Published in J Biol Chem on July 15, 1994
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci U S A (1996) 3.53
Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway. Mol Cell Biol (1998) 1.59
Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1. Mol Cell Biol (2001) 1.18
Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells. Mol Cell Biol (2005) 1.04
Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing. J Exp Med (1996) 0.86
Expression of endogenous granzyme B in a subset of human primary breast carcinomas. Br J Cancer (2003) 0.84
A colorimetric assay that specifically measures Granzyme B proteolytic activity: hydrolysis of Boc-Ala-Ala-Asp-S-Bzl. J Vis Exp (2014) 0.75
NKT cells: facts, functions and fallacies. Immunol Today (2000) 4.40
A novel progressive spongiform encephalopathy in cattle. Vet Rec (1987) 4.39
Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells. Nat Med (2001) 2.74
The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species. Proc Natl Acad Sci U S A (2001) 2.65
Extracellular adenosine triphosphate and adenosine in cancer. Oncogene (2010) 2.53
Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma. Leukemia (2009) 2.50
Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis. Blood (2001) 2.45
Primary parenteral transmission of bovine spongiform encephalopathy to the pig. Vet Rec (1990) 2.19
Detection of herpes simplex virus mRNA in latently infected trigeminal ganglion neurons by in situ hybridization. Ann Neurol (1982) 2.12
Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma. Proc Natl Acad Sci U S A (2007) 2.10
Preliminary observations on the pathogenesis of experimental bovine spongiform encephalopathy (BSE): an update. Vet Rec (1998) 2.05
NKT cells are phenotypically and functionally diverse. Eur J Immunol (1999) 1.97
Towards a differential polymerase chain reaction test for Chlamydia psittaci. Vet Rec (1991) 1.94
Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation. J Exp Med (2000) 1.89
Different forms of the bovine PrP gene have five or six copies of a short, G-C-rich element within the protein-coding exon. J Gen Virol (1991) 1.88
Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J Biol Chem (1997) 1.88
Markedly increased susceptibility to natural sheep scrapie of transgenic mice expressing ovine prp. J Virol (2001) 1.86
Role of ceramide in cellular senescence. J Biol Chem (1995) 1.74
Molecular screening of sheep for bovine spongiform encephalopathy. Neurosci Lett (1998) 1.74
Translational regulation: identification of the site on bacteriophage T4 rIIB mRNA recognized by the regA gene function. Proc Natl Acad Sci U S A (1981) 1.63
Cognitive mechanisms, specificity and neural underpinnings of visuospatial peaks in autism. Brain (2006) 1.62
P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death. Blood (1999) 1.61
Multiple physiological functions for multidrug transporter P-glycoprotein? Trends Biochem Sci (2000) 1.58
Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy. Br J Rheumatol (1997) 1.57
Electrophoretic separation and molecular weight characterization of Pseudomonas aeruginosa H-antigen flagellins. Infect Immun (1985) 1.55
Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation. Proc Natl Acad Sci U S A (1992) 1.55
Fibrils from brains of cows with new cattle disease contain scrapie-associated protein. Nature (1988) 1.54
NKT cells and tumor immunity--a double-edged sword. Nat Immunol (2000) 1.53
Effect of sequence variation in meningococcal PorA outer membrane protein on the effectiveness of a hexavalent PorA outer membrane vesicle vaccine. Vaccine (2000) 1.51
Bending and straightening of DNA induced by the same ligand: characterization with the atomic force microscope. Biochemistry (1994) 1.49
CD1-restricted T cells and tumor immunity. Curr Top Microbiol Immunol (2007) 1.45
Interleukin 2 receptor signaling regulates the perforin gene through signal transducer and activator of transcription (Stat)5 activation of two enhancers. J Exp Med (1999) 1.45
Routine application of enzyme-linked immunosorbent assay in comparison with complement fixation for the diagnosis of foot-and-mouth and swine vesicular diseases. Vet Microbiol (1988) 1.43
Targeting death-inducing receptors in cancer therapy. Oncogene (2007) 1.42
Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice. Int Immunol (2001) 1.40
A methodology based on NMR spectroscopy for the forensic analysis of condoms. J Forensic Sci (2001) 1.38
Three-dimensional imaging of magnetic domains. Nat Commun (2010) 1.38
Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent. J Biol Chem (1998) 1.36
A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells. Immunogenetics (1992) 1.33
Overexpression of eukaryotic initiation factor 4E (eIF4E) in breast carcinoma. Cancer (1997) 1.33
Mechanistic studies of transforming growth factor-beta inhibition of IL-2-dependent activation of CD3- large granular lymphocyte functions. Regulation of IL-2R beta (p75) signal transduction. J Immunol (1991) 1.31
Translational repression: biological activity of plasmid-encoded bacteriophage T4 RegA protein. J Mol Biol (1987) 1.26
Unlocking the secrets of cytotoxic granule proteins. J Leukoc Biol (2001) 1.25
Constitutive expression of pore-forming protein in peripheral blood gamma/delta T cells: implication for their cytotoxic role in vivo. J Exp Med (1990) 1.24
Design and utility of oligonucleotide gene probes for fungal polyketide synthases. Chem Biol (2001) 1.22
