Published in Proc Natl Acad Sci U S A on July 15, 1993
Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide. J Exp Med (1993) 3.48
Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. Proc Natl Acad Sci U S A (1998) 2.21
Collaboration of antibody and inflammation in clearance of rabies virus from the central nervous system. J Virol (1998) 2.15
Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions of interferon-gamma receptor or immunoglobulin mu chain genes. J Exp Med (1997) 1.81
Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-kappa B. Proc Natl Acad Sci U S A (2001) 1.78
Crucial role of interferon consensus sequence binding protein, but neither of interferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosis. J Exp Med (1997) 1.77
CTLA-4 blockade enhances the immune response induced by mycobacterial infection but does not lead to increased protection. Infect Immun (1999) 1.23
Expression of inducible nitric oxide synthase in human granulomas and histiocytic reactions. Am J Pathol (1999) 1.21
Effects of gamma interferon and nitric oxide on the interaction of Mycobacterium avium subsp. paratuberculosis with bovine monocytes. Infect Immun (1997) 1.11
Vaccination with calpain induces a Th1-biased protective immune response against Schistosoma japonicum. Infect Immun (2001) 1.09
Production and characterization of guinea pig recombinant gamma interferon and its effect on macrophage activation. Infect Immun (2006) 1.07
Mucosal inoculation with an attenuated mouse pneumovirus strain protects against virulent challenge in wild type and interferon-gamma receptor deficient mice. Vaccine (2006) 1.06
Differential expression of gamma interferon mRNA induced by attenuated and virulent Mycobacterium tuberculosis in guinea pig cells after Mycobacterium bovis BCG vaccination. Infect Immun (2003) 0.98
African trypanosome infections in mice that lack the interferon-gamma receptor gene: nitric oxide-dependent and -independent suppression of T-cell proliferative responses and the development of anaemia. Immunology (1998) 0.96
HIV infection and aging: enhanced Interferon- and Tumor Necrosis Factor-alpha production by the CD8+ CD28- T subset. BMC Immunol (2001) 0.90
Nitric oxide produced in the lungs of mice immunized with the radiation-attenuated schistosome vaccine is not the major agent causing challenge parasite elimination. Immunology (1998) 0.89
N(2)O(3) enhances the nitrosative potential of IFNgamma-primed macrophages in response to Salmonella. Immunobiology (2007) 0.89
Vaccination of mice with bacteria carrying a cloned herpesvirus genome reconstituted in vivo. J Virol (2003) 0.88
Biologic functions of the IFN-gamma receptors. Allergy (1999) 0.87
cIAP-1 controls innate immunity to C. pneumoniae pulmonary infection. PLoS One (2009) 0.86
The immune response modifier imiquimod requires STAT-1 for induction of interferon, interferon-stimulated genes, and interleukin-6. Antimicrob Agents Chemother (1999) 0.82
Intractable mycobacterial infections associated with genetic defects in the receptor for interferon gamma: what does this tell us about immunity to mycobacteria? Thorax (1997) 0.80
Synergistic induction of ICAM-1 expression by cisplatin and 5-fluorouracil in a cancer cell line via a NF-kappaB independent pathway. Br J Cancer (1999) 0.79
Unimpaired clearance of Mycobacterium bovis BCG infection in selectively T-cell anergic TCR-V beta 8.2 transgenic mice. Immunology (1995) 0.75
Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature (1992) 16.46
Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol (1988) 14.21
Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med (1983) 14.08
Altering the genome by homologous recombination. Science (1989) 12.73
Immune response in mice that lack the interferon-gamma receptor. Science (1993) 12.15
Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J Exp Med (1992) 10.08
Generation and analysis of interleukin-4 deficient mice. Science (1991) 8.80
Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J Exp Med (1989) 7.72
Requirement of endogenous interferon-gamma production for resolution of Listeria monocytogenes infection. Proc Natl Acad Sci U S A (1985) 7.15
Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol (1991) 6.92
Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature (1991) 5.51
Regulation of murine macrophage Ia antigen expression by a lymphokine with immune interferon activity. J Exp Med (1982) 5.33
Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors. J Exp Med (1986) 5.09
Evidence that tumor necrosis factor has an important role in antibacterial resistance. J Immunol (1989) 3.90
Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated macrophages by induction of tumor necrosis factor-alpha. J Immunol (1990) 3.79
Early gamma interferon production by natural killer cells is important in defense against murine listeriosis. Infect Immun (1991) 3.59
B cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigens. J Immunol (1987) 3.18
Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates. J Immunol (1989) 3.09
Regulation of activated macrophage antimicrobial activities. Identification of lymphokines that cooperate with IFN-gamma for induction of resistance to infection. J Immunol (1988) 2.82
