Overproduction of ornithine decarboxylase caused by relief of translational repression is associated with neoplastic transformation.

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Published in Cancer Res on May 01, 1994

Authors

L M Shantz1, A E Pegg

Author Affiliations

1: Department of Cellular and Molecular Physiology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey 17033.

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Identification of residues in ornithine decarboxylase essential for enzymic activity and for rapid protein turnover. Biochem J (1991) 1.13

Specific and potent inhibition of spermidine synthase by the transition-state analog, S-adenosyl-3-thio-1,8-diaminooctane. Biochem Biophys Res Commun (1980) 1.13

Resistance of the human O6-alkylguanine-DNA alkyltransferase containing arginine at codon 160 to inactivation by O6-benzylguanine. Cancer Res (1996) 1.12

Translational regulation of ornithine decarboxylase and other enzymes of the polyamine pathway. Int J Biochem Cell Biol (1999) 1.12

Effect of mutations at active site residues on the activity of ornithine decarboxylase and its inhibition by active site-directed irreversible inhibitors. J Biol Chem (1993) 1.12

Structure and regulation of mammalian S-adenosylmethionine decarboxylase. J Biol Chem (1988) 1.10

Polyamine biosynthesis and interconversion in rodent tissues. Fed Proc (1982) 1.10

DNA binding mechanism of O6-alkylguanine-DNA alkyltransferase: stoichiometry and effects of DNA base composition and secondary structure on complex stability. Biochemistry (1996) 1.09

Purification and characterization of spermidine/spermine N1-acetyltransferase from rat liver. Biochemistry (1982) 1.09

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Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res (1981) 1.09

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Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells. Cancer Res (2000) 1.08

Escherichia coli S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase. Purification, substrate specificity and mechanism of action. Biochem J (1985) 1.08

Role of the carboxyl terminal MATEE sequence of spermidine/spermine N1-acetyltransferase in the activity and stabilization by the polyamine analog N1,N12-bis(ethyl)spermine. Biochemistry (1995) 1.08

Resuscitation of the monkey brain after one hour complete ischemia. III. Indications of metabolic recovery. Brain Res (1975) 1.08

Ornithine decarboxylase (mouse kidney). Methods Enzymol (1983) 1.08

Enzymic synthesis of spermine in rat prostate. Arch Biochem Biophys (1970) 1.08

Synthesis and biochemical evaluation of adenosylspermidine, a nucleoside-polyamine adduct inhibitor of spermidine synthase. J Med Chem (1995) 1.07

Comparison of the rates of repair of O6-alkylguanines in DNA by rat liver and bacterial O6-alkylguanine-DNA alkyltransferase. Cancer Res (1984) 1.07

The role of polyamine depletion and accumulation of decarboxylated S-adenosylmethionine in the inhibition of growth of SV-3T3 cells treated with alpha-difluoromethylornithine. Biochem J (1984) 1.07

Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide. Amino Acids (2007) 1.07

S-adenosylmethionine decarboxylase: a brief review. Cell Biochem Funct (1984) 1.06

Topoisomerase I-mediated cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine: trapping of topoisomerase I by the O6-methylguanine. Cancer Res (2001) 1.06

O6-alkylguanine-DNA alkyltransferase activity in normal human tissues and cells. Cancer Res (1984) 1.06

Dimethylnitrosamine inhibits enzymatic removal of O6-methylguanine from DNA. Nature (1978) 1.06

Regulation of ornithine decarboxylase activity by spermidine and the spermidine analogue N1N8-bis(ethyl)spermidine. Biochem J (1987) 1.06

Effect of partial hepatectomy on removal of O6-methylguanine from alkylated DNA by rat liver extracts. Biochem J (1981) 1.06

Mechanism of stimulation of ornithine decarboxylase activity in transformed mouse fibroblasts. Biochemistry (1983) 1.05

Effects of S-adenosyl-1,8-diamino-3-thiooctane on polyamine metabolism. Biochemistry (1982) 1.05

Rapid exchange of subunits of mammalian ornithine decarboxylase. J Biol Chem (1994) 1.04

Comparison of inhibitors of S-adenosylmethionine decarboxylase from different species. Biochem J (1983) 1.04

Specificity of mammalian spermidine synthase and spermine synthase. Biochem J (1981) 1.04

Structure and critical residues at the active site of spermidine/spermine-N1-acetyltransferase. Biochem J (1996) 1.04

S-adenosylmethionine decarboxylase (rat liver). Methods Enzymol (1983) 1.03

Effect of inhibition of polyamine synthesis on the content of decarboxylated S-adenosylmethionine. Biochem J (1982) 1.03