Published in Nucleic Acids Res on September 25, 1993
Type I restriction systems: sophisticated molecular machines (a legacy of Bertani and Weigle). Microbiol Mol Biol Rev (2000) 3.55
Type I restriction enzymes and their relatives. Nucleic Acids Res (2013) 1.54
The diversity of alleles at the hsd locus in natural populations of Escherichia coli. Genetics (1995) 1.53
Repercussions of DNA tracking by the type IC restriction endonuclease EcoR124I on linear, circular and catenated substrates. EMBO J (1996) 1.45
The complex methylome of the human gastric pathogen Helicobacter pylori. Nucleic Acids Res (2013) 1.25
Structure and operation of the DNA-translocating type I DNA restriction enzymes. Genes Dev (2012) 1.13
DNA-binding induces a major structural transition in a type I methyltransferase. EMBO J (1994) 1.10
A prediction of the amino acids and structures involved in DNA recognition by type I DNA restriction and modification enzymes. Nucleic Acids Res (1997) 1.03
Purification and characterisation of a novel DNA methyltransferase, M.AhdI. Nucleic Acids Res (2003) 1.02
The complete genome and phenome of a community-acquired Acinetobacter baumannii. PLoS One (2013) 0.97
Structural model for the multisubunit Type IC restriction-modification DNA methyltransferase M.EcoR124I in complex with DNA. Nucleic Acids Res (2006) 0.97
Comparative genomic analyses of attenuated strains of Mycoplasma gallisepticum. Infect Immun (2010) 0.96
Domain movement within a gene: a novel evolutionary mechanism for protein diversification. PLoS One (2011) 0.95
The specificity of sty SKI, a type I restriction enzyme, implies a structure with rotational symmetry. Nucleic Acids Res (1997) 0.95
Generation of new DNA binding specificity by truncation of the type IC EcoDXXI hsdS gene. EMBO J (1996) 0.90
Impact of target site distribution for Type I restriction enzymes on the evolution of methicillin-resistant Staphylococcus aureus (MRSA) populations. Nucleic Acids Res (2013) 0.88
A motif conserved among the type I restriction-modification enzymes and antirestriction proteins: a possible basis for mechanism of action of plasmid-encoded antirestriction functions. Nucleic Acids Res (1995) 0.86
Interaction of the type I methyltransferase M.EcoR124I with modified DNA substrates: sequence discrimination and base flipping. Biochem J (1998) 0.85
Structural and functional analysis of the engineered type I DNA methyltransferase EcoR124I(NT). J Mol Biol (2010) 0.84
Four new type I restriction enzymes identified in Escherichia coli clinical isolates. Nucleic Acids Res (2005) 0.82
The HsdR subunit of R.EcoR124II: cloning and over-expression of the gene and unexpected properties of the subunit. Nucleic Acids Res (1997) 0.82
Deletion of one nucleotide within the homonucleotide tract present in the hsdS gene alters the DNA sequence specificity of type I restriction-modification system NgoAV. J Bacteriol (2011) 0.80
Removal of a frameshift between the hsdM and hsdS genes of the EcoKI Type IA DNA restriction and modification system produces a new type of system and links the different families of Type I systems. Nucleic Acids Res (2012) 0.78
EcoR124I: from plasmid-encoded restriction-modification system to nanodevice. Microbiol Mol Biol Rev (2008) 0.77
DNA target recognition domains in the Type I restriction and modification systems of Staphylococcus aureus. Nucleic Acids Res (2017) 0.75
Comparative Methylome Analysis of the Occasional Ruminant Respiratory Pathogen Bibersteinia trehalosi. PLoS One (2016) 0.75
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. Gene (1977) 114.87
The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. Gene (1982) 102.30
Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. J Bacteriol (1978) 75.38
Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. Anal Biochem (1979) 22.03
pEMBL: a new family of single stranded plasmids. Nucleic Acids Res (1983) 19.19
Segregation of New Lysogenic Types during Growth of a Doubly Lysogenic Strain Derived from Escherichia Coli K12. Genetics (1954) 18.73
Vectors for selective expression of cloned DNAs by T7 RNA polymerase. Gene (1987) 17.98
DNA restriction enzyme from E. coli. Nature (1968) 10.98
Sequence diversity among related genes for recognition of specific targets in DNA molecules. J Mol Biol (1983) 10.16
Restriction and modification of DNA. Annu Rev Biochem (1972) 5.67
[Not Available]. Ann Inst Pasteur (Paris) (1954) 5.46
Complementation analysis of temperature-sensitive host specificity mutations in Escherichia coli. J Mol Biol (1970) 2.90
Recombination of constant and variable modules alters DNA sequence recognition by type IC restriction-modification enzymes. EMBO J (1992) 2.17
