Published in Neuron on June 01, 1998
Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses. Proc Natl Acad Sci U S A (1999) 5.39
Molecular mechanisms governing Pcdh-gamma gene expression: evidence for a multiple promoter and cis-alternative splicing model. Genes Dev (2002) 3.14
Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding. Cell (2004) 3.10
Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. Genome Res (2001) 2.66
Protocadherins mediate dendritic self-avoidance in the mammalian nervous system. Nature (2012) 2.52
Drosophila N-cadherin mediates an attractive interaction between photoreceptor axons and their targets. Nat Neurosci (2005) 2.25
Dscam diversity is essential for neuronal wiring and self-recognition. Nature (2007) 2.18
Gamma protocadherins are required for synaptic development in the spinal cord. Proc Natl Acad Sci U S A (2004) 1.95
Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. Proc Natl Acad Sci U S A (2000) 1.90
Combinatorial homophilic interaction between gamma-protocadherin multimers greatly expands the molecular diversity of cell adhesion. Proc Natl Acad Sci U S A (2010) 1.86
gamma-Protocadherins regulate neuronal survival but are dispensable for circuit formation in retina. Development (2008) 1.85
Dscam-mediated cell recognition regulates neural circuit formation. Annu Rev Cell Dev Biol (2008) 1.80
Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Genome Res (2003) 1.71
Genetics and cell biology of building specific synaptic connectivity. Annu Rev Neurosci (2010) 1.71
Synapses: sites of cell recognition, adhesion, and functional specification. Annu Rev Biochem (2007) 1.65
Functional cis-heterodimers of N- and R-cadherins. J Cell Biol (2000) 1.57
Nectin: an adhesion molecule involved in formation of synapses. J Cell Biol (2002) 1.57
Identification of long-range regulatory elements in the protocadherin-alpha gene cluster. Proc Natl Acad Sci U S A (2006) 1.55
Paraxial protocadherin mediates cell sorting and tissue morphogenesis by regulating C-cadherin adhesion activity. J Cell Biol (2006) 1.53
Molecular heterogeneity in the choroid plexus epithelium: the 22-member γ-protocadherin family is differentially expressed, apically localized, and implicated in CSF regulation. J Neurochem (2011) 1.48
Xenopus paraxial protocadherin has signaling functions and is involved in tissue separation. EMBO J (2004) 1.47
Gene conversion and the evolution of protocadherin gene cluster diversity. Genome Res (2004) 1.42
Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact. J Cell Biol (2004) 1.42
Deep molecular diversity of mammalian synapses: why it matters and how to measure it. Nat Rev Neurosci (2012) 1.40
Clustered protocadherins. Development (2013) 1.32
Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes. Genetics (2005) 1.31
Functional significance of isoform diversification in the protocadherin gamma gene cluster. Neuron (2012) 1.30
Coelacanth genome sequence reveals the evolutionary history of vertebrate genes. Genome Res (2004) 1.29
Gamma-protocadherin homophilic interaction and intracellular trafficking is controlled by the cytoplasmic domain in neurons. Mol Cell Neurosci (2008) 1.24
Regulatory elements required for the activation and repression of the protocadherin-alpha gene cluster. Proc Natl Acad Sci U S A (2011) 1.21
The synaptic glycoprotein neuroplastin is involved in long-term potentiation at hippocampal CA1 synapses. Proc Natl Acad Sci U S A (2000) 1.21
Proteomics analysis reveals overlapping functions of clustered protocadherins. Mol Cell Proteomics (2009) 1.21
alpha- and gamma-Protocadherins negatively regulate PYK2. J Biol Chem (2008) 1.14
Identification of the cluster control region for the protocadherin-beta genes located beyond the protocadherin-gamma cluster. J Biol Chem (2011) 1.13
Protocadherin X ( PCDHX) and Y ( PCDHY) genes; multiple mRNA isoforms encoding variant signal peptides and cytoplasmic domains. Mamm Genome (2004) 1.10
Cell adhesion, the backbone of the synapse: "vertebrate" and "invertebrate" perspectives. Cold Spring Harb Perspect Biol (2009) 1.09
