Published in J Mol Biol on January 10, 1997
An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization. EMBO J (2002) 3.87
AdoMet-dependent methylation, DNA methyltransferases and base flipping. Nucleic Acids Res (2001) 3.16
Transcription termination control of the S box system: direct measurement of S-adenosylmethionine by the leader RNA. Proc Natl Acad Sci U S A (2003) 2.68
Composite genome map and recombination parameters derived from three archetypal lineages of Toxoplasma gondii. Nucleic Acids Res (2005) 2.64
The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor. Nat Struct Biol (2002) 1.63
2-Aminopurine as a fluorescent probe for DNA base flipping by methyltransferases. Nucleic Acids Res (1998) 1.60
Type I restriction enzymes and their relatives. Nucleic Acids Res (2013) 1.54
Structure of Type IIL Restriction-Modification Enzyme MmeI in Complex with DNA Has Implications for Engineering New Specificities. PLoS Biol (2016) 1.38
Structure of RsrI methyltransferase, a member of the N6-adenine beta class of DNA methyltransferases. Nucleic Acids Res (2000) 1.35
Structure, function and mechanism of exocyclic DNA methyltransferases. Biochem J (2006) 1.07
Substrate-dependent dihydroxylation of substituted cyclopentenes: toward the syntheses of carbocyclic sinefungin and noraristeromycin. J Org Chem (2006) 1.06
Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4. Nucleic Acids Res (2009) 1.03
Chemical display of thymine residues flipped out by DNA methyltransferases. Nucleic Acids Res (1998) 1.00
Molecular and enzymatic profiles of mammalian DNA methyltransferases: structures and targets for drugs. Curr Med Chem (2010) 0.99
Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase. Nucleic Acids Res (2010) 0.98
Substrate binding in vitro and kinetics of RsrI [N6-adenine] DNA methyltransferase. Nucleic Acids Res (2000) 0.98
RNA:(guanine-N2) methyltransferases RsmC/RsmD and their homologs revisited--bioinformatic analysis and prediction of the active site based on the uncharacterized Mj0882 protein structure. BMC Bioinformatics (2002) 0.96
Vesicular stomatitis viruses resistant to the methylase inhibitor sinefungin upregulate RNA synthesis and reveal mutations that affect mRNA cap methylation. J Virol (2007) 0.95
A theoretical examination of the factors controlling the catalytic efficiency of the DNA-(adenine-N6)-methyltransferase from Thermus aquaticus. Proc Natl Acad Sci U S A (2002) 0.93
Crystal structures of the tRNA:m2G6 methyltransferase Trm14/TrmN from two domains of life. Nucleic Acids Res (2012) 0.91
Crystal structure of MboIIA methyltransferase. Nucleic Acids Res (2003) 0.89
Hyperthermophilic DNA methyltransferase M.PabI from the archaeon Pyrococcus abyssi. Appl Environ Microbiol (2006) 0.88
Structural basis for binding of RNA and cofactor by a KsgA methyltransferase. Structure (2009) 0.87
Discovery of the β-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs. Nucleic Acids Res (2014) 0.86
Identification of DNMT1 selective antagonists using a novel scintillation proximity assay. J Biol Chem (2013) 0.84
Circular permutation of DNA cytosine-N4 methyltransferases: in vivo coexistence in the BcnI system and in vitro probing by hybrid formation. Nucleic Acids Res (2002) 0.83
Structural basis for S-adenosylmethionine binding and methyltransferase activity by mitochondrial transcription factor B1. Nucleic Acids Res (2013) 0.82
Development of a universal radioactive DNA methyltransferase inhibition test for high-throughput screening and mechanistic studies. Nucleic Acids Res (2013) 0.82
Sinefungin resistance of Saccharomyces cerevisiae arising from Sam3 mutations that inactivate the AdoMet transporter or from increased expression of AdoMet synthase plus mRNA cap guanine-N7 methyltransferase. Nucleic Acids Res (2007) 0.81
Enzyme-mediated cytosine deamination by the bacterial methyltransferase M.MspI. Biochem J (1998) 0.80
Structural and functional analyses of the archaeal tRNA m2G/m22G10 methyltransferase aTrm11 provide mechanistic insights into site specificity of a tRNA methyltransferase that contains common RNA-binding modules. Nucleic Acids Res (2016) 0.79
Sinefungin, a natural nucleoside analogue of S-adenosylmethionine, inhibits Streptococcus pneumoniae biofilm growth. Biomed Res Int (2014) 0.79
