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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Mechanism of action of the toxic lectins abrin and ricin. Nature 1974 2.83
2 Different biological properties of the two constituent peptide chains of ricin, a toxic protein inhibiting protein synthesis. Biochemistry 1973 2.30
3 Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and preparation of cytotoxic complexes with concanavalin A. J Biol Chem 1980 2.16
4 Kinetics of binding of the toxic lectins abrin and ricin to surface receptors of human cells. J Biol Chem 1976 2.12
5 Isolation and comparison of galactose-binding lectins from Abrus precatorius and Ricinus communis. J Biol Chem 1974 1.96
6 Entry of lethal doses of abrin, ricin and modeccin into the cytosol of HeLa cells. Exp Cell Res 1980 1.69
7 Ricin - a potent inhibitor of protein synthesis. FEBS Lett 1972 1.60
8 On the toxic proteins abrin and ricin. Studies of their binding to and entry into Ehrlich ascites cells. J Biol Chem 1974 1.54
9 Nude rat model for studying metastasis of human tumor cells to bone and bone marrow. J Natl Cancer Inst 1990 1.53
10 Treatment of abrin and ricin with -mercaptoethanol opposite effects on their toxicity in mice and their ability to inhibit protein synthesis in a cell-free system. FEBS Lett 1972 1.48
11 Isolation and properties of abrin: a toxic protein inhibiting protein synthesis. Evidence for different biological functions of its two constituent-peptide chains. Eur J Biochem 1973 1.44
12 Studies on the structure and properties of the lectins from Abrus precatorius and Ricinus communis. Biochim Biophys Acta 1975 1.43
13 On the current management of osteosarcoma. A critical evaluation and a proposal for a modified treatment strategy. Eur J Cancer 1997 1.42
14 Inhibitory effect of ammonium chloride and chloroquine on the entry of the toxic lectin modeccin into HeLa cells. Biochem Biophys Res Commun 1979 1.30
15 Extrapulmonary, tissue-specific metastasis formation in nude mice injected with FEMX-I human melanoma cells. Cancer Res 1988 1.29
16 Chimeric toxins. Pharmacol Ther 1981 1.25
17 A new experimental metastasis model in athymic nude mice, the human malignant melanoma LOX. Int J Cancer 1988 1.21
18 In vitro sensitivity of human melanoma xenografts to cytotoxic drugs. Correlation with in vivo chemosensitivity. Int J Cancer 1980 1.19
19 Translation of enzymically decapped messenger RNA. Eur J Biochem 1977 1.11
20 Binding, uptake and degradation of the toxic proteins abrin and ricin by toxin-resistant cell variants. Eur J Biochem 1978 1.11
21 Toxicity, distribution and elimination of the cancerostatic lectins abrin and ricin after parenteral injection into mice. Br J Cancer 1976 1.11
22 Comparison of two soft-agar methods for assaying chemosensitivity of human tumours in vitro: malignant melanomas. Br J Cancer 1981 1.10
23 Characteristics of a cell line established from a patient with multiple osteosarcoma, appearing 13 years after treatment for bilateral retinoblastoma. Int J Cancer 1986 1.09
24 On the mechanism of protein-synthesis inhibition by abrin and ricin. Inhibition of the GTP-hydrolysis site on the 60-S ribosomal subunit. Eur J Biochem 1975 1.07
25 Rates of different steps involved in the inhibition of protein synthesis by the toxic lectins abrin and ricin. J Biol Chem 1976 1.06
26 Inhibitory effect of abrin and ricin on the growth of transplantable murine tumors and of abrin on human cancers in nude mice. Cancer Res 1977 1.05
27 Colony growth and chemosensitivity in vitro of human melanoma biopsies. Relationship to clinical parameters. Int J Cancer 1982 1.04
28 Radioimmunoassays of abrin and ricin in blood. J Toxicol Environ Health 1981 1.03
29 Activity of mitozolomide (NSC 353451), a new imidazotetrazine, against xenografts from human melanomas, sarcomas, and lung and colon carcinomas. Cancer Res 1985 1.03
30 Assessment of tumour growth and of response to chemotherapy of human melanomas in athymic, nude mice. Br J Cancer Suppl 1980 1.00
31 Expression and characteristics of a novel human osteosarcoma-associated cell surface antigen. Cancer Res 1988 1.00
32 The usefulness of human tumor cell lines in the study of chemosensitivity. A study of malignant melanomas. Int J Cancer 1981 1.00
33 Elimination of B-lymphoma cells from human bone marrow: model experiments using monodisperse magnetic particles coated with primary monoclonal antibodies. Cancer Res 1987 1.00
