Published in Biochemistry on February 08, 1977
Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation. Proc Natl Acad Sci U S A (1981) 2.04
Function and induction of the microsomal heme oxygenase. Mol Cell Biochem (1983) 1.31
Suppression of hyperbilirubinemia in the rat neonate by chromium-protoporphyrin. Interactions of metalloporphyrins with microsomal heme oxygenase of human spleen. J Exp Med (1982) 1.05
Electron-transport pathway of the NADH-dependent haem oxygenase system of rat liver microsomal fraction induced by cobalt chloride. Biochem J (1979) 0.78
Formation of bile pigments by coupled oxidation of cobalt-substituted haemoglobin and myoglobin. Biochem J (1984) 0.78
Inhibition of platelet aggregation by carbon monoxide-releasing molecules (CO-RMs): comparison with NO donors. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.77
Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes. Front Immunol (2017) 0.75
Diagnosis of pseudomembranous colitis. Br Med J (1978) 5.96
Cobalt induction of hepatic heme oxygenase; with evidence that cytochrome P-450 is not essential for this enzyme activity. Proc Natl Acad Sci U S A (1974) 2.41
Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible. J Biol Chem (1986) 2.36
Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3. Eur J Biochem (1997) 2.16
Suppression of bilirubin production in the Crigler-Najjar type I syndrome: studies with the heme oxygenase inhibitor tin-mesoporphyrin. Pediatrics (1992) 2.14
Cobalt stimulation of heme degradation in the liver. Dissociation of microsomal oxidation of heme from cytochrome P-450. J Biol Chem (1975) 2.05
Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation. Proc Natl Acad Sci U S A (1981) 2.04
Plasma membranes of the rat liver. Isolation and enzymatic characterization of a fraction rich in bile canaliculi. J Cell Biol (1969) 1.95
Steroid induction of porphyrin synthesis in liver cell culture. I. Structural basis and possible physiological role in the control of heme formation. J Biol Chem (1967) 1.93
Influence of dietary protein and carbohydrate on antipyrine and theophylline metabolism in man. Clin Pharmacol Ther (1976) 1.87
Human heme oxygenase-2: characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal. Arch Biochem Biophys (1992) 1.87
Metals as regulators of heme metabolism. Science (1977) 1.86
Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene. Proc Natl Acad Sci U S A (1994) 1.85
Studies on the mechanism of induction of haem oxygenase by cobalt and other metal ions. Biochem J (1976) 1.84
Purification and properties of bovine spleen heme oxygenase. Amino acid composition and sites of action of inhibitors of heme oxidation. J Biol Chem (1982) 1.83
Induction of aminolevulinate synthase and porphyrins in cultured liver cells maintained in chemically defined medium. Permissive effects of hormones on induction process. J Biol Chem (1977) 1.83
Assays for porphyrins, delta-aminolevulinic-acid dehydratase, and porphyrinogen synthetase in microliter samples of whole blood: applications to metabolic defects involving the heme pathway. Proc Natl Acad Sci U S A (1972) 1.77
Steroid induction of porphyrin synthesis in liver cell culture. II. The effects of heme, uridine diphosphate glucuronic acid, and inhibitors of nucleic acid and protein synthesis on the induction process. J Biol Chem (1968) 1.76
Circulating endothelial cells are elevated in patients with type 2 diabetes mellitus independently of HbA(1)c. Diabetologia (2005) 1.69
Prevention of cyclical attacks of acute intermittent porphyria with a long-acting agonist of luteinizing hormone-releasing hormone. N Engl J Med (1984) 1.68
The influence of pregnancy and oral contraceptive steroids on the concentration of plasma proteins. Studies with a quantitative immunodiffusion method. Am J Obstet Gynecol (1970) 1.65
Purification and characterization of biliverdin reductase from rat liver. J Biol Chem (1981) 1.63
Porphyria cutanea tarda associated with the acquired immune deficiency syndrome. Am J Hematol (1987) 1.57
Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice. J Neurochem (1999) 1.55
Studies in lead poisoning. I. Microanalysis of erythrocyte protoporphyrin levels by spectrophotometry in the detection of chronic lead intoxication in the subclinical range. Biochem Med (1973) 1.53