Molecular codes for neuronal individuality and cell assembly in the brain. Front Mol Neurosci (2012) 1.09
Phosphorylation of protocadherin proteins by the receptor tyrosine kinase Ret. Proc Natl Acad Sci U S A (2010) 1.08
Listeria monocytogenes internalin and E-cadherin: from bench to bedside. Cold Spring Harb Perspect Biol (2009) 1.08
Identification of CTCF as a master regulator of the clustered protocadherin genes. Nucleic Acids Res (2011) 1.07
Extensive linkage disequilibrium, a common 16.7-kilobase deletion, and evidence of balancing selection in the human protocadherin alpha cluster. Am J Hum Genet (2003) 1.06
Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems. Front Mol Neurosci (2012) 1.04
LC3-dependent intracellular membrane tubules induced by gamma-protocadherins A3 and B2: a role for intraluminal interactions. J Biol Chem (2010) 1.01
Assessment of the developmental totipotency of neural cells in the cerebral cortex of mouse embryo by nuclear transfer. Proc Natl Acad Sci U S A (2001) 1.01
Combinatorial expression of alpha- and gamma-protocadherins alters their presenilin-dependent processing. Mol Cell Biol (2007) 1.01
Divergence between motoneurons: gene expression profiling provides a molecular characterization of functionally discrete somatic and autonomic motoneurons. Physiol Genomics (2005) 0.99
Elephant shark sequence reveals unique insights into the evolutionary history of vertebrate genes: A comparative analysis of the protocadherin cluster. Proc Natl Acad Sci U S A (2008) 0.99
Sorting out a promiscuous superfamily: towards cadherin connectomics. Trends Cell Biol (2014) 0.97
Growth factor-mediated Fyn signaling regulates alpha-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression in rodent neocortical neurons. Proc Natl Acad Sci U S A (1999) 0.97
Regulation of protocadherin gene expression by multiple neuron-restrictive silencer elements scattered in the gene cluster. Nucleic Acids Res (2010) 0.96
Gamma-protocadherins regulate the functional integrity of hypothalamic feeding circuitry in mice. Dev Biol (2009) 0.93
γ-protocadherins are enriched and transported in specialized vesicles associated with the secretory pathway in neurons. Eur J Neurosci (2010) 0.92
Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression. Sci Rep (2013) 0.90
PDCD10/CCM3 acts downstream of {gamma}-protocadherins to regulate neuronal survival. J Biol Chem (2010) 0.90
Protocadherins, not prototypical: a complex tale of their interactions, expression, and functions. Front Mol Neurosci (2013) 0.90
Total expression and dual gene-regulatory mechanisms maintained in deletions and duplications of the Pcdha cluster. J Biol Chem (2009) 0.90
Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia. Schizophr Res (2008) 0.90
Specification of synaptic connectivity by cell surface interactions. Nat Rev Neurosci (2015) 0.89
Sequencing and comparative analysis of fugu protocadherin clusters reveal diversity of protocadherin genes among teleosts. BMC Evol Biol (2007) 0.89
Postnatal development- and age-related changes in DNA-methylation patterns in the human genome. Nucleic Acids Res (2012) 0.89
Constitutively expressed Protocadherin-α regulates the coalescence and elimination of homotypic olfactory axons through its cytoplasmic region. Front Mol Neurosci (2012) 0.89
Molecular and functional interaction between protocadherin-γC5 and GABAA receptors. J Neurosci (2012) 0.88
Synaptic and nonsynaptic localization of protocadherin-gammaC5 in the rat brain. J Comp Neurol (2010) 0.87
Genetic basis of neuronal individuality in the mammalian brain. J Neurogenet (2013) 0.86
Protocadherin α (PCDHA) as a novel susceptibility gene for autism. J Psychiatry Neurosci (2013) 0.86
Protocadherins branch out: Multiple roles in dendrite development. Cell Adh Migr (2015) 0.85
Proteolytic processing of protocadherin proteins requires endocytosis. Proc Natl Acad Sci U S A (2010) 0.84
Geometric constraints on neuronal connectivity facilitate a concise synaptic adhesive code. Proc Natl Acad Sci U S A (2008) 0.83
Building and remodeling synapses. Hippocampus (2010) 0.83
The clustered protocadherins Pcdhα and Pcdhγ form a heteromeric complex in zebrafish. Neuroscience (2012) 0.83