Basis for changes in DNA recognition by the EcoR124 and EcoR124/3 type I DNA restriction and modification enzymes. J Mol Biol (1989) 1.92
Reassortment of DNA recognition domains and the evolution of new specificities. Mol Microbiol (1987) 1.76
Structural homologies among type I restriction-modification systems. EMBO J (1982) 1.62
Two DNA recognition domains of the specificity polypeptides of a family of type I restriction enzymes. Proc Natl Acad Sci U S A (1986) 1.56
A hybrid recognition sequence in a recombinant restriction enzyme and the evolution of DNA sequence specificity. Nature (1985) 1.48
Purification and biochemical characterisation of the EcoR124 type I modification methylase. Nucleic Acids Res (1992) 1.48
Conservation of organization in the specificity polypeptides of two families of type I restriction enzymes. J Mol Biol (1989) 1.48
A specific complex between a restriction endonuclease and its DNA substrate. Proc Natl Acad Sci U S A (1970) 1.46
EcoA and EcoE: alternatives to the EcoK family of type I restriction and modification systems of Escherichia coli. J Mol Biol (1985) 1.44
DNA modification methylase activity of Escherichia coli restriction endonucleases K and P. Proc Natl Acad Sci U S A (1972) 1.43
Genetics of host-controlled restriction and modification in Escherichia coli. Genet Res (1969) 1.29
Two type I restriction enzymes from Salmonella species. Purification and DNA recognition sequences. J Mol Biol (1985) 1.17
A new method for random mutagenesis of complete genes: enzymatic generation of mutant libraries in vitro. Protein Eng (1988) 1.16
Increased protein flexibility leads to promiscuous protein--DNA interactions in type IC restriction-modification systems. EMBO J (1991) 1.15
EcoR124 and EcoR124/3: the first members of a new family of type I restriction and modification systems. Eur J Biochem (1987) 1.10
High-level expression of the cloned genes encoding the subunits of and intact DNA methyltransferase, M.EcoR124. Gene (1992) 1.10
ATP hydrolysis by restriction endonuclease from E. coli K. Nat New Biol (1972) 1.08
The EcoR124 and EcoR124/3 restriction and modification systems: cloning the genes. Plasmid (1985) 0.98
The EcoDXX1 restriction and modification system: cloning the genes and homology to type I restriction and modification systems. Plasmid (1989) 0.96
Mutation in the specificity polypeptide of the type I restriction endonuclease R.EcoK that affects subunit assembly. J Mol Biol (1992) 0.84
A mutation that converts serine340 of the HsdSK polypeptide to phenylalanine and its effects on restriction and modification in Escherichia coli K-12. Gene (1990) 0.81
TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis. Leukemia (2009) 4.53
Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates. Leukemia (2009) 3.49
Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML. Leukemia (2009) 3.23
Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major. Circulation (2009) 2.85
The rat mixed lymphocyte reaction: roles of a dendritic cell in intestinal lymph and T-cell subsets defined by monoclonal antibodies. Immunology (1981) 2.75
IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis. Leukemia (2010) 2.65
Potential availability of cadaver organs for transplantation. BMJ (1991) 2.56
The roles of host and donor cells in the rejection of skin allografts by T cell-deprived rats injected with syngeneic T cells. Eur J Immunol (1982) 2.48
Expression of interleukin 8 and CD54 by human gastric epithelium after Helicobacter pylori infection in vitro. Gastroenterology (1995) 2.48
Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial. Gut (2010) 2.47
Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway. Circulation (2000) 2.22
PHF6 mutations in adult acute myeloid leukemia. Leukemia (2010) 2.20
Herpes simplex virus gE/gI sorts nascent virions to epithelial cell junctions, promoting virus spread. J Virol (2001) 2.18
Heart transplantation for end-stage heart failure due to cardiac sarcoidosis. Transplant Proc (2013) 2.15
A novel myelin-associated glycoprotein defined by a mouse monoclonal antibody. J Neuroimmunol (1984) 2.09
The tongue flap in the primary treatment of cleft palate: a report of 19 cases. Br J Plast Surg (1992) 1.95
Basis for changes in DNA recognition by the EcoR124 and EcoR124/3 type I DNA restriction and modification enzymes. J Mol Biol (1989) 1.92
Development of an electrically stimulated neoanal sphincter. Lancet (1991) 1.91
Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms. Leukemia (2011) 1.88
Clinical characteristics of paediatric H1N1 admissions in Birmingham, UK. Lancet (2009) 1.87