34 Repair of radiation damage to erythrocyte membranes. The reduction of radiation-induced disulfide groups. Radiat Res 1968 0.99
35 Antigenic difference between informofers and protein bound to polyribosomal mRNA from rat liver. Nat New Biol 1972 0.95
36 Estrogen receptors and long-term prognosis in breast cancer. Cancer 1984 0.94
37 Fidelity of protein synthesis in vitro is increased in the presence of spermidine. FEBS Lett 1979 0.94
38 Cultivation of human melanomas in soft agar. Factors influencing plating efficiency and chemosensitivity. Int J Cancer 1981 0.94
39 Isolation and characterization of viscumin, a toxic lectin from Viscum album L. (mistletoe). J Biol Chem 1982 0.94
40 New monoclonal antibodies specific for human sarcomas. Int J Cancer 1986 0.93
41 Protective effect of elongation factor 2 on the inactivation of ribosomes by the toxic lectins abrin and ricin. Eur J Biochem 1976 0.92
42 Properties and action mechanism of the toxic lectin modeccin: interaction with cell lines resistant to modeccin, abrin, and ricin. J Supramol Struct 1978 0.92
43 Content of estrogen receptors in human breast cancer. Eur J Cancer 1973 0.92
44 Action of viscumin, a toxic lectin from mistletoe, on cells in culture. J Biol Chem 1982 0.92
45 Chemosensitivity measurements of human tumour cells by soft agar assays are influenced by the culture conditions. Br J Cancer 1985 0.88
46 Human tumor xenografts transplanted under the renal capsule of conventional mice. Growth rates and host immune response. Int J Cancer 1984 0.88
47 Properties of volkensin, a toxic lectin from Adenia volkensii. J Biol Chem 1985 0.88
48 On the ability of nitrous oxide to convert hydrated electrons into hydroxyl radical. Radiat Res 1965 0.88
49 A human tumor lung metastasis model in athymic nude rats. Cancer Res 1989 0.88
50 Toxicity of abrin and ricin in mice and dogs. J Toxicol Environ Health 1979 0.87
51 Response to chemotherapy of human, malignant melanoma xenografts in athymic, nude mice. Int J Cancer 1980 0.87
52 Repair of radiation damage to membrane sulfhydryl groups of human erythrocytes. Biochim Biophys Acta 1967 0.87
53 Preparation and properties of chimeric toxins prepared from the constituent polypeptides of diphtheria toxin and ricin. Evidence for entry of ricin A-chain via the diphtheria toxin pathway. J Biol Chem 1982 0.87
54 Selective localisation of two radiolabelled anti-sarcoma monoclonal antibodies in human osteosarcoma xenografts. Br J Cancer 1987 0.85
55 Detection of cancer-related proteins by two-dimensional electrophoresis. Ann N Y Acad Sci 1984 0.84
56 Stimulation of fructose 1,6-diphosphatase by sulfhydryl reagents and interaction between the different enzymic sites in the molecule. Eur J Biochem 1969 0.84
57 Reduced antineoplastic activity in mice of cisplatin administered with high salt concentration in the vehicle. J Natl Cancer Inst 1984 0.83
58 Technical modifications of the 6-phosphogluconate dehydrogenase test of the vaginal fluid. Am J Obstet Gynecol 1967 0.83
59 Effect of ricin and abrin on survival of L1210 leukemic mice and on leukemic and normal bone-marrow cells. Int J Cancer 1978 0.83
60 Immune anti-tumor response in the preclinical period of lung cancer. Eur J Cancer Clin Oncol 1982 0.83
61 Immunotoxins directed against the high-molecular-weight melanoma-associated antigen. Identification of potent antibody-toxin combinations. Int J Cancer 1992 0.83
62 UICC Study Group on chemosensitivity testing of human tumors. Problems--applications--future prospects. Int J Cancer 1986 0.83
63 Effect of protein synthesis inhibitors on the fidelity of translation in eukaryotic systems. Biochim Biophys Acta 1983 0.83
64 Pharmacological studies of ricin in mice and humans. Cancer Chemother Pharmacol 1984 0.83
65 Chemosensitivity profiles of human cancers assessed by the 6-day SRC assay on serially xenografted tumors. Int J Cancer 1986 0.82
66 The use of multicellular spheroids in establishing human sarcoma cell lines in vitro. Int J Cancer 1985 0.82
67 Characteristics of human tumour xenografts transplanted under the renal capsule of immunocompetent mice. Br J Cancer 1985 0.82
68 Deoxycholate-induced release of monosomes from rat liver polyribosomes. Biochim Biophys Acta 1972 0.82
69 Antibody formation against the cytotoxic proteins abrin and ricin in humans and mice. Int J Cancer 1983 0.82
70 Do cell lines in vitro reflect the properties of the tumours of origin? A study of lines derived from human melanoma xenografts. Br J Cancer 1981 0.81
