Ultrastructural patterns of RNA synthesis during early embryogenesis of Drosophila melanogaster.

PubWeight™: 3.89‹?› | Rank: Top 1%

🔗 View Article (PMID 822943)

Published in Cell on June 01, 1976

Authors

S L McKnight, O L Miller

Articles citing this

Monoclonal antibody characterization of the C proteins of heterogeneous nuclear ribonucleoprotein complexes in vertebrate cells. J Cell Biol (1984) 4.18

Characterization of heterogeneous nuclear RNA-protein complexes in vivo with monoclonal antibodies. Mol Cell Biol (1984) 4.11

Primary structure of human nuclear ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA, and pre-rRNA-binding proteins. Mol Cell Biol (1987) 3.91

Unmasking activation of the zygotic genome using chromosomal deletions in the Drosophila embryo. PLoS Biol (2007) 3.53

Isolation of the heterogeneous nuclear RNA-ribonucleoprotein complex (hnRNP): a unique supramolecular assembly. Proc Natl Acad Sci U S A (1984) 3.51

Nucleotide sequence of the initiation site for ribosomal RNA transcription in Drosophila melanogaster: comparison of genes with and without insertions. Proc Natl Acad Sci U S A (1981) 3.21

In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genes. Mol Cell Biol (2003) 2.88

A uridylate tract mediates efficient heterogeneous nuclear ribonucleoprotein C protein-RNA cross-linking and functionally substitutes for the downstream element of the polyadenylation signal. Mol Cell Biol (1990) 2.43

Structure of nuclear ribonucleoprotein: identification of proteins in contact with poly(A)+ heterogeneous nuclear RNA in living HeLa cells. J Cell Biol (1981) 2.42

Rat liver nuclear skeleton and ribonucleoprotein complexes containing HnRNA. J Cell Biol (1978) 2.36

Numbers and organization of RNA polymerases, nascent transcripts, and transcription units in HeLa nuclei. Mol Biol Cell (1998) 2.30

Electron microscopic study of Saccharomyces cerevisiae rDNA chromatin replication. Mol Cell Biol (1986) 2.29

Evidence that sisterless-a and sisterless-b are two of several discrete "numerator elements" of the X/A sex determination signal in Drosophila that switch Sxl between two alternative stable expression states. Genetics (1988) 2.24

Nontranscribed spacer sequences promote in vitro transcription of Drosophila ribosomal DNA. Nucleic Acids Res (1982) 2.19

Nonessential Sequences, Genes, and the Polytene Chromosome Bands of DROSOPHILA MELANOGASTER. Genetics (1978) 2.18

Genes transcribed at diverse rates have a similar conformation in chromatin. Proc Natl Acad Sci U S A (1977) 2.17

Deletion of a ribosomal ribonucleic acid operon in Escherichia coli. J Bacteriol (1980) 2.10

Arabidopsis histone deacetylase HDA6 is required for maintenance of transcriptional gene silencing and determines nuclear organization of rDNA repeats. Plant Cell (2004) 2.03

Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition. PLoS Genet (2011) 1.95

Regulated expression of genes injected into early Drosophila embryos. EMBO J (1984) 1.89

Tor pathway regulates Rrn3p-dependent recruitment of yeast RNA polymerase I to the promoter but does not participate in alteration of the number of active genes. Mol Biol Cell (2003) 1.89

The achaete-scute complex is expressed in neurogenic regions of Drosophila embryos. EMBO J (1987) 1.55

Transcription of the tandem array of ribosomal DNA in Drosophila melanogaster does not terminate at any fixed point. EMBO J (1986) 1.54

The rare transcripts of interrupted rRNA genes in Drosophila melanogaster are processed or degraded during synthesis. EMBO J (1984) 1.53

Asymmetric lateral distribution of unshielded phosphate groups in nucleosomal DNA and its role in DNA bending. Proc Natl Acad Sci U S A (1979) 1.49

rRNA gene silencing and nucleolar dominance: insights into a chromosome-scale epigenetic on/off switch. Biochim Biophys Acta (2007) 1.48

Sequence variation within the rRNA gene loci of 12 Drosophila species. Genome Res (2007) 1.43

Repression of the Drosophila fushi tarazu (ftz) segmentation gene. EMBO J (1991) 1.43

DNA associated with hyperacetylated histone is preferentially digested by DNase I. Nucleic Acids Res (1978) 1.40

