Published in J Biol Chem on October 10, 1976
Extracellular nucleases of pseudomonas BAL 31. III. Use of the double-strand deoxyriboexonuclease activity as the basis of a convenient method for the mapping of fragments of DNA produced by cleavage with restriction enzymes. Nucleic Acids Res (1978) 5.62
Methyl-directed repair of DNA base-pair mismatches in vitro. Proc Natl Acad Sci U S A (1983) 5.34
Structure and function of type II restriction endonucleases. Nucleic Acids Res (2001) 4.78
The use of phosphorothioate-modified DNA in restriction enzyme reactions to prepare nicked DNA. Nucleic Acids Res (1985) 3.65
Catalytic activity of the yeast SWI/SNF complex on reconstituted nucleosome arrays. EMBO J (1997) 2.48
Involvement of outside DNA sequences in the major kinetic path by which EcoRI endonuclease locates and leaves its recognition sequence. Proc Natl Acad Sci U S A (1982) 2.29
Cloning of gene lon (capR) of Escherichia coli K-12 and identification of polypeptides specified by the cloned deoxyribonucleic acid fragment. J Bacteriol (1980) 1.83
Nucleotide sequence of a 5S ribosomal RNA gene in the sea urchin Lytechinus variegatus. Nucleic Acids Res (1980) 1.81
The EcoRI restriction endonuclease with bacteriophage lambda DNA. Kinetic studies. Biochem J (1980) 1.67
Palindromic oligonucleotides containing 7-deaza-2'-deoxyguanosine: solid-phase synthesis of d[(p)GG*AATTCC] octamers and recognition by the endodeoxyribonuclease EcoRI. Nucleic Acids Res (1986) 1.58
Purification, properties and specificity of the restriction endonuclease from Bacillus stearothermophilus. Biochem J (1979) 1.58
The reactions of the EcoRi and other restriction endonucleases. Biochem J (1979) 1.56
Positive-selection cloning vehicle useful for overproduction of hybrid proteins. J Bacteriol (1983) 1.42
The EcoRI restriction endonuclease with bacteriophage lambda DNA. Equilibrium binding studies. Biochem J (1980) 1.41
Mutations in the DNA gyrB gene that are temperature sensitive for lambda site-specific recombination, Mu growth, and plasmid maintenance. J Bacteriol (1984) 1.40
DNA and spermidine provide a switch mechanism to regulate the activity of restriction enzyme Nae I. Proc Natl Acad Sci U S A (1989) 1.39
A sequence-specific endonuclease (Xmn I) from Xanthomonas manihotis. Nucleic Acids Res (1980) 1.38
The presence of RNA in a double helix inhibits its interaction with histone protein. Nucleic Acids Res (1980) 1.36
Identification of the gene lon (capR) product as a 94-kilodalton polypeptide by cloning and deletion analysis. J Bacteriol (1981) 1.31
Non-specific binding of restriction endonuclease EcoR1 to DNA. Nucleic Acids Res (1980) 1.28
Substrate dependence of the mechanism of EcoRI endonuclease. Nucleic Acids Res (1978) 1.28
Relaxed circular SV40 DNA as cleavage intermediate of two restriction endonucleases. Nucleic Acids Res (1977) 1.28
Inhibition of Eco RI action by polynucleotides. A characterization of the non-specific binding of the enzyme to DNA. Nucleic Acids Res (1980) 1.25
Type II restriction endonucleases--a historical perspective and more. Nucleic Acids Res (2014) 1.22
Interaction of the intron-encoded mobility endonuclease I-PpoI with its target site. Mol Cell Biol (1993) 1.21
Laser crosslinking of E. coli RNA polymerase and T7 DNA. Nucleic Acids Res (1982) 1.14
Study of the expression of myelin proteolipid protein (lipophilin) using a cloned complementary DNA. Nucleic Acids Res (1985) 1.13
Changes in solvation during DNA binding and cleavage are critical to altered specificity of the EcoRI endonuclease. Proc Natl Acad Sci U S A (1998) 1.13
The EcoRI restriction endonuclease, covalently closed DNA and ethidium bromide. Biochem J (1981) 1.10
