Published in Biochem Pharmacol on January 25, 2010
The RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery. Genes Cancer (2011) 1.32
Activation and involvement of Ral GTPases in colorectal cancer. Cancer Res (2011) 1.18
Protein S-glutathiolation: redox-sensitive regulation of protein function. J Mol Cell Cardiol (2011) 0.99
Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis. Mol Cancer Ther (2011) 0.93
Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame. Biochim Biophys Acta (2014) 0.90
Delivery of intracellular-acting biologics in pro-apoptotic therapies. Curr Pharm Des (2011) 0.87
The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo. Eur J Cancer (2013) 0.85
Targeting p53-null neuroblastomas through RLIP76. Cancer Prev Res (Phila) (2011) 0.84
RLIP76, a glutathione-conjugate transporter, plays a major role in the pathogenesis of metabolic syndrome. PLoS One (2011) 0.83
RLIP76 (RalBP1): The first piece of the structural puzzle. Small GTPases (2010) 0.80
Early Steps of Jaagsiekte Sheep Retrovirus-Mediated Cell Transformation Involve the Interaction between Env and the RALBP1 Cellular Protein. J Virol (2015) 0.79
Inflammation Modulates RLIP76/RALBP1 Electrophile-Glutathione Conjugate Transporter and Housekeeping Genes in Human Blood-Brain Barrier Endothelial Cells. PLoS One (2015) 0.78
Emerging treatments in lung cancer - targeting the RLIP76 molecular transporter. Lung Cancer (Auckl) (2013) 0.77
RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma. Pharm Res (2017) 0.76
The structure of the RLIP76 RhoGAP-Ral binding domain dyad: fixed position of the domains leads to dual engagement of small G proteins at the membrane. Structure (2013) 0.76
Controversy about pharmacological modulation of Nrf2 for cancer therapy. Redox Biol (2017) 0.76
RLIP76 Targeted Therapy for Kidney Cancer. Pharm Res (2015) 0.75
Overexpression of RLIP76 Required for Proliferation in Meningioma Is Associated with Recurrence. PLoS One (2015) 0.75
Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C. Oncotarget (2016) 0.75
Multiple molecular mechanisms for multidrug resistance transporters. Nature (2007) 3.96
ABC multidrug transporters: structure, function and role in chemoresistance. Pharmacogenomics (2008) 3.35
Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. J Biol Chem (1995) 2.69
Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases. Mol Cell Biol (1995) 2.45
A putative effector of Ral has homology to Rho/Rac GTPase activating proteins. Oncogene (1995) 1.77
RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. J Biol Chem (2003) 1.69
Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin. Biochemistry (2000) 1.55
Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress. J Biol Chem (2001) 1.49
Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters. Int J Toxicol (2006) 1.43
Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-binding protein 1). Cancer Res (2007) 1.39
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration. J Cell Biol (2006) 1.38
RLIP76 is a major determinant of radiation sensitivity. Cancer Res (2005) 1.37
Depletion of RLIP76 sensitizes lung cancer cells to doxorubicin. Biochem Pharmacol (2005) 1.32
Regression of melanoma in a murine model by RLIP76 depletion. Cancer Res (2006) 1.31
HSF-1 interacts with Ral-binding protein 1 in a stress-responsive, multiprotein complex with HSP90 in vivo. J Biol Chem (2003) 1.30
Adenosine triphosphate-dependent transport of doxorubicin, daunomycin, and vinblastine in human tissues by a mechanism distinct from the P-glycoprotein. J Clin Invest (1994) 1.30
Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): a novel link between G-protein and tyrosine kinase signaling and drug resistance. Int J Cancer (2003) 1.30
Hsf-1 and POB1 induce drug sensitivity and apoptosis by inhibiting Ralbp1. J Biol Chem (2008) 1.26
