X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation.

PubWeight™: 3.14‹?› | Rank: Top 1%

🔗 View Article (PMC 322888)

Published in Proc Natl Acad Sci U S A on January 01, 1986

Authors

D A Kirschner, C Abraham, D J Selkoe

Articles citing this

3D structure of Alzheimer's amyloid-beta(1-42) fibrils. Proc Natl Acad Sci U S A (2005) 8.60

On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants. Proc Natl Acad Sci U S A (1996) 4.75

Structural classification of toxic amyloid oligomers. J Biol Chem (2008) 4.16

Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro. Proc Natl Acad Sci U S A (1987) 4.04

Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Nat Struct Mol Biol (2010) 3.75

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. J Physiol (2006) 3.74

Structure of beta-crystallite assemblies formed by Alzheimer beta-amyloid protein analogues: analysis by x-ray diffraction. Biophys J (1993) 2.77

pH-dependent structural transitions of Alzheimer amyloid peptides. Biophys J (1991) 2.33

Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. EMBO J (1988) 2.23

The toxicity in vitro of beta-amyloid protein. Biochem J (1995) 2.17

Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths. Biophys J (1994) 1.99

Template-assisted filament growth by parallel stacking of tau. Proc Natl Acad Sci U S A (2004) 1.89

Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42. Biochemistry (2006) 1.88

Molecular basis for amyloid-beta polymorphism. Proc Natl Acad Sci U S A (2011) 1.76

Designed protein tetramer zipped together with a hydrophobic Alzheimer homology: a structural clue to amyloid assembly. Proc Natl Acad Sci U S A (2000) 1.76

Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments. Proc Natl Acad Sci U S A (1995) 1.73

From Alzheimer to Huntington: why is a structural understanding so difficult? EMBO J (2003) 1.68

Synthetic peptides homologous to prion protein residues 106-147 form amyloid-like fibrils in vitro. Proc Natl Acad Sci U S A (1993) 1.68

Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-beta structure. Proc Natl Acad Sci U S A (2003) 1.67

Alzheimer disease. Dis Mon (2010) 1.64

Bacterial inclusion bodies contain amyloid-like structure. PLoS Biol (2008) 1.63

Towards a pharmacophore for amyloid. PLoS Biol (2011) 1.58

Amyloid structure: conformational diversity and consequences. Annu Rev Biochem (2011) 1.57

Toxic fibrillar oligomers of amyloid-β have cross-β structure. Proc Natl Acad Sci U S A (2012) 1.53

Atomic-resolution structure of a disease-relevant Aβ(1-42) amyloid fibril. Proc Natl Acad Sci U S A (2016) 1.51

2D IR provides evidence for mobile water molecules in beta-amyloid fibrils. Proc Natl Acad Sci U S A (2009) 1.49

Amyloid-beta peptide assembly: a critical step in fibrillogenesis and membrane disruption. Biophys J (2001) 1.37

Structural basis for increased toxicity of pathological aβ42:aβ40 ratios in Alzheimer disease. J Biol Chem (2011) 1.26

In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2000) 1.24

Amide solvent protection analysis demonstrates that amyloid-beta(1-40) and amyloid-beta(1-42) form different fibrillar structures under identical conditions. Biochem J (2007) 1.24

Monoclonal antibodies to a synthetic peptide homologous with the first 28 amino acids of Alzheimer's disease beta-protein recognize amyloid and diverse glial and neuronal cell types in the central nervous system. Am J Pathol (1989) 1.24

Solvent effects on the conformational transition of a model polyalanine peptide. Protein Sci (2004) 1.20

Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma. Proc Natl Acad Sci U S A (2001) 1.19

A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion. Biochem J (1992) 1.18

Probing solvent accessibility of amyloid fibrils by solution NMR spectroscopy. Proc Natl Acad Sci U S A (2002) 1.16

Hollow core of Alzheimer's Abeta42 amyloid observed by cryoEM is relevant at physiological pH. Proc Natl Acad Sci U S A (2010) 1.14

Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease. Proc Natl Acad Sci U S A (1991) 1.12

Structure of core domain of fibril-forming PHF/Tau fragments. Biophys J (2005) 1.09

Passive anti-amyloid immunotherapy in Alzheimer's disease: What are the most promising targets? Immun Ageing (2013) 1.08

Polymerization of intact beta 2-microglobulin in tissue causes amyloidosis in patients on chronic hemodialysis. Proc Natl Acad Sci U S A (1986) 1.07