Site directed mutagenesis experiments suggest that Glu 111, Glu 144 and Arg 145 are essential for endonucleolytic activity of EcoRI. Nucleic Acids Res (1986) 1.10
Transient cleavage kinetics of the Eco RI restriction endonuclease measured in a pulsed quench-flow apparatus: enzyme concentration-dependent activity change. Nucleic Acids Res (1981) 1.09
DNA unwinding induced by photoaddition of psoralen derivatives and determination of dark-binding equilibrium constants by gel electrophoresis. Proc Natl Acad Sci U S A (1978) 1.09
Cleavage of supercoiled plasmid DNA by autoantibody Fab fragment: application of the flow linear dichroism technique. Proc Natl Acad Sci U S A (1995) 1.08
RecA protein filaments can juxtapose DNA ends: an activity that may reflect a function in DNA repair. Proc Natl Acad Sci U S A (1986) 1.01
Single turnovers of the EcoRI restriction endonuclease. Biochem J (1983) 0.99
Stability of EcoRI restriction-modification enzymes in vivo differentiates the EcoRI restriction-modification system from other postsegregational cell killing systems. J Bacteriol (2005) 0.99
mRNA processing in Escherichia coli: an activity encoded by the host processes bacteriophage f1 mRNAs. Nucleic Acids Res (1984) 0.99
Restriction endonuclease RsrI from Rhodobacter sphaeroides, an isoschizomer of EcoRI: purification and properties. Nucleic Acids Res (1988) 0.93
Analysis of DNA double- and single-strand breaks by two dimensional electrophoresis: action of micrococcal nuclease on chromatin and DNA, and degradation in vivo of lens fiber chromatin. Nucleic Acids Res (1980) 0.92
High resolution footprinting of EcoRI and distamycin with Rh(phi)2(bpy)3+, a new photofootprinting reagent. Nucleic Acids Res (1989) 0.91
In vitro synthesis of double-stranded DNA from the Kilham rat virus single-stranded DNA genome. J Virol (1978) 0.87
Temperature-inducible amber suppressor: construction of plasmids containing the Escherichia coli serU- (supD-) gene under control of the bacteriophage lambda pL promoter. J Bacteriol (1983) 0.87
Physical and kinetic properties of the site specific endonuclease Bam HI from Bacillus amylolique-faciens. Nucleic Acids Res (1980) 0.86
BspRI restriction endonuclease: cloning, expression in Escherichia coli and sequential cleavage mechanism. Nucleic Acids Res (2010) 0.86
Phenotypically cryptic EcoRI endonuclease activity specified by the ColE1 plasmid. Proc Natl Acad Sci U S A (1978) 0.84
Binding of non-substrate nucleotides to a restriction endonuclease: a model for the interaction of bam HI with its recognition sequence. Nucleic Acids Res (1980) 0.83
Dimerization of the bacterial RsrI N6-adenine DNA methyltransferase. Nucleic Acids Res (2006) 0.83
Exploring both sequence detection and restriction endonuclease cleavage kinetics by recognition site via single-molecule microfluidic trapping. Lab Chip (2010) 0.81
Reaction kinetics of some important site-specific endonucleases. Nucleic Acids Res (1981) 0.81
Structural changes in simian virus 40 chromatin as probed by restriction endonucleases. J Virol (1979) 0.81
A gene adjacent to satellite DNA in Drosophila melanogaster. Proc Natl Acad Sci U S A (1978) 0.80
Positive co-operative interaction between the subunits of CeqI restriction endonuclease. Biochem J (1992) 0.78
Biospecific fractionation matrices for sequence specific endonucleases. Nucleic Acids Res (1978) 0.78
A rapid and sensitive method to measure DNA endonuclease activity. Nucleic Acids Res (1993) 0.77
A sequence-specific nicking endonuclease from streptomyces: purification, physical and catalytic properties. ISRN Biochem (2013) 0.75
Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell (1993) 6.61
