Published in J Nutr on December 01, 1995
Choline: critical role during fetal development and dietary requirements in adults. Annu Rev Nutr (2006) 2.83
Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB J (2006) 1.88
Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr (2007) 1.76
Importance of methyl donors during reproduction. Am J Clin Nutr (2008) 1.62
Choline and betaine in health and disease. J Inherit Metab Dis (2010) 1.61
Choline metabolism and risk of breast cancer in a population-based study. FASEB J (2008) 1.51
Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. FASEB J (2007) 1.42
Developmental periods of choline sensitivity provide an ontogenetic mechanism for regulating memory capacity and age-related dementia. Front Integr Neurosci (2008) 1.26
Perinatal choline influences brain structure and function. Nutr Rev (2006) 1.26
Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain. J Biol Chem (2008) 1.21
The fetal origins of memory: the role of dietary choline in optimal brain development. J Pediatr (2006) 1.19
Early embryonic lethality caused by disruption of the gene for choline kinase alpha, the first enzyme in phosphatidylcholine biosynthesis. J Biol Chem (2007) 1.17
Genetic polymorphisms in methyl-group metabolism and epigenetics: lessons from humans and mouse models. Brain Res (2008) 1.11
Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus. Proc Natl Acad Sci U S A (2010) 1.09
Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia. J Child Psychol Psychiatry (2009) 1.06
Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction. J Biol Chem (2010) 1.04
Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline. IUBMB Life (2007) 1.03
Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma. Am J Clin Nutr (2010) 0.99
Nutrition in pregnancy: the argument for including a source of choline. Int J Womens Health (2013) 0.98
Nutritional genomics: defining the dietary requirement and effects of choline. J Nutr (2011) 0.98
Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis (2013) 0.93
Dietary choline requirements of women: effects of estrogen and genetic variation. Am J Clin Nutr (2010) 0.92
Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice. Neurobiol Dis (2014) 0.91
Dietary intake of choline and plasma choline concentrations in pregnant women in Jamaica. West Indian Med J (2005) 0.89
Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted. J Am Diet Assoc (2009) 0.89
Dietary choline reverses some, but not all, effects of folate deficiency on neurogenesis and apoptosis in fetal mouse brain. J Nutr (2010) 0.87
The supply of choline is important for fetal progenitor cells. Semin Cell Dev Biol (2011) 0.87
Choline supply of preterm infants: assessment of dietary intake and pathophysiological considerations. Eur J Nutr (2012) 0.87
Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups. FASEB J (2014) 0.85
Choline Ameliorates Deficits in Balance Caused by Acute Neonatal Ethanol Exposure. Cerebellum (2015) 0.82
Choline: clinical nutrigenetic/nutrigenomic approaches for identification of functions and dietary requirements. J Nutrigenet Nutrigenomics (2011) 0.82
Choline: Dietary Requirements and Role in Brain Development. Nutr Today (2007) 0.82
Diet-gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice derived from studies on choline metabolism. Ann Nutr Metab (2012) 0.81
Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival. FASEB J (2008) 0.80
Maternal diet supplementation with methyl donors and increased parity affect the incidence of craniofacial defects in the offspring of twisted gastrulation mutant mice. J Nutr (2013) 0.78
Choline concentrations are lower in postnatal plasma of preterm infants than in cord plasma. Eur J Nutr (2014) 0.78
Maternal dietary intake of choline in mice regulates development of the cerebral cortex in the offspring. FASEB J (2015) 0.76
Nutritional deficiencies and phospholipid metabolism. Int J Mol Sci (2011) 0.76
Choline: clinical nutrigenetic/nutrigenomic approaches for identification of functions and dietary requirements. World Rev Nutr Diet (2010) 0.75
Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood. Brain Res (2011) 0.75
Characterization of choline transporters in the human placenta over gestation. Placenta (2015) 0.75
Evolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 Genes. PLoS One (2015) 0.75
The Pediatric Methionine Requirement Should Incorporate Remethylation Potential and Transmethylation Demands. Adv Nutr (2016) 0.75
Unexpected depletion in plasma choline and phosphatidylcholine concentrations in a pregnant woman with bipolar affective disorder being treated with lithuim, haloperidol and benztropine: a case report. J Med Case Rep (2008) 0.75
The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Cell (1998) 5.37
The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev (1994) 5.20
DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint. Cell (1995) 4.90
Diagnostic risk adjustment for Medicaid: the disability payment system. Health Care Financ Rev (1996) 4.34
A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis. N Engl J Med (1995) 4.30
Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. Nature (2001) 3.94
Translocation (8;21) in oligoblastic leukemia: is this a true myelodysplastic syndrome? Leuk Res (1994) 3.66
A primitive enantiornithine bird and the origin of feathers. Science (2000) 2.96
DNA damage and cell cycle regulation of ribonucleotide reductase. Bioessays (1993) 2.81
Fractional contribution of calcium to the cation current through glutamate receptor channels. Neuron (1993) 2.69
Risk of developing colorectal cancer and benign colorectal neoplasm in patients with chronic constipation. Aliment Pharmacol Ther (2014) 2.67
Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes. J Physiol (1995) 2.67
The prevalence of nocturia and its effect on health-related quality of life and sleep in a community sample in the USA. BJU Int (2003) 2.59
Inducible T cell antigen 4-1BB. Analysis of expression and function. J Immunol (1993) 2.40
Differential effect of steady versus oscillating flow on bone cells. J Biomech (1998) 2.38
Cystic fibrosis gene mutations and pancreatitis risk: relation to epithelial ion transport and trypsin inhibitor gene mutations. Gastroenterology (2001) 2.36
Safety and biological efficacy of a lipid-CFTR complex for gene transfer in the nasal epithelium of adult patients with cystic fibrosis. Mol Ther (2000) 2.34
MAP kinase-related FUS3 from S. cerevisiae is activated by STE7 in vitro. Nature (1993) 2.33
Oxygen-bridged dinuclear ruthenium amine complex specifically inhibits Ca2+ uptake into mitochondria in vitro and in situ in single cardiac myocytes. J Biol Chem (1998) 2.32
Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. Mol Cell (2000) 2.27
The smallest known non-avian theropod dinosaur. Nature (2000) 2.26
A novel mutation in the cystic fibrosis gene in patients with pulmonary disease but normal sweat chloride concentrations. N Engl J Med (1994) 2.25
Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein. J Cell Biol (2000) 2.22
Function of the Escherichia coli msbB gene, a multicopy suppressor of htrB knockouts, in the acylation of lipid A. Acylation by MsbB follows laurate incorporation by HtrB. J Biol Chem (1997) 2.17
PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats. J Control Release (2001) 2.15
Mechanism of block and identification of the verapamil binding domain to HERG potassium channels. Circ Res (1999) 2.10
Ribonucleotide reductase: regulation, regulation, regulation. Trends Biochem Sci (1992) 2.07
Odontogenic tumors. A demographic study of 759 cases in a Chinese population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (1998) 1.93
The impact on health-related quality of life of stress, urge and mixed urinary incontinence. BJU Int (2003) 1.93
Choline availability alters embryonic development of the hippocampus and septum in the rat. Brain Res Dev Brain Res (1999) 1.90
Occupational exposure to bisphenol-A (BPA) and the risk of self-reported male sexual dysfunction. Hum Reprod (2009) 1.87
A precision measurement of the mass of the top quark. Nature (2004) 1.87