Stability and structure of oligomers of the Alzheimer peptide Abeta16-22: from the dimer to the 32-mer. Biophys J (2006) 1.07

Immunodetection of the amyloid P component in Alzheimer's disease. Acta Neuropathol (1989) 1.06

Binding of amyloid beta-peptide to ganglioside micelles is dependent on histidine-13. Biochem J (2006) 1.05

Investigating how peptide length and a pathogenic mutation modify the structural ensemble of amyloid beta monomer. Biophys J (2012) 1.02

New insights into the mechanism of Alzheimer amyloid-beta fibrillogenesis inhibition by N-methylated peptides. Biophys J (2007) 1.02

Isolation and chemical characterization of Alzheimer's disease paired helical filament cytoskeletons: differentiation from amyloid plaque core protein. J Cell Biol (1988) 1.01

Formation and growth of oligomers: a Monte Carlo study of an amyloid tau fragment. PLoS Comput Biol (2008) 0.99

Towards revealing the structure of bacterial inclusion bodies. Prion (2009) 0.97

Cerebral amyloidosis: amyloid subunits, mutants and phenotypes. Cell Mol Life Sci (2009) 0.96

Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration. Front Neurol (2013) 0.96

Spontaneous fibril formation by polyalanines; discontinuous molecular dynamics simulations. J Am Chem Soc (2006) 0.94

Micelle formation by a fragment of human islet amyloid polypeptide. Biophys J (2003) 0.94

Fibers of tau fragments, but not full length tau, exhibit a cross beta-structure: implications for the formation of paired helical filaments. Protein Sci (2000) 0.92

Zn(++) binding disrupts the Asp(23)-Lys(28) salt bridge without altering the hairpin-shaped cross-β Structure of Aβ(42) amyloid aggregates. Biophys J (2011) 0.91

Characterization of intracellular amyloid fibrils in the human choroid plexus epithelial cells. Acta Neuropathol (1990) 0.91

Intrinsically disordered proteins in the neurodegenerative processes: formation of tau protein paired helical filaments and their analysis. Cell Mol Neurobiol (2006) 0.90

Responsive organogels formed by supramolecular self assembly of PEG-block-allyl-functionalized racemic polypeptides into β-sheet-driven polymeric ribbons. Soft Matter (2013) 0.90

Amino acid sequence in constitutionally isomeric tetrapeptide amphiphiles dictates architecture of one-dimensional nanostructures. J Am Chem Soc (2014) 0.90

Phase diagrams describing fibrillization by polyalanine peptides. Biophys J (2004) 0.90

Molecular origin of the self-assembly of lanreotide into nanotubes: a mutational approach. Biophys J (2007) 0.88

Effect of the Tottori familial disease mutation (D7N) on the monomers and dimers of Aβ40 and Aβ42. ACS Chem Neurosci (2013) 0.88

Effect of metals on kinetic pathways of amyloid-β aggregation. Biomolecules (2014) 0.87

Beta amyloid peptide: from different aggregation forms to the activation of different biochemical pathways. Eur Biophys J (2009) 0.86

Cationic dyes reveal proteoglycans structurally integrated within the characteristic lesions of Alzheimer's disease. Acta Neuropathol (1989) 0.85

Characteristics of Tau and Its Ligands in PET Imaging. Biomolecules (2016) 0.85

Intracellular neurofibrillary tangle-like aggregations. A constantly present amyloid alteration in the aging choroid plexus. Am J Pathol (1986) 0.84

Structural transitions of confined model proteins: molecular dynamics simulation and experimental validation. Biophys J (2006) 0.84

Mechanisms of enzymatic degradation of amyloid Beta microfibrils generating nanofilaments and nanospheres related to cytotoxicity. Biochemistry (2010) 0.83

The mechanism for heme to prevent Aβ(1-40) aggregation and its cytotoxicity. J Biol Inorg Chem (2011) 0.82

The Beta-amyloid protein of Alzheimer's disease: communication breakdown by modifying the neuronal cytoskeleton. Int J Alzheimers Dis (2013) 0.82

Exploring the sequence-structure relationship for amyloid peptides. Biochem J (2013) 0.82

Immunohistochemical colocalization of amyloid precursor protein with cerebrovascular amyloid of Alzheimer's disease. Am J Pathol (1991) 0.82

Atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-L-tryptophan inhibitor on Alzheimer's Aβ1-42 dimer in terms of aggregation and toxicity. ACS Chem Neurosci (2013) 0.81

