Role of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats.

PubWeight™: 1.75‹?› | Rank: Top 3%

🔗 View Article (PMC 1374252)

Published in Gut on June 01, 1993

Authors

T Yoshikawa1, Y Naito, A Kishi, T Tomii, T Kaneko, S Iinuma, H Ichikawa, M Yasuda, S Takahashi, M Kondo

Author Affiliations

1: First Department of Medicine, Kyoto Prefectural University of Medicine, Japan.

Articles citing this

Lung inflammatory response syndrome after cardiac-operations and treatment of lornoxicam. J Thorac Dis (2014) 1.40

Signal transduction pathways involved in oxidative stress-induced intestinal epithelial cell apoptosis. Pediatr Res (2005) 1.23

Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs. J Hematol Oncol (2009) 1.12

Protective effect of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats. Dig Dis Sci (2001) 1.11

A novel antiulcerogenic stable radical prevents gastric mucosal lesions in rats. Gut (1994) 0.97

Antioxidant action of mangrove polyphenols against gastric damage induced by absolute ethanol and ischemia-reperfusion in the rat. ScientificWorldJournal (2012) 0.95

Gastroprotective effect of desmosdumotin C isolated from Mitrella kentii against ethanol-induced gastric mucosal hemorrhage in rats: possible involvement of glutathione, heat-shock protein-70, sulfhydryl compounds, nitric oxide, and anti-Helicobacter pylori activity. BMC Complement Altern Med (2013) 0.93

Tissue expression and cellular localization of phospholipid hydroperoxide glutathione peroxidase (PHGPx) mRNA in male mice. J Mol Histol (2007) 0.90

Effects of polaprezinc on lipid peroxidation, neutrophil accumulation, and TNF-alpha expression in rats with aspirin-induced gastric mucosal injury. Dig Dis Sci (2001) 0.89

Transcriptome Analysis for Cytoprotective Actions of Rebamipide against Indomethacin-Induced Gastric Mucosal Injury in Rats. J Clin Biochem Nutr (2007) 0.89

Rebamipide reduces indomethacin-induced gastric injury in mice via down-regulation of ICAM-1 expression. Dig Dis Sci (2005) 0.88

Helicobacter pylori infection potentiates aspirin induced gastric mucosal injury in Mongolian gerbils. Gut (2002) 0.88

Black tea and theaflavins assist healing of indomethacin-induced gastric ulceration in mice by antioxidative action. Evid Based Complement Alternat Med (2010) 0.87

Effect of allopurinol, sulphasalazine, and vitamin C on aspirin induced gastroduodenal injury in human volunteers. Gut (1996) 0.87

The gastroprotective effect of menthol: involvement of anti-apoptotic, antioxidant and anti-inflammatory activities. PLoS One (2014) 0.86

Lansoprazole inhibits mitochondrial superoxide production and cellular lipid peroxidation induced by indomethacin in RGM1 cells. J Clin Biochem Nutr (2011) 0.85

Antioxidant activity of ethanol extract of rhizome ofPicrorhiza kurroa on indomethacin induced gastric ulcer during healing. Indian J Clin Biochem (2002) 0.85

Biphasic Effect of Phyllanthus emblica L. Extract on NSAID-Induced Ulcer: An Antioxidative Trail Weaved with Immunomodulatory Effect. Evid Based Complement Alternat Med (2010) 0.85

Effects of esomeprazole on glutathione levels and mitochondrial oxidative phosphorylation in the gastric mucosa of rats treated with indomethacin. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.85

Attenuation of gastric mucosal inflammation induced by aspirin through activation of A2A adenosine receptor in rats. World J Gastroenterol (2006) 0.84

Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats. World J Gastroenterol (2008) 0.83

Effects of dipyrone on inflammatory infiltration and oxidative metabolism in gastric mucosa: comparison with acetaminophen and diclofenac. Dig Dis Sci (2002) 0.83

Cellular membrane fluidity measurement by fluorescence polarization in indomethacin-induced gastric cellular injury in vitro. J Gastroenterol (2007) 0.83