Cysteine methylation controls radical generation in the Cfr radical AdoMet rRNA methyltransferase. PLoS One (2013) 0.78
High-throughput screening-compatible assays of As(III) S-adenosylmethionine methyltransferase activity. Anal Biochem (2015) 0.76
Crystallization and initial X-ray diffraction analysis of the tellurite-resistance S-adenosyl-L-methionine transferase protein TehB from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.76
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell (1986) 42.45
Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. Nucleic Acids Res (1984) 39.52
Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. Microbiol Rev (1983) 24.58
Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. Nucleic Acids Res (1981) 18.27
How do eucaryotic ribosomes select initiation regions in messenger RNA? Cell (1978) 12.04
Three-dimensional structure of cyanobacterial photosystem I at 2.5 A resolution. Nature (2001) 8.24
Influences of mRNA secondary structure on initiation by eukaryotic ribosomes. Proc Natl Acad Sci U S A (1986) 8.00
Point mutations close to the AUG initiator codon affect the efficiency of translation of rat preproinsulin in vivo. Nature (1984) 7.54
Crystal structure of photosystem II from Synechococcus elongatus at 3.8 A resolution. Nature (2001) 6.21
Bifunctional messenger RNAs in eukaryotes. Cell (1986) 6.18
Selection of initiation sites by eucaryotic ribosomes: effect of inserting AUG triplets upstream from the coding sequence for preproinsulin. Nucleic Acids Res (1984) 5.96
Regulation of herpesvirus macromolecular synthesis: nuclear retention of nontranslated viral RNA sequences. Proc Natl Acad Sci U S A (1974) 5.96
Evaluation of the "scanning model" for initiation of protein synthesis in eucaryotes. Cell (1980) 3.98
Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system. Nat Struct Biol (2000) 3.90
Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance. Science (1994) 3.49
Mechanism of mRNA recognition by eukaryotic ribosomes during initiation of protein synthesis. Curr Top Microbiol Immunol (1981) 3.31
Structure of the N6-adenine DNA methyltransferase M.TaqI in complex with DNA and a cofactor analog. Nat Struct Biol (2001) 3.04
Regulation of protein synthesis in virus-infected animal cells. Adv Virus Res (1986) 2.93
Influence of mRNA secondary structure on binding and migration of 40S ribosomal subunits. Cell (1980) 2.88
Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping. Nat Struct Biol (2001) 2.86
Migration of 40 S ribosomal subunits on messenger RNA in the presence of edeine. J Biol Chem (1978) 2.84
Translation of insulin-related polypeptides from messenger RNAs with tandemly reiterated copies of the ribosome binding site. Cell (1983) 2.77
Regulation of herpesvirus macromolecular synthesis: evidence for multilevel regulation of herpes simplex 1 RNA and protein synthesis. Cold Spring Harb Symp Quant Biol (1975) 2.77
Universal catalytic domain structure of AdoMet-dependent methyltransferases. J Mol Biol (1995) 2.36
Photosystem I at 4 A resolution represents the first structural model of a joint photosynthetic reaction centre and core antenna system. Nat Struct Biol (1996) 2.25
Adherence to the first-AUG rule when a second AUG codon follows closely upon the first. Proc Natl Acad Sci U S A (1995) 2.22
RNA synthesis in cells infected with herpes simplex virus. IX. Evidence for accumulation of abundant symmetric transcripts in nuclei. J Virol (1975) 2.15
DNA conformation is determined by economics in the hydration of phosphate groups. Nature (1987) 2.04
Three-dimensional structure of the E. coli DNA-binding protein FIS. Nature (1991) 2.01
Nucleotide sequences of 5'-terminal ribosome-protected initiation regions from two reovirus messages. Nature (1977) 1.98
Sequences and properties of two ribosome binding sites from the small size class of reovirus messenger RNA. J Biol Chem (1977) 1.93
The mycosubtilin synthetase of Bacillus subtilis ATCC6633: a multifunctional hybrid between a peptide synthetase, an amino transferase, and a fatty acid synthase. Proc Natl Acad Sci U S A (1999) 1.87
Characterization of ribosome-protected fragments from reovirus messenger RNA. J Biol Chem (1976) 1.87