Secondary nucleating sequences affect kinetics and thermodynamics of tau aggregation. Biochemistry (2011) 0.81

A synchrotron-based hydroxyl radical footprinting analysis of amyloid fibrils and prefibrillar intermediates with residue-specific resolution. Biochemistry (2014) 0.80

The role of beta-amyloid protein in synaptic function: implications for Alzheimer's disease therapy. Curr Neuropharmacol (2006) 0.80

Microscopic factors that control beta-sheet registry in amyloid fibrils formed by fragment 11-25 of amyloid beta peptide: insights from computer simulations. J Mol Biol (2009) 0.80

Neutron fibre diffraction studies of amyloid using H2O/D2O isotopic replacement. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.80

Age-related accumulation of amyloid inclusions in adrenal cortical cells. Am J Pathol (1990) 0.79

Multi-responsive Hydrogels Derived from the Self-assembly of Tethered Allyl-functionalized Racemic Oligopeptides. J Mater Chem B Mater Biol Med (2014) 0.79

The presence of a novel protein in calf serum that recognizes beta amyloid in the formalin-fixed section. Am J Pathol (1990) 0.78

Intrinsic structural heterogeneity and long-term maturation of amyloid β peptide fibrils. ACS Chem Neurosci (2013) 0.78

Alzheimer paired helical filaments: a comparison with the twisted ribbon model. Acta Neuropathol (1995) 0.78

Wogonin increases β-amyloid clearance and inhibits tau phosphorylation via inhibition of mammalian target of rapamycin: potential drug to treat Alzheimer's disease. Neurol Sci (2015) 0.78

Aggregation of Aß(25-35) on DOPC and DOPC/DHA bilayers: an atomic force microscopy study. PLoS One (2014) 0.77

Investigating the Neuroprotective Effects of Turmeric Extract: Structural Interactions of β-Amyloid Peptide with Single Curcuminoids. Sci Rep (2016) 0.75

Curcumin: A multi-target disease-modifying agent for late-stage transthyretin amyloidosis. Sci Rep (2016) 0.75

High-level expression and in vitro mutagenesis of a fibrillogenic 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein. Biochem J (1993) 0.75

Tau Structures. Front Aging Neurosci (2016) 0.75

Orientation of tyrosine side chain in neurotoxic Aβ differs in two different secondary structures of the peptide. R Soc Open Sci (2016) 0.75

Secondary Metabolites in Ramalina terebrata Detected by UHPLC/ESI/MS/MS and Identification of Parietin as Tau Protein Inhibitor. Int J Mol Sci (2016) 0.75

Platelets are responsible for the accumulation of β-amyloid in blood clots inside and around blood vessels in mouse brain after thrombosis. Brain Res Bull (2016) 0.75

Medicinal value of asiaticoside for Alzheimer's disease as assessed using single-molecule-detection fluorescence correlation spectroscopy, laser-scanning microscopy, transmission electron microscopy, and in silico docking. BMC Complement Altern Med (2015) 0.75

Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin. Sci Rep (2016) 0.75

Aβ Peptide Originated from Platelets Promises New Strategy in Anti-Alzheimer's Drug Development. Biomed Res Int (2017) 0.75

Articles cited by this

Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun (1984) 20.07

Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A (1985) 16.10

Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). N Engl J Med (1980) 9.38

Alzheimer's disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea. Science (1982) 5.42

Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants. Nature (1982) 4.93

Paired helical filaments in electron microscopy of Alzheimer's disease. Nature (1963) 4.62

X-ray diffraction studies on amyloid filaments. J Histochem Cytochem (1968) 4.54

Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins. Nature (1983) 3.67

THE FINE STRUCTURE OF NEUROFIBRILLARY TANGLES IN ALZHEIMER'S DISEASE. J Neuropathol Exp Neurol (1963) 3.14

"Cross-beta" conformation in proteins. J Mol Biol (1968) 2.83

Neurofibrillary tangles of paired helical filaments. J Neurol Sci (1976) 2.80

Neurofilament architecture combines structural principles of intermediate filaments with carboxy-terminal extensions increasing in size between triplet proteins. EMBO J (1983) 2.64

Ultrastructural morphology of amyloid fibrils from neuritic and amyloid plaques. Acta Neuropathol (1983) 2.23

Evidence for a repeating cross-beta sheet structure in the adenovirus fibre. EMBO J (1983) 2.09

Alzheimer's disease: immunoreactivity of neurofibrillary tangles with anti-neurofilament and anti-paired helical filament antibodies. Brain Res (1984) 1.98

