Adenosine triphosphate-dependent transport of doxorubicin, daunomycin, and vinblastine in human tissues by a mechanism distinct from the P-glycoprotein.

PubWeight™: 1.30‹?› | Rank: Top 10%

🔗 View Article (PMC 294005)

Published in J Clin Invest on March 01, 1994

Authors

S Awasthi1, S S Singhal, S K Srivastava, P Zimniak, K K Bajpai, M Saxena, R Sharma, S A Ziller, E P Frenkel, S V Singh

Author Affiliations

1: Department of Internal Medicine, University of Texas Medical Branch, Galveston 77555.

Associated clinical trials:

Studies on the Expression and Functions of RLIP76 in Blood Samples of Healthy Human Subjects | NCT00762801

Articles citing this

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc Natl Acad Sci U S A (1994) 2.52

Tissue distribution of the multidrug resistance protein. Am J Pathol (1996) 1.84

Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein. Br J Cancer (1995) 1.32

Hsf-1 and POB1 induce drug sensitivity and apoptosis by inhibiting Ralbp1. J Biol Chem (2008) 1.26

Pink-eyed dilution protein modulates arsenic sensitivity and intracellular glutathione metabolism. Mol Biol Cell (2002) 1.14

Opiates inhibit paclitaxel uptake by P-glycoprotein in preparations of human placental inside-out vesicles. Biochem Pharmacol (2009) 1.07

RLIP76 and Cancer. Clin Cancer Res (2008) 1.07

RLIP76: a target for kidney cancer therapy. Cancer Res (2009) 1.03

Modulation of human placental P-glycoprotein expression and activity by MDR1 gene polymorphisms. Biochem Pharmacol (2009) 1.02

Transport and epithelial secretion of the cardiac glycoside, digoxin, by human intestinal epithelial (Caco-2) cells. Br J Pharmacol (1996) 1.02

RLIP76: A novel glutathione-conjugate and multi-drug transporter. Biochem Pharmacol (2008) 0.99

RLIP76: a versatile transporter and an emerging target for cancer therapy. Biochem Pharmacol (2010) 0.97

Regression of prostate cancer xenografts by RLIP76 depletion. Biochem Pharmacol (2008) 0.96

Role of RLIP76 in doxorubicin resistance in lung cancer. Int J Oncol (2009) 0.94

Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis. Mol Cancer Ther (2011) 0.93

RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization. Cancer Res (2012) 0.90

Functional reconstitution of RLIP76 catalyzing ATP-dependent transport of glutathione-conjugates. Int J Oncol (2009) 0.88

Diminished drug transport and augmented radiation sensitivity caused by loss of RLIP76. FEBS Lett (2008) 0.88

The DrrAB efflux system of Streptomyces peucetius is a multidrug transporter of broad substrate specificity. J Biol Chem (2014) 0.85

Overexpression of RalBP1 in colorectal cancer is an independent predictor of poor survival and early tumor relapse. Cancer Biol Ther (2012) 0.83

A central role of RLIP76 in regulation of glycemic control. Diabetes (2009) 0.83

Role of transporter-mediated efflux in the placental biodisposition of bupropion and its metabolite, OH-bupropion. Biochem Pharmacol (2010) 0.83

MOAT4, a novel multispecific organic-anion transporter for glucuronides and mercapturates in mouse L1210 cells and human erythrocytes. Biochem J (1996) 0.83

ATP-dependent transport of glutathione conjugate of 7beta, 8alpha-dihydroxy-9alpha,10alpha-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene in murine hepatic canalicular plasma membrane vesicles. Biochem J (1998) 0.78

Emerging treatments in lung cancer - targeting the RLIP76 molecular transporter. Lung Cancer (Auckl) (2013) 0.77

RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma. Pharm Res (2017) 0.76

RLIP76 regulates HIF-1 activity, VEGF expression and secretion in tumor cells, and secretome transactivation of endothelial cells. FASEB J (2014) 0.76

