Tight-binding repressors of the lactose operon.

A perfectly symmetric lac operator binds the lac repressor very tightly. Proc Natl Acad Sci U S A (1983) 4.24

Sequence-specific DNA uptake in Haemophilus transformation. Proc Natl Acad Sci U S A (1979) 2.94

Binding of synthetic lactose operator DNAs to lactose represessors. Proc Natl Acad Sci U S A (1977) 2.86

Mutational studies with the trp repressor of Escherichia coli support the helix-turn-helix model of repressor recognition of operator DNA. Proc Natl Acad Sci U S A (1985) 2.48

Site-specific DNA-affinity chromatography of the lac repressor. Nucleic Acids Res (1980) 1.85

lac repressor blocks in vivo transcription of lac control region DNA. Proc Natl Acad Sci U S A (1987) 1.66

Construction of plasmids for expression of Rous sarcoma virus transforming protein, p60src, in Escherichia coli. Proc Natl Acad Sci U S A (1982) 1.63

Studies of gene control regions. III. Binding of synthetic and modified synthetic lac operator DNAs to lactose repressor. Nucleic Acids Res (1977) 1.44

Studies on gene control regions. VI. The 5- methyl of thymine, a lac repressor recognition site. Nucleic Acids Res (1977) 1.30

Sequence-specific interactions of the tight-binding I12-X86 lac repressor with non-operator DNA. Nucleic Acids Res (1980) 1.00

Concentration-affinity equivalence in gene regulation: convergence of genetic and environmental effects. Proc Natl Acad Sci U S A (1988) 0.82

Tight-binding repressors of the lac operon: selection system and in vitro analysis. J Bacteriol (1979) 0.82

Specificities of three tight-binding Lac repressors. Nucleic Acids Res (1992) 0.81

Interaction of the tight-binding I12-X86 lac repressor with non operator DNA: salt dependence of complex formation. Nucleic Acids Res (1986) 0.75

Statistical characterization of nucleic acid sequence functional domains. Nucleic Acids Res (1983) 20.31

A perfectly symmetric lac operator binds the lac repressor very tightly. Proc Natl Acad Sci U S A (1983) 4.24

Regulatory pattern identification in nucleic acid sequences. Nucleic Acids Res (1983) 3.90

The nature of lactose operator constitive mutations. J Mol Biol (1971) 3.14

Plasmids containing many tandem copies of a synthetic lactose operator. Gene (1980) 3.03

lac Repressor-operator interaction. IX. The binding of lac repressor to operators containing Oc mutations. J Mol Biol (1974) 2.31

Mapping of the lactose operator. J Mol Biol (1971) 1.94

Herpes simplex virus types 1 and 2 induce shutoff of host protein synthesis by different mechanisms in Friend erythroleukemia cells. J Virol (1983) 1.45

Genetic analysis of amidase mutants of Pseudomonas aeruginosa. Genet Res (1974) 1.19

Mutational inversion of control of the lactose operon of Escherichia coli. J Mol Biol (1971) 1.18

Cloning of chemically synthesized lactose operators. Gene (1977) 1.15

Variants of a cloned synthetic lactose operator. I. A palindromic dimer lactose operator derived from one stand of the cloned 40-base pair operator. Gene (1981) 1.10

Base substitution mutants of the lac operator: in vivo and in vitro affinities for lac repressor. Gene (1986) 1.08

Cloning of the lacI gene into A ColE1 plasmid. Gene (1978) 1.08

Cloning and characterization of the natural lactose operator. Gene (1981) 1.06

Regulation of transcription in vitro from herpes simplex virus genes. J Virol (1986) 1.06

Evolution in action. Nature (1974) 1.06

Cloning of chemically synthesized lactose operators. II. EcoRI-linkered operators. Gene (1978) 1.03

Virion component of herpes simplex virus type 1 KOS interferes with early shutoff of host protein synthesis induced by herpes simplex virus type 2 186. J Virol (1985) 1.03

RNAs transcribed from a 3.6-kilobase SmaI fragment of the short unique region of the herpes simplex virus type 1 genome. J Virol (1983) 0.97

Variants of a cloned synthetic lactose operator. II. Chloramphenicol-resistant revertants retaining a lactose operator in the CAT gene of plasmid pBR325. Gene (1981) 0.95

Threonine deaminases from Saccharomyces cerevisiae mutationally altered in regulatory properties. Biochemistry (1971) 0.95

Selective evolution of phenylacetamide-utilizing strains of Pseudomonas aeruginosa. J Gen Microbiol (1972) 0.95

Unbalanced chromosomal translocation, der(17)t(13;17)(q14;p11) in a solid and cystic papillary epithelial neoplasm of the pancreas. Am J Surg Pathol (1996) 0.94

Specific binding of lac repressor to linear versus circular polyoperator molecules. Biochemistry (1990) 0.92

Recovery of operator DNA binding activity from denatured lactose repressor. Biochemistry (1976) 0.89

Symmetric lac operator derivatives: effects of half-operator sequence and spacing on repressor affinity. Gene (1990) 0.86

The promoter context is a decisive factor in establishing selective responsiveness to nuclear class II receptors. EMBO J (1997) 0.84

Leukemia: the sophisticated subversion of hematopoiesis by nuclear receptor oncoproteins. Biochim Biophys Acta (1999) 0.84

Characterization of i-d repressor mutations of the lactose operon. J Mol Biol (1977) 0.83

The nucleotide sequence of dolphin and bovine 5S ribosomal ribonucleic acid. FEBS Lett (1975) 0.82

Pseudoreversion of lactose operator-constitutive mutants. J Bacteriol (1977) 0.82

Transcription from the BamHI J fragment of herpes simplex virus type 1 (KOS). J Virol (1983) 0.80

Cloning and characterization of several dominant-negative and tight-binding mutants of lac repressor. Gene (1986) 0.79

Regulated high-level expression of the Herpes simplex type I thymidine kinase gene in Escherichia coli. Gene (1984) 0.77

NMR study of the interaction between the lac repressor and the lac operator. Eur J Biochem (1983) 0.77

Determination of the ligand-binding characteristics of several tight-binding mutants of the lactose repressor protein. Biochim Biophys Acta (1981) 0.77

Fast-acting human insulin analogs: a promising innovation in diabetes care. Diabetes Educ (1995) 0.77

A silent deletion in the beta-globin gene cluster. Nucleic Acids Res (1986) 0.75

Growth of high density bacterial cultures: a simple device. Lab Pract (1974) 0.75

A mammalian cell line designed to test the mutagenic activity of anti-herpes nucleosides. Int J Cancer (1987) 0.75

Dietary fat add tissue cholesterol in female rats. Experientia (1971) 0.75

Growth of pseudomonas species on phenylacetamide. J Gen Microbiol (1973) 0.75

Nitrogen retention of young men who consumed isonitrogenous diets containing normal, opaque-2 or sugary-2 opaque-2 corn. J Nutr (1977) 0.75