Does cell lineage in the developing cerebral cortex contribute to its columnar organization? Front Neuroanat (2010) 0.82
Differential expression of four protocadherin alpha and gamma clusters in the developing and adult zebrafish: DrPcdh2gamma but not DrPcdh1gamma is expressed in neuronal precursor cells, ependymal cells and non-neural epithelia. Dev Genes Evol (2007) 0.82
A variable cytoplasmic domain segment is necessary for γ-protocadherin trafficking and tubulation in the endosome/lysosome pathway. Mol Biol Cell (2011) 0.81
Identification and comparative analysis of the protocadherin cluster in a reptile, the green anole lizard. PLoS One (2009) 0.81
Restoration of contralateral representation in the mouse somatosensory cortex after crossing nerve transfer. PLoS One (2012) 0.81
Evolution of orthologous tandemly arrayed gene clusters. BMC Bioinformatics (2011) 0.80
1H, 13C and 15N resonance assignments of the first cadherin domain of Cadherin-related neuronal receptor (CNR)/protocadherin alpha. J Biomol NMR (2005) 0.79
Ig Superfamily Ligand and Receptor Pairs Expressed in Synaptic Partners in Drosophila. Cell (2015) 0.79
The γ-Protocadherin-C3 isoform inhibits canonical Wnt signalling by binding to and stabilizing Axin1 at the membrane. Sci Rep (2016) 0.78
Establishment of high reciprocal connectivity between clonal cortical neurons is regulated by the Dnmt3b DNA methyltransferase and clustered protocadherins. BMC Biol (2016) 0.78
The classic cadherins in synaptic specificity. Cell Adh Migr (2015) 0.78
Protocadherin of the liver, kidney, and colon associates with detergent-resistant membranes during cellular differentiation. J Biol Chem (2010) 0.78
Spatio-temporally restricted expression of cell adhesion molecules during chicken embryonic development. PLoS One (2014) 0.77
Increasing the specificity of neurotrophic factors. Proc Natl Acad Sci U S A (2010) 0.77
Dendritic self-avoidance: protocadherins have it covered. Cell Res (2012) 0.77
Olanzapine-induced methylation alters cadherin gene families and associated pathways implicated in psychosis. BMC Neurosci (2014) 0.76
Clustered Protocadherins Are Required for Building Functional Neural Circuits. Front Mol Neurosci (2017) 0.76
Characterization of a Single Genomic Locus Encoding the Clustered Protocadherin Receptor Diversity in Xenopus tropicalis. G3 (Bethesda) (2016) 0.75
Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting. Front Mol Neurosci (2016) 0.75
Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse. Elife (2016) 0.75
Pharmacology of cell adhesion molecules of the nervous system. Curr Neuropharmacol (2007) 0.75
The clustered protocadherin endolysosomal trafficking motif mediates cytoplasmic association. BMC Cell Biol (2015) 0.75
Regulation of neural circuit formation by protocadherins. Cell Mol Life Sci (2017) 0.75
All-atom empirical potential for molecular modeling and dynamics studies of proteins. J Phys Chem B (1998) 54.00
Biology, immunology, and cariogenicity of Streptococcus mutans. Microbiol Rev (1980) 13.40
Direct observation of the rotation of F1-ATPase. Nature (1997) 9.57
Urban residential environments and senior citizens' longevity in megacity areas: the importance of walkable green spaces. J Epidemiol Community Health (2002) 7.79
Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance. Nature (1988) 6.35
Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels. Pflugers Arch (1986) 6.15
Convenient test for screening metallo-beta-lactamase-producing gram-negative bacteria by using thiol compounds. J Clin Microbiol (2000) 5.69
In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science (1992) 5.47
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature (1994) 5.33
Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science (1997) 5.13
Regional and strain-specific gene expression mapping in the adult mouse brain. Proc Natl Acad Sci U S A (2000) 5.01
Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor. Nature (1986) 4.97
Action spectra for phytochrome A- and B-specific photoinduction of seed germination in Arabidopsis thaliana. Proc Natl Acad Sci U S A (1996) 4.48
