PubRank

D P McDonnell

Author PubWeight™ 100.32‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology 1999 3.67
2 Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc Natl Acad Sci U S A 1988 3.53
3 Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. Mol Endocrinol 1993 2.89
4 Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. Science 1987 2.71
5 Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. Mol Endocrinol 1994 2.62
6 The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. J Biol Chem 2001 2.45
7 The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor. Cell 1992 2.37
8 Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol. Mol Cell Endocrinol 1998 2.18
9 Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta. Mol Cell Biol 1999 2.13
10 Variant human breast tumor estrogen receptor with constitutive transcriptional activity. Cancer Res 1991 1.92
11 Peptide antagonists of the human estrogen receptor. Science 1999 1.86
12 The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. Mol Cell Biol 2000 1.83
13 Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers. J Biol Chem 1995 1.78
14 Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay. Toxicol Appl Pharmacol 1997 1.75
15 Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay. J Clin Invest 1994 1.72
16 Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1. J Biol Chem 2000 1.70
17 Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors. Mol Cell Biol 1996 1.70
18 Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae. Mol Cell Biol 1999 1.66
19 Evaluation of a recombinant yeast cell estrogen screening assay. Environ Health Perspect 1997 1.65
20 The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor. Mol Cell Biol 1998 1.61
21 Analysis of repetitive sequence elements containing tRNA-like sequences. Nucleic Acids Res 1985 1.53
22 Comparative analyses of mechanistic differences among antiestrogens. Endocrinology 1999 1.52
23 Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta. Proc Natl Acad Sci U S A 1999 1.52
24 The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells. Mol Cell Biol 1994 1.48
25 Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium. Proc Natl Acad Sci U S A 1999 1.46
26 Vitamin D receptor interaction with specific DNA requires a nuclear protein and 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A 1990 1.42
27 Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor. Cancer Res 2001 1.38
28 Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors. Cancer Res 1992 1.30
29 The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene. Recent Prog Horm Res 1999 1.30
30 Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta. Endocrinology 1999 1.29
31 Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies. Mol Pharmacol 2000 1.28
32 BRCA1 expression is not directly responsive to estrogen. Oncogene 1997 1.24
33 Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. J Steroid Biochem Mol Biol 1994 1.24
34 Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo. Mol Endocrinol 1999 1.23
35 Transactivation functions facilitate the disruption of chromatin structure by estrogen receptor derivatives in vivo. J Biol Chem 1991 1.20
36 Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast. Mol Endocrinol 1992 1.19
37 Enhancement of estrogen receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation function 2 in determining estrogen receptor pharmacology. J Biol Chem 1998 1.17
38 Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. Endocrinology 1997 1.16
39 Mapping and characterization of the functional domains responsible for the differential activity of the A and B isoforms of the human progesterone receptor. J Biol Chem 1997 1.14
40 Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers. Proc Natl Acad Sci U S A 1991 1.14
41 Expression of functional chicken oviduct progesterone receptors in yeast (Saccharomyces cerevisiae). J Biol Chem 1989 1.11
42 Molecular biology of the vitamin D hormone. Recent Prog Horm Res 1988 1.11
43 Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics. Endocrinology 2001 1.10
44 Estrogen-related receptor alpha as a therapeutic target in cancer. Endocr Relat Cancer 2006 1.10
45 Ligand-selective interactions of ER detected in living cells by fluorescence resonance energy transfer. Mol Endocrinol 2002 1.08
46 Expression of human vitamin D receptor in Saccharomyces cerevisiae. Purification, properties, and generation of polyclonal antibodies. J Biol Chem 1990 1.08
47 Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. J Biol Chem 2001 1.05
48 Potency of combined estrogenic pesticides. Science 1997 1.04
49 Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity. Mol Endocrinol 1996 1.02
50 Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells. Mol Endocrinol 1994 1.01
51 Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor. Mol Endocrinol 2000 0.99
52 Glucocorticoids manifest androgenic activity in a cell line derived from a metastatic prostate cancer. Cancer Res 2001 0.99
53 Identification of a third autonomous activation domain within the human estrogen receptor. Mol Endocrinol 1997 0.98
54 Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells. Toxicol Appl Pharmacol 1998 0.98
55 Development of peptide antagonists that target estrogen receptor beta-coactivator interactions. Mol Endocrinol 2000 0.96
56 Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone. Endocrinology 1997 0.94
57 High level expression of a truncated chicken progesterone receptor in Escherichia coli. J Biol Chem 1990 0.94
58 Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol. Toxicol Appl Pharmacol 1997 0.92
59 Positive regulation of the vitamin D receptor by its cognate ligand in heterologous expression systems. Mol Endocrinol 1993 0.88
60 Identification of an estrogen response element in the 3'-flanking region of the murine c-fos protooncogene. J Biol Chem 1992 0.87
61 16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity. Proc Natl Acad Sci U S A 1996 0.86
62 Structural organization and regulation of the chicken estrogen receptor. Mol Endocrinol 1987 0.84
63 Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506. Biochemistry 1994 0.82
64 Creatine kinase activity as an indicator of unopposed estrogen action in the mouse uterus associated with anti-progesterone treatment. J Steroid Biochem Mol Biol 1994 0.81
65 Assessing the infrequent oral supplementation of olanzapine long-acting injection in the treatment of schizophrenia. Eur Psychiatry 2010 0.81
66 The novel progesterone receptor antagonists RTI 3021-012 and RTI 3021-022 exhibit complex glucocorticoid receptor antagonist activities: implications for the development of dissociated antiprogestins. Endocrinology 1999 0.81
67 Identification of novel steroid-response elements. Gene Expr 1992 0.81
68 Modulation of progesterone receptor binding to progesterone response elements by positioned nucleosomes. Biochemistry 1992 0.80
69 Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells. Mol Endocrinol 1992 0.80
70 Estrogen receptor-cofactor interactions as targets for novel drug discovery. Ernst Schering Res Found Workshop 2001 0.79
71 Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor. J Steroid Biochem Mol Biol 1995 0.79
72 Chicken progesterone receptor expressed in Saccharomyces cerevisiae is correctly phosphorylated at all four Ser-Pro phosphorylation sites. Biochemistry 1993 0.78
73 The molecular pharmacology of ovarian steroid receptors. Vitam Horm 1996 0.77
74 A novel, highly regulated, rapidly inducible system for the expression of chicken progesterone receptor, cPRA, in Saccharomyces cerevisiae. Gene 1992 0.77
75 Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling. Oncogene 2017 0.76
76 Creation of an active estrogen-responsive element by a single base change in the flanking sequence of a cellular oncogene: a possible mechanism for hormonal carcinogenesis? Mol Carcinog 1993 0.75
77 Immunoselection of cDNAs to avian intestinal calcium binding protein 28K and a novel calmodulin-like protein: assessment of mRNA regulation by the vitamin D hormone. Biochemistry 1987 0.75