Recognition sequence of the dam methylase of Escherichia coli K12 and mode of cleavage of Dpn I endonuclease. J Biol Chem (1979) 5.75
Effects of high levels of DNA adenine methylation on methyl-directed mismatch repair in Escherichia coli. Genetics (1983) 5.43
Methyl-directed repair of DNA base-pair mismatches in vitro. Proc Natl Acad Sci U S A (1983) 5.34
DNA mismatch correction. Annu Rev Biochem (1987) 5.33
DNA mismatch correction in a defined system. Science (1989) 4.98
Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs. Proc Natl Acad Sci U S A (1986) 4.71
Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science (1995) 4.48
Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines. Proc Natl Acad Sci U S A (1990) 4.33
Mispair specificity of methyl-directed DNA mismatch correction in vitro. J Biol Chem (1988) 4.20
Enzymatic joining of polynucleotides. IX. A simple and rapid assay of polynucleotide joining (ligase) activity by measurement of circle formation from linear deoxyadenylate-deoxythymidylate copolymer. J Biol Chem (1970) 3.57
Mismatch repair deficiency in phenotypically normal human cells. Science (1995) 3.55
Bacteriophage T7 deoxyribonucleic acid replication invitro. Bacteriophage T7 DNA polymerase: an an emzyme composed of phage- and host-specific subunits. J Biol Chem (1975) 3.36
Genomic mismatch scanning: a new approach to genetic linkage mapping. Nat Genet (1993) 3.35
Isolation and characterization of the Escherichia coli mutL gene product. J Biol Chem (1989) 3.22
Bacteriophage T7 Deoxyribonucleic acid replication in vitro. A protein of Escherichia coli required for bacteriophage T7 DNA polymerase activity. J Biol Chem (1975) 3.18
Genetic and enzymatic characterization of a conditional lethal mutant of Escherichia coli K12 with a temperature-sensitive DNA ligase. J Mol Biol (1973) 3.12
An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. Proc Natl Acad Sci U S A (1993) 3.07
Deoxyribonucleic acid ligase. Isolation and physical characterization of the homogeneous enzyme from Escherichia coli. J Biol Chem (1973) 3.04
Repair of DNA base-pair mismatches in extracts of Escherichia coli. Cold Spring Harb Symp Quant Biol (1984) 2.96
Isolation and characterization of the Escherichia coli mutH gene product. J Biol Chem (1987) 2.94
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs. Proc Natl Acad Sci U S A (1995) 2.93
Escherichia coli mutY gene encodes an adenine glycosylase active on G-A mispairs. Proc Natl Acad Sci U S A (1989) 2.87
Mismatch repair proteins MutS and MutL inhibit RecA-catalyzed strand transfer between diverged DNAs. Proc Natl Acad Sci U S A (1994) 2.84
Initiation of methyl-directed mismatch repair. J Biol Chem (1992) 2.82
T7-induced DNA polymerase. Characterization of associated exonuclease activities and resolution into biologically active subunits. J Biol Chem (1979) 2.76
Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha. J Biol Chem (1998) 2.67
DNA sequences of structural genes for Eco RI DNA restriction and modification enzymes. J Biol Chem (1981) 2.63
Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct. Proc Natl Acad Sci U S A (1996) 2.57
MutS mediates heteroduplex loop formation by a translocation mechanism. EMBO J (1997) 2.52
Structures and mechanisms of DNA restriction and modification enzymes. Q Rev Biophys (1979) 2.51
Escherichia coli dam methylase. Physical and catalytic properties of the homogeneous enzyme. J Biol Chem (1982) 2.45
Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction. J Biol Chem (1993) 2.38
EcoRI methylase. Physical and catalytic properties of the homogeneous enzyme. J Biol Chem (1977) 2.32
