Published in Proc Natl Acad Sci U S A on November 08, 1994
Type I restriction systems: sophisticated molecular machines (a legacy of Bertani and Weigle). Microbiol Mol Biol Rev (2000) 3.55
AdoMet-dependent methylation, DNA methyltransferases and base flipping. Nucleic Acids Res (2001) 3.16
Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene. Nucleic Acids Res (2002) 2.51
Crystal structure of a fibrillarin homologue from Methanococcus jannaschii, a hyperthermophile, at 1.6 A resolution. EMBO J (2000) 2.20
Critical residues of Semliki Forest virus RNA capping enzyme involved in methyltransferase and guanylyltransferase-like activities. J Virol (1997) 1.86
Structure of pvu II DNA-(cytosine N4) methyltransferase, an example of domain permutation and protein fold assignment. Nucleic Acids Res (1997) 1.84
2-Aminopurine as a fluorescent probe for DNA base flipping by methyltransferases. Nucleic Acids Res (1998) 1.60
Type I restriction enzymes and their relatives. Nucleic Acids Res (2013) 1.54
Structure of Type IIL Restriction-Modification Enzyme MmeI in Complex with DNA Has Implications for Engineering New Specificities. PLoS Biol (2016) 1.38
Lysine 2,3-aminomutase from Clostridium subterminale SB4: mass spectral characterization of cyanogen bromide-treated peptides and cloning, sequencing, and expression of the gene kamA in Escherichia coli. J Bacteriol (2000) 1.28
cDNA cloning of Batis maritima methyl chloride transferase and purification of the enzyme. Proc Natl Acad Sci U S A (1998) 1.11
Catalysis by the second class of tRNA(m1G37) methyl transferase requires a conserved proline. Biochemistry (2006) 1.09
Sequence permutations in the molecular evolution of DNA methyltransferases. BMC Evol Biol (2002) 1.09
Escherichia coli TehB requires S-adenosylmethionine as a cofactor to mediate tellurite resistance. J Bacteriol (2000) 1.08
Structure, function and mechanism of exocyclic DNA methyltransferases. Biochem J (2006) 1.07
A prediction of the amino acids and structures involved in DNA recognition by type I DNA restriction and modification enzymes. Nucleic Acids Res (1997) 1.03
Chemical display of thymine residues flipped out by DNA methyltransferases. Nucleic Acids Res (1998) 1.00
High resolution footprinting of a type I methyltransferase reveals a large structural distortion within the DNA recognition site. Nucleic Acids Res (1996) 0.99
Substrate binding in vitro and kinetics of RsrI [N6-adenine] DNA methyltransferase. Nucleic Acids Res (2000) 0.98
Structural model for the multisubunit Type IC restriction-modification DNA methyltransferase M.EcoR124I in complex with DNA. Nucleic Acids Res (2006) 0.97
Sequence-specific recognition of cytosine C5 and adenine N6 DNA methyltransferases requires different deformations of DNA. Proc Natl Acad Sci U S A (1996) 0.95
Tyrosine 27 of the specificity polypeptide of EcoKI can be UV crosslinked to a bromodeoxyuridine-substituted DNA target sequence. Nucleic Acids Res (1995) 0.95
The specificity of sty SKI, a type I restriction enzyme, implies a structure with rotational symmetry. Nucleic Acids Res (1997) 0.95
Substrate DNA and cofactor regulate the activities of a multi-functional restriction-modification enzyme, BcgI. Nucleic Acids Res (1997) 0.93
A theoretical examination of the factors controlling the catalytic efficiency of the DNA-(adenine-N6)-methyltransferase from Thermus aquaticus. Proc Natl Acad Sci U S A (2002) 0.93
Autographa californica nucleopolyhedrovirus orf69 encodes an RNA cap (nucleoside-2'-O)-methyltransferase. J Virol (2003) 0.91
A dual role for substrate S-adenosyl-L-methionine in the methylation reaction with bacteriophage T4 Dam DNA-[N6-adenine]-methyltransferase. Nucleic Acids Res (2001) 0.90
Changing the target base specificity of the EcoRV DNA methyltransferase by rational de novo protein-design. Nucleic Acids Res (2001) 0.89
Identification of essential residues in the Erm(B) rRNA methyltransferase of Clostridium perfringens. Antimicrob Agents Chemother (2002) 0.88