Pharmacogenetics of ABCB5, ABCC5 and RLIP76 and doxorubicin pharmacokinetics in Asian breast cancer patients. Pharmacogenomics J (2016) 0.76

RLIP76 Targeted Therapy for Kidney Cancer. Pharm Res (2015) 0.75

Articles cited by this

A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol (1961) 45.34

The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. Arch Biochem Biophys (1963) 20.43

Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. J Biol Chem (1977) 9.67

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta (1976) 7.41

Preparation of impermeable ghosts and inside-out vesicles from human erythrocyte membranes. Methods Enzymol (1974) 5.46

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells. Proc Natl Acad Sci U S A (1988) 2.44

Glutathione transferases and cancer. Crit Rev Biochem Mol Biol (1992) 2.09

A filter paper dye-binding assay for quantitative determination of protein without interference from reducing agents or detergents. Anal Biochem (1990) 1.89

The transport of oxidized glutathione from human erythrocytes. J Biol Chem (1969) 1.55

Characterization of adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane protein. J Biol Chem (1990) 1.46

Pharmacological and biological evidence for differing mechanisms of doxorubicin resistance in two human tumor cell lines. Cancer Res (1988) 1.43

Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line. Cancer Res (1990) 1.39

Correlation of multidrug resistance with decreased drug accumulation, altered subcellular drug distribution, and increased P-glycoprotein expression in cultured SW-1573 human lung tumor cells. Cancer Res (1989) 1.22

Energy-dependent processes involved in reduced drug accumulation in multidrug-resistant human lung cancer cell lines without P-glycoprotein expression. Cancer Res (1992) 1.21

Analysis of the steady-state and initial rate of doxorubicin efflux from a series of multidrug-resistant cells expressing different levels of P-glycoprotein. Biochemistry (1992) 1.19

Kinetics of daunorubicin transport by P-glycoprotein of intact cancer cells. Eur J Biochem (1992) 1.15

Enzymatic conjugation of erythrocyte glutathione with 1-chloro-2,4-dinitrobenzene: the fate of glutathione conjugate in erythrocytes and the effect of glutathione depletion on hemoglobin. Blood (1981) 1.12

Retention of activity by selected anthracyclines in a multidrug resistant human large cell lung carcinoma line without P-glycoprotein hyperexpression. Br J Cancer (1991) 1.06

Interactions of glutathione S-transferase-pi with ethacrynic acid and its glutathione conjugate. Biochim Biophys Acta (1993) 1.03

P-glycoprotein as multidrug transporter: a critical review of current multidrug resistant cell lines. Biochim Biophys Acta (1992) 1.02

Genetic aspects of multidrug resistance. Cancer (1992) 0.92

Studies on glutathione transport utilizing inside-out vesicles prepared from human erythrocytes. Biochim Biophys Acta (1981) 0.89

Purification and characterization of dinitrophenylglutathione ATPase of human erythrocytes and its expression in other tissues. Biochem Biophys Res Commun (1990) 0.89

Dinitrophenyl glutathione efflux from human erythrocytes is primary active ATP-dependent transport. Biochem J (1986) 0.89

Pharmacokinetics of adriamycin (NSC-123127) in patients with sarcomas. Cancer Chemother Rep (1974) 0.87

A novel dinitrophenylglutathione-stimulated ATPase is present in human erythrocyte membranes. FEBS Lett (1988) 0.86

The anionic conjugates of bilirubin and bile acids stimulate ATP hydrolysis by S-(dinitrophenyl)glutathione ATPase of human erythrocyte. FEBS Lett (1991) 0.86

Dinitrophenyl S-glutathione ATPase purified from human muscle catalyzes ATP hydrolysis in the presence of leukotrienes. Arch Biochem Biophys (1992) 0.83

Increased levels of glutathione S-transferase pi transcript as a mechanism of resistance to ethacrynic acid. Biochem J (1992) 0.82