RLIP76 transports vinorelbine and mediates drug resistance in non-small cell lung cancer. Cancer Res (2005) 1.16
Identification of membrane-anchoring domains of RLIP76 using deletion mutant analyses. Biochemistry (2004) 1.12
Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer. Int J Cancer (2010) 1.10
RLIP76 in defense of radiation poisoning. Int J Radiat Oncol Biol Phys (2008) 1.10
Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76. Int J Oncol (2003) 1.06
Cytocentrin is a Ral-binding protein involved in the assembly and function of the mitotic apparatus. J Cell Sci (1999) 1.06
Linking stress-signaling, glutathione metabolism, signaling pathways and xenobiotic transporters. Cancer Metastasis Rev (2007) 1.05
RLIP76: a target for kidney cancer therapy. Cancer Res (2009) 1.03
Determinants of differential doxorubicin sensitivity between SCLC and NSCLC. FEBS Lett (2006) 1.02
Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity. Int J Oncol (2003) 1.01
Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells. Int J Oncol (2003) 1.01
RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytes. Arch Biochem Biophys (2001) 1.01
REPS2/POB1 is downregulated during human prostate cancer progression and inhibits growth factor signalling in prostate cancer cells. Oncogene (2003) 1.00
Functional reassembly of ATP-dependent xenobiotic transport by the N- and C-terminal domains of RLIP76 and identification of ATP binding sequences. Biochemistry (2001) 0.99
RLIP76, a novel transporter catalyzing ATP-dependent efflux of xenobiotics. Drug Metab Dispos (2002) 0.99
RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance. Int J Cancer (2004) 0.99
Regression of prostate cancer xenografts by RLIP76 depletion. Biochem Pharmacol (2008) 0.96
ATP-Dependent human erythrocyte glutathione-conjugate transporter. II. Functional reconstitution of transport activity. Biochemistry (1998) 0.95
RLIP76, a non-ABC transporter, and drug resistance in epilepsy. BMC Neurosci (2005) 0.94
POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis. Biochem Biophys Res Commun (2005) 0.94
The role of PKCalpha and RLIP76 in transport-mediated doxorubicin-resistance in lung cancer. FEBS Lett (2005) 0.92
ATP-Dependent human erythrocyte glutathione-conjugate transporter. I. Purification, photoaffinity labeling, and kinetic characteristics of ATPase activity. Biochemistry (1998) 0.91
Mitogenic and drug-resistance mediating effects of PKCalpha require RLIP76. Biochem Biophys Res Commun (2006) 0.91
The non-ABC drug transporter RLIP76 (RALBP-1) plays a major role in the mechanisms of drug resistance. Curr Drug Metab (2007) 0.90
Purification and characterization of dinitrophenylglutathione ATPase of human erythrocytes and its expression in other tissues. Biochem Biophys Res Commun (1990) 0.89
Dinitrophenyl glutathione efflux from human erythrocytes is primary active ATP-dependent transport. Biochem J (1986) 0.89
Mass spectroscopic phosphoprotein mapping of Ral binding protein 1 (RalBP1/Rip1/RLIP76). Biochem Biophys Res Commun (2007) 0.88
Functional reconstitution of RLIP76 catalyzing ATP-dependent transport of glutathione-conjugates. Int J Oncol (2009) 0.88
Diminished drug transport and augmented radiation sensitivity caused by loss of RLIP76. FEBS Lett (2008) 0.88
RALBP1/RLIP76 mediates multidrug resistance. Int J Oncol (2007) 0.88
ATP-Dependent colchicine transport by human erythrocyte glutathione conjugate transporter. Toxicol Appl Pharmacol (1999) 0.86
Increased expression of cdc2 inhibits transport function of RLIP76 and promotes apoptosis. Cancer Lett (2009) 0.85
The association between polymorphisms in RLIP76 and drug response in epilepsy. Pharmacogenomics (2007) 0.79
Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling. Acta Biochim Pol (2003) 1.67
Role of 4-hydroxynonenal in stress-mediated apoptosis signaling. Mol Aspects Med (2003) 1.57
Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma. Cancer Prev Res (Phila) (2011) 1.44
Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases. Free Radic Biol Med (2004) 1.40
Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-binding protein 1). Cancer Res (2007) 1.39
RLIP76 is a major determinant of radiation sensitivity. Cancer Res (2005) 1.37
Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse. Toxicol Appl Pharmacol (2004) 1.36
Antioxidant role of glutathione S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosis. Antioxid Redox Signal (2004) 1.33
Depletion of RLIP76 sensitizes lung cancer cells to doxorubicin. Biochem Pharmacol (2005) 1.32
Regression of melanoma in a murine model by RLIP76 depletion. Cancer Res (2006) 1.31
Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): a novel link between G-protein and tyrosine kinase signaling and drug resistance. Int J Cancer (2003) 1.30
Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells. Cancer Res (2006) 1.27
Hsf-1 and POB1 induce drug sensitivity and apoptosis by inhibiting Ralbp1. J Biol Chem (2008) 1.26
Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death. Free Radic Biol Med (2008) 1.23
Regulation of 4-hydroxynonenal mediated signaling by glutathione S-transferases. Methods Enzymol (2005) 1.21
RLIP76 transports vinorelbine and mediates drug resistance in non-small cell lung cancer. Cancer Res (2005) 1.16
Identification of membrane-anchoring domains of RLIP76 using deletion mutant analyses. Biochemistry (2004) 1.12
Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer. Int J Cancer (2010) 1.10
RLIP76 in defense of radiation poisoning. Int J Radiat Oncol Biol Phys (2008) 1.10
4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells. Arch Biochem Biophys (2008) 1.10
Cells preconditioned with mild, transient UVA irradiation acquire resistance to oxidative stress and UVA-induced apoptosis: role of 4-hydroxynonenal in UVA-mediated signaling for apoptosis. J Biol Chem (2003) 1.10
Regulation of CD95 (Fas) expression and Fas-mediated apoptotic signaling in HLE B-3 cells by 4-hydroxynonenal. Biochemistry (2006) 1.09
The sensors and regulators of cell-matrix surveillance in anoikis resistance of tumors. Int J Cancer (2010) 1.08
RLIP76 and Cancer. Clin Cancer Res (2008) 1.07
Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76. Int J Oncol (2003) 1.06
Linking stress-signaling, glutathione metabolism, signaling pathways and xenobiotic transporters. Cancer Metastasis Rev (2007) 1.05
RLIP76: a target for kidney cancer therapy. Cancer Res (2009) 1.03
Therapeutic resistance in lung cancer. Expert Opin Drug Metab Toxicol (2006) 1.02
Determinants of differential doxorubicin sensitivity between SCLC and NSCLC. FEBS Lett (2006) 1.02
Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells. Int J Oncol (2003) 1.01
Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity. Int J Oncol (2003) 1.01
Mechanisms of 4-hydroxy-2-nonenal induced pro- and anti-apoptotic signaling. Biochemistry (2010) 1.01
Role of lipid peroxidation in cellular responses to D,L-sulforaphane, a promising cancer chemopreventive agent. Biochemistry (2010) 1.00
RLIP76, a novel transporter catalyzing ATP-dependent efflux of xenobiotics. Drug Metab Dispos (2002) 0.99
RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance. Int J Cancer (2004) 0.99
4-Hydroxynonenal self-limits fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas. Biochemistry (2007) 0.97
Membrane association of glutathione S-transferase mGSTA4-4, an enzyme that metabolizes lipid peroxidation products. J Biol Chem (2001) 0.96
Regression of prostate cancer xenografts by RLIP76 depletion. Biochem Pharmacol (2008) 0.96
POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis. Biochem Biophys Res Commun (2005) 0.94
RLIP76, a non-ABC transporter, and drug resistance in epilepsy. BMC Neurosci (2005) 0.94
