Published in N Engl J Med on October 06, 1994
Defect in IgV gene somatic hypermutation in common variable immuno-deficiency syndrome. Proc Natl Acad Sci U S A (1998) 1.51
Treatment of idiopathic CD4 T lymphocytopenia with IL-2. Clin Exp Immunol (1999) 1.19
Autoimmunity in common variable immunodeficiency. J Clin Immunol (2008) 0.88
Cytokines in common variable immunodeficiency as signs of immune dysregulation and potential therapeutic targets - a review of the current knowledge. J Clin Immunol (2014) 0.86
A double-blind, placebo-controlled, crossover therapy study with natural human IL-2 (nhuIL-2) in combination with regular intravenous gammaglobulin (IVIG) infusions in 10 patients with common variable immunodeficiency (CVID). Clin Exp Immunol (1997) 0.76
A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med (1997) 10.67
Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med (1999) 6.24
Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med (1990) 5.65
Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions. N Engl J Med (1981) 5.44
The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Cell (1998) 5.37
The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev (1994) 5.20
DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint. Cell (1995) 4.90
Diagnostic risk adjustment for Medicaid: the disability payment system. Health Care Financ Rev (1996) 4.34
A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis. N Engl J Med (1995) 4.30
Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. Nature (2001) 3.94
Translocation (8;21) in oligoblastic leukemia: is this a true myelodysplastic syndrome? Leuk Res (1994) 3.66
Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Mol Cell (2000) 3.65
Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain. Nature (1985) 3.38
A primitive enantiornithine bird and the origin of feathers. Science (2000) 2.96
DNA damage and cell cycle regulation of ribonucleotide reductase. Bioessays (1993) 2.81
Infliximab in the treatment of severe, steroid-refractory ulcerative colitis: a pilot study. Inflamm Bowel Dis (2001) 2.80
Immunophysiology of experimental food allergy. Mucosal Immunol (2008) 2.76
Bulgeless dwarf galaxies and dark matter cores from supernova-driven outflows. Nature (2010) 2.71
Fractional contribution of calcium to the cation current through glutamate receptor channels. Neuron (1993) 2.69
Risk of developing colorectal cancer and benign colorectal neoplasm in patients with chronic constipation. Aliment Pharmacol Ther (2014) 2.67
Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes. J Physiol (1995) 2.67
Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease. Gastroenterology (1999) 2.62
The prevalence of nocturia and its effect on health-related quality of life and sleep in a community sample in the USA. BJU Int (2003) 2.59
Incidence of AD may decline in the early 90s for men, later for women: The Cache County study. Neurology (2002) 2.52
Massive outbreak of antimicrobial-resistant salmonellosis traced to pasteurized milk. JAMA (1987) 2.47
Inducible T cell antigen 4-1BB. Analysis of expression and function. J Immunol (1993) 2.40
Differential effect of steady versus oscillating flow on bone cells. J Biomech (1998) 2.38
Cystic fibrosis gene mutations and pancreatitis risk: relation to epithelial ion transport and trypsin inhibitor gene mutations. Gastroenterology (2001) 2.36
Safety and biological efficacy of a lipid-CFTR complex for gene transfer in the nasal epithelium of adult patients with cystic fibrosis. Mol Ther (2000) 2.34
MAP kinase-related FUS3 from S. cerevisiae is activated by STE7 in vitro. Nature (1993) 2.33
Oxygen-bridged dinuclear ruthenium amine complex specifically inhibits Ca2+ uptake into mitochondria in vitro and in situ in single cardiac myocytes. J Biol Chem (1998) 2.32
Human T cell hybridomas secreting factors for IgA-specific help, polyclonal B cell activation, and B cell proliferation. J Exp Med (1982) 2.27
Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. Mol Cell (2000) 2.27
The smallest known non-avian theropod dinosaur. Nature (2000) 2.26
A novel mutation in the cystic fibrosis gene in patients with pulmonary disease but normal sweat chloride concentrations. N Engl J Med (1994) 2.25
Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein. J Cell Biol (2000) 2.22
Function of the Escherichia coli msbB gene, a multicopy suppressor of htrB knockouts, in the acylation of lipid A. Acylation by MsbB follows laurate incorporation by HtrB. J Biol Chem (1997) 2.17
PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats. J Control Release (2001) 2.15
Mechanism of block and identification of the verapamil binding domain to HERG potassium channels. Circ Res (1999) 2.10
Ribonucleotide reductase: regulation, regulation, regulation. Trends Biochem Sci (1992) 2.07
Odontogenic tumors. A demographic study of 759 cases in a Chinese population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (1998) 1.93
The impact on health-related quality of life of stress, urge and mixed urinary incontinence. BJU Int (2003) 1.93
Occupational exposure to bisphenol-A (BPA) and the risk of self-reported male sexual dysfunction. Hum Reprod (2009) 1.87
A precision measurement of the mass of the top quark. Nature (2004) 1.87
Making risk adjustment work for everyone. Inquiry (1995) 1.85
Pulmonary epithelial sodium-channel dysfunction and excess airway liquid in pseudohypoaldosteronism. N Engl J Med (1999) 1.81
The Community Medical Alliance: an integrated system of care in Greater Boston for people with severe disability and AIDS. Manag Care Q (1996) 1.81
Evidence for altered regulation of I kappa B alpha degradation in human colonic epithelial cells. J Immunol (1997) 1.80
Rapid disease progression correlates with instability of mutant SOD1 in familial ALS. Neurology (2005) 1.78
Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death. Science (2000) 1.77
Breast cancer metastatic potential correlates with a breakdown in homospecific and heterospecific gap junctional intercellular communication. Cancer Res (2001) 1.72
Covalent regulation of ULVWF string formation and elongation on endothelial cells under flow conditions. J Thromb Haemost (2008) 1.68
Molecular cloning of pertussis toxin genes. Nucleic Acids Res (1986) 1.64
Mechanically stimulated osteocytes regulate osteoblastic activity via gap junctions. Am J Physiol Cell Physiol (2006) 1.63
Differential involvement of the hyaluronan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis. J Biol Chem (2001) 1.60
Disulfide bond reduction of von Willebrand factor by ADAMTS-13. J Thromb Haemost (2010) 1.59
4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-mu-primed splenic B cells. Eur J Immunol (1994) 1.58
Age-dependent prevalence of mutations at the GLC1A locus in primary open-angle glaucoma. Am J Ophthalmol (2000) 1.57
Ca(2+)-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons. Nat Neurosci (2002) 1.56
Human malignant T cells capable of inducing an immunoglobulin class switch. J Exp Med (1985) 1.56
Functional gap junctions between osteocytic and osteoblastic cells. J Bone Miner Res (2000) 1.55
Health-related quality of life among adults with symptoms of overactive bladder: results from a U.S. community-based survey. Urology (2001) 1.53
Germline mutations in an intermediate chain dynein cause primary ciliary dyskinesia. Am J Respir Cell Mol Biol (2001) 1.50
The gut origin septic states in blunt multiple trauma (ISS = 40) in the ICU. Ann Surg (1987) 1.50
Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. J Nutr (1995) 1.49
Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride. Am J Physiol (1997) 1.47
Avoiding laparotomy in nonsurgical pneumoperitoneum. Am J Surg (1992) 1.47
Fast gradient-based methods for Bayesian reconstruction of transmission and emission PET images. IEEE Trans Med Imaging (1994) 1.46
Lung disease associated with the IVS8 5T allele of the CFTR gene. Am J Respir Crit Care Med (2000) 1.46
WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis. Cell Death Differ (2008) 1.45
Identification of immune system and response genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster. Genetics (1996) 1.43
A PheWAS approach in studying HLA-DRB1*1501. Genes Immun (2013) 1.42
Novel mechanism associated with an inherited cardiac arrhythmia: defective protein trafficking by the mutant HERG (G601S) potassium channel. Circulation (1999) 1.42
Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels. Science (1989) 1.39
CXCL13 expression in the gut promotes accumulation of IL-22-producing lymphoid tissue-inducer cells, and formation of isolated lymphoid follicles. Mucosal Immunol (2009) 1.39
Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity. Antimicrob Agents Chemother (1988) 1.36
Persistent infection of human adenovirus type 5 in human monocyte cell lines. Virology (1992) 1.34
Cellular pharmacology of 3'-azido-3'-deoxythymidine with evidence of incorporation into DNA of human bone marrow cells. Mol Pharmacol (1989) 1.32
CD1d is involved in T cell-intestinal epithelial cell interactions. J Exp Med (1993) 1.31
Interleukin 6 induces secretion of IgG1 by coordinated transcriptional activation and differential mRNA accumulation. Proc Natl Acad Sci U S A (1989) 1.30
Will minority physician supply meet U.S. needs? Health Aff (Millwood) (1997) 1.30
The regulation and functional consequence of proinflammatory cytokine binding on human intestinal epithelial cells. J Immunol (1998) 1.29
Evidence for a defect in "switch" T cells in patients with immunodeficiency and hyperimmunoglobulinemia M. N Engl J Med (1986) 1.29
Gastrointestinal manifestations of primary immunodeficiency disorders. Semin Gastrointest Dis (1997) 1.25
Long-term use of IgA-depleted intravenous immunoglobulin in immunodeficient subjects with anti-IgA antibodies. J Clin Immunol (1993) 1.24
Long QT syndrome: cellular basis and arrhythmia mechanism in LQT2. J Cardiovasc Electrophysiol (2000) 1.24
Treatment of intractable gastrointestinal manifestations of chronic granulomatous disease with cyclosporine. J Pediatr (1995) 1.23
In vitro and in vivo disposition and metabolism of 3'-deoxy-2',3'-didehydrothymidine. Antimicrob Agents Chemother (1993) 1.23
Polyclonal immunoglobulin secretion in patients with common variable immunodeficiency using monoclonal B cell differentiation factors. J Clin Invest (1984) 1.23
Characterization of an inducible, epidermal-specific knockout system: differential expression of lacZ in different Cre reporter mouse strains. Genesis (2000) 1.23
Chylomicron assembly and catabolism: role of apolipoproteins and receptors. Biochim Biophys Acta (1996) 1.23
Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis. J Biol Chem (2000) 1.22
Fluid flow-induced prostaglandin E2 response of osteoblastic ROS 17/2.8 cells is gap junction-mediated and independent of cytosolic calcium. Bone (2003) 1.21
Attenuation of doxorubicin chronic toxicity in metallothionein-overexpressing transgenic mouse heart. Cancer Res (2001) 1.21
Hydroxychloroquine treatment of patients with human immunodeficiency virus type 1. Clin Ther (1996) 1.21
Epithelial-mesenchymal transition markers expressed in circulating tumor cells in hepatocellular carcinoma patients with different stages of disease. Cell Death Dis (2013) 1.20
Characterization of the binding of amyloid-beta peptide to cell culture-derived native apolipoprotein E2, E3, and E4 isoforms and to isoforms from human plasma. J Neurochem (1997) 1.20
Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer. Oncogene (2006) 1.19
FURTHER STUDIES IN OSTEOGENESIS. Ann Surg (1919) 1.19