Glutathione disulfide-stimulated Mg2+-ATPase of human erythrocyte membranes. Proc Natl Acad Sci U S A (1987) 0.82

The relationship of doxorubicin binding to membrane lipids with drug resistance. Cancer Lett (1992) 0.80

Identification of an anion-transport ATPase that catalyzes glutathione conjugate-dependent ATP hydrolysis in canalicular plasma membranes from normal rats and rats with conjugated hyperbilirubinemia (GY mutant). Arch Biochem Biophys (1992) 0.80

Articles by these authors

Emergence of novel strain of Vibrio cholerae with epidemic potential in southern and eastern India. Lancet (1993) 10.82

Performance of four computer-based diagnostic systems. N Engl J Med (1994) 9.40

Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. Arch Gen Psychiatry (2000) 5.12

Circulating factor associated with increased glomerular permeability to albumin in recurrent focal segmental glomerulosclerosis. N Engl J Med (1996) 4.41

Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene. Nature (1983) 4.34

The atypical lymphocyte. Am J Med (1967) 2.83

High prevalence of diabetes, obesity and dyslipidaemia in urban slum population in northern India. Int J Obes Relat Metab Disord (2001) 2.79

CopA: An Escherichia coli Cu(I)-translocating P-type ATPase. Proc Natl Acad Sci U S A (2000) 2.75

Dynamic changes of the inflammation-based index predict mortality following chemoembolisation for hepatocellular carcinoma: a prospective study. Aliment Pharmacol Ther (2014) 2.66

Left-sided Amyand's hernia. Singapore Med J (2005) 2.22

Tuberculous osteomyelitis. J Bone Joint Surg Br (1997) 2.21

Performance of an age series of Alnus-cardamom plantations in the Sikkim Himalaya: nutrient dynamics. Ann Bot (2002) 2.14

Retracted The nitrile-degrading enzymes: current status and future prospects. Appl Microbiol Biotechnol (2002) 2.14

Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties. Eur J Biochem (1994) 2.05

Mode of action of anti-lymphocyte globulin. I. The distribution of rabbit anti-lymphocyte globulin injected into rats and mice. Immunology (1968) 1.98

Prevalence of exercise-induced left ventricular outflow tract obstruction in symptomatic patients with non-obstructive hypertrophic cardiomyopathy. Heart (2007) 1.97

An innovative technique for oral to nasal endotracheal tube exchange in children. Minerva Anestesiol (2009) 1.93

An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Proc Natl Acad Sci U S A (2002) 1.91

Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by negative charge in the R domain. J Biol Chem (1993) 1.80

Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor. J Exp Med (2001) 1.79

Mask for stoma ventilation: rescue using a Rendell-Baker-Soucek mask after a dislodged tracheostomy tube. Acta Anaesthesiol Scand (2008) 1.70

Assessment of HER-2/neu status in breast cancer. Automated Cellular Imaging System (ACIS)-assisted quantitation of immunohistochemical assay achieves high accuracy in comparison with fluorescence in situ hybridization assay as the standard. Am J Clin Pathol (2001) 1.69

Hypercalcemia associated with increased serum calcitriol levels in three patients with lymphoma. Ann Intern Med (1984) 1.67

Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV. Phys Rev Lett (2010) 1.67

Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP. Eur J Immunol (1999) 1.67

Performance of an age series of alnus-cardamom plantations in the Sikkim Himalaya: productivity, energetics and efficiencies. Ann Bot (2002) 1.65

Head of the Medical Council of India removed for corruption. BMJ (2001) 1.64

Magnetic resonance identification of an accessory submandibular duct and gland: an unusual variant. J Laryngol Otol (2007) 1.63

Hexosaminidase-A and hexosaminidase-B: studies in Tay-Sachs' and Sandhoff's disease. Nature (1973) 1.60

A novel, externally validated inflammation-based prognostic algorithm in hepatocellular carcinoma: the prognostic nutritional index (PNI). Br J Cancer (2012) 1.59

