Published in Proc Natl Acad Sci U S A on October 25, 1994
The Yin and Yang of P-TEFb regulation: implications for human immunodeficiency virus gene expression and global control of cell growth and differentiation. Microbiol Mol Biol Rev (2006) 3.44
Second generation hybrid polar compounds are potent inducers of transformed cell differentiation. Proc Natl Acad Sci U S A (1996) 2.72
PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. Genes Dev (2008) 2.15
Modulation of a P-TEFb functional equilibrium for the global control of cell growth and differentiation. Mol Cell Biol (2006) 1.99
Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent. Mol Cell Biol (1996) 1.78
A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb. Mol Cell Biol (2004) 1.68
Hexamethylbisacetamide remodels the human immunodeficiency virus type 1 (HIV-1) promoter and induces Tat-independent HIV-1 expression but blunts cell activation. J Virol (2006) 1.29
Fli-1, an Ets-related transcription factor, regulates erythropoietin-induced erythroid proliferation and differentiation: evidence for direct transcriptional repression of the Rb gene during differentiation. Mol Cell Biol (1999) 1.28
Hexamethylene bisacetamide induces programmed cell death (apoptosis) and down-regulates BCL-2 expression in human myeloma cells. Proc Natl Acad Sci U S A (1998) 1.24
Differential expression of cyclin-dependent kinase 6 in cortical thymocytes and T-cell lymphoblastic lymphoma/leukemia. Am J Pathol (1998) 1.24
Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate. Br J Cancer (1999) 1.19
Global modulation of chromatin dynamics mediated by dephosphorylation of linker histone H1 is necessary for erythroid differentiation. Proc Natl Acad Sci U S A (2006) 1.03
Differentiation-dependent photodynamic therapy regulated by porphobilinogen deaminase in B16 melanoma. Br J Cancer (2004) 0.93
JNK-mediated turnover and stabilization of the transcription factor p45/NF-E2 during differentiation of murine erythroleukemia cells. Proc Natl Acad Sci U S A (2009) 0.92
Function of the c-Myc antagonist Mad1 during a molecular switch from proliferation to differentiation. Mol Cell Biol (1997) 0.91
Study of the role of retinoblastoma protein in terminal differentiation of murine erythroleukemia cells. Proc Natl Acad Sci U S A (1995) 0.88
P27(Kip1), regulated by glycogen synthase kinase-3β, results in HMBA-induced differentiation of human gastric cancer cells. BMC Cancer (2011) 0.85
Stimulation of erythroleukaemia cell differentiation by extracellular high-mobility group-box protein 1 is independent of the receptor for advanced glycation end-products. Biochem J (2002) 0.84
Mad1 function is regulated through elements within the carboxy terminus. Mol Cell Biol (2000) 0.81
Vorinostat approved in Japan for treatment of cutaneous T-cell lymphomas: status and prospects. Onco Targets Ther (2012) 0.79
Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0. J Gene Med (2008) 0.78
Growth arrest and apoptosis of human hepatocellular carcinoma cells induced by hexamethylene bisacetamide. World J Gastroenterol (2004) 0.77
Determination of hexamethylene bisacetamide, an antineoplastic compound, in mouse and human plasma by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci (2011) 0.76
HEXIM1 induces differentiation of human pluripotent stem cells. PLoS One (2013) 0.76
Cholesterol esterification during differentiation of mouse erythroleukemia (Friend) cells. Hematol Rep (2011) 0.75
Adsorption properties of polar/apolar inducers at a charged interface and their relevance to leukemia cell differentiation. Biophys J (1995) 0.75
Hexamethylene bisacetamide as a treatment for T-cell leukemia (T-ALL). Leuk Res (2007) 0.75
N-Methylformamide in advanced squamous cancer of the uterine cervix: an Eastern Cooperative Oncology Group phase II trial. Invest New Drugs (2001) 0.75
The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science (1989) 16.54
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell (1988) 12.69
Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide. Proc Natl Acad Sci U S A (1971) 11.41
Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature (1988) 10.98
G1 events and regulation of cell proliferation. Science (1989) 9.73
Mammalian G1 cyclins. Cell (1993) 9.04
Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell (1991) 8.00
A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature (1991) 7.98
Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. Nature (1990) 7.34
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science (1992) 6.40
Association of human cyclin E with a periodic G1-S phase protein kinase. Science (1992) 5.98