Selective translational regulation of ribosomal protein gene expression during early development of Drosophila melanogaster. Mol Cell Biol (1985) 1.36

Two Drosophila melanogaster tropomyosin genes: structural and functional aspects. Mol Cell Biol (1986) 1.35

Coupling of zygotic transcription to mitotic control at the Drosophila mid-blastula transition. Development (2009) 1.34

Nuclear RNA-protein interactions and messenger RNA processing. J Cell Biol (1983) 1.33

Cell-type-specific nuclei purification from whole animals for genome-wide expression and chromatin profiling. Genome Res (2012) 1.32

Delays in anaphase initiation occur in individual nuclei of the syncytial Drosophila embryo. Mol Biol Cell (1993) 1.29

Reconstitution of nucleoprotein complexes with mammalian heterogeneous nuclear ribonucleoprotein (hnRNP) core proteins. J Cell Biol (1983) 1.28

Isolation and characterization of a Xenopus laevis C protein cDNA: structure and expression of a heterogeneous nuclear ribonucleoprotein core protein. Proc Natl Acad Sci U S A (1988) 1.28

Integration of Bombyx mori R2 sequences into the 28S ribosomal RNA genes of Drosophila melanogaster. Mol Cell Biol (2000) 1.19

Epigenetic regulation of retrotransposons within the nucleolus of Drosophila. Mol Cell Biol (2008) 1.18

The release of 40S hnRNP particles by brief digestion of HeLa nuclei with micrococcal nuclease. Nucleic Acids Res (1980) 1.16

Expression of ribosomal proteins during Drosophila early development. Proc Natl Acad Sci U S A (1980) 1.14

Chromatin structure and transcription of the R1- and R2-inserted rRNA genes of Drosophila melanogaster. Mol Cell Biol (2006) 1.14

Active RNA polymerase I is fixed within the nucleus of HeLa cells. EMBO J (1990) 1.13

Developmental regulation of bicoid mRNA stability is mediated by the first 43 nucleotides of the 3' untranslated region. Mol Cell Biol (1998) 1.12

Grainyhead and Zelda compete for binding to the promoters of the earliest-expressed Drosophila genes. Dev Biol (2010) 1.11

Nucleosome binding by the polymerase I transactivator upstream binding factor displaces linker histone H1. Mol Cell Biol (1997) 1.11

Genetics of 51D-52A, a region containing several maternal-effect genes and two maternal-specific transcripts in Drosophila. Genetics (1990) 1.09

Chromatin structure of a hyperactive secretory protein gene (in Balbiani ring 2) of Chironomus. EMBO J (1984) 1.09

Genetic modulation of RNA metabolism in Drosophilia. I. Increased rate of ribosomal RNA synthesis. Genetics (1977) 1.08

The pattern of R2 retrotransposon activity in natural populations of Drosophila simulans reflects the dynamic nature of the rDNA locus. PLoS Genet (2009) 1.06

Identification of early zygotic genes in the yellow fever mosquito Aedes aegypti and discovery of a motif involved in early zygotic genome activation. PLoS One (2012) 1.06

Drosophila maternal and embryo mRNAs transcribed from a single transcription unit use alternate combinations of exons. EMBO J (1984) 1.05

TOR-dependent reduction in the expression level of Rrn3p lowers the activity of the yeast RNA Pol I machinery, but does not account for the strong inhibition of rRNA production. Nucleic Acids Res (2010) 1.05

Tissue localization of Drosophila melanogaster insulin receptor transcripts during development. Mol Cell Biol (1988) 1.03

Visualization of Drosophila melanogaster chorion genes undergoing amplification. Mol Cell Biol (1988) 1.01

Analysis of autoregulation at the level of pre-mRNA splicing of the suppressor-of-white-apricot gene in Drosophila. Genetics (1994) 1.01

Invariant temporal order of replication of the four actin gene loci during the naturally synchronous mitotic cycles of Physarum polycephalum. Proc Natl Acad Sci U S A (1984) 1.00

Transcription of endogenous and exogenous R2 elements in the rRNA gene locus of Drosophila melanogaster. Mol Cell Biol (2003) 0.98

RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation. Gene (2011) 0.96

A RNA helix-destabilizing protein is a major component of Artemia salina nuclear ribonucleoproteins. Proc Natl Acad Sci U S A (1981) 0.96

Histone modification in early and late Drosophila embryos. Biochem J (1984) 0.95

Translational regulation of a specific gene during oogenesis and embryogenesis of Drosophila. Proc Natl Acad Sci U S A (1983) 0.95

