processing. Mol Cell Biol (1986) 1.04
Tissue-specific transformation by epidermal growth factor receptor: a single point mutation within the ATP-binding pocket of the erbB product increases its intrinsic kinase activity and activates its sarcomagenic potential. Proc Natl Acad Sci U S A (1990) 1.04
Potential role of the src gene product in inhibition of gap-junctional communication in NIH/3T3 cells. Proc Natl Acad Sci U S A (1985) 1.04
Tyrosine kinases and gastric cancer. Oncogene (2000) 1.03
MEQ and V-IL8: cellular genes in disguise? Acta Virol (2000) 1.03
Extensive homology exists between Marek disease herpesvirus and its vaccine virus, herpesvirus of turkeys. Proc Natl Acad Sci U S A (1984) 1.03
Amplification and rearrangement of the Kirsten ras oncogene in virus-transformed BALB/c 3T3 cells during malignant tumor progression. Proc Natl Acad Sci U S A (1987) 1.02
A flavonoid antioxidant, silymarin, inhibits activation of erbB1 signaling and induces cyclin-dependent kinase inhibitors, G1 arrest, and anticarcinogenic effects in human prostate carcinoma DU145 cells. Cancer Res (1998) 1.02
Kinase activation of the non-receptor tyrosine kinase Etk/BMX alone is sufficient to transactivate STAT-mediated gene expression in salivary and lung epithelial cells. J Biol Chem (1999) 1.02
Integration of multiple chicken retroviruses into multiple chicken herpesviruses: herpesviral gD as a common target of integration. Virology (1994) 1.02
Id2 promotes apoptosis by a novel mechanism independent of dimerization to basic helix-loop-helix factors. Mol Cell Biol (1998) 1.01
Novel DNA binding specificities of a putative herpesvirus bZIP oncoprotein. J Virol (1996) 1.01
tie-1 protein tyrosine kinase: a novel independent prognostic marker for gastric cancer. Clin Cancer Res (1999) 1.00
Disease tropism of c-erbB: effects of carboxyl-terminal tyrosine and internal mutations on tissue-specific transformation. Proc Natl Acad Sci U S A (1989) 0.99
Marek's disease herpesvirus transforming protein MEQ: a c-Jun analogue with an alternative life style. Virus Genes (2000) 0.98
Avian lymphoid leukosis virus infection and DNA integration in the preleukotic bursal tissues: a comparative study of susceptible and resistant lines. Virology (1982) 0.97
Growth hormone interacts with the Marek's disease virus SORF2 protein and is associated with disease resistance in chicken. Proc Natl Acad Sci U S A (2001) 0.96
C-erbB and the epidermal growth-factor receptor: a molecule with dual identity. Biochim Biophys Acta (1989) 0.96
Proviral insertional activation of c-erbB: differential processing of the protein products arising from two alternate transcripts. Mol Cell Biol (1988) 0.96
A new defective retroviral vector system based on the Bryan strain of Rous sarcoma virus. Virology (1993) 0.96
Identification and characterization of dimeric and trimeric circular forms of avian sarcoma virus-specific DNA. Virology (1980) 0.95
Synthesis, processing, and secretion of the Marek's disease herpesvirus A antigen glycoprotein. J Virol (1986) 0.95
Transcriptional interaction between retroviral long terminal repeats (LTRs): mechanism of 5' LTR suppression and 3' LTR promoter activation of c-myc in avian B-cell lymphomas. J Virol (1992) 0.95
An alternatively processed mRNA from the avian c-erbB gene encodes a soluble, truncated form of the receptor that can block ligand-dependent transformation. Mol Cell Biol (1992) 0.95
Retroviral insertional mutagenesis of a herpesvirus: a Marek's disease virus mutant attenuated for oncogenicity but not for immunosuppression or in vivo replication. Avian Dis (1997) 0.94
Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases. J Biol Chem (2000) 0.94
Etk/Bmx, a PH-domain containing tyrosine kinase, protects prostate cancer cells from apoptosis induced by photodynamic therapy or thapsigargin. Oncogene (1999) 0.94
Structure and molecular length of the large subunits of RD-114 viral RNA. J Virol (1974) 0.93
Molecular characterization of Marek's disease herpesvirus B antigen. J Virol (1986) 0.92