Erythroleukemic differentiation. Annu Rev Biochem (1978) 5.19
A new group of potent inducers of differentiation in murine erythroleukemia cells. Proc Natl Acad Sci U S A (1976) 3.70
Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation. Cell (1990) 3.61
Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta. Science (1993) 3.28
TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest. Cell (1993) 2.57
Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts. Proc Natl Acad Sci U S A (1992) 2.43
Effect of hexamethylene bisacetamide on the commitment to differentiation of murine erythroleukemia cells. Cancer Res (1977) 2.26
Independent regulation of human D-type cyclin gene expression during G1 phase in primary human T lymphocytes. J Biol Chem (1993) 2.23
Induction of erythroid differentiation by dimethylsulfoxide in cells infected with Friend virus: relationship to the cell cycle. Proc Natl Acad Sci U S A (1975) 2.12
The retinoblastoma protein and the regulation of cell cycling. Trends Biochem Sci (1992) 1.68
Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene. J Biol Chem (1992) 1.66
Differentiation of malignant to benign cells. Cancer Res (1971) 1.56
DP and E2F proteins: components of a heterodimeric transcription factor implicated in cell cycle control. Curr Opin Cell Biol (1994) 1.55
Stimulation of differentiated functions in human melanoma cells by tumor-promoting agents and dimethyl sulfoxide. Cancer Res (1979) 1.50
Murine erythroleukemia cell differentiation: relationship of globin gene expression and of prolongation of G1 to inducer effects during G1/early S. Proc Natl Acad Sci U S A (1979) 1.50
Hexamethylene bisacetamide in myelodysplastic syndrome and acute myelogenous leukemia: a phase II clinical trial with a differentiation-inducing agent. Blood (1992) 1.46
The cell cycle and the retinoblastoma protein family. Cancer Metastasis Rev (1994) 1.38
Cloning of a D-type cyclin from murine erythroleukemia cells. Proc Natl Acad Sci U S A (1992) 1.35
Protein kinase C activity and hexamethylenebisacetamide-induced erythroleukemia cell differentiation. Proc Natl Acad Sci U S A (1987) 1.34
Chemically induced murine erythroleukemic differentiation. Biochim Biophys Acta (1980) 1.33
Potent cytodifferentiating agents related to hexamethylenebisacetamide. Proc Natl Acad Sci U S A (1991) 1.23
Expression and phosphorylation of the retinoblastoma protein during induced differentiation of murine erythroleukemia cells. Cell Growth Differ (1992) 1.13
Erythroid colony induction without erythropoietin by Friend leukemia virus in vitro. Proc Natl Acad Sci U S A (1975) 1.12
Effects of differentiation-inducing agents on maturation of human MCF-7 breast cancer cells. J Cell Physiol (1990) 1.09
Phase I trial and clinical pharmacological evaluation of hexamethylene bisacetamide administration by ten-day continuous intravenous infusion at twenty-eight-day intervals. Cancer Res (1988) 1.08
Synthesis of globin mRNA in relation to the cell cycle during induced murine erythroleukemia differentiation. Proc Natl Acad Sci U S A (1978) 1.06
Polar/apolar chemical inducers of differentiation of transformed cells: strategies to improve therapeutic potential. Proc Natl Acad Sci U S A (1989) 1.04
Cell differentiation and bypassing of genetic defects in the suppression of malignancy. Cancer Res (1987) 1.03
Phase I clinical and pharmacokinetic study of hexamethylene bisacetamide (NSC 95580) administered as a five-day continuous infusion. Cancer Res (1987) 1.01
Polar/apolar compounds induce leukemia cell differentiation by modulating cell-surface potential. Proc Natl Acad Sci U S A (1993) 0.94
Molecular and cellular mechanisms of leukemic hemopoietic cell differentiation: an analysis of the Friend system. Anticancer Res (1985) 0.93
Differentiation modifiers. Cancer (1984) 0.93
Differential modulation of protein kinase C isoforms in erythroleukemia during induced differentiation. Cancer Res (1993) 0.90
A rise and fall in 1,2-diacylglycerol content signal hexamethylene bisacetamide-induced erythropoiesis. J Biol Chem (1992) 0.85
Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer (2001) 9.12
Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature (1999) 7.47
Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc Natl Acad Sci U S A (2000) 5.53
Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J Natl Cancer Inst (2000) 5.21
Erythroleukemic differentiation. Annu Rev Biochem (1978) 5.19
Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity. Mol Cell Biol (1999) 4.42
Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1. Proc Natl Acad Sci U S A (2004) 3.86
Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo. Cancer Res (2000) 3.83