Antioxidant effect ofPhyllanthus emblica fruits on healing of indomethacin induced gastric ulcer in rats. Indian J Clin Biochem (2003) 0.82

Effect of some natural products either alone or in combination on gastritis induced in experimental rats. Dig Dis Sci (2008) 0.81

Neutrophil accumulation in development gastric ulcer induced by submucosal injection of endothelin-1 in rats. Dig Dis Sci (2000) 0.81

Prevention by rebamipide of acute reflux esophagitis in rats. Dig Dis Sci (2005) 0.81

Effects of Rhizophora mangle on Experimental Colitis Induced by TNBS in Rats. Evid Based Complement Alternat Med (2012) 0.81

Effect of vitamin E on aspirin-induced gastric mucosal injury in rats. Dig Dis Sci (2000) 0.80

Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats. J Gastroenterol (2009) 0.80

Healing potential of Picrorhiza kurroa (Scrofulariaceae) rhizomes against indomethacin-induced gastric ulceration: a mechanistic exploration. BMC Complement Altern Med (2008) 0.80

Gastroprotective bio-guiding study of fruits from Mimusops balata. Naunyn Schmiedebergs Arch Pharmacol (2015) 0.79

Therapeutic effect of DA-9601 on chronic reflux gastritis induced by sodium taurocholate in rats. World J Gastroenterol (2005) 0.79

Low-Level Laser Therapy (LLLT) in Dystrophin-Deficient Muscle Cells: Effects on Regeneration Capacity, Inflammation Response and Oxidative Stress. PLoS One (2015) 0.79

Protective effect of 3,4-methylenedioxyphenol (sesamol) on stress-related mucosal disease in rats. Biomed Res Int (2013) 0.79

Gastroprotective Effects of Glutinous Rice Extract against Ethanol-, Indomethacin-, and Stress-induced Ulcers in Rats. Chonnam Med J (2014) 0.79

Rolipram, a specific type IV phosphodiesterase inhibitor, ameliorates aspirin-induced gastric mucosal injury in rats. Dig Dis Sci (2005) 0.78

Gastric toxicity of racemic ketoprofen and its enantiomers in rat: oxygen radical generation and COX-expression. Inflamm Res (2002) 0.78

Healing, antioxidant and cytoprotective properties of Indigofera truxillensis in different models of gastric ulcer in rats. Int J Mol Sci (2012) 0.78

Inhibitory effect of fluvastatin on ileal ulcer formation in rats induced by nonsteroidal antiinflammatory drug. World J Gastroenterol (2005) 0.78

Effects of esomeprazole magnesium on nonsteroidal anti-inflammatory drug gastropathy. Dig Dis Sci (2005) 0.78

Hydrogen potassium adenosine triphosphatase activity inhibition and downregulation of its expression by bioactive fraction DLBS2411 from Cinnamomum burmannii in gastric parietal cells. Int J Gen Med (2013) 0.77

Attenuation of gastric mucosal inflammation induced by aspirin through inhibition of selective type III phospshodiesterase in rats. Dig Dis Sci (2007) 0.77

Gastroprotective effect of Cochinchina momordica seed extract in nonsteroidal anti-inflammatory drug-induced acute gastric damage in a rat model. Gut Liver (2013) 0.77

Diclofenac-induced gastric mucosal fluorescence in rats. Dig Dis Sci (2001) 0.77

Mechanisms involved in the attenuation of intestinal toxicity induced by (S)-(+)-ketoprofen in re-fed rats. Dig Dis Sci (2002) 0.77

Effect of ECQ on Iodoacetamide-Induced Chronic Gastritis in Rats. Korean J Physiol Pharmacol (2013) 0.77

Comparison of Indomethacin, Diclofenac and Aspirin-Induced Gastric Damage according to Age in Rats. Gut Liver (2012) 0.77

Polysaccharide-rich fraction of Termitomyces eurhizus accelerate healing of indomethacin induced gastric ulcer in mice. Glycoconj J (2013) 0.77

Investigation of antiulcer and antioxidant activity of moclobemide in rats. Eurasian J Med (2015) 0.76