Molecular distinction between fetal and adult forms of muscle acetylcholine receptor. Nature (1986) 4.30
Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120. DNA Res (2001) 4.27
A requirement for neuropilin-1 in embryonic vessel formation. Development (1999) 3.95
Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature (1997) 3.66
The metabolism of phosphoinositide-derived messenger molecules. Science (1986) 3.58
Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes (1997) 3.08
The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin. Nat Genet (2001) 3.01
The S receptor kinase determines self-incompatibility in Brassica stigma. Nature (2000) 2.96
Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice. Neuron (1997) 2.93
Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit. Nature (1995) 2.91
Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase. Proc Natl Acad Sci U S A (1997) 2.91
Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection. Neuron (1997) 2.77
Constitutive activation of Src family kinases in mouse embryos that lack Csk. Cell (1993) 2.75
The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organization: when to start, when to stop, which drug to choose, and how to predict response? Am J Gastroenterol (2010) 2.74
Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression. EMBO J (1998) 2.74
Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes Cells (1997) 2.72
Direct ligand-receptor complex interaction controls Brassica self-incompatibility. Nature (2001) 2.69
Plasmid specifying total degradation of 3-chlorobenzoate by a modified ortho pathway. J Bacteriol (1981) 2.66
Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells. EMBO J (1999) 2.66
Diabetes Attitudes, Wishes and Needs second study (DAWN2™): cross-national benchmarking of diabetes-related psychosocial outcomes for people with diabetes. Diabet Med (2013) 2.63
Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice. Neuron (1996) 2.62
Six Arabidopsis thaliana homologues of the human respiratory burst oxidase (gp91phox). Plant J (1998) 2.59
DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae. Antimicrob Agents Chemother (1995) 2.57
Plasma brain natriuretic peptide levels increase in proportion to the extent of right ventricular dysfunction in pulmonary hypertension. J Am Coll Cardiol (1998) 2.52
The pollen determinant of self-incompatibility in Brassica campestris. Proc Natl Acad Sci U S A (2000) 2.50
Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor. J Biol Chem (2001) 2.46
The effect of tetraethylammonium chloride on potassium permeability in the smooth muscle cell membrane of canine trachea. J Physiol (1981) 2.45
Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles. Antimicrob Agents Chemother (1996) 2.42
Expression of functional acetylcholine receptor from cloned cDNAs. Nature (1984) 2.41
Prefrontal and cingulate unit activity during timing behavior in the monkey. Brain Res (1979) 2.41
Location of functional regions of acetylcholine receptor alpha-subunit by site-directed mutagenesis. Nature (1985) 2.40
Ampulla cardiomyopathy ('Takotusbo' cardiomyopathy)--reversible left ventricular dysfunction: with ST segment elevation. Jpn Circ J (2000) 2.39
Does the type of anomalous arrangement of pancreaticobiliary ducts influence the surgery and prognosis of choledochal cyst? J Pediatr Surg (1992) 2.37
Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest (1996) 2.36
Mice develop normally without tenascin. Genes Dev (1992) 2.35
Interfacial phase-change memory. Nat Nanotechnol (2011) 2.30
Impairment of AMPA receptor function in cerebellar granule cells of ataxic mutant mouse stargazer. J Neurosci (1999) 2.27
Enhanced proliferative potential in culture of cells from p53-deficient mice. Oncogene (1993) 2.25
Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice. Cell (1995) 2.25
Longitudinal study of cerebrospinal fluid levels of tau, A beta1-40, and A beta1-42(43) in Alzheimer's disease: a study in Japan. Ann Neurol (1998) 2.25
Flat neoplastic lesions of the colon and rectum detected by high-resolution video endoscopy and chromoscopy. Gastrointest Endosc (1995) 2.22