Purification and properties of uroporphyrinogen decarboxylase from human erythrocytes. A single enzyme catalyzing the four sequential decarboxylations of uroporphyrinogens I and III. J Biol Chem (1983) 1.50
Polychlorinated biphenyls: a new type of inducer of cytochrome P-448 in the liver. Proc Natl Acad Sci U S A (1973) 1.48
A microassay for uroporphyrinogen I synthase, one of three abnormal enzyme activities in acute intermittent porphyria, and its application to the study of the genetics of this disease. Proc Natl Acad Sci U S A (1974) 1.48
Human heme oxygenase-1 gene transfer lowers blood pressure and promotes growth in spontaneously hypertensive rats. Hypertension (2001) 1.48
Interactions between nutritional factors and drug biotransformations in man. Proc Natl Acad Sci U S A (1976) 1.47
Heme oxygenase-2 is a hemoprotein and binds heme through heme regulatory motifs that are not involved in heme catalysis. J Biol Chem (1997) 1.44
Control of hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient newborns using an inhibitor of bilirubin production, Sn-mesoporphyrin. Pediatrics (1998) 1.44
Operative choledochoscopy. Br J Surg (1979) 1.43
Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death. J Neurochem (2000) 1.42
Zinc . protoporphyrin is a selective inhibitor of heme oxygenase activity in the neonatal rat. Biochim Biophys Acta (1981) 1.42
Steroid control of porphyrin and heme biosynthesis: a new biological function of steroid hormone metabolites. Proc Natl Acad Sci U S A (1967) 1.41
Stimulation of hemoglobin synthesis in chick blastoderms by certain 5beta androstane and 5beta pregnane steroids. Proc Natl Acad Sci U S A (1967) 1.41
Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity. Proc Natl Acad Sci U S A (1995) 1.41
Heme biosynthesis and drug metabolism in mice with hereditary hemolytic anemia. Heme oxygenase induction as an adaptive response for maintaining cytochrome P-450 in chronic hemolysis. J Biol Chem (1979) 1.39
Induction of aryl hydrocarbon hydroxylase in human skin. Drug Metab Dispos (1974) 1.39
Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: heme oxygenase 2 is not a heat shock protein. Proc Natl Acad Sci U S A (1991) 1.39
Stimulatory effect of brussels sprouts and cabbage on human drug metabolism. Clin Pharmacol Ther (1979) 1.38
Alterations in drug metabolism in workers exposed to polychlorinated biphenyls. Clin Pharmacol Ther (1977) 1.38
Purification and characterization of the major constitutive form of testicular heme oxygenase. The noninducible isoform. J Biol Chem (1986) 1.36
Chemoprevention of neonatal jaundice: potency of tin-protoporphyrin in an animal model. Science (1982) 1.36
Lead and methyl mercury: effects of acute exposure on cytochrome P-450 and the mixed function oxidase system in the liver. J Exp Med (1972) 1.35
Studies of the influence of chloro-substituent sites and conformational energy in polychlorinated biphenyls on uroporphyrin formation in chick-embryo liver cell cultures. Biochem J (1986) 1.35
Biologic actions of some natural steroids on the liver. N Engl J Med (1968) 1.34
Dual control mechanism for heme oxygenase: tin(IV)-protoporphyrin potently inhibits enzyme activity while markedly increasing content of enzyme protein in liver. Proc Natl Acad Sci U S A (1987) 1.31
Evidence suggesting that the two forms of heme oxygenase are products of different genes. J Biol Chem (1988) 1.29
Tin: a potent inducer of heme oxygenase in kidney. Science (1976) 1.27
Characterization of two heme oxygenase isoforms in rat spleen: comparison with the hematin-induced and constitutive isoforms of the liver. Biochem Biophys Res Commun (1986) 1.26
Control of heme oxygenase and plasma levels of bilirubin by a synthetic heme analogue, tin-protoporphyrin. Hepatology (1984) 1.26
On the genetic activity of benzimidazole and thiophanate fungicides on diploid Aspergillus nidulans. Mutat Res (1974) 1.25
Effect of lead and genetic factors on heme biosynthesis in the human red cell. Ann N Y Acad Sci (1975) 1.24
Tissue distribution and disposition of tin-protoporphyrin, a potent competitive inhibitor of heme oxygenase. J Pharmacol Exp Ther (1984) 1.24
Contingency detection and the contingent organization of behavior in interactions: implications for socioemotional development in infancy. Psychol Bull (1996) 1.24