Establishment of mouse colonic carcinoma cell lines with different metastatic properties. Cancer Res (1980) 1.87
The effete in the heat: heat-related hospital presentations during a ten day heat wave. Aust N Z J Med (1995) 1.83
Is blastocyst transfer useful as an alternative treatment for patients with multiple in vitro fertilization failures? Fertil Steril (1999) 1.76
Prediction of adult height from height and bone age in childhood. A new system of equations (TW Mark II) based on a sample including very tall and very short children. Arch Dis Child (1983) 1.69
Interrelationships between the utilization of magnesium and the uptake of other bivalent cations by bacteria. Biochim Biophys Acta (1970) 1.68
Functions of metallothionein. Biochem Pharmacol (1982) 1.66
Inhibition of mixed lymphocyte response by monoclonal antibody specific for a rat T lymphocyte subset. Nature (1980) 1.65
The utilization of magnesium by certain Gram-positive and Gram-negative bacteria. J Gen Microbiol (1966) 1.65
Cadmium-thionein and the protection by cadmium against the nephrotoxicity of mercury. Chem Biol Interact (1976) 1.56
Randomized, double-blinded, placebo-controlled study of effect of wheat bran fiber and calcium on fecal bile acids in patients with resected adenomatous colon polyps. J Natl Cancer Inst (1996) 1.51
Non-spindle microtubule organizing centers in metaphase II-arrested mouse oocytes. J Cell Biol (1985) 1.50
Purification and biochemical characterisation of the EcoR124 type I modification methylase. Nucleic Acids Res (1992) 1.48
Plastic surgeon as an ostrich in the surgical treatment of cleft palate. Plast Reconstr Surg (1992) 1.47
Sleep patterns in intensive care unit patients: a study using the bispectral index. Crit Care Resusc (2001) 1.46
Mechanism of polar body formation in the mouse oocyte: an interaction between the chromosomes, the cytoskeleton and the plasma membrane. J Embryol Exp Morphol (1986) 1.45
Repercussions of DNA tracking by the type IC restriction endonuclease EcoR124I on linear, circular and catenated substrates. EMBO J (1996) 1.45
Serum paraoxonase after myocardial infarction. Arterioscler Thromb Vasc Biol (1999) 1.42
Candida blastospores and pseudohyphae in blood smears. N Engl J Med (1971) 1.42
Serine protease inhibitor-6 differentially affects the survival of effector and memory alloreactive CD8-T cells. Am J Transplant (2015) 1.41
Characterization of peripheral-type benzodiazepine binding sites in brain using [3H]Ro 5-4864. Mol Pharmacol (1982) 1.38
An audit of out of hours interventional vascular radiology. Eur J Vasc Endovasc Surg (2003) 1.38
First admission incidence study of mania, 1975-1981. Br J Psychiatry (1995) 1.38
Post placement. Br Dent J (2013) 1.38
Efficacy of a novel PEGylated humanized anti-TNF fragment (CDP870) in patients with rheumatoid arthritis: a phase II double-blinded, randomized, dose-escalating trial. Rheumatology (Oxford) (2002) 1.37
The type I restriction endonuclease R.EcoR124I: over-production and biochemical properties. J Mol Biol (1996) 1.36
Vimentin: an evaluation of its role as a tumour marker. Histopathology (1987) 1.36
Analysis of the subunit assembly of the typeIC restriction-modification enzyme EcoR124I. Nucleic Acids Res (1998) 1.36
Accuracy of results obtained by performing a second ligase chain reaction assay and PCR analysis on urine samples with positive or near-cutoff results in the LCx test for Chlamydia trachomatis. J Clin Microbiol (2002) 1.35
Pharmacological differences between the human and rat vanilloid receptor 1 (VR1). Br J Pharmacol (2001) 1.35
Calcium-dependent enhancement of depletion-activated calcium current in Jurkat T lymphocytes. J Membr Biol (1996) 1.35
Gunshot injuries to the extremities: experience of a U.K. trauma centre. Injury (2005) 1.35
Pooling cervical swabs and testing by ligase chain reaction are accurate and cost-saving strategies for diagnosis of Chlamydia trachomatis. J Clin Microbiol (2000) 1.34
Binding of cadmium ions by rat liver and kidney. Biochem Pharmacol (1972) 1.32
Sudden cardiac death and antipsychotic drugs: do we know enough? Arch Gen Psychiatry (2001) 1.32
Selection of non-specific DNA cleavage sites by the type IC restriction endonuclease EcoR124I. J Mol Biol (1997) 1.25
Phorbol esters induce multidrug resistance in human breast cancer cells. Proc Natl Acad Sci U S A (1988) 1.24
Phorbol esters inhibit agonist-induced [3H] inositol-1-phosphate accumulation in rat hippocampal slices. Biochem Biophys Res Commun (1984) 1.24
The interactions of selenium with cadmium and mercury. Crit Rev Toxicol (1980) 1.23
The influence of certain trace metals on bacterial growth and magnesium utilization. J Gen Microbiol (1968) 1.21