Establishment of regions of genomic activity during the Drosophila maternal to zygotic transition. Elife (2014) 0.93

Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. Dev Biol (2012) 0.92

Primer RNA for DNA synthesis on single-stranded DNA template in a cell free system from Drosophila melanogaster embryos. Nucleic Acids Res (1983) 0.92

Transchip: single-molecule detection of transcriptional elongation complexes. Anal Biochem (2006) 0.91

Determinants of Drosophila fushi tarazu mRNA instability. Mol Cell Biol (1996) 0.91

The transcription elongation factor Spt5 influences transcription by RNA polymerase I positively and negatively. J Biol Chem (2011) 0.91

Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry. Mol Biol Cell (2012) 0.89

Maternal inheritance of transcripts from three Drosophila src-related genes. Nucleic Acids Res (1985) 0.88

Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development. Elife (2014) 0.87

The Drosophila melanogaster homologue of the Xeroderma pigmentosum D gene product is located in euchromatic regions and has a dynamic response to UV light-induced lesions in polytene chromosomes. Mol Biol Cell (1999) 0.87

Retrotransposition of R2 elements in somatic nuclei during the early development of Drosophila. Mob DNA (2011) 0.86

Nuclease sensitivity of active chromatin. Nucleic Acids Res (1980) 0.85

Specific regions of the intervening sequences of beta-globin RNA are resistant to nuclease in 50S heterogeneous nuclear RNA-protein complexes. Proc Natl Acad Sci U S A (1985) 0.84

Two Drosophila chorion genes terminate transcription in discrete regions near their poly(A) sites. EMBO J (1986) 0.84

The Reb1-homologue Ydr026c/Nsi1 is required for efficient RNA polymerase I termination in yeast. EMBO J (2012) 0.84

A population genetic model for the maintenance of R2 retrotransposons in rRNA gene loci. PLoS Genet (2013) 0.83

Abundance and distribution of RNA polymerase II in Arabidopsis interphase nuclei. J Exp Bot (2015) 0.82

Subnuclear fractionation by mild micrococcal-nuclease treatment of nuclei of different transcriptional activities causes a partition of expressed and non-expressed genes. Biochem J (1980) 0.81

Genomic clones coding for some of the initial genes expressed during Drosophila development. Proc Natl Acad Sci U S A (1982) 0.80

Specific regions of beta-globin RNA are resistant to nuclease digestion in RNA-protein complexes in chicken reticulocyte nuclei. Mol Cell Biol (1985) 0.80

Introns and gene expression: cellular constraints, transcriptional regulation, and evolutionary consequences. Bioessays (2014) 0.79

Developmental genetical analysis and molecular cloning of the abnormal oocyte gene of Drosophila melanogaster. Genetics (1995) 0.78

Chromatin structure of ribosomal RNA genes in dipterans and its relationship to the location of nucleolar organizers. PLoS One (2012) 0.78

The Regulation of rRNA Gene Transcription during Directed Differentiation of Human Embryonic Stem Cells. PLoS One (2016) 0.78

Concentrations of individual RNA sequences in polyadenylated nuclear and cytoplasmic RNA populations of Drosophila cells. Nucleic Acids Res (1980) 0.77

Transcription and tyranny in the nucleolus: the organization, activation, dominance and repression of ribosomal RNA genes. Arabidopsis Book (2002) 0.75

Integration, Regulation, and Long-Term Stability of R2 Retrotransposons. Microbiol Spectr (2015) 0.75

Family of developmentally regulated, maternally expressed Drosophila RNA species detected by a v-myc probe. Mol Cell Biol (1985) 0.75

Articles by these authors

The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science (1988) 27.01

Transcriptional control signals of a eukaryotic protein-coding gene. Science (1982) 25.38

Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region. Cell (1981) 12.73

Eukaryotic transcriptional regulatory proteins. Annu Rev Biochem (1989) 11.73

A conserved family of prolyl-4-hydroxylases that modify HIF. Science (2001) 11.50

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev (1991) 11.10

The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene. Nucleic Acids Res (1980) 9.96

Isolation of a recombinant copy of the gene encoding C/EBP. Genes Dev (1988) 9.11

Scissors-grip model for DNA recognition by a family of leucine zipper proteins. Science (1989) 8.98

Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression. Genes Dev (1988) 8.82