Attenuation of indomethacin-induced gastric mucosal injury by prophylactic administration of sake yeast-derived thioredoxin. J Gastroenterol (2012) 0.76

Effect of Cinnamomum zeylanicumon on Spermatogenesis. Iran Red Crescent Med J (2015) 0.76

Protective Effects of Simvastatin Against Alendronate-Induced Gastric Mucosal Injury in Rats. Dig Dis Sci (2015) 0.76

Effects of rebamipide, a novel anti-ulcer agent, on gastric mucosal injury induced by platelet-activating factor in rats. Dig Dis Sci (1997) 0.75

The Gastroprotective Effect of Vitex pubescens Leaf Extract against Ethanol-Provoked Gastric Mucosal Damage in Sprague-Dawley Rats. PLoS One (2016) 0.75

Biochemical mechanism of healing activity of the natural phenolic, allylpyrocatechol against indomethacin-induced gastric ulceration in mice. Dig Dis Sci (2008) 0.75

Morphologic and pharmacological investigations in the epicatechin gastroprotective effect. Evid Based Complement Alternat Med (2012) 0.75

The gastroprotective effect of pogostone from Pogostemonis Herba against indomethacin-induced gastric ulcer in rats. Exp Biol Med (Maywood) (2015) 0.75

The protective effect of aged garlic extract on nonsteroidal anti-inflammatory drug-induced gastric inflammations in male albino rats. Evid Based Complement Alternat Med (2014) 0.75

Benzimidazole derivatives: search for GI-friendly anti-inflammatory analgesic agents. Acta Pharm Sin B (2015) 0.75

Protective effect of hydro-alcoholic extract of Ruta graveolens Linn. leaves on indomethacin and pylorus ligation-induced gastric ulcer in rats. J Ayurveda Integr Med (2016) 0.75

Antiulcerogenic Activity and Toxicity of Bauhinia holophylla Hydroalcoholic Extract. Evid Based Complement Alternat Med (2015) 0.75

Royal Jelly and its dual role in TNBS colitis in mice. ScientificWorldJournal (2015) 0.75

Role of active oxygen species and lipid peroxidation in mepirizole-induced duodenal ulcers in rats. Dig Dis Sci (1998) 0.75

Dual Alpha2C/5HT1A Receptor Agonist Allyphenyline Induces Gastroprotection and Inhibits Fundic and Colonic Contractility. Dig Dis Sci (2016) 0.75

Articles cited by this

Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem (1979) 41.65

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem (1980) 10.52

A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med (1976) 4.28

Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Clin Chem (1973) 3.69

Toward an epidemiology of gastropathy associated with nonsteroidal antiinflammatory drug use. Gastroenterology (1989) 3.60

Lipid peroxidation damage to cell components. Fed Proc (1973) 2.93

Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. Am J Physiol (1990) 2.36

Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat. Gastroenterology (1981) 2.13

A monoclonal antibody against the CD18 leukocyte adhesion molecule prevents indomethacin-induced gastric damage in the rabbit. Gastroenterology (1991) 1.97

Superoxide mediates reperfusion-induced leukocyte-endothelial cell interactions. Am J Physiol (1989) 1.65

Lipid peroxidation and cellular damage in toxic liver injury. Lab Invest (1985) 1.64

Role of oxygen-derived free radicals in hemorrhagic shock-induced gastric lesions in the rat. Gastroenterology (1985) 1.38

Role of oxygen radicals in ischemia-induced lesions in the cat stomach. Gastroenterology (1986) 1.26

Role of oxygen-derived free radicals in gastric mucosal injury induced by ischemia or ischemia-reperfusion in rats. Free Radic Res Commun (1989) 1.18

The production of acute gastric ulceration by indomethacin in the rat. Scand J Gastroenterol (1969) 1.15

Mechanistic aspects of enhanced lipid peroxidation following glutathione depletion in vivo. Chem Biol Interact (1981) 1.13

Relationship of gastric mucosal damage induced in pigs by antiinflammatory drugs to their effects on prostaglandin production. Dig Dis Sci (1982) 1.11