A new group of potent inducers of differentiation in murine erythroleukemia cells. Proc Natl Acad Sci U S A (1976) 3.70
A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci U S A (1998) 3.62
Histone deacetylase inhibitors as new cancer drugs. Curr Opin Oncol (2001) 2.91
Second generation hybrid polar compounds are potent inducers of transformed cell differentiation. Proc Natl Acad Sci U S A (1996) 2.72
The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression. Genes Dev (1996) 2.61
Induction of erythroid differentiation in murine virus infected eythroleukemia cells by highly polar compounds. Proc Natl Acad Sci U S A (1975) 2.60
Erythropoietic differentiation in colonies of cells transformed by Friend virus. Proc Natl Acad Sci U S A (1974) 2.47
Effect of hexamethylene bisacetamide on the commitment to differentiation of murine erythroleukemia cells. Cancer Res (1977) 2.26
Cloning and characterization of a histone deacetylase, HDAC9. Proc Natl Acad Sci U S A (2001) 2.19
Formation of p27-CDK complexes during the human mitotic cell cycle. Cell Growth Differ (1996) 2.18
Induction of erythroid differentiation by dimethylsulfoxide in cells infected with Friend virus: relationship to the cell cycle. Proc Natl Acad Sci U S A (1975) 2.12
Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma. Proc Natl Acad Sci U S A (2007) 2.10
Tumor promoters inhibit spontaneous and induced differentiation of murine erythroleukemia cells in culture. Proc Natl Acad Sci U S A (1977) 2.09
The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells. Cancer Res (2001) 2.08
Polyribosome dissociation and formation in intact reticulocytes with conservation of messenger ribonucleic acid. Proc Natl Acad Sci U S A (1965) 2.06
Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1. Genes Dev (1997) 2.05
Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest. J Biol Chem (1997) 2.05
Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia. J Clin Invest (2001) 2.00
Erythroid cell differentiation: murine erythroleukemia cell variant with unique pattern of induction by polar compounds. Proc Natl Acad Sci U S A (1976) 1.99
Changes in gene expression associated with induced differentiation of erythroleukemia: protooncogenes, globin genes, and cell division. Proc Natl Acad Sci U S A (1986) 1.99
Rapamycin resistance tied to defective regulation of p27Kip1. Mol Cell Biol (1996) 1.89
Murine erythroleukemia cell differentiation: DNase I hypersensitivity and DNA methylation near the globin genes. Proc Natl Acad Sci U S A (1982) 1.77
Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5. Proc Natl Acad Sci U S A (2000) 1.71
Tumor-related leukocytosis is linked with poor prognosis in patients with lung carcinoma. Cancer (2001) 1.65
Protein synthesis: its control in erythropoiesis. Science (1972) 1.65
Inducer-mediated commitment of murine erythroleukemia cells to differentiation: a multistep process. Proc Natl Acad Sci U S A (1982) 1.59
Transient inhibition of initiation of S-phase associated with dimethyl sulfoxide induction of murine erythroleukemia cells to erythroid differentiation. Proc Natl Acad Sci U S A (1977) 1.56
An ultrastructural study of early morphogenetic events during the establishment of fetal hepatic erythropoiesis. J Cell Biol (1969) 1.55
Hybrid polar histone deacetylase inhibitor induces apoptosis and CD95/CD95 ligand expression in human neuroblastoma. Cancer Res (1999) 1.51
The effect of erythropoietin on colonial growth of erythroid precursor cells in vitro. Proc Natl Acad Sci U S A (1974) 1.51
Murine erythroleukemia cell differentiation: relationship of globin gene expression and of prolongation of G1 to inducer effects during G1/early S. Proc Natl Acad Sci U S A (1979) 1.50
Purification of erythropoietin-responsive cells by immune hemolysis. Proc Natl Acad Sci U S A (1972) 1.50
Destruction of injured red cells in vivo. Am J Med (1966) 1.49
Gene expression in murine erythroleukemia cells. Transcriptional control and chromatin structure of the alpha 1-globin gene. J Mol Biol (1984) 1.46
Hexamethylene bisacetamide in myelodysplastic syndrome and acute myelogenous leukemia: a phase II clinical trial with a differentiation-inducing agent. Blood (1992) 1.46
Changes in DNA associated with induction of erythroid differentiation by dimethyl sulfoxide in murine erythroleukemia cells. Cancer Res (1978) 1.41
Histone deacetylase inhibitors: development of suberoylanilide hydroxamic acid (SAHA) for the treatment of cancers. Blood Cells Mol Dis (2001) 1.40
Globin messenger RNA activity in erythroid precursor cells and the effect of erythropoietin. Proc Natl Acad Sci U S A (1972) 1.37
