The general affinity of lac repressor for E. coli DNA: implications for gene regulation in procaryotes and eucaryotes.

PubWeight™: 3.73‹?› | Rank: Top 1%

🔗 View Article (PMID 1092468)

Published in Cell on February 01, 1975

Authors

S Lin, A D Riggs

Articles citing this

A single polypeptide possesses the binding and transcription activities of the adenovirus major late transcription factor. Mol Cell Biol (1986) 7.49

A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting components. Mol Cell Biol (1985) 6.44

Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm. PLoS Biol (2008) 6.30

Comprehensive genome-wide protein-DNA interactions detected at single-nucleotide resolution. Cell (2011) 6.29

Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions. Genome Biol (2009) 5.23

Transcriptional regulation by the numbers: applications. Curr Opin Genet Dev (2005) 3.40

Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection. Proc Natl Acad Sci U S A (2003) 3.29

Yeast TATA-binding protein TFIID binds to TATA elements with both consensus and nonconsensus DNA sequences. Proc Natl Acad Sci U S A (1989) 3.18

On the specificity of DNA-protein interactions. Proc Natl Acad Sci U S A (1986) 3.11

Specific stimulation of actin gene transcription by epidermal growth factor and cycloheximide. Proc Natl Acad Sci U S A (1984) 3.00

Binding of synthetic lactose operator DNAs to lactose represessors. Proc Natl Acad Sci U S A (1977) 2.86

Transcriptional regulatory cascades in development: initial rates, not steady state, determine network kinetics. Proc Natl Acad Sci U S A (2003) 2.70

Nonspecific DNA binding of genome-regulating proteins as a biological control mechanism: measurement of DNA-bound Escherichia coli lac repressor in vivo. Proc Natl Acad Sci U S A (1977) 2.70

The role of chromatin accessibility in directing the widespread, overlapping patterns of Drosophila transcription factor binding. Genome Biol (2011) 2.68

Quantitative models of the mechanisms that control genome-wide patterns of transcription factor binding during early Drosophila development. PLoS Genet (2011) 2.65

Purification of the c-fos enhancer-binding protein. Mol Cell Biol (1987) 2.64

Measurement of the binding of transcription factor Sp1 to a single GC box recognition sequence. Nucleic Acids Res (1989) 2.47

Half a century of "the nuclear matrix". Mol Biol Cell (2000) 2.09

Genome-wide transcription factor binding: beyond direct target regulation. Trends Genet (2011) 1.97

Yeast proteins that recognize nuclear localization sequences. J Cell Biol (1989) 1.92

Quantitative proteomic analysis of purified yeast kinetochores identifies a PP1 regulatory subunit. Genes Dev (2009) 1.91

Site-specific DNA-affinity chromatography of the lac repressor. Nucleic Acids Res (1980) 1.85

DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1. Genes Dev (2003) 1.68

A comparison of in vivo and in vitro DNA-binding specificities suggests a new model for homeoprotein DNA binding in Drosophila embryos. EMBO J (1999) 1.67

Kinetic studies on the cleavage of adenovirus DNA by restriction endonuclease Eco RI. Nucleic Acids Res (1976) 1.64

Cooperativity and rapid evolution of cobound transcription factors in closely related mammals. Cell (2013) 1.52

The properties of a new polymerase III transcription factor reveal that transcription complexes can assemble by more than one pathway. EMBO J (1987) 1.49

Quantitative analysis of the Drosophila segmentation regulatory network using pattern generating potentials. PLoS Biol (2010) 1.40

DNA regions bound at low occupancy by transcription factors do not drive patterned reporter gene expression in Drosophila. Proc Natl Acad Sci U S A (2012) 1.39

Specificity of DNA binding activity of the Bacillus subtilis catabolite control protein CcpA. J Bacteriol (1995) 1.37

Comparison of protein binding to DNA in vivo and in vitro: defining an effective intracellular target. EMBO J (1995) 1.37

Modeling the dynamics of transcriptional gene regulatory networks for animal development. Dev Biol (2008) 1.37