Structure and function of the NMDA receptor channel. Neuropharmacology (1995) 2.22
Normal and abnormal development of human embryos: first report of the analysis of 1,213 intact embryos. Teratology (1968) 2.20
Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. J Biol Chem (2001) 2.19
Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature (1992) 2.18
Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Nature (2000) 2.17
Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Nature (2000) 2.16
Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J Clin Invest (1995) 2.16
Mental-physical co-morbidity and its relationship with disability: results from the World Mental Health Surveys. Psychol Med (2008) 2.15
Delay activity of orbital and lateral prefrontal neurons of the monkey varying with different rewards. Cereb Cortex (2000) 2.15
Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function. Science (1997) 2.13
Screening for age-related macular degeneration using nonstereo digital fundus photographs. Eye (Lond) (2006) 2.13
Genomic organization of the S locus: Identification and characterization of genes in SLG/SRK region of S(9) haplotype of Brassica campestris (syn. rapa). Genetics (1999) 2.12
Molecular characterization of a surface protein antigen gene from serotype c Streptococcus mutans, implicated in dental caries. Mol Microbiol (1989) 2.11
Developmental changes in distribution of NMDA receptor channel subunit mRNAs. Neuroreport (1992) 2.11
Laparoscopic observations of congenital anomalies of the liver. Gastrointest Endosc (1998) 2.10
Statistical analysis of the 5' untranslated region of human mRNA using "Oligo-Capped" cDNA libraries. Genomics (2000) 2.09
Initial events of myelination involve Fyn tyrosine kinase signalling. Nature (1994) 2.08
A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2. J Biol Chem (2000) 2.08
An autopsy case of troglitazone-induced fulminant hepatitis. Diabetes Care (1998) 2.08
Pause and rotation of F(1)-ATPase during catalysis. Proc Natl Acad Sci U S A (2001) 2.07
Cloning of a surface protein antigen gene from serotype c Streptococcus mutans. Mol Microbiol (1989) 2.07
Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats. J Neurosci Res (2002) 2.06
Purified poloxamer 188 for treatment of acute vaso-occlusive crisis of sickle cell disease: A randomized controlled trial. JAMA (2001) 2.06
Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition. Gut (2008) 2.05
Phylogenetic relationships between toxic and non-toxic strains of the genus Microcystis based on 16S to 23S internal transcribed spacer sequence. FEMS Microbiol Lett (1999) 2.04
Right-handed rotation of an actin filament in an in vitro motile system. Nature (1993) 2.04
Effects of Sho-saiko-to, a Japanese herbal medicine, on hepatic fibrosis in rats. Hepatology (1999) 2.02
Location of a delta-subunit region determining ion transport through the acetylcholine receptor channel. Nature (1987) 1.99
Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV in quinolone-resistant clinical isolates of Klebsiella pneumoniae. Antimicrob Agents Chemother (1997) 1.99
Selective scarcity of NMDA receptor channel subunits in the stratum lucidum (mossy fibre-recipient layer) of the mouse hippocampal CA3 subfield. Eur J Neurosci (1998) 1.95
Stepping rotation of F1-ATPase visualized through angle-resolved single-fluorophore imaging. Proc Natl Acad Sci U S A (2000) 1.91
Successful screening for early esophageal cancer in alcoholics using endoscopy and mucosa iodine staining. Cancer (1995) 1.91
Ataxia with oculomotor apraxia type 2: clinical, biological and genotype/phenotype correlation study of a cohort of 90 patients. Brain (2009) 1.91
Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. Eur J Neurosci (1998) 1.90
Efficient production of Cre-mediated site-directed recombinants through the utilization of the puromycin resistance gene, pac: a transient gene-integration marker for ES cells. Nucleic Acids Res (1998) 1.90
Production and properties of bacteriocins (mutacins) from Streptococcus mutans. Arch Oral Biol (1975) 1.89