Involvement of outside DNA sequences in the major kinetic path by which EcoRI endonuclease locates and leaves its recognition sequence. Proc Natl Acad Sci U S A (1982) 2.29
Escherichia coli mutY gene product is required for specific A-G----C.G mismatch correction. Proc Natl Acad Sci U S A (1988) 2.29
Methyl-directed mismatch repair is bidirectional. J Biol Chem (1993) 2.26
Escherichia coli K-12 clones that overproduce dam methylase are hypermutable. J Bacteriol (1981) 2.21
In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repair. Proc Natl Acad Sci U S A (2001) 2.18
Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line. J Biol Chem (1996) 2.01
Studies on sequence recognition by type II restriction and modification enzymes. CRC Crit Rev Biochem (1982) 2.01
Kinetic mechanism of the DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase. J Biol Chem (1993) 1.98
Requirement for d(GATC) sequences in Escherichia coli mutHLS mismatch correction. Proc Natl Acad Sci U S A (1987) 1.90
Facilitated diffusion during catalysis by EcoRI endonuclease. Nonspecific interactions in EcoRI catalysis. J Biol Chem (1985) 1.87
Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems. Mol Cell Biol (1997) 1.79
Thermodynamic parameters governing interaction of EcoRI endonuclease with specific and nonspecific DNA sequences. J Biol Chem (1983) 1.76
Redundant exonuclease involvement in Escherichia coli methyl-directed mismatch repair. J Biol Chem (2001) 1.75
Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism. J Biol Chem (1998) 1.66
The negative charge of Glu-111 is required to activate the cleavage center of EcoRI endonuclease. J Biol Chem (1989) 1.65
DNA determinants important in sequence recognition by Eco RI endonuclease. J Biol Chem (1981) 1.64
hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage. Proc Natl Acad Sci U S A (1999) 1.63
The DNA sequences encoding plsB and dgk loci of Escherichia coli. J Biol Chem (1983) 1.62
MutS and MutL activate DNA helicase II in a mismatch-dependent manner. J Biol Chem (1998) 1.62
DNA polymerase delta is required for human mismatch repair in vitro. J Biol Chem (1997) 1.61
Nucleotide sequence of a cDNA for a member of the human 90-kDa heat-shock protein family. Gene (1987) 1.60
Mismatch-, MutS-, MutL-, and helicase II-dependent unwinding from the single-strand break of an incised heteroduplex. J Biol Chem (1998) 1.59
DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair. Proc Natl Acad Sci U S A (1997) 1.58
Bidirectional excision in methyl-directed mismatch repair. J Biol Chem (1993) 1.57
Mismatch-containing oligonucleotide duplexes bound by the E. coli mutS-encoded protein. Nucleic Acids Res (1988) 1.48
Mechanisms of DNA-mismatch correction. Mutat Res (1990) 1.44
The kinetic mechanism of EcoRI endonuclease. J Biol Chem (1999) 1.43
Positive-selection cloning vehicle useful for overproduction of hybrid proteins. J Bacteriol (1983) 1.42
The MutL ATPase is required for mismatch repair. J Biol Chem (2000) 1.40
Modulation of MutS ATP hydrolysis by DNA cofactors. Biochemistry (2000) 1.37
DNA chain length dependence of formation and dynamics of hMutSalpha.hMutLalpha.heteroduplex complexes. J Biol Chem (2001) 1.37
MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2. Curr Biol (1996) 1.35
Removal of polymerase-produced mutant sequences from PCR products. Proc Natl Acad Sci U S A (1997) 1.34
Distinct MutS DNA-binding modes that are differentially modulated by ATP binding and hydrolysis. J Biol Chem (2001) 1.31
Substrate dependence of the mechanism of EcoRI endonuclease. Nucleic Acids Res (1978) 1.28
Glu-111 is required for activation of the DNA cleavage center of EcoRI endonuclease. J Biol Chem (1989) 1.27