Thermodynamics of Cro protein-DNA interactions. Proc Natl Acad Sci U S A (1992) 1.35

Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution. Science (2014) 1.34

Model for lactose repressor protein and its interaction with ligands. Proc Natl Acad Sci U S A (1980) 1.28

DNA binding specificity of two homeodomain proteins in vitro and in Drosophila embryos. Proc Natl Acad Sci U S A (1996) 1.27

Assembly of an active chromatin structure during replication. Nucleic Acids Res (1979) 1.23

Binding of E.coli lac repressor to non-operator DNA. Nucleic Acids Res (1977) 1.22

Structural aspects of protein-DNA recognition. Biochem J (1991) 1.21

Ligand-induced conformational changes and conformational dynamics in the solution structure of the lactose repressor protein. J Mol Biol (2007) 1.20

Accurate prediction of inducible transcription factor binding intensities in vivo. PLoS Genet (2012) 1.10

Mechanisms by which transcription factors gain access to target sequence elements in chromatin. Curr Opin Genet Dev (2012) 1.09

Regulation of transcription of the repA1 gene in the replication control region of IncFII plasmid NR1 by gene dosage of the repA2 transcription repressor protein. J Bacteriol (1985) 1.07

Determinator-inhibitor pairs as a mechanism for threshold setting in development: a possible function for pseudogenes. Proc Natl Acad Sci U S A (1986) 1.07

Relationship of eukaryotic DNA replication to committed gene expression: general theory for gene control. Microbiol Rev (1991) 1.06

Nuclear proteins. II. Similarity of nonhistone proteins in nuclear sap and chromatin, and essential absence of contractile proteins from mouse liver nuclei. J Cell Biol (1976) 1.04

Preferential protection of the minor groove of non-operator DNA by lac repressor against methylation by dimethyl sulphate. Nucleic Acids Res (1976) 1.04

Glucocorticoid receptor DNA-binding specificity is increased by the organization of DNA in nucleosomes. Proc Natl Acad Sci U S A (1992) 1.00

Making sense of transcription networks. Cell (2015) 0.94

In vivo tests of thermodynamic models of transcription repressor function. Biophys Chem (2011) 0.91

lac repressor is an antivirulence factor of Salmonella enterica: its role in the evolution of virulence in Salmonella. PLoS One (2009) 0.90

DNA binding restricts the intrinsic conformational flexibility of methyl CpG binding protein 2 (MeCP2). J Biol Chem (2011) 0.89

A protein-induced DNA bend increases the specificity of a prokaryotic enhancer-binding protein. Genes Dev (1998) 0.88

Cytochemical observation of regulated bacterial beta-galactosidase gene expression in mammalian cells. Proc Natl Acad Sci U S A (1989) 0.88

New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217. J Biol Chem (2013) 0.85

The DNA-protein cross: a method for detecting specific DNA-protein complexes in crude mixtures. EMBO J (1983) 0.84

Binding of a novel host factor to the pT181 plasmid replication enhancer. J Bacteriol (1997) 0.84

Comparison of the sensitivities of two Escherichia coli genes to in vivo variation of Lrp concentration. J Bacteriol (1998) 0.82

DNA-binding nonhistone proteins: DNA site reassociation. Nucleic Acids Res (1978) 0.82

Highly recurring sequence elements identified in eukaryotic DNAs by computer analysis are often homologous to regulatory sequences or protein binding sites. Nucleic Acids Res (1987) 0.81

The nuclear pore complex mediates binding of the Mig1 repressor to target promoters. PLoS One (2011) 0.81

Modified nucleotides reveal the indirect role of the central base pairs in stabilizing the lac repressor-operator complex. Nucleic Acids Res (1995) 0.81

The isolation and partial characterization of low-molecular-weight phosphorylated component of the non-histone proteins of mouse nuclei. Biochem J (1978) 0.79

DNA length is a critical parameter for eukaryotic transcription in vivo. Mol Cell Biol (1996) 0.79

Whole genome duplications and a 'function' for junk DNA? Facts and hypotheses. PLoS One (2009) 0.79