Novel polymorphisms in the caprine PrP gene: a codon 142 mutation associated with scrapie incubation period. J Gen Virol (1996) 1.21
Asymmetry of gait initiation in hemiparetic stroke subjects. Arch Phys Med Rehabil (1997) 1.21
Synthesis of a thymidyl pentamer of deoxyribonucleic guanidine and binding studies with DNA homopolynucleotides. Proc Natl Acad Sci U S A (1995) 1.20
Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth. Cell Immunol (2001) 1.19
The ribosomal intergenic spacer region: a target for the PCR based diagnosis of tuberculosis. Tuber Lung Dis (1994) 1.18
Infectivity in the ileum of cattle challenged orally with bovine spongiform encephalopathy. Vet Rec (1994) 1.18
Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis. J Biol Chem (1996) 1.17
Immunopurification of functional Asp-ase (natural killer cell granzyme B) using a monoclonal antibody. Biochem Biophys Res Commun (1993) 1.14
Molecular mechanisms of natural killer cell activation in response to cellular stress. Cell Death Differ (2013) 1.11
Identification of two new bacteriophage T4 genes that may have roles in transcription and DNA replication. J Virol (1987) 1.11
p53-dependent ceramide response to genotoxic stress. J Clin Invest (1998) 1.11
Bovine spongiform encephalopathy: the effect of oral exposure dose on attack rate and incubation period in cattle. J Gen Virol (2007) 1.10
Genetic analysis of capsular status of meningococcal carrier isolates. Epidemiol Infect (2003) 1.09
Global survey of serological evidence of caprine arthritis-encephalitis virus infection. Vet Rec (1984) 1.07
Redirecting mouse CTL against colon carcinoma: superior signaling efficacy of single-chain variable domain chimeras containing TCR-zeta vs Fc epsilon RI-gamma. J Immunol (2001) 1.07
Exploration of the Common Bile Duct for Stone. Drainage with T-Tube and Cholangiography. Br Med J (1941) 1.07
CTL granules: evolution of vesicles essential for combating virus infections. Immunol Today (1999) 1.07
Evolution in action. Nature (1974) 1.06
Relationships between chemical changes and histological damage in the brains of scrapie affected mice. J Comp Pathol (1967) 1.05
Transmission of bovine spongiform encephalopathy to mice. Vet Rec (1988) 1.05
Frequencies of PrP genotypes in 38 breeds of sheep sampled in the National Scrapie Plan for Great Britain. Vet Rec (2005) 1.05
NK cells and apoptosis. Immunol Cell Biol (1999) 1.04
Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo. Curr Opin Immunol (2000) 1.02
Antigenic and morphological differentiation of placental and intestinal isolates of Chlamydia psittaci of ovine origin. Vet Microbiol (1992) 1.01
Comparison of serological tests used in three state veterinary laboratories to identify maedi-visna virus infection. Vet Rec (1982) 1.01
Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen. Gene Ther (2010) 1.00
HMBA induces activation of a caspase-independent cell death pathway to overcome P-glycoprotein-mediated multidrug resistance. Blood (2000) 1.00
Umbilical cord circumference at birth. Am J Dis Child (1989) 1.00
A role for P-glycoprotein in regulating cell death. Leuk Lymphoma (2000) 0.99
Aberrant sphingolipid signaling is involved in the resistance of prostate cancer cell lines to chemotherapy. Cancer Res (1999) 0.99
Retinoid-resistant estrogen receptor-negative human breast carcinoma cells transfected with retinoic acid receptor-alpha acquire sensitivity to growth inhibition by retinoids. J Biol Chem (1994) 0.99
Maedi/visna: a review. Vet Rec (1980) 0.97
P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation. Cell Death Differ (2002) 0.97
Immunoperoxidase detection of chlamydia ovis in experimentally-infected cell culture. Br Vet J (1981) 0.97
Genetic mapping of the amino-terminal domain of bacteriophage T4 DNA polymerase. Genetics (1987) 0.97
Improved expression of human interleukin-2 in high-cell-density fermentor cultures of Escherichia coli K-12 by a phosphotransacetylase mutant. Appl Environ Microbiol (1990) 0.97
RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist. Br J Pharmacol (1999) 0.97
Mutation testing in Treacher Collins Syndrome. J Orthod (2002) 0.96
Pathogenesis of maedi-visna. Vet Rec (1987) 0.96
Factors affecting the frequency infection in renal transplant recipients. Arch Intern Med (1976) 0.96
Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux. Cell Death Differ (2004) 0.96
Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines. Cell Death Differ (2013) 0.95
Redirected perforin-dependent lysis of colon carcinoma by ex vivo genetically engineered CTL. J Immunol (2000) 0.94
Multiple cases of maedi and visna in a flock in East Anglia. Vet Rec (1995) 0.93
Automated single-cell manipulation and sorting by light trapping. Appl Opt (1987) 0.93
4-Amino-3-(3'-methoxycarbonyl-2'-thioureido)benzophenone, a prodrug of mebendazole. Eur J Drug Metab Pharmacokinet (1984) 0.93
Novel properties of the protein kinase CK2-site-regulated nuclear- localization sequence of the interferon-induced nuclear factor IFI 16. Biochem J (2001) 0.93
Use of computerized neuropsychological tests (CANTAB) to assess cognitive effects of antihypertensive drugs in the elderly. Cambridge Neuropsychological Test Automated Battery. J Hypertens (1999) 0.93
Immunoregulation in cancer-bearing hosts. Down-regulation of gene expression and cytotoxic function in CD8+ T cells. J Immunol (1992) 0.92
Bcl-2 acts upstream of the PARP protease and prevents its activation. Cell Death Differ (1997) 0.92