Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes.

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Published in J Exp Med on October 01, 1993

Authors

N M Valiante1, G Trinchieri

Author Affiliations

1: Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104.

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Monoclonal antibodies that detect differentiation surface antigens on human myelomonocytic cells. Blood (1982) 1.57

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Regulation of NK cell functions by TGF-beta 1. J Immunol (1995) 1.51

The cytotoxic effector cells in preparations of adherent mononuclear cells from human peripheral blood. J Immunol (1984) 1.50

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Differentiation of human NK cells into NK1 and NK2 subsets. J Immunol (1998) 1.43

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Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis. J Immunol (1998) 1.39

Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFkappaB. J Biol Chem (1999) 1.38

Interleukin-12: a proinflammatory cytokine with immunoregulatory functions. Res Immunol (1996) 1.37

Regulation of interleukin-12 production in antigen-presenting cells. Adv Immunol (2001) 1.37

Expression and function of IL-12 and IL-18 receptors on human tonsillar B cells. J Immunol (2000) 1.34

Mapping of H-2 genes associated with T cell-mediated cytotoxic responses to SV40-tumour-associated specific antigens. Nature (1978) 1.33

The detection of Australia antigen and anti-Au antibodies by a rapid procedure combining electrophoresis and immunoprecipitation. Haematologica (1969) 1.33

Enhancing effect of natural killer cell stimulatory factor (NKSF/interleukin-12) on cell-mediated cytotoxicity against tumor-derived and virus-infected cells. Eur J Immunol (1993) 1.32

Role of interleukin-12 in primary influenza virus infection. J Virol (1998) 1.30

Terminal differentiation surface antigens of myelomonocytic cells are expressed in human promyelocytic leukemia cells (HL60) treated with chemical inducers. Blood (1981) 1.30

Inhibition of IL-12 production in human monocyte-derived macrophages by TNF. J Immunol (2000) 1.30

Suppression of Il-12 transcription in macrophages following Fc gamma receptor ligation. J Immunol (2001) 1.29

Interferon-gamma transcriptionally modulates the expression of the genes for the high affinity IgG-Fc receptor and the 47-kDa cytosolic component of NADPH oxidase in human polymorphonuclear leukocytes. J Biol Chem (1991) 1.29

Decreased production of interleukin-12 and other Th1-type cytokines in patients with recent-onset systemic lupus erythematosus. Arthritis Rheum (1998) 1.29