Catalytic function of Drosophila melanogaster glutathione S-transferase DmGSTS1-1 (GST-2) in conjugation of lipid peroxidation end products. Eur J Biochem (2001) 1.59

Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin. Biochemistry (2000) 1.55

The transport of oxidized glutathione from human erythrocytes. J Biol Chem (1969) 1.55

Sinus of Valsalva aneurysms: 20 years' experience. J Card Surg (1998) 1.54

Tissue Doppler, strain, and strain rate echocardiography for the assessment of left and right systolic ventricular function. Heart (2003) 1.53

Sodium nitroprusside increases glomerular capillary hydraulic conductivity in isolated rat glomeruli. J Lab Clin Med (1995) 1.51

Ras p21 proteins with high or low GTPase activity can efficiently transform NIH/3T3 cells. Cell (1986) 1.51

Technical cost of CT examinations. Radiology (2001) 1.50

Mode of action of anti-lymphocyte globulin. II. Changes in the lymphoid cell population in rats treated with anti-lymphocyte globulin. Immunology (1968) 1.49

Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress. J Biol Chem (2001) 1.49

Reversible osmotic blood-brain barrier disruption in humans: implications for the chemotherapy of malignant brain tumors. Neurosurgery (1980) 1.49

Correction of cubitus varus by French or dome osteotomy: a comparative study. J Trauma (2000) 1.49

High prevalence of insulin resistance in postpubertal Asian Indian children is associated with adverse truncal body fat patterning, abdominal adiposity and excess body fat. Int J Obes Relat Metab Disord (2004) 1.48

Purification and properties of human erythrocyte glutathione peroxidase. J Biol Chem (1975) 1.48

Metabolism of the lipid peroxidation product, 4-hydroxy-trans-2-nonenal, in isolated perfused rat heart. J Biol Chem (1998) 1.47

A rare presentation of falciparum malaria. J Assoc Physicians India (1995) 1.47

Serum S100B protein levels are correlated with subclinical neurocognitive declines after carotid endarterectomy. Neurosurgery (2001) 1.47

"The FSGS factor:" enrichment and in vivo effect of activity from focal segmental glomerulosclerosis plasma. J Am Soc Nephrol (1999) 1.47

Integrated community-based screening for cardiovascular diseases of childhood. World Health Forum (1997) 1.47

Amoxicillin-clavulanic acid for treating drug-resistant Mycobacterium tuberculosis. Chest (1991) 1.47

Studies on human beta-D-N-acetylhexosaminidases. 3. Biochemical genetics of Tay-Sachs and Sandhoff's diseases. J Biol Chem (1974) 1.46

Retracted DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers. Br J Cancer (2005) 1.45

Studies on human beta-D-N-acetylhexosaminidases. I. Purification and properties. J Biol Chem (1974) 1.44

p53 and bcl-2 immunohistochemistry in pretreatment prostate needle biopsies to predict recurrence of prostate cancer after radical prostatectomy. J Urol (1999) 1.44

Frequency of molecular alterations affecting ras protooncogenes in human urinary tract tumors. Proc Natl Acad Sci U S A (1985) 1.43

CXCL12-CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: a novel target for therapy. Br J Cancer (2010) 1.43

Role of glutathione S-transferases in protection against lipid peroxidation. Overexpression of hGSTA2-2 in K562 cells protects against hydrogen peroxide-induced apoptosis and inhibits JNK and caspase 3 activation. J Biol Chem (2001) 1.43

The predictive value of pre-treatment inflammatory markers in advanced non-small-cell lung cancer. Curr Oncol (2010) 1.43

Measurement of albumin reflection coefficient with isolated rat glomeruli. J Am Soc Nephrol (1992) 1.41

Diagnostic dilemma: aspergillosis. J Assoc Physicians India (2000) 1.41

Miosis with haloperidol. J Assoc Physicians India (1992) 1.40

Accurate measurement of oxidized glutathione content of human, rabbit, and rat red blood cells and tissues. Anal Biochem (1968) 1.40