Nonspecific defence mechanism: the role of nitric oxide. Immunol Today (1991) 2.37
Interferon-gamma induces enhanced expression of Ia and H-2 antigens on B lymphoid, macrophage, and myeloid cell lines. J Immunol (1983) 2.30
Effect of gamma interferon on cachectin expression by mononuclear phagocytes. Reversal of the lpsd (endotoxin resistance) phenotype. J Exp Med (1986) 2.28
Antagonistic effect of interferon-beta on the interferon-gamma-induced expression of Ia antigen in murine macrophages. J Immunol (1985) 2.15
Interferon gamma and lymphotoxin or tumor necrosis factor act synergistically to induce macrophage killing of tumor cells and schistosomula of Schistosoma mansoni. J Exp Med (1987) 1.75
Innate immunity to a facultative intracellular bacterial pathogen. Curr Opin Immunol (1992) 1.64
Evidence for effects of interleukin 4 (B cell stimulatory factor 1) on macrophages: enhancement of antigen presenting ability of bone marrow-derived macrophages. J Immunol (1987) 1.62
Contrasting effect of alpha/beta- and gamma-interferons on expression of macrophage Ia antigens. J Exp Med (1986) 1.55
Granulocyte-macrophage colony-stimulating factor activates macrophages derived from bone marrow cultures to synthesis of MHC class II molecules and to augmented antigen presentation function. J Immunol (1988) 1.46
Analysis of Ia antigen expression in macrophages derived from bone marrow cells cultured in granulocyte-macrophage colony-stimulating factor or macrophage colony-stimulating factor. J Immunol (1988) 1.30
Autocrine secretion of tumor necrosis factor under the influence of interferon-gamma amplifies HLA-DR gene induction in human monocytes. Proc Natl Acad Sci U S A (1988) 1.17
The interferon-macrophage alliance. Interferon (1987) 1.00
Embryonic stem cells and homologous recombination. Curr Opin Immunol (1992) 0.91
Requirement for protein synthesis for induction of macrophage tumoricidal activity by IFN-alpha and IFN-beta but not by IFN-gamma. J Immunol (1984) 0.84
Listeria monocytogenes-induced interferon-gamma primes the host for production of tumor necrosis factor and interferon-alpha/beta. J Infect Dis (1993) 0.79
Concern Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N Engl J Med (2000) 29.03
Inducible gene targeting in mice. Science (1995) 21.22
Functional role of type I and type II interferons in antiviral defense. Science (1994) 18.92
Geometric control of cell life and death. Science (1997) 18.13
Immune response in mice that lack the interferon-gamma receptor. Science (1993) 12.15
Mice devoid of PrP are resistant to scrapie. Cell (1993) 11.46
Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell (1996) 10.49
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature (1992) 9.01
Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity (1999) 8.33
Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities. Lab Invest (1987) 7.95
Combining independent studies of a diagnostic test into a summary ROC curve: data-analytic approaches and some additional considerations. Stat Med (1993) 7.29
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J (1995) 6.94
Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci U S A (1998) 6.82
VEGF is required for growth and survival in neonatal mice. Development (1999) 6.16
Production of high-titered interferon in cultures of human diploid cells. Antimicrob Agents Chemother (1972) 5.86
Induction of beta 2-interferon by tumor necrosis factor: a homeostatic mechanism in the control of cell proliferation. Cell (1986) 5.79
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J (2001) 5.29
Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors. J Exp Med (1986) 4.99
The IFN gamma receptor: a paradigm for cytokine receptor signaling. Annu Rev Immunol (1997) 4.76
Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science (1995) 4.59
Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science (1994) 4.50
Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection. J Natl Cancer Inst (1998) 4.42
Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci U S A (1996) 4.20
Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors. J Virol (1995) 4.16
Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members. Oncogene (2008) 4.13
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature (2000) 4.08
Strong, constitutive expression of the Arabidopsis ACT2/ACT8 actin subclass in vegetative tissues. Plant J (1996) 4.08
How a protein binds B12: A 3.0 A X-ray structure of B12-binding domains of methionine synthase. Science (1994) 3.93
Further delineation of the 15q13 microdeletion and duplication syndromes: a clinical spectrum varying from non-pathogenic to a severe outcome. J Med Genet (2009) 3.87
Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. J Biol Chem (1998) 3.80
Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon. Science (1982) 3.67
S proteins control rejection of incompatible pollen in Petunia inflata. Nature (1994) 3.54
Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide. J Exp Med (1993) 3.48
Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice. J Immunol (1997) 3.35
IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice. J Immunol (1989) 3.15