Nuclear physics (of the cell, not the atom). Mol Biol Cell (2014) 0.79

A novel prokaryotic promoter identified in the genome of some monopartite begomoviruses. PLoS One (2013) 0.76

Perturbation of lac operator DNA modification by tryptic core protein from lac repressor. Proc Natl Acad Sci U S A (1983) 0.75

Comparing binding site information to binding affinity reveals that Crp/DNA complexes have several distinct binding conformers. Nucleic Acids Res (2011) 0.75

Evidence for the presence of an essential arginine residue in photoreactivating enzyme from Streptomyces griseus. Biochem J (1985) 0.75

lac repressor changes conformation upon binding to poly[dA-T)]. Proc Natl Acad Sci U S A (1979) 0.75

TrmBL2 from Pyrococcus furiosus Interacts Both with Double-Stranded and Single-Stranded DNA. PLoS One (2016) 0.75

Genome-wide analysis of canonical Wnt target gene regulation in Xenopus tropicalis challenges β-catenin paradigm. Genesis (2017) 0.75

Computation of diffusion limited controlled actions for gene regulating repressor particles. J Biol Phys (2004) 0.75

Articles by these authors

DNA methylation and gene function. Science (1980) 14.01

Lac repressor-operator interaction. I. Equilibrium studies. J Mol Biol (1970) 13.32

The lac repressor-operator interaction. 3. Kinetic studies. J Mol Biol (1970) 10.07

Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin. Science (1977) 9.28

X inactivation, differentiation, and DNA methylation. Cytogenet Cell Genet (1975) 8.74

On the mechanism of DNA replication in mammalian chromosomes. J Mol Biol (1968) 8.34

Genomic sequencing and methylation analysis by ligation mediated PCR. Science (1989) 7.38

Lac repressor binding to non-operator DNA: detailed studies and a comparison of eequilibrium and rate competition methods. J Mol Biol (1972) 5.62

Evaluation of coliform tests for chlorinated secondary effluents. J Water Pollut Control Fed (1973) 5.51

Synthetic lac operator DNA is functional in vivo. Nature (1976) 5.36

DNA binding of the lac repressor. J Mol Biol (1968) 5.02

Mammalian X-chromosome inactivation. Annu Rev Genet (1983) 4.89

Chemical synthesis of restriction enzyme recognition sites useful for cloning. Science (1977) 4.81

Expression in Escherichia coli of chemically synthesized genes for human insulin. Proc Natl Acad Sci U S A (1979) 4.72

Oligonucleotide-directed mutagenesis as a general and powerful method for studies of protein function. Proc Natl Acad Sci U S A (1982) 4.64

Purification and DNA-binding properties of the catabolite gene activator protein. Proc Natl Acad Sci U S A (1971) 4.43

The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes. J Immunol (1989) 4.30

Clonal analysis using recombinant DNA probes from the X-chromosome. Cancer Res (1987) 4.25

Efficient correction of a mutation by use of chemically synthesized DNA. Proc Natl Acad Sci U S A (1978) 4.13

HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation. EMBO J (2000) 4.11

Methylation of mouse liver DNA studied by means of the restriction enzymes msp I and hpa II. Science (1979) 4.06

Presence of an SH2 domain in the actin-binding protein tensin. Science (1991) 4.03

Dynamics and segregation of cell-matrix adhesions in cultured fibroblasts. Nat Cell Biol (2000) 3.99

Use of a HpaII-polymerase chain reaction assay to study DNA methylation in the Pgk-1 CpG island of mouse embryos at the time of X-chromosome inactivation. Mol Cell Biol (1990) 3.78

Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase. Gene (1984) 3.67

Schizophrenia after prenatal famine. Further evidence. Arch Gen Psychiatry (1996) 3.65

Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J Biol Chem (1996) 3.63

T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. Proc Natl Acad Sci U S A (1998) 3.61

Ancestral, mammalian-wide subfamilies of LINE-1 repetitive sequences. J Mol Biol (1995) 3.50