Hyperthermophilic DNA methyltransferase M.PabI from the archaeon Pyrococcus abyssi. Appl Environ Microbiol (2006) 0.88
S-adenosyl methionine alters the DNA contacts of the EcoKI methyltransferase. Nucleic Acids Res (1995) 0.87
Structural basis for binding of RNA and cofactor by a KsgA methyltransferase. Structure (2009) 0.87
DNA methyltransferases of the cyanobacterium Anabaena PCC 7120. Nucleic Acids Res (2001) 0.87
Electrospray ionization mass spectrometric characterization of photocrosslinked DNA-EcoRI DNA methyltransferase complexes. Nucleic Acids Res (1998) 0.86
Structure of the Q237W mutant of HhaI DNA methyltransferase: an insight into protein-protein interactions. Biol Chem (2004) 0.85
Crystal structure of human L-isoaspartyl-O-methyl-transferase with S-adenosyl homocysteine at 1.6-A resolution and modeling of an isoaspartyl-containing peptide at the active site. Protein Sci (2002) 0.80
How Large Should the QM Region Be in QM/MM Calculations? The Case of Catechol O-Methyltransferase. J Phys Chem B (2016) 0.79
Overproduction, purification and characterization of M.EcoHK31I, a bacterial methyltransferase with two polypeptides. Biochem J (1996) 0.79
Crystal structure of threonine synthase from Arabidopsis thaliana. Protein Sci (2001) 0.79
Chemoenzymatic synthesis and utilization of a SAM analog with an isomorphic nucleobase. Org Biomol Chem (2016) 0.76
Cloning and characterization of Sse9I DNA-methyltransferase recognizing 5'-AATT-3'. Nucleic Acids Res (1996) 0.75
Dam methylase from Escherichia coli: kinetic studies using modified DNA oligomers: hemimethylated substrates. Nucleic Acids Res (1995) 0.75
Biochemical and structural characterization of a DNA N6-adenine methyltransferase from Helicobacter pylori. Oncotarget (2016) 0.75
Computational Investigation of the Interplay of Substrate Positioning and Reactivity in Catechol O-Methyltransferase. PLoS One (2016) 0.75
Purification, crystallization and preliminary X-ray analysis of the BseCI DNA methyltransferase from Bacillus stearothermophilus in complex with its cognate DNA. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.75
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63
Crystallographic R factor refinement by molecular dynamics. Science (1987) 15.90
Prediction of the occurrence of the ADP-binding beta alpha beta-fold in proteins, using an amino acid sequence fingerprint. J Mol Biol (1986) 9.13
HhaI methyltransferase flips its target base out of the DNA helix. Cell (1994) 8.72
Predictive motifs derived from cytosine methyltransferases. Nucleic Acids Res (1989) 7.63
Kinetic and catalytic mechanism of HhaI methyltransferase. J Biol Chem (1987) 4.84
Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine. Cell (1993) 3.96
Sequence motifs characteristic of DNA[cytosine-N4]methyltransferases: similarity to adenine and cytosine-C5 DNA-methylases. Nucleic Acids Res (1989) 3.39
Direct identification of the active-site nucleophile in a DNA (cytosine-5)-methyltransferase. Biochemistry (1991) 2.77
The sequence specificity domain of cytosine-C5 methylases. Nucleic Acids Res (1991) 1.94
Cloning, sequencing and expression of the Taq I restriction-modification system. Nucleic Acids Res (1987) 1.71
How M.MspI and M.HpaII decide which base to methylate. Nucleic Acids Res (1992) 1.43
Cloning and sequence analysis of the genes coding for Eco57I type IV restriction-modification enzymes. Nucleic Acids Res (1992) 1.31
On the mechanism of DNA-adenine methylase. J Biol Chem (1988) 1.20
Amino acid sequence arrangements of DNA-methyltransferases. Methods Enzymol (1992) 1.17
PRISM: topologically constrained phased refinement for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (1993) 1.14
Stereochemical studies of the C-methylation of deoxycytidine catalyzed by HhaI methylase and the N-methylation of deoxyadenosine catalyzed by EcoRI methylase. Arch Biochem Biophys (1991) 1.10