Importance of gastric motility in the pathogenesis of indomethacin-induced gastric lesions in rats. Dig Dis Sci (1986) 1.10

Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in rat. Gastroenterology (1983) 1.08

High concentrations of glutathione in glandular stomach: possible implications for carcinogenesis. Science (1979) 1.08

Oxidative hemolysis of erythrocytes and its inhibition by free radical scavengers. J Biol Chem (1988) 1.04

Protective role of intracellular glutathione against ethanol-induced damage in cultured rat gastric mucosal cells. Gastroenterology (1990) 0.98

Nonsteroidal anti-inflammatory drugs inhibit gastric peroxidase activity. Biochim Biophys Acta (1990) 0.97

Gastric motility is an important factor in the pathogenesis of indomethacin-induced gastric mucosal lesions in rats. Dig Dis Sci (1988) 0.96

Increased microvascular permeability and lesion formation during gastric hypermotility caused by indomethacin and 2-deoxy-D-glucose in the rat. J Clin Gastroenterol (1990) 0.96

Role of superoxide and hydroxyl radicals in rat gastric mucosal injury induced by ethanol. Gastroenterol Jpn (1989) 0.93

Gastric glutathione depletion and acute ulcerogenesis by diethylmaleate given subcutaneously to rats. Life Sci (1981) 0.92

Vitamin E in gastric mucosal injury induced by ischemia-reperfusion. Am J Clin Nutr (1991) 0.89

Dimethylsulfoxide prevents chemoattractant-induced leukocyte adherence. Am J Physiol (1989) 0.87

A highly sensitive method for determining both Mn- and Cu-Zn superoxide dismutase activities in tissues and blood cells. Anal Biochem (1990) 0.84

Action of histamine and 3-isobutyl-1-methylxanthine on cAMP activation of protein kinase in dog gastric mucosa. Agents Actions (1983) 0.83

Quantitative determination of tocopherols by high-speed liquid chromatography. J Nutr Sci Vitaminol (Tokyo) (1975) 0.80

Dimethylsulfoxide protection against gastric stress ulceration. Curr Surg (1984) 0.80

Effect of indomethacin, tiaprofenic acid and dicrofenac on rat gastric mucosal damage and content of prostacyclin and prostaglandin E2. Prostaglandins (1985) 0.78

Articles by these authors

Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions. DNA Res (1996) 28.37

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun (1997) 14.09

Ecology of Vibrio parahaemolyticus in Chesapeake Bay. J Bacteriol (1973) 11.24

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem (2000) 5.75

Nrl is required for rod photoreceptor development. Nat Genet (2001) 5.68

Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA (2005) 5.60

SCE-129, antipseudomonal cephalosporin: in vitro and in vivo antibacterial activities. Antimicrob Agents Chemother (1978) 5.24

Rapid procedure for isolation of plasmid DNA and application to epidemiological analysis. J Clin Microbiol (1984) 5.09

Observation of the spin Seebeck effect. Nature (2008) 4.90

Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res (1995) 4.52

Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm (2000) 4.52

Adsorption of Vibrio parahaemolyticus onto chitin and copepods. Appl Microbiol (1975) 4.43

Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120. DNA Res (2001) 4.27

Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell (1997) 4.18

Reactivated triton-extracted models o paramecium: modification of ciliary movement by calcium ions. Science (1972) 4.18

Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. J Natl Cancer Inst (2001) 4.14

Transmission of electrical signals by spin-wave interconversion in a magnetic insulator. Nature (2010) 4.10

SCE-963, a new broad-spectrum cephalosporin: in vitro and in vivo antibacterial activities. Antimicrob Agents Chemother (1978) 4.06

Identification of the heme compound copurified with deoxyribonucleic acid (DNA) from bloodstains, a major inhibitor of polymerase chain reaction (PCR) amplification. J Forensic Sci (1994) 4.02

The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol (2007) 3.81

Proliferative activity of intratumoral CD8(+) T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity. Cancer Res (2001) 3.51

Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A. J Virol (1995) 3.41

Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1. Dev Cell (2001) 3.29

Agar-like polysaccharide produced by a pseudomonas species: production and basic properties. Appl Environ Microbiol (1982) 3.28

Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases. Ann Oncol (2011) 3.07

Base-change mutagenesis and prophage induction in strains of Escherichia coli with different DNA repair capacities. Genetics (1970) 3.05

Cefmenoxime (SCE-1365), a novel broad-spectrum cephalosporin: in vitro and in vivo antibacterial activities. Antimicrob Agents Chemother (1981) 3.03

Spin Seebeck insulator. Nat Mater (2010) 3.01

Nrf2-deficient female mice develop lupus-like autoimmune nephritis. Kidney Int (2001) 2.90

Room-temperature reversible spin Hall effect. Phys Rev Lett (2007) 2.80

CSF hypovolemia vs intracranial hypotension in "spontaneous intracranial hypotension syndrome". Neurology (2003) 2.79

2,4-Dichlorophenoxybutyric acid-resistant mutants of Arabidopsis have defects in glyoxysomal fatty acid beta-oxidation. Plant Cell (1998) 2.79

Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing. J Virol (1995) 2.76

Diffusion-weighted MRI abnormalities as an early diagnostic marker for Creutzfeldt-Jakob disease. Neurology (2004) 2.76

Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex. Neuron (1998) 2.73

Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes Cells (1997) 2.72

Biological and Immunological Properties of Encapsulated Strains of Staphylococcus aureus from Human Sources. Infect Immun (1970) 2.68

Complete structure of the chloroplast genome of Arabidopsis thaliana. DNA Res (1999) 2.63

TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. Mol Cell Biol (1990) 2.60

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins (1994) 2.60

DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae. Antimicrob Agents Chemother (1995) 2.57

Expression of the Fas ligand in cells of T cell lineage. J Immunol (1995) 2.54

Deoxyribonucleic acid relatedness between Bacillus anthracis, Bacillus cereus and Bacillus thuringiensis. Microbiol Immunol (1978) 2.52

The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Annu Rev Immunol (1996) 2.50

Fragmin: a calcium ion sensitive regulatory factor on the formation of actin filaments. Biochemistry (1980) 2.48

Distribution of Vibrio parahaemolyticus and related organisms in the Atlantic Ocean off South Carolina and Georgia. Appl Microbiol (1974) 2.45

Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles. Antimicrob Agents Chemother (1996) 2.42

Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust. Toxicol Appl Pharmacol (2001) 2.40

The COOH terminus of Rho-kinase negatively regulates rho-kinase activity. J Biol Chem (1999) 2.32

Subunit structure of Q-beta replicase. Nature (1970) 2.30

Submillisecond protein folding kinetics studied by ultrarapid mixing. Proc Natl Acad Sci U S A (1997) 2.29

A new technique for monitoring the behaviour of free-ranging Adélie penguins. J Exp Biol (2001) 2.24

Requirements for the solubilization of immune aggregates by complement. The role of the classical pathway. J Clin Invest (1978) 2.24

P23H rhodopsin transgenic rat: correlation of retinal function with histopathology. Invest Ophthalmol Vis Sci (2000) 2.23

Establishment of human peripheral lung epithelial cell lines (HPL1) retaining differentiated characteristics and responsiveness to epidermal growth factor, hepatocyte growth factor, and transforming growth factor beta1. Cancer Res (1997) 2.22

Normal and abnormal development of human embryos: first report of the analysis of 1,213 intact embryos. Teratology (1968) 2.20

Overexpression of cyclooxygenase-2 in carcinoma of the pancreas. Clin Cancer Res (1999) 2.20

A detailed linkage map of medaka, Oryzias latipes: comparative genomics and genome evolution. Genetics (2000) 2.19

Solubilization of antigen-antibody complexes: a new function of complement as a regulator of immune reactions. Prog Allergy (1980) 2.19

Sporulation regulatory protein GerE from Bacillus subtilis binds to and can activate or repress transcription from promoters for mother-cell-specific genes. J Mol Biol (1992) 2.19

Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Nature (2000) 2.17

Letter: Two beta-lactamase inhibitors produced by a streptomyces. J Antibiot (Tokyo) (1973) 2.16

Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Nature (2000) 2.16

CyanoBase, a www database containing the complete nucleotide sequence of the genome of Synechocystis sp. strain PCC6803. Nucleic Acids Res (1998) 2.15

Penguin-mounted cameras glimpse underwater group behaviour. Proc Biol Sci (2004) 2.15

Chemical and electron microscope studies on fractions prepared from coats of Bacillus spores. J Gen Microbiol (1967) 2.14

Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function. Science (1997) 2.13

NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus. Mol Cell Biol (1995) 2.13

Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast. EMBO J (2001) 2.13

Buoyancy and maximal diving depth in penguins: do they control inhaling air volume? J Exp Biol (2002) 2.12

Low carbohydrate intake before oral glucose-tolerance tests. Lancet (1998) 2.11

Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. J Biol Chem (1999) 2.09

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o) Nature (1993) 2.08

Randomised clinical trial: rabeprazole improves symptoms in patients with functional dyspepsia in Japan. Aliment Pharmacol Ther (2013) 2.08

Incidence of Vibrio parahaemolyticus in Chesapeake Bay. Appl Microbiol (1975) 2.07

In vitro and in vivo antibacterial activities of carumonam (AMA-1080), a new N-sulfonated monocyclic beta-lactam antibiotic. Antimicrob Agents Chemother (1985) 2.03

Effects of Sho-saiko-to, a Japanese herbal medicine, on hepatic fibrosis in rats. Hepatology (1999) 2.02

Stepwise formation of alpha-helices during cytochrome c folding. Nat Struct Biol (2000) 2.02

Effects of membrane potential on the voltage dependence of motility-related charge in outer hair cells of the guinea-pig. J Physiol (1998) 2.01

Regulation of lens fiber cell differentiation by transcription factor c-Maf. J Biol Chem (1999) 2.00

Precise monitoring of porpoising behaviour of Adélie penguins determined using acceleration data loggers. J Exp Biol (1999) 2.00

Diffusion-weighted single-shot echoplanar MR imaging for liver disease. AJR Am J Roentgenol (1999) 2.00

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV in quinolone-resistant clinical isolates of Klebsiella pneumoniae. Antimicrob Agents Chemother (1997) 1.99

Acarbose alone or in combination with ethanol potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen in rats. Hepatology (1999) 1.99

A new chromogenic endotoxin-specific assay using recombined limulus coagulation enzymes and its clinical applications. Clin Chim Acta (1985) 1.99

Activation of stress signaling pathways by the end product of lipid peroxidation. 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production. J Biol Chem (1999) 1.98

Compilation of all genes encoding bacterial two-component signal transducers in the genome of the cyanobacterium, Synechocystis sp. strain PCC 6803. DNA Res (1996) 1.98

Effect of a thromboxane A(2) antagonist on sputum production and its physicochemical properties in patients with mild to moderate asthma. Chest (2000) 1.98

Involvement of oxygen-sensitive pyruvate formate-lyase in mixed-acid fermentation by Streptococcus mutans under strictly anaerobic conditions. J Bacteriol (1982) 1.97

Electric manipulation of spin relaxation using the spin Hall effect. Phys Rev Lett (2008) 1.96

Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype. Proc Natl Acad Sci U S A (2000) 1.96

Monitoring of methyl jasmonate-responsive genes in Arabidopsis by cDNA macroarray: self-activation of jasmonic acid biosynthesis and crosstalk with other phytohormone signaling pathways. DNA Res (2001) 1.92

Control of ciliary activities by adenosinetriphosphate and divalent cations in triton-extracted models of Paramecium caudatum. J Exp Biol (1973) 1.91

Inhibition of light- or glutamate-induced mPer1 expression represses the phase shifts into the mouse circadian locomotor and suprachiasmatic firing rhythms. J Neurosci (1999) 1.90

Field test of quantum key distribution in the Tokyo QKD Network. Opt Express (2011) 1.89

Reconstitution of Q replicase lacking subunit with protein-synthesis-interference factor i. Eur J Biochem (1972) 1.88

Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice. Gut (2005) 1.88