Cytochalasins block actin filament elongation by binding to high affinity sites associated with F-actin. J Biol Chem (1980) 3.49

5-methylcytosine, gene regulation, and cancer. Adv Cancer Res (1983) 3.27

Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis. J Cell Biol (2000) 3.13

Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids. Toxicol In Vitro (2014) 3.10

Beta-galactosidase. Rates of synthesis and degradation of incomplete chains. J Biol Chem (1972) 3.06

Mutations in familial Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker's syndrome. Exp Neurol (1989) 3.00

An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-L-arabinose to lipid A: induction on polymyxin-resistant mutants and role of a novel lipid-linked donor. J Biol Chem (2001) 2.95

Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proc Natl Acad Sci U S A (2001) 2.95

On the assay, isolation and characterization of the lac repressor. J Mol Biol (1968) 2.94

Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. J Exp Med (1999) 2.92

Tiggers and DNA transposon fossils in the human genome. Proc Natl Acad Sci U S A (1996) 2.89

A quantitative HpaII-PCR assay to measure methylation of DNA from a small number of cells. Nucleic Acids Res (1990) 2.81

Cytochalasins inhibit nuclei-induced actin polymerization by blocking filament elongation. J Cell Biol (1980) 2.74

Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists. J Med Chem (1999) 2.73

Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science (1996) 2.71

In vivo footprint and methylation analysis by PCR-aided genomic sequencing: comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1. Genes Dev (1990) 2.71

Cytochalasin B, its interaction with actin and actomyosin from muscle (cell movement-microfilaments-rabbit striated muscle). Proc Natl Acad Sci U S A (1972) 2.68

Cytochalasin D inhibits actin polymerization and induces depolymerization of actin filaments formed during platelet shape change. Nature (1981) 2.63

The effect of hiatus hernia on gastro-oesophageal junction pressure. Gut (1999) 2.60

Lipid A modifications characteristic of Salmonella typhimurium are induced by NH4VO3 in Escherichia coli K12. Detection of 4-amino-4-deoxy-L-arabinose, phosphoethanolamine and palmitate. J Biol Chem (1999) 2.56

Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability. Proc Natl Acad Sci U S A (1990) 2.51

lac repressor--operator interaction. II. Effect of galactosides and other ligands. J Mol Biol (1970) 2.42

Interaction of effecting ligands with lac repressor and repressor-operator complex. Biochemistry (1975) 2.41

GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development (1997) 2.38

Lac operator analogues: bromodeoxyuridine substitution in the lac operator affects the rate of dissociation of the lac repressor. Proc Natl Acad Sci U S A (1972) 2.36

Active X chromosome DNA is unmethylated at eight CCGG sites clustered in a guanine-plus-cytosine-rich island at the 5' end of the gene for phosphoglycerate kinase. Mol Cell Biol (1986) 2.35

Specific interaction of vinculin with alpha-actinin. Biochem Biophys Res Commun (1987) 2.34

A comparison of lac repressor binding to operator and to nonoperator DNA. Biochem Biophys Res Commun (1975) 2.32

5-Methylcytosine content of rat hepatoma DNA substituted with bromodeoxyuridine. J Biol Chem (1977) 2.32

Lipid A modifications in polymyxin-resistant Salmonella typhimurium: PMRA-dependent 4-amino-4-deoxy-L-arabinose, and phosphoethanolamine incorporation. J Biol Chem (2001) 2.30

A comparison of batch effect removal methods for enhancement of prediction performance using MAQC-II microarray gene expression data. Pharmacogenomics J (2010) 2.30

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals. EMBO J (1998) 2.29

Bacterial activity in South Pole snow. Appl Environ Microbiol (2000) 2.28

Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor. EMBO J (1997) 2.26

Chromatin differences between active and inactive X chromosomes revealed by genomic footprinting of permeabilized cells using DNase I and ligation-mediated PCR. Genes Dev (1991) 2.20

Photochemical attachment of lac repressor to bromodeoxyuridine-substituted lac operator by ultraviolet radiation. Proc Natl Acad Sci U S A (1974) 2.20