Chemoprevention of carcinogen-induced mammary tumorigenesis by the hybrid polar cytodifferentiation agent, suberanilohydroxamic acid (SAHA). Anticancer Res (2000) 1.36
Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l. Leukemia (2012) 1.36
Cloning of a D-type cyclin from murine erythroleukemia cells. Proc Natl Acad Sci U S A (1992) 1.35
The absence of p27Kip1, an inhibitor of G1 cyclin-dependent kinases, uncouples differentiation and growth arrest during the granulosa->luteal transition. Cell Growth Differ (1998) 1.34
Protein kinase C activity and hexamethylenebisacetamide-induced erythroleukemia cell differentiation. Proc Natl Acad Sci U S A (1987) 1.34
Induction of transformed cells to terminal differentiation and the modulation of gene expression. Cancer Res (1987) 1.34
Early stimulation of RNA synthesis by erythropoietin in cultures of erythroid precursor cells. Proc Natl Acad Sci U S A (1973) 1.33
Inhibitors of histone deacetylase are potentially effective anticancer agents. Clin Cancer Res (2001) 1.33
Chemically induced murine erythroleukemic differentiation. Biochim Biophys Acta (1980) 1.33
Replication of alpha and beta globin DNA sequences occurs during early S phase in murine erythroleukemia cells. Proc Natl Acad Sci U S A (1981) 1.33
Changes in globin messenger RNA content during erythroid cell differentiation. J Biol Chem (1975) 1.32
Erythropoietin effects on fetal mouse erythroid cells. II. Nucleic acid synthesis and the erythropoietin-sensitive cell. J Biol Chem (1972) 1.32
Multiple mechanisms of resistance to cis-diamminedichloroplatinum(II) in murine leukemia L1210 cells. Cancer Res (1987) 1.29
Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells. Mol Cell Biol (1994) 1.29
Expression of the retinoblastoma protein is regulated in normal human tissues. Am J Pathol (1994) 1.28
Erythropoietin effects on fetal mouse erythroid cells. I. Cell population and hemoglobin synthesis. J Cell Biol (1971) 1.27
Hepatitis C and hepatitis B in the etiology of hepatocellular carcinoma in the Japanese population. Cancer Res (1991) 1.27
Erythroid cell-development in fetal mice: synthetic capacity for different proteins. J Mol Biol (1968) 1.25
Differential effects of chemical inducers on expression of beta globin genes in murine erythroleukemia cells. Proc Natl Acad Sci U S A (1977) 1.25
The histone deacetylase inhibitor, CBHA, inhibits growth of human neuroblastoma xenografts in vivo, alone and synergistically with all-trans retinoic acid. Cancer Res (2001) 1.24
Hexamethylene bisacetamide induces programmed cell death (apoptosis) and down-regulates BCL-2 expression in human myeloma cells. Proc Natl Acad Sci U S A (1998) 1.24
Potent cytodifferentiating agents related to hexamethylenebisacetamide. Proc Natl Acad Sci U S A (1991) 1.23
Heinz body anemia: an ultrastructural study. II. Red cell sequestration and destruction. Blood (1965) 1.23
Tumor promoter-mediated inhibition of cell differentiation: suppression of the expression of erythroid functions in murine erythroleukemia cells. Proc Natl Acad Sci U S A (1979) 1.18
Posttranslational regulation of cyclin D1 by retinoic acid: a chemoprevention mechanism. Proc Natl Acad Sci U S A (1997) 1.17
Heterogeneity of murine erythroleukemia cells with respect to tumor promoter-mediated inhibition of cell differentiation. Cancer Res (1978) 1.16
Cell cycle regulatory proteins are targets for induced differentiation of transformed cells: Molecular and clinical studies employing hybrid polar compounds. Int J Hematol (1996) 1.16
Induction of murine erythroleukemia differentiation by actinomycin D. Proc Natl Acad Sci U S A (1978) 1.15
Expression and phosphorylation of the retinoblastoma protein during induced differentiation of murine erythroleukemia cells. Cell Growth Differ (1992) 1.13
Transcriptional and post-transcriptional regulation of globin gene accumulation in murine erythroleukemia cells. Mol Cell Biol (1983) 1.13
Vincristine-resistant erythroleukemia cell line has marked increased sensitivity to hexamethylenebisacetamide-induced differentiation. Proc Natl Acad Sci U S A (1988) 1.12
Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras. Proc Natl Acad Sci U S A (2000) 1.12
Two cytodifferentiation agent-induced pathways, differentiation and apoptosis, are distinguished by the expression of human papillomavirus 16 E7 in human bladder carcinoma cells. Cancer Res (1997) 1.11
Histone deacetylase inhibitors and retinoic acids inhibit growth of human neuroblastoma in vitro. Med Pediatr Oncol (2000) 1.10
Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin Cancer Res (2001) 1.09
Elevation of antibodies to cytomegalovirus and other herpes viruses in pulmonary fibrosis. Eur Respir J (1997) 1.09