The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease. Nat Genet (1998) 3.12
Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells. Blood (1991) 3.12
Functional analysis of T lymphocyte subsets in antiviral host defense. J Immunol (1987) 3.11
How stable is stable? Function versus community composition. Appl Environ Microbiol (1999) 3.08
Immune defence in mice lacking type I and/or type II interferon receptors. Immunol Rev (1995) 2.97
Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems. Proc Natl Acad Sci U S A (2000) 2.83
Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha. J Exp Med (1995) 2.80
Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region. Oncogene (2010) 2.73
Nucleolar components involved in ribosome biogenesis cycle between the nucleolus and nucleoplasm in interphase cells. J Cell Biol (2001) 2.70
Interleukin 6: a multifunctional cytokine regulating immune reactions and the acute phase protein response. Lab Invest (1989) 2.69
Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells. Proc Natl Acad Sci U S A (1985) 2.65
Stabilization of interferon messenger RNA activity by treatment of cells with metabolic inhibitors and lowering of the incubation temperature. Proc Natl Acad Sci U S A (1973) 2.64
Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. Nature (1998) 2.62
High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors. J Immunol (1997) 2.59
Two antigenically distinct species of human interferon. Proc Natl Acad Sci U S A (1975) 2.59
Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci U S A (1989) 2.59
The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. J Exp Med (1998) 2.55
Cardiovascular thrombotic events in controlled, clinical trials of rofecoxib. Circulation (2001) 2.55
A cytokine network in human diploid fibroblasts: interactions of beta-interferons, tumor necrosis factor, platelet-derived growth factor, and interleukin-1. Mol Cell Biol (1987) 2.52
Fluorescence photooxidation with eosin: a method for high resolution immunolocalization and in situ hybridization detection for light and electron microscopy. J Cell Biol (1994) 2.48
Construction and initial characterization of a mouse-human chimeric anti-TNF antibody. Mol Immunol (1993) 2.47
Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections. J Immunol (2001) 2.47
Contrasting patterns of retinoblastoma protein expression in mouse embryonic stem cells and embryonic fibroblasts. Oncogene (1994) 2.46
The role of antibody concentration and avidity in antiviral protection. Science (1997) 2.45
Cost-effectiveness of thiopurine methyltransferase genotype screening in patients about to commence azathioprine therapy for treatment of inflammatory bowel disease. Aliment Pharmacol Ther (2004) 2.38
Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways. Proc Natl Acad Sci U S A (1989) 2.38
Human beta 2 interferon and B-cell differentiation factor BSF-2 are identical. Science (1987) 2.37
Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion. Oncogene (2011) 2.36
Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes. EMBO J (1992) 2.34
Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6. Proc Natl Acad Sci U S A (1988) 2.34
Interrelationships of human interferon-gamma with lymphotoxin and monocyte cytotoxin. J Exp Med (1984) 2.33
Post-transcriptional control of interferon synthesis. J Virol (1971) 2.30
Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science (1994) 2.28
Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes. EMBO J (1994) 2.27
Tumor necrosis factor provokes superoxide anion generation from neutrophils. Biochem Biophys Res Commun (1986) 2.27
Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence. Mol Cell Biol (1990) 2.22
Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors. J Exp Med (1995) 2.19
The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression. EMBO J (1994) 2.19
Mice from a genetically resistant background lacking the interferon gamma receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response. J Exp Med (1995) 2.17
A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44. J Cell Biol (1992) 2.15
Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis. Am J Pathol (1997) 2.15
Synthesis of human interferon by Xenopus laevis oocytes: two structural genes for interferons in human cells. Proc Natl Acad Sci U S A (1977) 2.12
Chromatin boundaries and chromatin domains. Cold Spring Harb Symp Quant Biol (2004) 2.08
Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Oncogene (2006) 2.07
Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase. J Biol Chem (2001) 2.02
Demonstration of a deficiency of glucocerebroside-cleaving enzyme in Gaucher's disease. J Clin Invest (1966) 2.01
Micropatterned surfaces for control of cell shape, position, and function. Biotechnol Prog (1998) 2.01
Functional characterization of the rat chemokine KC and its importance in neutrophil recruitment in a rat model of pulmonary inflammation. J Immunol (1995) 2.01
Aberrant FoxM1B expression increases matrix metalloproteinase-2 transcription and enhances the invasion of glioma cells. Oncogene (2007) 1.98
Acid-labile human leukocyte interferon in homosexual men with Kaposi's sarcoma and lymphadenopathy. J Infect Dis (1982) 1.98