Published in Nucleic Acids Res on March 01, 1977
Binding of synthetic lactose operator DNAs to lactose represessors. Proc Natl Acad Sci U S A (1977) 2.86
Contacts between the lac repressor and the thymines in the lac operator. Proc Natl Acad Sci U S A (1977) 2.52
How lac repressor recognizes lac operator. Proc Natl Acad Sci U S A (1978) 2.15
Studies on gene control regions XII. The functional significance of a lac operator constitutive mutation. Nucleic Acids Res (1979) 1.70
Lac repressor - lac operator interaction. Circular dichroism study. Nucleic Acids Res (1981) 1.56
Studies on gene control regions. VI. The 5- methyl of thymine, a lac repressor recognition site. Nucleic Acids Res (1977) 1.30
A new approach to the synthesis of a protected 2-aminopurine derivative and its incorporation into oligodeoxynucleotides containing the Eco RI and Bam HI recognition sites. Nucleic Acids Res (1988) 1.17
The synthesis of 2-pyrimidinone nucleosides and their incorporation into oligodeoxynucleotides. Nucleic Acids Res (1989) 1.11
Isolation and characterization of a highly repetitious inverted terminal repeat sequence from Oxytricha macronuclear DNA. Proc Natl Acad Sci U S A (1978) 0.97
Synthesis and properties of oligodeoxynucleotides containing the analogue 2'-deoxy-4'-thiothymidine. Nucleic Acids Res (1993) 0.96
Studies on gene control regions X. The effect of specific adenine-thymine transversions on the lac repressor-lac operator interaction. Nucleic Acids Res (1979) 0.87
A simple method for the preparation of 32-P-labelled adenosine triphosphate of high specific activity. Biochem J (1964) 41.13
Lac repressor-operator interaction. I. Equilibrium studies. J Mol Biol (1970) 13.32
Physical characterization and simultaneous purification of bacteriophage T4 induced polynucleotide kinase, polynucleotide ligase, and deoxyribonucleic acid polymerase. Biochemistry (1973) 11.45
The nucleotide sequence of the lac operator. Proc Natl Acad Sci U S A (1973) 11.28
Enzymatic synthesis of deoxyribonucleic acid. XXVI. Physical and chemical studies of a homogeneous deoxyribonucleic acid polymerase. J Biol Chem (1969) 10.45
The lac repressor-operator interaction. 3. Kinetic studies. J Mol Biol (1970) 10.07
Genetic regulation: the Lac control region. Science (1975) 9.48
Use of DNA polymerase I primed by a synthetic oligonucleotide to determine a nucleotide sequence in phage fl DNA. Proc Natl Acad Sci U S A (1973) 7.11
Lac repressor. Specific proteolytic destruction of the NH 2 -terminal region and loss of the deoxyribonucleic acid-binding activity. J Biol Chem (1973) 4.96
Lac repressor and lac operator. Prog Biophys Mol Biol (1975) 3.08
Chemical synthesis and sequence studies of deoxyribooligonucleotides which constitute the duplex sequence of the lactose operator of Escherichia coli. J Biol Chem (1975) 2.79
Photochemical attachment of lac repressor to bromodeoxyuridine-substituted lac operator by ultraviolet radiation. Proc Natl Acad Sci U S A (1974) 2.20
Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 1. General introduction. J Biol Chem (1976) 1.91
Studies on polynucleotides. XCVI. Repair replications of short synthetic DNA's as catalyzed by DNA polymerases. J Mol Biol (1971) 1.87
The lac repressor-operator interaction. VII. A repressor with unique binding properties: the X86 repressor. J Mol Biol (1972) 1.78
Lac repressor binding to operator analogues: comparison of poly(d(A-T)), poly(d(A-BrU)), and poly(d(A-U)). Biochem Biophys Res Commun (1971) 1.62
Phosphorylation of double-stranded DNAs by T4 polynucleotide kinase. Biochemistry (1976) 1.59
Tight-binding repressors of the lactose operon. J Mol Biol (1976) 1.55
Chemical and enzymatic synthesis of lactose operator of Escherichia coli and its binding to lactose repressor. Proc Natl Acad Sci U S A (1976) 1.48
Improved free-energy parameters for predictions of RNA duplex stability. Proc Natl Acad Sci U S A (1986) 19.52
Vascular endothelial growth factor is a secreted angiogenic mitogen. Science (1989) 16.71
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. Nature (1985) 13.04
NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science (1998) 11.70
Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue. Nature (1983) 10.64
Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature (1985) 10.13
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell (1996) 9.68
TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell (1996) 8.89
The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell (1995) 8.80
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science (1997) 7.57
TRAF6 is a signal transducer for interleukin-1. Nature (1996) 7.38
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell (1995) 7.18
Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature (1990) 7.15
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev (1999) 6.93
Identification and characterization of an IkappaB kinase. Cell (1997) 6.71
Expression of human immune interferon cDNA in E. coli and monkey cells. Nature (1982) 6.55
Comparative biochemical properties of normal and activated human ras p21 protein. Nature (1984) 6.50
TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. Science (1995) 6.41
Human tumor necrosis factor. Production, purification, and characterization. J Biol Chem (1985) 6.28
Biological properties of human c-Ha-ras1 genes mutated at codon 12. Nature (1984) 6.21
Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity (1997) 6.15
Use of the Escherichia coli lac repressor and operator to control gene expression in Bacillus subtilis. Proc Natl Acad Sci U S A (1984) 6.00
A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell (1994) 5.94
Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene. Nature (1983) 5.90
Human leukocyte interferon produced by E. coli is biologically active. Nature (1980) 5.86
Resolving the functions of overlapping viral genes by site-specific mutagenesis at a mRNA splice site. Nature (1982) 5.61
A novel domain within the 55 kd TNF receptor signals cell death. Cell (1993) 5.59
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity (1996) 5.45
Human transforming growth factor-alpha: precursor structure and expression in E. coli. Cell (1984) 5.39
FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science (1998) 5.29
Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli. Nature (1983) 5.27
Cloning and expression of murine immune interferon cDNA. Proc Natl Acad Sci U S A (1983) 5.25
Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization. Nucleic Acids Res (1985) 5.22
Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3' consensus sequence AAUAAA. Nature (1983) 5.18
Two TNF receptors. Immunol Today (1992) 4.87
Tumour necrosis factors alpha and beta inhibit virus replication and synergize with interferons. Nature (1986) 4.81
Gene synthesis machines: DNA chemistry and its uses. Science (1985) 4.76
Expression in Escherichia coli of chemically synthesized genes for human insulin. Proc Natl Acad Sci U S A (1979) 4.72
In situ activation of bis-dialkylaminophosphines--a new method for synthesizing deoxyoligonucleotides on polymer supports. Nucleic Acids Res (1984) 4.55
The structure of eight distinct cloned human leukocyte interferon cDNAs. Nature (1981) 4.50
Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors. Cancer Res (1987) 4.44
Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor. Proc Natl Acad Sci U S A (1985) 4.42
Effect of interleukin 2, interferon-gamma, and mitogens on the production of tumor necrosis factors alpha and beta. J Immunol (1985) 4.41
Structure of the human immune interferon gene. Nature (1982) 4.25
Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations. Nature (1983) 4.15
The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation. Proc Natl Acad Sci U S A (1996) 4.03
Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone. Nature (1979) 3.80
Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice. Immunity (1999) 3.78
Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc Natl Acad Sci U S A (1991) 3.76
Synthesis of human fibroblast interferon by E. coli. Nucleic Acids Res (1980) 3.75
Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. Proc Natl Acad Sci U S A (1997) 3.68
The murine transforming growth factor-beta precursor. J Biol Chem (1986) 3.67
Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta chemokines attract distinct populations of lymphocytes. J Exp Med (1993) 3.64
Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism. Science (1988) 3.60
The two different receptors for tumor necrosis factor mediate distinct cellular responses. Proc Natl Acad Sci U S A (1991) 3.40
Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice. Nature (1994) 3.34
Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development. Immunity (2000) 3.29
Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor. Cell (1989) 3.29
Polymer-supported RNA synthesis and its application to test the nearest-neighbor model for duplex stability. Biochemistry (1986) 3.21
A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor. Nature (1989) 3.21
Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice. Science (2001) 3.11
NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. Proc Natl Acad Sci U S A (1998) 3.04
Binding of synthetic lactose operator DNAs to lactose represessors. Proc Natl Acad Sci U S A (1977) 2.86
Nucleotide and amino acid sequence coding for polypeptides of foot-and-mouth disease virus type A12. J Virol (1985) 2.65
The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. Proc Natl Acad Sci U S A (1996) 2.62
Metal ion catalysis in the Tetrahymena ribozyme reaction. Nature (1993) 2.62
Total synthesis of the gene for an alanine transfer ribonucleic acid from yeast. Nature (1970) 2.51
IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. J Biol Chem (2001) 2.50
Expression of a human gene for interferon in yeast. Nature (1981) 2.46
Rational design of potent antagonists to the human growth hormone receptor. Science (1992) 2.45
Termination of transcription in the mouse alpha-amylase gene Amy-2a occurs at multiple sites downstream of the polyadenylation site. Cell (1984) 2.44
Expression in rat fibroblasts of a human transforming growth factor-alpha cDNA results in transformation. Cell (1986) 2.41
Tumor necrosis factors: gene structure and biological activities. Cold Spring Harb Symp Quant Biol (1986) 2.38
Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes. Cell (1987) 2.36
Molecular cloning and expression of Pgp-1. The mouse homolog of the human H-CAM (Hermes) lymphocyte homing receptor. J Immunol (1989) 2.34
Stability of XGCGCp, GCGCYp, and XGCGCYp helixes: an empirical estimate of the energetics of hydrogen bonds in nucleic acids. Biochemistry (1986) 2.32
New chemical methods for synthesizing polynucleotides. Nucleic Acids Symp Ser (1980) 2.32
Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor. J Biol Chem (1993) 2.29
Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). Science (1991) 2.25
Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin. Proc Natl Acad Sci U S A (1991) 2.24
In vitro anti-human immunodeficiency virus activities of tumor necrosis factor-alpha and interferon-gamma. J Immunol (1988) 2.21
Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor. Cell (1993) 2.17
The amino acid sequence of murine p53 determined from a c-DNA clone. Virology (1984) 2.15
How lac repressor recognizes lac operator. Proc Natl Acad Sci U S A (1978) 2.15
Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins. J Biol Chem (1996) 2.14
Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. Science (1999) 2.14
Increased synthesis in E. coli of fibroblast and leukocyte interferons through alterations in ribosome binding sites. DNA (1982) 2.09
Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways. J Immunol (1994) 2.06
Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase. EMBO J (1994) 2.06
Natural killer-sensitive targets stimulate production of TNF-alpha but not TNF-beta (lymphotoxin) by highly purified human peripheral blood large granular lymphocytes. J Immunol (1986) 2.05
Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron (1991) 2.03
Human fibroblast interferon gene lacks introns. Nucleic Acids Res (1981) 1.98
Leukocyte and fibroblast interferon genes are located on human chromosome 9. Proc Natl Acad Sci U S A (1981) 1.98
Identification of human uromodulin as the Tamm-Horsfall urinary glycoprotein. Science (1987) 1.92