Toward a resolution of the introns early/late debate: only phase zero introns are correlated with the structure of ancient proteins. Proc Natl Acad Sci U S A (1998) 2.16

The cellular metabolism and systemic toxicity of arsenic. Toxicol Appl Pharmacol (2001) 2.15

Zebrafish pigmentation mutations and the processes of neural crest development. Development (1996) 2.14

Amino acid sequence requirements of the transmembrane and cytoplasmic domains of influenza virus hemagglutinin for viable membrane fusion. Mol Biol Cell (1999) 2.10

Purification and initial characterization of a protein from skeletal muscle that caps the barbed ends of actin filaments. J Biol Chem (1986) 2.08

Neurological impairment in violent schizophrenic inpatients. Am J Psychiatry (1989) 2.07

Neuropathology in mice expressing human alpha-synuclein. J Neurosci (2000) 2.06

Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern. Proc Natl Acad Sci U S A (1997) 2.04

Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b. Immunity (1997) 2.04

Lac repressor-operator interaction. V. Characterization of super- and pseudo-wild-type repressors. J Mol Biol (1972) 2.02

Actin polymerization induced by a motility-related high-affinity cytochalasin binding complex from human erythrocyte membrane. Proc Natl Acad Sci U S A (1979) 1.99

Timing, propagation, coordination, and effect of esophageal shortening during peristalsis. Gastroenterology (1997) 1.94

The RAD50 gene, a member of the double strand break repair epistasis group, is not required for spontaneous mitotic recombination in yeast. Curr Genet (1990) 1.93

Identification of a calcium channel modulator using a high throughput yeast two-hybrid screen. Nat Biotechnol (1998) 1.92

Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells. Clin Cancer Res (1996) 1.88

Instant MR labeling of stem cells using magnetoelectroporation. Magn Reson Med (2005) 1.88

Measurement by quantitative PCR of changes in HPRT, PGK-1, PGK-2, APRT, MTase, and Zfy gene transcripts during mouse spermatogenesis. Nucleic Acids Res (1990) 1.86

MIRs are classic, tRNA-derived SINEs that amplified before the mammalian radiation. Nucleic Acids Res (1995) 1.86

Biochemical studies on the mode of action of cytochalasin B. Cytochalasin B binding to red cell membrane in relation to glucose transport. J Biol Chem (1974) 1.86

A sensitive, quantitative assay for measurement of allele-specific transcripts differing by a single nucleotide. PCR Methods Appl (1992) 1.84

High-affinity interaction of vinculin with actin filaments in vitro. Cell (1982) 1.83

Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo. J Immunol (1997) 1.80

(R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability. J Med Chem (1994) 1.80

Oxygen requirement for the biosynthesis of the S-2-hydroxymyristate moiety in Salmonella typhimurium lipid A. Function of LpxO, A new Fe2+/alpha-ketoglutarate-dependent dioxygenase homologue. J Biol Chem (2000) 1.76

The lac repressor-operator interaction. IV. Assay and purification of operator DNA. Biochem Biophys Res Commun (1970) 1.75

The 200-MeV proton therapy project at the Paul Scherrer Institute: conceptual design and practical realization. Med Phys (1995) 1.75

Biphasic calcium phosphate bioceramics: preparation, properties and applications. J Mater Sci Mater Med (2003) 1.74

Isolation of a cDNA clone for human X-linked 3-phosphoglycerate kinase by use of a mixture of synthetic oligodeoxyribonucleotides as a detection probe. Proc Natl Acad Sci U S A (1983) 1.71

Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2. Curr Opin Lipidol (2001) 1.70

Methylation of DNA in mouse early embryos, teratocarcinoma cells and adult tissues of mouse and rabbit. Nucleic Acids Res (1979) 1.69

Closure mechanisms of laryngeal vestibule during swallow. Am J Physiol (1992) 1.67

An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy. Nature (2001) 1.65

Outcome in schizophrenia and related disorders compared between developing and developed countries. A recursive partitioning re-analysis of the WHO DOSMD data. Br J Psychiatry (1997) 1.65