Ultrastructure of paired helical filaments of Alzheimer's neurofibrillary tangle. J Neuropathol Exp Neurol (1984) 1.86

Characterization of the amyloid fibril as a cross-beta protein. Proc Soc Exp Biol Med (1969) 1.66

Brain transglutaminase: in vitro crosslinking of human neurofilament proteins into insoluble polymers. Proc Natl Acad Sci U S A (1982) 1.63

High-resolution electron microscopic analysis of the amyloid fibril in Alzheimer's disease. J Neuropathol Exp Neurol (1980) 1.59

The relation of the properties of Congo red-stained amyloid fibrils to the -conformation. J Histochem Cytochem (1972) 1.32

An immunoperoxidase study of senile cerebral amyloidosis with pathogenetic considerations. J Neuropathol Exp Neurol (1981) 1.22

The distal half of the tail fibre of bacteriophage T4. Rigidly linked domains and cross-beta structure. J Mol Biol (1979) 1.19

Structural similarities and differences amongst neurofilaments. J Mol Biol (1983) 1.08

Histogenesis of primary localized cutaneous amyloidosis: sequential change of epidermal keratinocytes to amyloid via filamentous degeneration. J Invest Dermatol (1979) 1.06

Cerebral amyloid angiopathy. Hum Pathol (1981) 1.02

Evidence that paired helical filaments originate from neurofilaments--electron microscope observations of neurites in senile plaques in the brain in Alzheimer's disease. Clin Neuropathol (1984) 0.97

Histogenesis of amyloid in the skin. Am J Dermatopathol (1980) 0.89

Articles by these authors

Making psychological theory useful for implementing evidence based practice: a consensus approach. Qual Saf Health Care (2005) 12.73

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature (1999) 8.28

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc Natl Acad Sci U S A (1986) 6.56

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature (1992) 6.51

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science (1990) 6.03

Alzheimer's disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea. Science (1982) 5.42

Clinically diagnosed Alzheimer's disease: autopsy results in 150 cases. Ann Neurol (1988) 4.76

On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants. Proc Natl Acad Sci U S A (1996) 4.75

Psychosocial correlates of heterosexual condom use: a meta-analysis. Psychol Bull (1999) 4.70

Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. J Biol Chem (1999) 4.64

Skeletal and CNS defects in Presenilin-1-deficient mice. Cell (1997) 4.50

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Science (2001) 4.18

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med (1997) 4.10

Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro. Proc Natl Acad Sci U S A (1987) 4.04

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J Neurosci (1999) 3.92

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem (1998) 3.77

Systemic inflammatory response syndrome after cardiac operations. Ann Thorac Surg (1996) 3.77

Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins. Nature (1983) 3.67

Kinetic theory of fibrillogenesis of amyloid beta-protein. Proc Natl Acad Sci U S A (1997) 3.40

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. Biochemistry (2000) 3.31

Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease. J Neurochem (1986) 3.31

Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease. Science (1987) 3.23

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature (1992) 3.22

Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science (2000) 3.16

A European evidence-based guideline for the prevention of type 2 diabetes. Horm Metab Res (2010) 3.15

Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell (1988) 3.11

Molecular determinants of amyloid deposition in Alzheimer's disease: conformational studies of synthetic beta-protein fragments. Biochemistry (1990) 2.93

Myelin membrane structure at 10 A resolution. Nat New Biol (1971) 2.92

Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell (1993) 2.89

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. Nat Cell Biol (2000) 2.84

Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science (1992) 2.82

Structure of beta-crystallite assemblies formed by Alzheimer beta-amyloid protein analogues: analysis by x-ray diffraction. Biophys J (1993) 2.77

Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture. J Biol Chem (1995) 2.68

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. J Biol Chem (1999) 2.57

Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochem Soc Trans (2002) 2.55

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiol Dis (1996) 2.50

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nat Med (1995) 2.44

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J Biol Chem (2001) 2.42

Impact of a theoretically based sex education programme (SHARE) delivered by teachers on NHS registered conceptions and terminations: final results of cluster randomised trial. BMJ (2006) 2.41

Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein. Biochemistry (1992) 2.36

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins. J Biol Chem (1997) 2.33

pH-dependent structural transitions of Alzheimer amyloid peptides. Biophys J (1991) 2.33

Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease. Ann Neurol (2000) 2.30

Mass spectrometry of purified amyloid beta protein in Alzheimer's disease. J Biol Chem (1992) 2.26