Role of RLIP76 in doxorubicin resistance in lung cancer. Int J Oncol (2009) 0.94
Transfection with 4-hydroxynonenal-metabolizing glutathione S-transferase isozymes leads to phenotypic transformation and immortalization of adherent cells. Eur J Biochem (2004) 0.93
Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis. Mol Cancer Ther (2011) 0.93
The role of PKCalpha and RLIP76 in transport-mediated doxorubicin-resistance in lung cancer. FEBS Lett (2005) 0.92
Mitogenic and drug-resistance mediating effects of PKCalpha require RLIP76. Biochem Biophys Res Commun (2006) 0.91
The non-ABC drug transporter RLIP76 (RALBP-1) plays a major role in the mechanisms of drug resistance. Curr Drug Metab (2007) 0.90
Physiological and pharmacological significance of glutathione-conjugate transport. J Toxicol Environ Health B Crit Rev (2009) 0.90
RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization. Cancer Res (2012) 0.90
Lipid peroxidation products in human health and disease. Oxid Med Cell Longev (2013) 0.89
Protection of HLE B-3 cells against hydrogen peroxide- and naphthalene-induced lipid peroxidation and apoptosis by transfection with hGSTA1 and hGSTA2. Invest Ophthalmol Vis Sci (2002) 0.89
LR-90 prevents methylglyoxal-induced oxidative stress and apoptosis in human endothelial cells. Apoptosis (2014) 0.88
The determination of glutathione-4-hydroxynonenal (GSHNE), E-4-hydroxynonenal (HNE), and E-1-hydroxynon-2-en-4-one (HNO) in mouse liver tissue by LC-ESI-MS. Anal Bioanal Chem (2008) 0.88
Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol (2007) 0.88
Role of 4-hydroxynonenal in epidermal growth factor receptor-mediated signaling in retinal pigment epithelial cells. Exp Eye Res (2010) 0.88
Transport functions and physiological significance of 76 kDa Ral-binding GTPase activating protein (RLIP76). Acta Biochim Pol (2002) 0.88
Nutlin-3 enhances sorafenib efficacy in renal cell carcinoma. Mol Carcinog (2011) 0.88
Functional reconstitution of RLIP76 catalyzing ATP-dependent transport of glutathione-conjugates. Int J Oncol (2009) 0.88
Inhibition of aldose reductase prevents colon cancer metastasis. Carcinogenesis (2011) 0.88
Diminished drug transport and augmented radiation sensitivity caused by loss of RLIP76. FEBS Lett (2008) 0.88
RALBP1/RLIP76 mediates multidrug resistance. Int J Oncol (2007) 0.88
RLIP76 regulates PI3K/Akt signaling and chemo-radiotherapy resistance in pancreatic cancer. PLoS One (2012) 0.87
Depletion of 4-hydroxynonenal in hGSTA4-transfected HLE B-3 cells results in profound changes in gene expression. Biochem Biophys Res Commun (2005) 0.87
2'-hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL-mutant renal cell carcinoma. Carcinogenesis (2011) 0.86
Association of rash with outcomes in a randomized phase II trial evaluating cetuximab in combination with mitoxantrone plus prednisone after docetaxel for metastatic castration-resistant prostate cancer. Clin Genitourin Cancer (2012) 0.85
Increased expression of cdc2 inhibits transport function of RLIP76 and promotes apoptosis. Cancer Lett (2009) 0.85
Regression of lung cancer by hypoxia-sensitizing ruthenium polypyridyl complexes. Mol Cancer Ther (2013) 0.84
The expression and function of vascular endothelial growth factor in retinal pigment epithelial (RPE) cells is regulated by 4-hydroxynonenal (HNE) and glutathione S-transferaseA4-4. Biochem Biophys Res Commun (2011) 0.84
Role of SMC1 in overcoming drug resistance in triple negative breast cancer. PLoS One (2013) 0.84
Targeting p53-null neuroblastomas through RLIP76. Cancer Prev Res (Phila) (2011) 0.84
Functional reconstitution of Ral-binding GTPase activating protein, RLIP76, in proteoliposomes catalyzing ATP-dependent transport of glutathione conjugate of 4-hydroxynonenal. Acta Biochim Pol (2002) 0.83
A central role of RLIP76 in regulation of glycemic control. Diabetes (2009) 0.83