Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice.

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Published in J Exp Med on August 01, 1993

Authors

T M Scharton1, P Scott

Author Affiliations

1: Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104.

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Leishmania major-infected C3H mice treated with anti-IL-12 mAb develop but do not maintain a Th2 response. J Immunol (1997) 0.91

Low caloric expenditure in cardiac rehabilitation. Am Heart J (2000) 0.90

Investigation into the ability of roots of the poikilohydric plant Craterostigma plantagineum to survive dehydration stress. J Exp Bot (2003) 0.89

Modulation of susceptibility and resistance to an autoimmune model of multiple sclerosis in prototypically susceptible and resistant strains by neutralization of interleukin-12 and interleukin-4, respectively. Clin Immunol (2001) 0.88

The role of IL-12 in the maintenance of an established Th1 immune response in experimental leishmaniasis. Eur J Immunol (1998) 0.88

Host susceptibility factors to cutaneous leishmaniasis. Front Biosci (1998) 0.88

Separation of the Baragwanath craniopagus twins. Br J Plast Surg (1991) 0.87

A randomised controlled trial of abdominal versus laparoscopic sacrocolpopexy for the treatment of post-hysterectomy vaginal vault prolapse: LAS study. Reply to comment. Int Urogynecol J (2014) 0.87

Gastric bezoars. A technique of endoscopic removal. Am J Dig Dis (1978) 0.86

Impaired macrophage leishmanicidal activity at cutaneous temperature. Parasite Immunol (1985) 0.86

Acute stroke teams: results of a national survey. National Acute Stroke Team Group. Stroke (1998) 0.85

Observations on the function of the round window. J Physiol (1940) 0.85

Germ-free mice produce high levels of interferon-gamma in response to infection with Leishmania major but fail to heal lesions. Parasitology (2005) 0.85

A proposed approach to regulating contaminated soil: identify safe concentrations for seven of the most frequently encountered exposure scenarios. Regul Toxicol Pharmacol (1992) 0.84

Production of interleukin-10 in human fracture soft-tissue hematomas. Shock (1996) 0.84

Differential requirement of CD28 for IL-12 receptor expression and function in CD4(+) and CD8(+) T cells. Eur J Immunol (2001) 0.84

Maintenance of IL-12-responsive CD4+ T cells during a Th2 response in Leishmania major-infected mice. Eur J Immunol (2000) 0.84

Curd and whey proteins in the nutrition of low birthweight babies. Arch Dis Child (1979) 0.83

Biologic effect of 5-fluoro-2'-deoxyuridine incorporation in L1210 deoxyribonucleic acid. Biochem Pharmacol (1983) 0.83

Hypoxia enhances cellular proliferation and inositol 1,4, 5-triphosphate generation in fibroblasts from bovine pulmonary artery but not from mesenteric artery. Am J Respir Crit Care Med (1998) 0.83

The aerobic bacterial flora of the reproductive tract of the mare. Vet Rec (1971) 0.82