Tumour regression and ERCC1 nuclear protein expression predict clinical outcome in patients with gastro-oesophageal cancer treated with neoadjuvant chemotherapy. Br J Cancer (2010) 1.19
Identification, characterization, and functional correlation of calmodulin-dependent protein phosphatase in sperm. J Cell Biol (1988) 1.19
Female twin with Hunter disease due to nonrandom inactivation of the X-chromosome: a consequence of twinning. Am J Med Genet (1992) 1.18
Variations in sialomucins in the mucosa of the large intestine in malignancy: a quantimet and statistical analysis. Histochem J (1978) 1.18
The most commonly reported variant in ASXL1 (c.1934dupG;p.Gly646TrpfsX12) is not a somatic alteration. Leukemia (2010) 1.18
Orthotopic liver transplantation for benign hepatic neoplasms. Arch Surg (1995) 1.17
Enhanced diagnosis of HIV-1-associated tuberculosis by relating T-SPOT.TB and CD4 counts. Eur Respir J (2010) 1.17
Content and intracellular distribution of the inducing metal in the primary rhabdomyosarcomata induced in the rat by cobalt, nickel and cadmium. Br J Cancer (1967) 1.17
Clinical, psychiatric and manometric profile of cyclic vomiting syndrome in adults and response to tricyclic therapy. Neurogastroenterol Motil (2007) 1.17
Aberrant neurofilament phosphorylation in sensory neurons of rats with diabetic neuropathy. Diabetes (1999) 1.16
Treatment options and recurrence potential for cystosarcoma phyllodes. Surg Gynecol Obstet (1990) 1.15
Localisation of the MRC OX-2 glycoprotein on the surfaces of neurones. J Neurochem (1984) 1.14
Separation and quantification of ropinirole and some impurities using capillary liquid chromatography. J Chromatogr B Biomed Sci Appl (1999) 1.13
Epigenetic inactivation of the tissue inhibitor of metalloproteinase-2 (TIMP-2) gene in human prostate tumors. Oncogene (2007) 1.13
Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine. Genomics (2001) 1.11
Induced synthesis of metallothionein by pig kidney cells in vitro in response to cadmium. Chem Biol Interact (1975) 1.10
High-level expression of the cloned genes encoding the subunits of and intact DNA methyltransferase, M.EcoR124. Gene (1992) 1.10
Protein-protein and protein-DNA interactions in the type I restriction endonuclease R.EcoR124I. Biol Chem (1998) 1.10
Mechanical and structural properties underlying contraction of skeletal muscle fibers after partial 1-ethyl-3-[3-dimethylamino)propyl]carbodiimide cross-linking. Biophys J (1996) 1.09
Axillary lymph node metastasis from an occult breast cancer. Cancer (1981) 1.09
The impact on accuracy and cost of ligase chain reaction testing by pooling urine specimens for the diagnosis of Chlamydia trachomatis infections. Sex Transm Dis (1999) 1.07
Phorbol ester causes desensitization of gonadotropin-responsive adenylate cyclase in a murine Leydig tumor cell line. J Biol Chem (1985) 1.07
Targeting apoptosis in prostate cancer. Hematol Oncol Clin North Am (2001) 1.06
Lactic acid is the factor in blood cell extracts which enhances the ability of CMP-NANA to sialylate gonococcal lipopolysaccharide and induce serum resistance. Microb Pathog (1996) 1.06
Protection by zinc against cadmium toxicity. Biochem Pharmacol (1972) 1.04
Nomenclature of metallothionein. Experientia Suppl (1987) 1.04
The thermoluminescence response of doped SiO2 optical fibres subjected to photon and electron irradiations. Appl Radiat Isot (2008) 1.04
The discrimination of dyslipidaemia using anthropometric measures in ethnically diverse populations of the Asia-Pacific Region: the Obesity in Asia Collaboration. Obes Rev (2009) 1.04
Leukocyte-derived interferon (alpha) in human breast carcinoma. The American Cancer Society phase II trial. Ann Intern Med (1982) 1.03
Preservation of splenic function by autotransplantation of traumatized spleen in man. Surgery (1981) 1.03
Electroconvulsive therapy (ECT) increases plasma growth hormone, prolactin, luteinising hormone and follicle-stimulating hormone but not thyrotropin or substance P. Psychoneuroendocrinology (1981) 1.02
Chronic caffeine consumption increases the number of brain adenosine receptors. Life Sci (1983) 1.02
Remission onset and relapse in depression. An 18-month prospective study of course for 100 first admission patients. J Affect Disord (2000) 1.01
Plasminogen activator activity and composition in human breast cancer. Cancer Res (1982) 1.01
Respiratory syncytial virus infection and the immunocompromised host. Pediatr Infect Dis J (1988) 1.00
Deletions within the DNA recognition subunit of M.EcoR124I that identify a region involved in protein-protein interactions between HsdS and HsdM. J Mol Biol (1994) 0.99