Studies on human beta-D-N-acetylhexosaminidases. II. Kinetic and structural properties. J Biol Chem (1974) 1.39

Anomalous drainage of right superior vena cava into the left atrium. Indian Heart J (1998) 1.39

Evaluation of bone marrow iron stores in anemia associated with chronic disease: a comparative study of serum and red cell ferritin. Am J Hematol (1993) 1.39

Aneurysm of sinus of Valsalva dissecting into interventricular septum. Ann Thorac Surg (1998) 1.39

Cost variation of some commonly used antimicrobial agents. J Indian Med Assoc (1997) 1.38

Radioisotopic assay of serum vitamin B 12 with the use of DEAE cellulose. J Lab Clin Med (1966) 1.38

Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery. J Clin Invest (1979) 1.37

Structural and kinetic determinants of aldehyde reduction by aldose reductase. Biochemistry (1999) 1.34

Cutaneous manifestations of dabrafenib (GSK2118436): a selective inhibitor of mutant BRAF in patients with metastatic melanoma. Br J Dermatol (2012) 1.33

Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells. Br J Cancer (2009) 1.33

Involvement of cysteine residues in catalysis and inhibition of human aldose reductase. Site-directed mutagenesis of Cys-80, -298, and -303. J Biol Chem (1992) 1.33

Cross-talk between cyclooxygenase and nitric oxide pathways: prostaglandin E2 negatively modulates induction of nitric oxide synthase by interleukin 1. Proc Natl Acad Sci U S A (1994) 1.33

Desmosomal glycoproteins 2 and 3 (desmocollins) show N-terminal similarity to calcium-dependent cell-cell adhesion molecules. J Cell Sci (1990) 1.32

Surgical experience with intracardiac myxomas: long-term follow-up. Ann Thorac Surg (1998) 1.32

Rapid reversible substrate regulation of fructose transporter expression in rat small intestine and kidney. Am J Physiol (1994) 1.31

An unusual cause of respiratory distress: live leech in the larynx. Anesth Analg (2000) 1.30

Increased expression of MMP-2 and MMP-9 in esophageal squamous cell carcinoma. J Cancer Res Clin Oncol (2003) 1.29

Association of glutathione S-transferase (GSTM1, T1 and P1) gene polymorphisms with type 2 diabetes mellitus in north Indian population. J Postgrad Med (2010) 1.27

Validation of drying models and rehydration characteristics of betel (Piper betel L.) leaves. J Food Sci Technol (2010) 1.25

Congenital anterior urethral diverticulum: sonographic diagnosis. J Clin Ultrasound (1997) 1.24

Early detection of cervical cancer with visual inspection methods: a summary of completed and on-going studies in India. Salud Publica Mex (2003) 1.24

The effect of immunologically induced lymphopenia on antibody formation. J Immunol (1969) 1.23

Characterization of human neuroblastoma cell lines established before and after therapy. J Natl Cancer Inst (1986) 1.22

Risk of alloimmunization and delayed hemolytic transfusion reactions in patients with sickle cell disease. Arch Intern Med (1988) 1.22

A human gene encoding morphine modulating peptides related to NPFF and FMRFamide. FEBS Lett (1997) 1.22

Intrapericardial streptokinase in purulent pericarditis. Arch Dis Child (1999) 1.21

VEGF/VEGFR pathway inhibitors as anti-angiogenic agents: present and future. Curr Cancer Drug Targets (2011) 1.21

TNF-alpha increases albumin permeability of isolated rat glomeruli through the generation of superoxide. J Am Soc Nephrol (1998) 1.21

Seizure identification in the ICU using quantitative EEG displays. Neurology (2010) 1.20

Meropenem: a unusual cause of metabolic alkalosis in critical care patients. Anaesth Intensive Care (2008) 1.20

Electrogenicity of Ca2+ transport catalyzed by the Ca2+-ATPase from sarcoplasmic reticulum. J Biol Chem (1978) 1.20

Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation. J Biol Chem (2000) 1.20