71 Immunomagnetic removal of B-lymphoma cells from human bone marrow: a procedure for clinical use. Bone Marrow Transplant 1988 0.81
72 Inhibition of peptide chain elongation. Nature 1972 0.81
73 Detection of preinvasive and early invasive cancer by 6-phosphogluconate dehydrogenase determinations. Am J Obstet Gynecol 1967 0.81
74 Immunomagnetic removal of B-lymphoma cells using a novel mono-sized magnetizable polymer bead, M-280, in conjunction with primary IgM and IgG antibodies. Bone Marrow Transplant 1989 0.81
75 Phase I study of the plant protein ricin. Cancer Res 1984 0.81
76 Adverse events are common on the intensive care unit: results from a structured record review. Acta Anaesthesiol Scand 2012 0.80
77 Variable rate of polypeptide chain elongation in vitro. Effect of spermidine. Eur J Biochem 1980 0.80
78 Translation of mouse globin mRNA by isolated ribosomal subunits from rabbit reticulocytes. Biochim Biophys Acta 1972 0.80
79 Involvement of highly reactive sulfhydryl groups in the action of RNA polymerase from E. coli. FEBS Lett 1971 0.80
80 Interactions between abrus lectins and Sephadex particles possessing immobilized desialylated fetuin. Model studies of the interaction of lectins with cell surface receptors. Eur J Biochem 1978 0.80
81 Cultivation of human breast carcinoma in soft agar. Experience with 237 fresh tumour specimens. Br J Cancer 1988 0.80
82 Inactivation of DNA-dependent RNA polymerase from Escherichia coli by x-rays in solution. Biochim Biophys Acta 1972 0.79
83 Effect of abrin on peptide chain initiation. Eur J Biochem 1977 0.79
84 Studies on the mechanism of action of abrin-9.2.27 immunotoxin in human melanoma cell lines. Cancer Res 1987 0.79
85 Chemical modifications of the toxic lectins abrin and ricin. Eur J Biochem 1978 0.79
86 Effect of glucocorticoid steroids on cells in tissue culture. Biochem Pharmacol 1965 0.78
87 New indirect approach to the therapeutic use of immunotoxins. J Natl Cancer Inst 1988 0.78
88 Role of intermolecular reactions in the formation of secondary radicals in proteins irradiated in the dry state. Radiat Res 1968 0.78
89 Heterogeneity of chromosomal RNA. FEBS Lett 1972 0.78
90 Synergistic effect of adriamycin and ricin on L1210 leukemic cells in mice. Cancer Res 1980 0.78
91 Spontaneous alteration in growth rates of two human melanoma xenografts. Concurrent changes in chemosensitivity. Eur J Cancer Clin Oncol 1983 0.78
92 Radiation sensitivity of cells and base composition of DNA: an electron spin resonance study. Radiat Res 1966 0.78
93 Human melanoma cell lines showing striking inherent differences in sensitivity to immunotoxins containing holotoxins. J Natl Cancer Inst 1986 0.78
94 Successful clinical use of an anti-HLA-DR monoclonal antibody for autologous bone marrow transplantation. J Natl Cancer Inst 1988 0.77
95 Some procedures to reduce cis-platinum toxicity reduce antitumour activity. Cancer Treat Rev 1987 0.77
96 Colony forming ability of human breast carcinomas: lack of prognostic significance. Br J Cancer 1989 0.77
97 An effective immunomagnetic method for bone marrow purging in T cell malignancies. Bone Marrow Transplant 1992 0.76
98 Different metastasis patterns of a human melanoma cell line in nude mice and rats: influence of microenvironment. J Natl Cancer Inst 1991 0.76
99 Predictive chemosensitivity testing in malignant melanoma: reliable methodology--ineffective drugs. Br J Cancer 1988 0.76
100 Protein synthesis in the presence of non-ionic detergents in a cell-free system from rabbit reticulocytes. Biochem J 1972 0.75
101 Inactivation of eucaryotic ribosomes by the toxic plant proteins abrin and ricin. Mol Biol Rep 1973 0.75
102 An inverse relationship between the growth rate of human melanoma xenografts and their response to some cytostatic drugs. Br J Cancer 1980 0.75
103 Selection of tumour cell subpopulations occurs during cultivation of human tumours in soft agar. A DNA flow cytometric study. Br J Cancer 1985 0.75
104 [Enzymes: definitions, nomenclature, specifity and cellular localization]. Tidsskr Nor Laegeforen 1970 0.75
105 Clinical significance of estrogen receptors in human breast cancer. Biomedicine 1974 0.75
106 The role of the allosteric sites in the x-ray inactivation of phosphorylase b. Eur J Biochem 1967 0.75
107 Inhibition of mitochondrial protein synthesis and energy coupling by fragment A of diphtheria toxin. Eur J Biochem 1982 0.75