Identification of features in 5' terminal fragments from reovirus mRNA which are important for ribosome binding. Cell (1978) 1.86
A structural model for the polyadenylic acid single helix. J Mol Biol (1975) 1.83
Role of ATP in binding and migration of 40S ribosomal subunits. Cell (1980) 1.82
Three-dimensional structure of the adenine-specific DNA methyltransferase M.Taq I in complex with the cofactor S-adenosylmethionine. Proc Natl Acad Sci U S A (1994) 1.79
The complex formed between Tet repressor and tetracycline-Mg2+ reveals mechanism of antibiotic resistance. J Mol Biol (1995) 1.78
Human herpersviruses I: a model for molecular organization and regulation of herpesviruses-a review. IARC Sci Publ (1975) 1.66
Specific protein-nucleic acid recognition in ribonuclease T1-2'-guanylic acid complex: an X-ray study. Nature (1982) 1.60
2-Aminopurine as a fluorescent probe for DNA base flipping by methyltransferases. Nucleic Acids Res (1998) 1.60
Photosystem I of Synechococcus elongatus at 4 A resolution: comprehensive structure analysis. J Mol Biol (1997) 1.58
Ribonuclease T1 with free recognition and catalytic site: crystal structure analysis at 1.5 A resolution. J Mol Biol (1991) 1.56
Sequences of two 5'-terminal ribosome-protected fragments from reovirus messenger RNAs. J Mol Biol (1977) 1.53
Conformational changes of the Tet repressor induced by tetracycline trapping. J Mol Biol (1998) 1.51
Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis. Biochemistry (1998) 1.48
Evaluation of a human generic formulation of ciclosporin in the treatment of canine atopic dermatitis with in vitro assessment of the functional capacity of phagocytic cells. Vet Rec (2011) 1.47
Structure and dynamics of water surrounding biomolecules. Annu Rev Biophys Biophys Chem (1987) 1.46
Three-dimensional structure of the "long" neurotoxin from cobra venom. Proc Natl Acad Sci U S A (1980) 1.44
Oxidatively modified LDL contains phospholipids with platelet-activating factor-like activity and stimulates the growth of smooth muscle cells. J Clin Invest (1995) 1.44
Translation of the genome of a ribonucleic acid bacteriophage. Bacteriol Rev (1972) 1.40
Analysis of ribosome binding sites from the s1 message of reovirus. Initiation at the first and second AUG codons. J Mol Biol (1982) 1.39
An integrated approach to structural genomics. Prog Biophys Mol Biol (2000) 1.33
V-Amylose at atomic resolution: X-ray structure of a cycloamylose with 26 glucose residues (cyclomaltohexaicosaose). Proc Natl Acad Sci U S A (1999) 1.31
Crystal structure of omega transcriptional repressor encoded by Streptococcus pyogenes plasmid pSM19035 at 1.5 A resolution. J Mol Biol (2001) 1.31
Crystal and molecular structure of adenosine 5'-O-phosphorothioate O-p-nitrophenyl ester (Sp diastereomer). Substrate stereospecificity of snake venom phosphodiesterase. Eur J Biochem (1979) 1.29
A common ancestor for oxygenic and anoxygenic photosynthetic systems: a comparison based on the structural model of photosystem I. J Mol Biol (1998) 1.29
Migration of 40 S ribosomal subunits on messenger RNA when initiation is perturbed by lowering magnesium or adding drugs. J Biol Chem (1979) 1.25
Crystal structure of the hexameric replicative helicase RepA of plasmid RSF1010. J Mol Biol (2001) 1.25
Molecular structure of deoxyadenylyl-3'-methylphosphonate-5'-thymidine dihydrate, (d-ApT x 2H2O), a dinucleoside monophosphate with neutral phosphodiester backbone. An X-ray crystal study. Nucleic Acids Res (1983) 1.25
Molecular structure of poly-2-thiouridylic acid, a double helix with non-equivalent polynucleotide chains. J Mol Biol (1974) 1.23
The mechanism of DNA cytosine-5 methylation. Kinetic and mutational dissection of Hhai methyltransferase. J Biol Chem (2001) 1.22
The refined crystal structure of alpha-cobratoxin from Naja naja siamensis at 2.4-A resolution. J Biol Chem (1991) 1.19
Crystal structure of the factor for inversion stimulation FIS at 2.0 A resolution. J Mol Biol (1992) 1.18
Studies on RNase T1 mutants affecting enzyme catalysis. Eur J Biochem (1991) 1.18
Functional roles of the conserved threonine 250 in the target recognition domain of HhaI DNA methyltransferase. J Biol Chem (2000) 1.18