The seminal role of beta-amyloid in the pathogenesis of Alzheimer disease. Alzheimer Dis Assoc Disord (1992) 2.24

Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles. Proc Natl Acad Sci U S A (1984) 2.22

Structural analysis of Alzheimer's beta(1-40) amyloid: protofilament assembly of tubular fibrils. Biophys J (1998) 2.22

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci (2000) 2.22

Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease. Nature (1989) 2.04

India's physicians debate whether to go abroad or go private. CMAJ (1992) 2.02

beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms. J Biol Chem (1993) 2.01

Alzheimer's disease: immunoreactivity of neurofibrillary tangles with anti-neurofilament and anti-paired helical filament antibodies. Brain Res (1984) 1.98

Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein. Proc Natl Acad Sci U S A (1987) 1.98

Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease. Am J Pathol (1989) 1.95

Protein topology of presenilin 1. Neuron (1996) 1.94

Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue. Neurobiol Dis (1997) 1.92

Immunostaining of neurofibrillary tangles in Alzheimer's senile dementia with a neurofilament antiserum. J Neurosci (1982) 1.88

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology. Nat Med (1996) 1.86

The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention. Biochem Soc Trans (2005) 1.84

Permeability and residual plasma volume of human, Dutch variant, and rat amyloid beta-protein 1-40 at the blood-brain barrier. Neurobiol Dis (1997) 1.83

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch. J Biol Chem (1999) 1.82

Generation of amyloid beta protein from its precursor is sequence specific. Neuron (1995) 1.82

Gene dosage of the amyloid beta precursor protein in Alzheimer's disease. Science (1987) 1.81

alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins. Proc Natl Acad Sci U S A (2001) 1.80

Extent of regretted sexual intercourse among young teenagers in Scotland: a cross sectional survey. BMJ (2000) 1.79

Morphology and antibody recognition of synthetic beta-amyloid peptides. J Neurosci Res (1991) 1.77

The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid. Proc Natl Acad Sci U S A (1989) 1.73

Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin. Neuron (1994) 1.71

Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion. J Neurosci (1991) 1.70

Amyloid beta protein enhances the survival of hippocampal neurons in vitro. Science (1989) 1.69

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry (1999) 1.67

The origins of Alzheimer disease: a is for amyloid. JAMA (2000) 1.67

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. J Biol Chem (1998) 1.66

Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. J Biol Chem (1993) 1.64

Brain transglutaminase: in vitro crosslinking of human neurofilament proteins into insoluble polymers. Proc Natl Acad Sci U S A (1982) 1.63

Amyloid beta-peptide is transported on lipoproteins and albumin in human plasma. J Biol Chem (1996) 1.61

Protein chemical and immunocytochemical studies of meningovascular beta-amyloid protein in Alzheimer's disease and normal aging. Brain Res (1988) 1.59

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi. Biochemistry (1998) 1.57

An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments. Amyloid (2000) 1.56

Neurofibrillary tangles and senile plaques in aged bears. J Neuropathol Exp Neurol (1988) 1.56

Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody. J Cell Sci (1996) 1.56

Epidermal Langerhans cells promote skin allograft rejection in mice with NF-kappa B-impaired T cells. Am J Transplant (2007) 1.55

Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor. J Biol Chem (1994) 1.54

Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red. Biochemistry (1998) 1.54

Conformation and fibrillogenesis of Alzheimer A beta peptides with selected substitution of charged residues. J Mol Biol (1994) 1.52

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities. Proc Natl Acad Sci U S A (1996) 1.52

Why don't young people volunteer to give blood? An investigation of the correlates of donation intentions among young nondonors. Transfusion (2005) 1.51

Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons. J Cell Biol (1995) 1.51

Water diffusion, T(2), and compartmentation in frog sciatic nerve. Magn Reson Med (1999) 1.51

Accumulation of phosphorylated neurofilaments in anterior horn motoneurons of amyotrophic lateral sclerosis patients. J Neuropathol Exp Neurol (1988) 1.49

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease. Proc Natl Acad Sci U S A (1997) 1.48

X-ray diffraction of scrapie prion rods and PrP peptides. J Mol Biol (1995) 1.47

Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells. J Biol Chem (1997) 1.43

Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease. Am J Pathol (1991) 1.43

Altered structural proteins in plaques and tangles: what do they tell us about the biology of Alzheimer's disease? Neurobiol Aging (1987) 1.42