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev (1997) 8.51

In situ detection of sequence-specific DNA binding activity specified by a recombinant bacteriophage. Genes Dev (1988) 6.97

The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite. Science (1989) 6.46

Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev (1995) 6.03

Homologous recognition of a promoter domain common to the MSV LTR and the HSV tk gene. Cell (1986) 5.92

Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses. Genes Dev (1987) 5.86

CCAAT-enhancer binding protein: a component of a differentiation switch. Science (1991) 5.61

Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein. Genes Dev (1989) 5.51

The distal transcription signals of the herpesvirus tk gene share a common hexanucleotide control sequence. Cell (1984) 5.10

Functional relationships between transcriptional control signals of the thymidine kinase gene of herpes simplex virus. Cell (1982) 5.03

Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science (2001) 5.03

Convergence of Ets- and notch-related structural motifs in a heteromeric DNA binding complex. Science (1991) 4.98

An interleukin-4-induced transcription factor: IL-4 Stat. Science (1994) 4.71

CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells. Genes Dev (1989) 4.47

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev (1998) 4.11

Visualization of nucleolar genes. Science (1969) 3.99

NPAS2: an analog of clock operative in the mammalian forebrain. Science (2001) 3.88

Identification of Ets- and notch-related subunits in GA binding protein. Science (1991) 3.69

Evidence of DNA: protein interactions that mediate HSV-1 immediate early gene activation by VP16. Genes Dev (1988) 3.46

The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA. Science (1998) 3.38

Expression of the herpes thymidine kinase gene in Xenopus laevis oocytes: an assay for the study of deletion mutants constructed in vitro. Nucleic Acids Res (1980) 3.36

Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerization. Trends Biochem Sci (1991) 3.18

Visualization of bacterial genes in action. Science (1970) 3.18

Transcription of DNA injected into Xenopus oocytes is influenced by template topology. Nature (1983) 3.02

Morphological studies of transcription. Acta Endocrinol Suppl (Copenh) (1972) 2.81

A genetic approach to promoter recognition during trans induction of viral gene expression. Science (1986) 2.77

RNP particles at splice junction sequences on Drosophila chorion transcripts. Cell (1985) 2.69

Transcriptional and post-transcriptional controls establish the cascade of herpes simplex virus protein synthesis. J Mol Biol (1987) 2.47

tk Enzyme expression in differentiating muscle cells is regulated through an internal segment of the cellular tk gene. Mol Cell Biol (1984) 2.44

Cognate DNA binding specificity retained after leucine zipper exchange between GCN4 and C/EBP. Science (1989) 2.44

Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. Genes Dev (1992) 2.42

Electron microscopic study of Saccharomyces cerevisiae rDNA chromatin replication. Mol Cell Biol (1986) 2.29

Electron microscopic analysis of chromatin replication in the cellular blastoderm Drosophila melanogaster embryo. Cell (1977) 2.21

Identification of two polypeptide segments of CCAAT/enhancer-binding protein required for transcriptional activation of the serum albumin gene. Genes Dev (1990) 2.18

Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. Proc Natl Acad Sci U S A (1997) 2.15

Impaired cued and contextual memory in NPAS2-deficient mice. Science (2000) 2.14

Promoter domains required for expression of plasmid-borne copies of the herpes simplex virus thymidine kinase gene in virus-infected mouse fibroblasts and microinjected frog oocytes. Mol Cell Biol (1985) 2.09

Expression of a truncated viral trans-activator selectively impedes lytic infection by its cognate virus. Nature (1988) 2.06

Correlation of hnRNP structure and nascent transcript cleavage. Cell (1981) 2.06

Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells. Proc Natl Acad Sci U S A (1995) 2.03

Evidence of changes in protease sensitivity and subunit exchange rate on DNA binding by C/EBP. Science (1990) 1.95

Electron microscopic analysis of chromosome metabolism in the Drosophila melanogaster embryo. Cold Spring Harb Symp Quant Biol (1978) 1.93

Ribonucleoprotein structure in nascent hnRNA is nonrandom and sequence-dependent. Cell (1980) 1.93

Identification and purification of human Stat proteins activated in response to interleukin-2. Immunity (1995) 1.90

Reinforcing self-help group activities of welfare recipients. J Appl Behav Anal (1970) 1.89

rRNA transcription rate in Escherichia coli. J Bacteriol (1991) 1.86

The terminal balls characteristic of eukaryotic rRNA transcription units in chromatin spreads are rRNA processing complexes. Genes Dev (1993) 1.81