Fate of maturation protein during infection by coliphage MS2. Nat New Biol (1971) 1.17
Three-dimensional structure of proteinase K at 0.15-nm resolution. Eur J Biochem (1988) 1.16
Molecular and crystal structure of 2'-chloro-2'-deoxyuridine. Biochim Biophys Acta (1972) 1.15
Synchrotron X-ray data collection and restrained least-squares refinement of the crystal structure of proteinase K at 1.5 A resolution. Acta Crystallogr B (1988) 1.13
Functional roles of the conserved aromatic amino acid residues at position 108 (motif IV) and position 196 (motif VIII) in base flipping and catalysis by the N6-adenine DNA methyltransferase from Thermus aquaticus. Biochemistry (1999) 1.12
On the mechanism of ribonuclease A. Crystal and molecular structure of uridine 3'-O-thiophosphate methyl ester triethylammonium salt. Eur J Biochem (1974) 1.12
Molecular dynamics simulation of the hydration shell of a B-DNA decamer reveals two main types of minor-groove hydration depending on groove width. Proc Natl Acad Sci U S A (1991) 1.11
Decamer-like conformation of a nona-peptide bound to HLA-B*3501 due to non-standard positioning of the C terminus. J Mol Biol (1999) 1.10
Molecular and crystal structure of 6-methyluridine. A pyrimidine nucleoside in the syn conformation. J Am Chem Soc (1972) 1.08
X-ray structure of 3',5'-diacetyl-2'-deoxy-2'-fluorouridine: a pyrimidine nucleoside in the syn conformation. Biochim Biophys Acta (1974) 1.07
Development of a technology for automation and miniaturization of protein crystallization. J Biotechnol (2001) 1.07
Structure of the complex of proteinase K with a substrate analogue hexapeptide inhibitor at 2.2-A resolution. J Biol Chem (1993) 1.07
Photosystem I, an improved model of the stromal subunits PsaC, PsaD, and PsaE. J Biol Chem (1999) 1.06
Three-dimensional structure of fungal proteinase K reveals similarity to bacterial subtilisin. EMBO J (1984) 1.06
Identification of an RcsA/RcsB recognition motif in the promoters of exopolysaccharide biosynthetic operons from Erwinia amylovora and Pantoea stewartii subspecies stewartii. J Biol Chem (1999) 1.06
Localization of two phylloquinones, QK and QK', in an improved electron density map of photosystem I at 4-A resolution. J Biol Chem (1999) 1.06
Structural studies of cysteine proteases and their inhibitors. Acta Biochim Pol (2001) 1.05
Protein dynamics. A time-resolved fluorescence, energetic and molecular dynamics study of ribonuclease T1. Biophys Chem (1987) 1.05
The enzymatic activity of proteinase K is controlled by calcium. Eur J Biochem (1988) 1.04
X-ray structure of acarbose bound to amylomaltase from Thermus aquaticus. Implications for the synthesis of large cyclic glucans. Eur J Biochem (2000) 1.04
Crystal structure of calf spleen purine nucleoside phosphorylase in a complex with hypoxanthine at 2.15 A resolution. J Mol Biol (1997) 1.03
Structure and function of nucleosides and nucleotides. Angew Chem Int Ed Engl (1973) 1.02
A pyrimidine nucleoside in the syn conformation: molecular and crystal structure of 4-thiouridine-hydrate. J Mol Biol (1970) 1.02
Characterization of non-inducible Tet repressor mutants suggests conformational changes necessary for induction. Nat Struct Biol (1995) 1.01
Crystal structure of amylomaltase from thermus aquaticus, a glycosyltransferase catalysing the production of large cyclic glucans. J Mol Biol (2000) 1.01
X-ray and model-building studies on the specificity of the active site of proteinase K. Proteins (1988) 1.00
How do eukaryotic ribosomes recognize the unique AUG initiator codon in messenger RNA? Biochem Soc Symp (1982) 1.00
Chemical display of thymine residues flipped out by DNA methyltransferases. Nucleic Acids Res (1998) 1.00
Huntingtin aggregation monitored by dynamic light scattering. Proc Natl Acad Sci U S A (1998) 0.99
High-resolution structure of HLA-A*0201 in complex with a tumour-specific antigenic peptide encoded by the MAGE-A4 gene. J Mol Biol (2001) 0.99
Long-range structural changes in proteinase K triggered by calcium ion removal. Nature (1989) 0.97
Structurally conserved water molecules in ribonuclease T1. J Biol Chem (1991) 0.97
Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N,N-dimethylglycylamido)- 6-demethyl-6-deoxy-tetracycline. J Mol Biol (1999) 0.96