Overexpression, purification and crystallization of BamHI endonuclease. Nucleic Acids Res (1991) 1.05
DNA methylation: a phoenix rises. Proc Natl Acad Sci U S A (1993) 1.02
The corrected nucleotide sequences of the TaqI restriction and modification enzymes reveal a thirteen-codon overlap. Gene (1992) 0.90
Three-dimensional structure of cyanobacterial photosystem I at 2.5 A resolution. Nature (2001) 8.24
Crystal structure of photosystem II from Synechococcus elongatus at 3.8 A resolution. Nature (2001) 6.21
FokI dimerization is required for DNA cleavage. Proc Natl Acad Sci U S A (1998) 5.31
Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system. Nat Struct Biol (2000) 3.90
Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance. Science (1994) 3.49
Structure of the multimodular endonuclease FokI bound to DNA. Nature (1997) 3.25
Zanamivir in the prevention of influenza among healthy adults: a randomized controlled trial. JAMA (1999) 2.98
Protein splicing elements: inteins and exteins--a definition of terms and recommended nomenclature. Nucleic Acids Res (1994) 2.97
Intervening sequences in an Archaea DNA polymerase gene. Proc Natl Acad Sci U S A (1992) 2.92
Structure of FokI has implications for DNA cleavage. Proc Natl Acad Sci U S A (1998) 2.82
Structure of Bam HI endonuclease bound to DNA: partial folding and unfolding on DNA binding. Science (1995) 2.80
Nucleotide sequence of the FokI restriction-modification system: separate strand-specificity domains in the methyltransferase. Gene (1989) 2.69
A type II restriction endonuclease with an eight nucleotide specificity from Streptomyces fimbriatus. Nucleic Acids Res (1984) 2.64
Universal catalytic domain structure of AdoMet-dependent methyltransferases. J Mol Biol (1995) 2.36
Involvement of outside DNA sequences in the major kinetic path by which EcoRI endonuclease locates and leaves its recognition sequence. Proc Natl Acad Sci U S A (1982) 2.29
Photosystem I at 4 A resolution represents the first structural model of a joint photosynthetic reaction centre and core antenna system. Nat Struct Biol (1996) 2.25
Understanding the immutability of restriction enzymes: crystal structure of BglII and its DNA substrate at 1.5 A resolution. Nat Struct Biol (2000) 2.22
Protein splicing removes intervening sequences in an archaea DNA polymerase. Nucleic Acids Res (1992) 2.20
DNA conformation is determined by economics in the hydration of phosphate groups. Nature (1987) 2.04
Three-dimensional structure of the E. coli DNA-binding protein FIS. Nature (1991) 2.01
Structure of restriction endonuclease BamHI and its relationship to EcoRI. Nature (1994) 1.98
Facilitated diffusion during catalysis by EcoRI endonuclease. Nonspecific interactions in EcoRI catalysis. J Biol Chem (1985) 1.87
The mycosubtilin synthetase of Bacillus subtilis ATCC6633: a multifunctional hybrid between a peptide synthetase, an amino transferase, and a fatty acid synthase. Proc Natl Acad Sci U S A (1999) 1.87
Two new restriction endonucleases from Proteus vulgaris. Nucleic Acids Res (1981) 1.84
A structural model for the polyadenylic acid single helix. J Mol Biol (1975) 1.83
Determinants of nucleotide sugar recognition in an archaeon DNA polymerase. Nucleic Acids Res (1999) 1.80
Alteration of apparent restriction endonuclease recognition specificities by DNA methylases. Nucleic Acids Res (1984) 1.80
Structure of PvuII endonuclease with cognate DNA. EMBO J (1994) 1.80
The complex formed between Tet repressor and tetracycline-Mg2+ reveals mechanism of antibiotic resistance. J Mol Biol (1995) 1.78
Thermodynamic parameters governing interaction of EcoRI endonuclease with specific and nonspecific DNA sequences. J Biol Chem (1983) 1.76
DNA determinants important in sequence recognition by Eco RI endonuclease. J Biol Chem (1981) 1.64
NotI and SfiI: restriction endonucleases with octanucleotide recognition sequences. Methods Enzymol (1987) 1.62