108 The six-day subrenal capsule assay (SRCA) for testing the response of human tumours to anticancer agents. Validity and usefulness in cancer research and treatment. Ann Chir Gynaecol Suppl 1985 0.75
109 Biochemical effects of prednisolone on human liver cells in tissue culture. Biochem Pharmacol 1966 0.75
110 Radiation effects on an allosteric enzyme with two catalytic activities. X-ray inactivation of the threonine-sensitive asparto-kinase-homoserine dehydrogenase from Escherichia coli. Biochim Biophys Acta 1970 0.75
111 Protection of RNA polymerase against ionizing radiation by mixed disulphide formation. Int J Radiat Biol Relat Stud Phys Chem Med 1971 0.75
112 Formation of ATP from the poly-adenylated region of eukaryotic messenger RNAs. FEBS Lett 1978 0.75
113 Sodium thiosulfate fails to increase the therapeutic index of intravenously administered cis-diamminedichloroplatinum (II) in mice bearing murine and human tumors. Cancer Chemother Pharmacol 1988 0.75
114 Kinetics of uptake and degradation of an abrin immunotoxin by melanoma cells and studies of the rates of cellular intoxication. Int J Cancer 1988 0.75
115 [Effect of ionizing radiation on enzymes]. Tidsskr Nor Laegeforen 1970 0.75
116 Transfer of radiation energy between macromolecules at 77 degrees K. Int J Radiat Biol Relat Stud Phys Chem Med 1970 0.75
117 Binding of rat liver ribosomes to nuclear complementary RNA. Biochim Biophys Acta 1972 0.75
118 The alleged usefulness of 6-phosphogluconate dehydrogenase determinations in screening for uterine cancer. Acta Obstet Gynecol Scand 1970 0.75
119 Immunoscintigraphy of bone sarcomas--results in 5 patients. Eur J Cancer 1994 0.75
120 Synergistic effect of ricin in combination with daunorubicin, cis-dichlorodiammineplatinum(II) and vincristine in systemic L1210 leukemia. Cancer Res 1982 0.75
121 X-ray inactivation of phosphofructokinase. The relative radiation sensitivity of the catalytic and the allosteric properties. Biochim Biophys Acta 1969 0.75
122 Kinetics of enzyme inactivation in solution by ionizing radiation. Eur J Biochem 1967 0.75
123 Turnover of the poly(A) moiety of mRNA in wheat-germ extract. Eur J Biochem 1980 0.75
124 Polypeptide synthesis by mitoplasts isolated from mouse liver. Exp Cell Res 1981 0.75
125 Effect of x-rays on the regulatory functions of glutamate dehydrogenase from beef liver. Radiat Res 1972 0.75
126 Athymic rats in preclinical immunodiagnostic studies. Anticancer Res 1991 0.75
127 Sulfhydryl groups in radiation damage. Scand J Clin Lab Invest Suppl 1968 0.75
128 An immunocytochemical method for assaying oestrogen receptors in breast cancers. A comparison with the steroid binding assay. Histol Histopathol 1988 0.75
129 Methodological aspects of the 6-day subrenal capsule assay for measuring the response of human tumors to anticancer agents. Anticancer Res 1985 0.75
130 X-ray modification of the catalytic and allosteric functions of fructose-I, 6-diphosphatase. Biochim Biophys Acta 1969 0.75
131 Doxorubicin and ricin, a strongly synergistic combination in mouse leukemia. Cancer Treat Rep 1980 0.75
132 Significance and mechanism of the indirect effect in bacterial cells. The relative protective effect of added compounds in Escherichia coli B, irradiated in liquid and in frozen suspension. Radiat Res 1969 0.75
133 Preferential protection of the regulatory function of phosphorylase b against X-ray inactivation in solution. Biochim Biophys Acta 1967 0.75
134 Radical transfer reactions and chemical protection in the dry state. Electron spin resonance studies on irradiated mixtures of ribonuclease and glycyl-glycine. Eur J Biochem 1967 0.75
135 Preferential inactivation of the allosteric function of aspartate transcarbamylase by x-rays. Biochim Biophys Acta 1966 0.75
136 Transfer of radiation energy between different solutes in frozen aqueous solutions. Radiat Res 1967 0.75
137 Identification of the water radicals involved in x-ray inactivation of enzymes in solution and determination of their rate of interaction with the enzyme. Biochim Biophys Acta 1967 0.75
138 Cleavage of adenovirus-5 DNA by an endonuclease from Haemophilus parainfluenzae. FEBS Lett 1975 0.75
139 Effect of pH on the formation and intermolecular transfer of radiation-induced unpaired spins in frozen aqueous mixtures. Radiat Res 1968 0.75
140 Removal of wheat-germ agglutinin increases protein synthesis in wheat-germ extracts. Eur J Biochem 1982 0.75