Components of a Stat recognition code: evidence for two layers of molecular selectivity. Immunity (1995) 1.77

Delineation of transcriptional control signals within the Moloney murine sarcoma virus long terminal repeat. Mol Cell Biol (1985) 1.77

Post-replicative nonribosomal transcription units in D. melanogaster embryos. Cell (1979) 1.64

Extrachromosomal nucleolar genes in amphibian oocytes. Genetics (1969) 1.64

Purification of a set of cellular polypeptides that bind to the purine-rich cis-regulatory element of herpes simplex virus immediate early genes. Genes Dev (1989) 1.61

Novel amplification and transcriptional activity of chorion genes in Drosophila melanogaster follicle cells. Cell (1983) 1.59

Electronmicroscopy of genetic activity. Annu Rev Biochem (1973) 1.56

Visualization of RNA synthesis on chromosomes. Int Rev Cytol (1972) 1.56

The rare transcripts of interrupted rRNA genes in Drosophila melanogaster are processed or degraded during synthesis. EMBO J (1984) 1.53

Transcription mapping of the Escherichia coli chromosome by electron microscopy. J Bacteriol (1989) 1.50

Genetic and physical analysis of the chicken tk gene. Mol Cell Biol (1984) 1.47

Management of major tracheobronchial injuries: a 28-year experience. Ann Thorac Surg (1998) 1.43

PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase. Proc Natl Acad Sci U S A (2001) 1.36

Visualization of ribosomal ribonucleic acid synthesis in a ribonuclease III-Deficient strain of Escherichia coli. J Bacteriol (1977) 1.25

Accurate transcription of cloned Xenopus rRNA genes by RNA polymerase I: demonstration by S1 nuclease mapping. Nucleic Acids Res (1982) 1.24

Phosphorylation of CCAAT-enhancer binding protein by protein kinase C attenuates site-selective DNA binding. J Biol Chem (1992) 1.23

Molecular and genetic characterization of GABP beta. Genes Dev (1994) 1.23

Structure and composition of peripheral nucleoli of salamander oocytes. Natl Cancer Inst Monogr (1966) 1.22

Identification and characterization of a mouse cell mutant defective in the intracellular transport of glycoproteins. J Cell Biol (1987) 1.21

Identification and characterization of an immunophilin expressed during the clonal expansion phase of adipocyte differentiation. Proc Natl Acad Sci U S A (1995) 1.19

Metazoan rDNA enhancer acts by making more genes transcriptionally active. J Cell Biol (1996) 1.18

Visualization of the major late R strand transcription unit of adenovirus serotype 2. J Mol Biol (1981) 1.17

Building better vasculature. Genes Dev (2001) 1.11

Coronary arterial bypass operations without antibiotic coverage. Chest (1979) 1.04

Alternate utilization of two regulatory domains within the Moloney murine sarcoma virus long terminal repeat. Mol Cell Biol (1985) 1.04

The nucleolus, chromosomes, and visualization of genetic activity. J Cell Biol (1981) 1.04

Visualization of Drosophila melanogaster chorion genes undergoing amplification. Mol Cell Biol (1988) 1.01

Fine structure of lampbrush chromosomes. Natl Cancer Inst Monogr (1965) 0.99

Visualization of the silk fibroin transcription unit and nascent silk fibroin molecules on polyribosomes of Bombyx mori. Prog Nucleic Acid Res Mol Biol (1976) 0.97

Portrait of a gene. J Cell Physiol (1969) 0.95

A stable mitochondrial DNA in Tetrahymena pyriformis. J Exp Zool (1965) 0.93

The yeast metabolic cycle: insights into the life of a eukaryotic cell. Cold Spring Harb Symp Quant Biol (2007) 0.92

Systemic availability of itraconazole in lung transplantation. Antimicrob Agents Chemother (1996) 0.90

Transcription of circular and linear DNAs in amphibian oocytes. Cold Spring Harb Symp Quant Biol (1983) 0.89

Constitutive transcriptional control signals of the herpes simplex virus tk gene. Cold Spring Harb Symp Quant Biol (1983) 0.89

Some ultrastructural aspects of genetic activity in eukaryotes. J Cell Sci Suppl (1984) 0.88

Regulation of adipose maturation and energy homeostasis. Curr Opin Cell Biol (1995) 0.87

Macronuclear cytology of synchronized Tetrahymena pyriformis. J Protozool (1966) 0.87