Regulation of photomorphogenesis by expression of mammalian biliverdin reductase in transgenic Arabidopsis plants. Plant Cell (1997) 1.23
Control of heme metabolism with synthetic metalloporphyrins. J Clin Invest (1986) 1.23
Hereditary tyrosinemia and the heme biosynthetic pathway. Profound inhibition of delta-aminolevulinic acid dehydratase activity by succinylacetone. J Clin Invest (1983) 1.22
Heme oxygenase 2 is present in interstitial cell networks of the mouse small intestine. Gastroenterology (1998) 1.20
Solubilization and partial purification of heme oxygenase from rat liver. J Biol Chem (1977) 1.19
Prematurely evoked synthesis and induction of delta-aminolevulinate synthetase in neonatal liver. Evidence for metal ion repression of enzyme formation. J Biol Chem (1978) 1.19
Studies in lead poisoning. II. Correlation between the ratio of activated to inactivated delta-aminolevulinic acid dehydratase of whole blood and the blood lead level. Biochem Med (1973) 1.19
Developmental expression of heme oxygenase isozymes in rat brain. Two HO-2 mRNAs are detected. J Biol Chem (1990) 1.19
Regulation of heme pathway enzymes and cellular glutathione content by metals that do not chelate with tetrapyrroles: blockade of metal effects by thiols. Proc Natl Acad Sci U S A (1977) 1.18
Cobalt inhibition of synthesis and induction of delta-aminolevulinate synthase in liver. Proc Natl Acad Sci U S A (1976) 1.18
Cobalt regulation of heme synthesis and degradation in avian embryo liver cell culture. J Biol Chem (1977) 1.18
Stimulation of mammalian erythropoiesis by 5beta-H steroid metabolites. Proc Natl Acad Sci U S A (1970) 1.17
Hormones and the liver. The effect of estrogens, progestins, and pregnancy on hepatic function. Am J Obstet Gynecol (1969) 1.16
Tin-protoporphyrin suppression of hyperbilirubinemia in mutant mice with severe hemolytic anemia. Blood (1983) 1.15
Effects of polychlorinated biphenyl compounds, 2,3,7,8-tetrachlorodibenzo-p-dioxin, phenobarbital and iron on hepatic uroporphyrinogen decarboxylase. Implications for the pathogenesis of porphyria. Biochem J (1983) 1.15
Reduction of the C2 and C4 vinyl groups of Sn-protoporphyrin to form Sn-mesoporphyrin markedly enhances the ability of the metalloporphyrin to inhibit in vivo heme catabolism. Arch Biochem Biophys (1987) 1.14
Studies in porphyria. IV. Expression of the gene defect of acute intermittent porphyria in cultured human skin fibroblasts and amniotic cells: prenatal diagnosis of the porphyric trait. J Exp Med (1975) 1.14
Molecular aspects of the inherited porphyrias. J Intern Med (2000) 1.13
Additive effect of erythropoietin and heme on murine hematopoietic recovery after azidothymidine treatment. Blood (1993) 1.13
Hyperbeta-lipoproteinemia in acute intermittent porphyria; preliminary report. N Engl J Med (1970) 1.12
Drug metabolism in normal children, lead-poisoned children, and normal adults. Clin Pharmacol Ther (1975) 1.12
Study of the developmental pattern of heme catabolism in liver and the effects of cobalt on cytochrome P-450 and the rate of heme oxidation during the neonatal period. J Exp Med (1975) 1.12
Isolation, characterization, and expression in Escherichia coli of a cDNA encoding rat heme oxygenase-2. J Biol Chem (1990) 1.12
Drug metabolism by the human hepatoma cell, Hep G2. Biochem Biophys Res Commun (1987) 1.11
The induction of heme oxidation in various tissues by trace metals: evidence for the catabolism of endogenous heme by hepatic heme oxygenase. Ann Clin Res (1976) 1.11
The occurrence of substances in human plasma capable of inducing the enzyme delta-aminolevulinate synthetase in liver cells. Proc Natl Acad Sci U S A (1969) 1.11
Resolution of the rat brain heme oxygenase activity: absence of a detectable amount of the inducible form (HO-1). Arch Biochem Biophys (1988) 1.11
Diet-hormone interactions: protein/carbohydrate ratio alters reciprocally the plasma levels of testosterone and cortisol and their respective binding globulins in man. Life Sci (1987) 1.10
Glutathione depletion induces heme oxygenase-1 (HSP32) mRNA and protein in rat brain. J Neurochem (1993) 1.10
The degradative effects of porphyrins and heme compounds on components of the microsomal mixed function oxidase system. J Biol Chem (1975) 1.10
Genetic, metabolic, and biochemical aspects of the porphyrias. Adv Hum Genet (1981) 1.10