Isolation of gram quantities of EcoRI restriction and modification enzymes from an overproducing strain. J Biol Chem (1984) 1.26
Enzymatic joining of polynucleotides. XI. Reversal of Escherichia coli deoxyribonucleic acid ligase reaction. J Biol Chem (1972) 1.24
Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft. Cancer Res (1997) 1.24
Misincorporation and mispaired primer extension by human immunodeficiency virus reverse transcriptase. J Biol Chem (1994) 1.20
Enzymatic characterization of a mutant of Escherichia coli with an altered DNA ligase. Proc Natl Acad Sci U S A (1971) 1.19
Membrane phospholipid synthesis in Escherichia coli. Cloning of a structural gene (plsB) of the sn-glycerol-3-phosphate acyl/transferase. J Biol Chem (1980) 1.18
DNA-dependent activation of the hMutSalpha ATPase. J Biol Chem (1998) 1.17
Role of the 2-amino group of deoxyguanosine in sequence recognition by EcoRI restriction and modification enzymes. J Biol Chem (1977) 1.14
A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype. Mol Cell Biol (1998) 1.11
Regulation of phospholipid biosynthesis in Escherichia coli. Cloning of the structural gene for the biosynthetic sn-glycerol-3-phosphate dehydrogenase. J Biol Chem (1980) 1.10
Diverse hypermutability of multiple expressed sequence motifs present in a cancer with microsatellite instability. Oncogene (1996) 1.09
A structural basis for a phosphoramide mustard-induced DNA interstrand cross-link at 5'-d(GAC). Proc Natl Acad Sci U S A (1995) 1.07
T7-induced DNA polymerase. Requirement for thioredoxin sulfhydryl groups. J Biol Chem (1983) 1.06
Membrane phospholipid synthesis in Escherichia coli. Identification of the sn-glycerol-3-phosphate acyltransferase polypeptide as the plsB gene product. J Biol Chem (1980) 1.06
Mutation detection with MutH, MutL, and MutS mismatch repair proteins. Proc Natl Acad Sci U S A (1996) 1.00
Gap formation is associated with methyl-directed mismatch correction under conditions of restricted DNA synthesis. Genome (1989) 0.99
Direct atomic force microscope imaging of EcoRI endonuclease site specifically bound to plasmid DNA molecules. Proc Natl Acad Sci U S A (1996) 0.98
The DNA helicase activities of Rad3 protein of Saccharomyces cerevisiae and helicase II of Escherichia coli are differentially inhibited by covalent and noncovalent DNA modifications. J Biol Chem (1993) 0.98
Methyl-directed DNA mismatch repair in Escherichia coli. Mutat Res (1988) 0.95
In vitro maturation of circular bacteriophage P2 DNA. Purification of ter components and characterization of the reaction. J Biol Chem (1985) 0.94
High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6. Proc Natl Acad Sci U S A (2001) 0.94
Repair of large insertion/deletion heterologies in human nuclear extracts is directed by a 5' single-strand break and is independent of the mismatch repair system. J Biol Chem (1999) 0.93
'Interactive' recognition in EcoRI restriction enzyme-DNA complex. Nucleic Acids Res (1984) 0.91
Purification and properties of EcoRI endonuclease. Methods Enzymol (1980) 0.90
Effect of hypoxic hypoxia on transmural gut and subcutaneous tissue oxygen tension. Adv Exp Med Biol (1997) 0.89
DNA synthesis in strains of Escherichia coli K12 with temperature-sensitive DNA ligase and DNA polymerase I. J Mol Biol (1974) 0.89
Stereochemical course of nucleotidyl transfer catalyzed by bacteriophage T7 induced DNA polymerase. Biochemistry (1982) 0.86
Mechanism of specific site location and DNA cleavage by EcoR I endonuclease. Gene Amplif Anal (1987) 0.86
Preliminary x-ray diffraction studies of EcoRI restriction endonuclease-DNA complex. J Mol Biol (1981) 0.86
Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase. Cancer Chemother Pharmacol (1999) 0.86