Making risk adjustment work for everyone. Inquiry (1995) 1.85
Pulmonary epithelial sodium-channel dysfunction and excess airway liquid in pseudohypoaldosteronism. N Engl J Med (1999) 1.81
The Community Medical Alliance: an integrated system of care in Greater Boston for people with severe disability and AIDS. Manag Care Q (1996) 1.81
Rapid disease progression correlates with instability of mutant SOD1 in familial ALS. Neurology (2005) 1.78
Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death. Science (2000) 1.77
Breast cancer metastatic potential correlates with a breakdown in homospecific and heterospecific gap junctional intercellular communication. Cancer Res (2001) 1.72
Covalent regulation of ULVWF string formation and elongation on endothelial cells under flow conditions. J Thromb Haemost (2008) 1.68
Maternal dietary choline availability alters mitosis, apoptosis and the localization of TOAD-64 protein in the developing fetal rat septum. Brain Res Dev Brain Res (1999) 1.65
Mechanically stimulated osteocytes regulate osteoblastic activity via gap junctions. Am J Physiol Cell Physiol (2006) 1.63
Differential involvement of the hyaluronan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis. J Biol Chem (2001) 1.60
Disulfide bond reduction of von Willebrand factor by ADAMTS-13. J Thromb Haemost (2010) 1.59
4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-mu-primed splenic B cells. Eur J Immunol (1994) 1.58
Age-dependent prevalence of mutations at the GLC1A locus in primary open-angle glaucoma. Am J Ophthalmol (2000) 1.57
Ca(2+)-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons. Nat Neurosci (2002) 1.56
Functional gap junctions between osteocytic and osteoblastic cells. J Bone Miner Res (2000) 1.55
Health-related quality of life among adults with symptoms of overactive bladder: results from a U.S. community-based survey. Urology (2001) 1.53
Germline mutations in an intermediate chain dynein cause primary ciliary dyskinesia. Am J Respir Cell Mol Biol (2001) 1.50
Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride. Am J Physiol (1997) 1.47
Fast gradient-based methods for Bayesian reconstruction of transmission and emission PET images. IEEE Trans Med Imaging (1994) 1.46
Lung disease associated with the IVS8 5T allele of the CFTR gene. Am J Respir Crit Care Med (2000) 1.46
WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis. Cell Death Differ (2008) 1.45
Identification of immune system and response genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster. Genetics (1996) 1.43
Severe folate deficiency causes secondary depletion of choline and phosphocholine in rat liver. J Nutr (1994) 1.42
A PheWAS approach in studying HLA-DRB1*1501. Genes Immun (2013) 1.42
Novel mechanism associated with an inherited cardiac arrhythmia: defective protein trafficking by the mutant HERG (G601S) potassium channel. Circulation (1999) 1.42
Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels. Science (1989) 1.39
Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity. Antimicrob Agents Chemother (1988) 1.36
Cellular pharmacology of 3'-azido-3'-deoxythymidine with evidence of incorporation into DNA of human bone marrow cells. Mol Pharmacol (1989) 1.32
Will minority physician supply meet U.S. needs? Health Aff (Millwood) (1997) 1.30
Choline and choline esters in human and rat milk and in infant formulas. Am J Clin Nutr (1996) 1.27
Long-term use of IgA-depleted intravenous immunoglobulin in immunodeficient subjects with anti-IgA antibodies. J Clin Immunol (1993) 1.24
Long QT syndrome: cellular basis and arrhythmia mechanism in LQT2. J Cardiovasc Electrophysiol (2000) 1.24
Chylomicron assembly and catabolism: role of apolipoproteins and receptors. Biochim Biophys Acta (1996) 1.23
In vitro and in vivo disposition and metabolism of 3'-deoxy-2',3'-didehydrothymidine. Antimicrob Agents Chemother (1993) 1.23
Characterization of an inducible, epidermal-specific knockout system: differential expression of lacZ in different Cre reporter mouse strains. Genesis (2000) 1.23
Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis. J Biol Chem (2000) 1.22
Fluid flow-induced prostaglandin E2 response of osteoblastic ROS 17/2.8 cells is gap junction-mediated and independent of cytosolic calcium. Bone (2003) 1.21
Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos. Teratology (2001) 1.21
Attenuation of doxorubicin chronic toxicity in metallothionein-overexpressing transgenic mouse heart. Cancer Res (2001) 1.21
Epithelial-mesenchymal transition markers expressed in circulating tumor cells in hepatocellular carcinoma patients with different stages of disease. Cell Death Dis (2013) 1.20
Characterization of the binding of amyloid-beta peptide to cell culture-derived native apolipoprotein E2, E3, and E4 isoforms and to isoforms from human plasma. J Neurochem (1997) 1.20
Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer. Oncogene (2006) 1.19
A novel high-throughput method for accurate, rapid, and economical measurement of multiple type 1 diabetes autoantibodies. J Immunol Methods (2000) 1.18
Characterization of active sites on Rh/SiO(2) model catalysts. J Phys Condens Matter (2009) 1.17
Within 1 h, HIV-1 uses viral synapses to enter efficiently the inner, but not outer, foreskin mucosa and engages Langerhans-T cell conjugates. Mucosal Immunol (2010) 1.17
WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer. Oncogene (2009) 1.16
Maternal choline availability alters the localization of p15Ink4B and p27Kip1 cyclin-dependent kinase inhibitors in the developing fetal rat brain hippocampus. Dev Neurosci (2001) 1.15
A comparative molecular-physiological study of submergence response in lowland and deepwater rice. Plant Physiol (2001) 1.15
Genome-wide profiling of multiple histone methylations in olfactory cells: further implications for cellular susceptibility to oxidative stress in schizophrenia. Mol Psychiatry (2012) 1.14
Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1. Oncogene (2009) 1.14
Neointimal hyperplasia after arterial injury is increased in a rat model of non-insulin-dependent diabetes mellitus. Circulation (2001) 1.12
Functional overlap of tRNA nucleotidyltransferase, poly(A) polymerase I, and polynucleotide phosphorylase. J Biol Chem (1997) 1.12
Prolongation of cardiac allograft survival using dendritic cells treated with NF-kB decoy oligodeoxyribonucleotides. Mol Ther (2000) 1.10
Identification of ALOX5 as a gene regulating adiposity and pancreatic function. Diabetologia (2008) 1.10
A Ran-independent pathway for export of spliced mRNA. Nat Cell Biol (2001) 1.10
Transgenic approaches to define the functional role of dual site phospholamban phosphorylation. J Biol Chem (1998) 1.09
SOX4 is associated with poor prognosis in prostate cancer and promotes epithelial-mesenchymal transition in vitro. Prostate Cancer Prostatic Dis (2013) 1.08
Novel T cell antigen 4-1BB associates with the protein tyrosine kinase p56lck1. J Immunol (1993) 1.07
Enhanced T cell apoptosis in common variable immunodeficiency: negative role of the fas/fasligand system and of the Bcl-2 family proteins and possible role of TNF-RS. Clin Exp Immunol (2001) 1.07
Effects of fluid flow on intracellular calcium in bovine articular chondrocytes. Am J Physiol (1997) 1.06
In vivo monitoring of cystic fibrosis-like lung disease in mice by volumetric computed tomography. Eur Respir J (2011) 1.05
Inhibiting gap junctional intercellular communication alters expression of differentiation markers in osteoblastic cells. Bone (1999) 1.05
Effect of lactate therapy upon cognitive deficits after traumatic brain injury in the rat. Acta Neurochir (Wien) (2007) 1.05
Differentiation of human fetal osteoblastic cells and gap junctional intercellular communication. Am J Physiol Cell Physiol (2000) 1.05
Isolation and identification of stilbenes in two varieties of Polygonum cuspidatum. J Agric Food Chem (2000) 1.05
Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors. Bioorg Med Chem Lett (2001) 1.03
Exercise intensity-related responses of beta-endorphin and catecholamines. Med Sci Sports Exerc (1987) 1.03