Published in Cell on April 01, 1976
Sequence of protein synthesis in cells infected by human cytomegalovirus: early and late virus-induced polypeptides. J Virol (1978) 4.65
Viral DNA sequences and gene products in hamster cells transformed by adenovirus type 2. J Virol (1978) 1.69
Identification of a purified complement-fixing antigen as the Epstein-Barr-virus determined nuclear antigen (EBNA) by its binding to metaphase chromosomes. Proc Natl Acad Sci U S A (1977) 1.30
Immunofluorescence study of the adenovirus type 2 single-stranded DNA binding protein in infected and transformed cells. J Virol (1977) 1.21
Adenovirus type 2 coded single-stranded DNA binding protein: in vivo phosphorylation and modification. J Virol (1977) 1.16
Early gene expression of adenovirus type 2: R-loop mapping of mRNA and time course of viral DNA, mRNA, and protein synthesis. J Virol (1977) 1.14
Phosphorylation and nucleic acid binding properties of m1 Moloney murine sarcoma virus-specific pP60gag. J Virol (1977) 1.05
The adenovirus type 2 DNA-binding protein interacts with the major late promoter attenuated RNA. J Virol (1989) 0.89
Characterization of DNA-protein complexes from simian adenovirus SA7. J Virol (1978) 0.84
Affinity adsorbents consisting of nucleic acids immobilized via bisoxirane activated polysaccharides. Nucleic Acids Res (1978) 0.80
Adenovirus-specific DNA-binding protein inhibits the hydrolysis of DNA by DNase in vitro. J Virol (1980) 0.79
The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. J Biol Chem (1969) 142.11
The sequence of the human genome. Science (2001) 101.55
Sequence and organization of the human mitochondrial genome. Nature (1981) 57.39
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (2001) 57.23
Surfing the p53 network. Nature (2000) 35.36
Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays. Proc Natl Acad Sci U S A (1999) 35.16
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell (1990) 20.60
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell (1992) 16.53
Measurement of molecular weights by electrophoresis on SDS-acrylamide gel. Methods Enzymol (1972) 14.68
Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell (1979) 14.05
Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science (1990) 12.88
The Women's Interagency HIV Study. WIHS Collaborative Study Group. Epidemiology (1998) 12.32
Complete sequence of bovine mitochondrial DNA. Conserved features of the mammalian mitochondrial genome. J Mol Biol (1982) 11.71
The p53 proto-oncogene can act as a suppressor of transformation. Cell (1989) 11.67
Actin antibody: the specific visualization of actin filaments in non-muscle cells. Proc Natl Acad Sci U S A (1974) 11.64
The p53-mdm-2 autoregulatory feedback loop. Genes Dev (1993) 11.19
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science (1996) 9.48
Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells. Cell (1982) 9.27
Shotgun DNA sequencing using cloned DNase I-generated fragments. Nucleic Acids Res (1981) 8.23
Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet (2000) 7.16
Functional association of cyclophilin A with HIV-1 virions. Nature (1994) 6.82
Identification of essential genes in cultured mammalian cells using small interfering RNAs. J Cell Sci (2001) 6.66
Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol Cell Biol (1988) 6.44
Simian virus 40 gene A function and maintenance of transformation. J Virol (1975) 6.40
Intermediate filaments: structure, dynamics, function, and disease. Annu Rev Biochem (1994) 6.32
Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein. Genes Dev (1991) 6.30
Translation of globin messenger RNA in a heterologous cell-free system. Nature (1971) 6.29
Different intermediate-sized filaments distinguished by immunofluorescence microscopy. Proc Natl Acad Sci U S A (1978) 6.28
Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells. Mol Cell Biol (1981) 6.02
Antibody against tuberlin: the specific visualization of cytoplasmic microtubules in tissue culture cells. Proc Natl Acad Sci U S A (1975) 5.99
Antibody to myosin: the specific visualization of myosin-containing filaments in nonmuscle cells. Proc Natl Acad Sci U S A (1974) 5.93
Validation studies for models projecting the risk of invasive and total breast cancer incidence. J Natl Cancer Inst (1999) 5.92
The complete amino acid sequence of actins from bovine aorta, bovine heart, bovine fast skeletal muscle, and rabbit slow skeletal muscle. A protein-chemical analysis of muscle actin differentiation. Differentiation (1979) 5.90
Testing a tripartite model: I. Evaluating the convergent and discriminant validity of anxiety and depression symptom scales. J Abnorm Psychol (1995) 5.86
Standardized surgery for colonic cancer: complete mesocolic excision and central ligation--technical notes and outcome. Colorectal Dis (2009) 5.72
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev (1994) 5.68
Determinants and consequences of smoke-free homes: findings from the International Tobacco Control (ITC) Four Country Survey. Tob Control (2006) 5.63
Cytoplasmic microtubules in tissue culture cells appear to grow from an organizing structure towards the plasma membrane. Proc Natl Acad Sci U S A (1976) 5.56
p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci U S A (1994) 5.49
Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med (1995) 5.45
At least six different actins are expressed in a higher mammal: an analysis based on the amino acid sequence of the amino-terminal tryptic peptide. J Mol Biol (1978) 5.34
Grip and pinch strength: normative data for adults. Arch Phys Med Rehabil (1985) 5.34
Mapping of the p53 and mdm-2 interaction domains. Mol Cell Biol (1993) 5.31
Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer. N Engl J Med (1995) 5.27
Amino-terminal sequence analysis of proteins purified on a nanomole scale by gel electrophoresis. J Biol Chem (1972) 5.24
Determinants of HIV-1 shedding in the genital tract of women. Lancet (2001) 5.10
Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev (2000) 5.04
Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBO J (1998) 4.98
A short primer for sequencing DNA cloned in the single-stranded phage vector M13mp2. Nucleic Acids Res (1980) 4.98
Lac repressor. Specific proteolytic destruction of the NH 2 -terminal region and loss of the deoxyribonucleic acid-binding activity. J Biol Chem (1973) 4.96
Growth regulation of a cellular tumour antigen, p53, in nontransformed cells. Nature (1984) 4.86
Patterns of organization of actin and myosin in normal and transformed cultured cells. Proc Natl Acad Sci U S A (1975) 4.86
Villin is a major protein of the microvillus cytoskeleton which binds both G and F actin in a calcium-dependent manner. Cell (1980) 4.83
Reversible denaturation of enzymes by sodium dodecyl sulfate. J Biol Chem (1971) 4.66
Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation. J Virol (1989) 4.63
Reliability and validity of grip and pinch strength evaluations. J Hand Surg Am (1984) 4.63
Widespread occurrence of intermediate-sized filaments of the vimentin-type in cultured cells from diverse vertebrates. Exp Cell Res (1979) 4.61
Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays. Cancer Res (2001) 4.50
DNA replication in SV40 infected cells. I. Analysis of replicating SV40 DNA. J Mol Biol (1970) 4.49
Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes. Cell Growth Differ (1990) 4.32
Distinctive sequence of human mitochondrial ribosomal RNA genes. Nature (1980) 4.30
Gain of function mutations in p53. Nat Genet (1993) 4.19
Wild-type p53 binds to the TATA-binding protein and represses transcription. Proc Natl Acad Sci U S A (1992) 4.06
Mapping genetic elements of Epstein-Barr virus that facilitate extrachromosomal persistence of Epstein-Barr virus-derived plasmids in human cells. Mol Cell Biol (1985) 4.03
Structurally distinct bacterial luciferases. Biochemistry (1969) 4.03
p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts. Genes Dev (1991) 4.01
The amino acid sequence of chicken muscle desmin provides a common structural model for intermediate filament proteins. EMBO J (1982) 4.01
Antibody to prekeratin. Decoration of tonofilament like arrays in various cells of epithelial character. Exp Cell Res (1978) 4.01
Measurement of stress as it affects the work of the general practitioner. Fam Pract (1985) 4.00
Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6. Mol Cell Biol (1998) 3.99
Localization of actin and microfilament-associated proteins in the microvilli and terminal web of the intestinal brush border by immunofluorescence microscopy. J Cell Biol (1978) 3.98
Testing a tripartite model: II. Exploring the symptom structure of anxiety and depression in student, adult, and patient samples. J Abnorm Psychol (1995) 3.97
Specific visualization of tubulin-containing structures in tissue culture cells by immunofluorescence. Cytoplasmic microtubules, vinblastine-induced paracrystals, and mitotic figures. Exp Cell Res (1975) 3.95
Fimbrin, a new microfilament-associated protein present in microvilli and other cell surface structures. J Cell Biol (1980) 3.93
Adult norms for the Box and Block Test of manual dexterity. Am J Occup Ther (1985) 3.92
Tumor diagnosis by intermediate filament typing: a novel tool for surgical pathology. Lab Invest (1983) 3.91
MSI and MSII made on ribosome in idling step of protein synthesis. Nature (1972) 3.89
The process of infection with bacteriophage phiX174. XXV. Studies with bacteriophage phiX174 mutants blocked in progeny replicative form DNA synthesis. J Mol Biol (1969) 3.87
The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: a map of ten nonrepetitive epitopes starting at the Z line extends close to the M line. J Cell Biol (1988) 3.86
Glomeruli and blood pressure. Less of one, more the other? Am J Hypertens (1988) 3.86
The detertent-resistant cytoskeleton of tissue culture cells includes the nucleus and the microfilament bundles. Exp Cell Res (1977) 3.84
A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. Ticlopidine Aspirin Stroke Study Group. N Engl J Med (1989) 3.83
Radioimmunoassay for tubulin: a quantitative comparison of the tubulin content of different established tissue culture cells and tissues. Cell (1978) 3.79
P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2. Proc Natl Acad Sci U S A (1999) 3.78
Different pattern of codon recognition by mammalian mitochondrial tRNAs. Proc Natl Acad Sci U S A (1980) 3.74
Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. Proc Natl Acad Sci U S A (2000) 3.74
WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc Natl Acad Sci U S A (1998) 3.73