Specific protein-nucleic acid recognition in ribonuclease T1-2'-guanylic acid complex: an X-ray study. Nature (1982) 1.60
Photosystem I of Synechococcus elongatus at 4 A resolution: comprehensive structure analysis. J Mol Biol (1997) 1.58
Ribonuclease T1 with free recognition and catalytic site: crystal structure analysis at 1.5 A resolution. J Mol Biol (1991) 1.56
Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to the adenine-specific DNA methyltransferase M.TaqI. J Mol Biol (1997) 1.55
Conformational changes of the Tet repressor induced by tetracycline trapping. J Mol Biol (1998) 1.51
Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis. Biochemistry (1998) 1.48
Structure and dynamics of water surrounding biomolecules. Annu Rev Biophys Biophys Chem (1987) 1.46
Three-dimensional structure of the "long" neurotoxin from cobra venom. Proc Natl Acad Sci U S A (1980) 1.44
Crystal structure of restriction endonuclease BglI bound to its interrupted DNA recognition sequence. EMBO J (1998) 1.44
The kinetic mechanism of EcoRI endonuclease. J Biol Chem (1999) 1.43
Selective inhibition of the replication of herpes simplex virus by 5-halogenated analogues of deoxycytidine. Mol Pharmacol (1975) 1.40
Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria. Biochemistry (1998) 1.37
The cleavage site for the restriction endonuclease EcoRV is 5'-GAT/ATC-3'. Gene (1984) 1.35
An integrated approach to structural genomics. Prog Biophys Mol Biol (2000) 1.33
V-Amylose at atomic resolution: X-ray structure of a cycloamylose with 26 glucose residues (cyclomaltohexaicosaose). Proc Natl Acad Sci U S A (1999) 1.31
Crystal structure of omega transcriptional repressor encoded by Streptococcus pyogenes plasmid pSM19035 at 1.5 A resolution. J Mol Biol (2001) 1.31
Crystal and molecular structure of adenosine 5'-O-phosphorothioate O-p-nitrophenyl ester (Sp diastereomer). Substrate stereospecificity of snake venom phosphodiesterase. Eur J Biochem (1979) 1.29
Isolation of BamHI variants with reduced cleavage activities. J Biol Chem (1991) 1.29
A common ancestor for oxygenic and anoxygenic photosynthetic systems: a comparison based on the structural model of photosystem I. J Mol Biol (1998) 1.29
Crystal structure of the hexameric replicative helicase RepA of plasmid RSF1010. J Mol Biol (2001) 1.25
Molecular structure of deoxyadenylyl-3'-methylphosphonate-5'-thymidine dihydrate, (d-ApT x 2H2O), a dinucleoside monophosphate with neutral phosphodiester backbone. An X-ray crystal study. Nucleic Acids Res (1983) 1.25
Molecular structure of poly-2-thiouridylic acid, a double helix with non-equivalent polynucleotide chains. J Mol Biol (1974) 1.23
The refined crystal structure of alpha-cobratoxin from Naja naja siamensis at 2.4-A resolution. J Biol Chem (1991) 1.19
The energetics of the interaction of BamHI endonuclease with its recognition site GGATCC. J Mol Biol (2001) 1.18
Crystal structure of the factor for inversion stimulation FIS at 2.0 A resolution. J Mol Biol (1992) 1.18
Studies on RNase T1 mutants affecting enzyme catalysis. Eur J Biochem (1991) 1.18
Three-dimensional structure of proteinase K at 0.15-nm resolution. Eur J Biochem (1988) 1.16
Molecular and crystal structure of 2'-chloro-2'-deoxyuridine. Biochim Biophys Acta (1972) 1.15
A unique restriction endonuclease, BcgI, from Bacillus coagulans. Nucleic Acids Res (1993) 1.13
Synchrotron X-ray data collection and restrained least-squares refinement of the crystal structure of proteinase K at 1.5 A resolution. Acta Crystallogr B (1988) 1.13
On the mechanism of ribonuclease A. Crystal and molecular structure of uridine 3'-O-thiophosphate methyl ester triethylammonium salt. Eur J Biochem (1974) 1.12
Molecular dynamics simulation of the hydration shell of a B-DNA decamer reveals two main types of minor-groove hydration depending on groove width. Proc Natl Acad Sci U S A (1991) 1.11
Structure of restriction endonuclease bamhi phased at 1.95 A resolution by MAD analysis. Structure (1994) 1.10
Decamer-like conformation of a nona-peptide bound to HLA-B*3501 due to non-standard positioning of the C terminus. J Mol Biol (1999) 1.10
Crystallization and preliminary X-ray analysis of restriction endonuclease FokI bound to DNA. FEBS Lett (1997) 1.09
5-Halogenated analogs of deoxycytidine as selective inhibitors of the replication of herpes simplex viruses in cell culture and related studies of intracranial herpes simplex virus infections in mice. Ann N Y Acad Sci (1975) 1.09
M.FokI methylates adenine in both strands of its asymmetric recognition sequence. Gene (1989) 1.08
Molecular and crystal structure of 6-methyluridine. A pyrimidine nucleoside in the syn conformation. J Am Chem Soc (1972) 1.08
Structure of the complex of proteinase K with a substrate analogue hexapeptide inhibitor at 2.2-A resolution. J Biol Chem (1993) 1.07
X-ray structure of 3',5'-diacetyl-2'-deoxy-2'-fluorouridine: a pyrimidine nucleoside in the syn conformation. Biochim Biophys Acta (1974) 1.07
Development of a technology for automation and miniaturization of protein crystallization. J Biotechnol (2001) 1.07
Photosystem I, an improved model of the stromal subunits PsaC, PsaD, and PsaE. J Biol Chem (1999) 1.06
Three-dimensional structure of fungal proteinase K reveals similarity to bacterial subtilisin. EMBO J (1984) 1.06
Functional analysis of CpG methylation in the BRCA1 promoter region. Oncogene (2001) 1.06
A site-specific single strand endonuclease activity induced by NYs-1 virus infection of a Chlorella-like green alga. Nucleic Acids Res (1988) 1.06
Identification of an RcsA/RcsB recognition motif in the promoters of exopolysaccharide biosynthetic operons from Erwinia amylovora and Pantoea stewartii subspecies stewartii. J Biol Chem (1999) 1.06
Localization of two phylloquinones, QK and QK', in an improved electron density map of photosystem I at 4-A resolution. J Biol Chem (1999) 1.06
Protein dynamics. A time-resolved fluorescence, energetic and molecular dynamics study of ribonuclease T1. Biophys Chem (1987) 1.05
Overexpression, purification and crystallization of BamHI endonuclease. Nucleic Acids Res (1991) 1.05
X-ray structure of acarbose bound to amylomaltase from Thermus aquaticus. Implications for the synthesis of large cyclic glucans. Eur J Biochem (2000) 1.04
The enzymatic activity of proteinase K is controlled by calcium. Eur J Biochem (1988) 1.04
Crystal structure of calf spleen purine nucleoside phosphorylase in a complex with hypoxanthine at 2.15 A resolution. J Mol Biol (1997) 1.03
Structure and function of nucleosides and nucleotides. Angew Chem Int Ed Engl (1973) 1.02
A pyrimidine nucleoside in the syn conformation: molecular and crystal structure of 4-thiouridine-hydrate. J Mol Biol (1970) 1.02
Characterization of non-inducible Tet repressor mutants suggests conformational changes necessary for induction. Nat Struct Biol (1995) 1.01
Crystal structure of amylomaltase from thermus aquaticus, a glycosyltransferase catalysing the production of large cyclic glucans. J Mol Biol (2000) 1.01
X-ray and model-building studies on the specificity of the active site of proteinase K. Proteins (1988) 1.00
Direct selection of binding proficient/catalytic deficient variants of BamHI endonuclease. Nucleic Acids Res (1994) 0.99
Huntingtin aggregation monitored by dynamic light scattering. Proc Natl Acad Sci U S A (1998) 0.99
High-resolution structure of HLA-A*0201 in complex with a tumour-specific antigenic peptide encoded by the MAGE-A4 gene. J Mol Biol (2001) 0.99
Long-range structural changes in proteinase K triggered by calcium ion removal. Nature (1989) 0.97
Structurally conserved water molecules in ribonuclease T1. J Biol Chem (1991) 0.97
Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N,N-dimethylglycylamido)- 6-demethyl-6-deoxy-tetracycline. J Mol Biol (1999) 0.96
Identification of the metal-binding sites of restriction endonucleases by Fe2+-mediated oxidative cleavage. Biochemistry (2000) 0.96