Published in Proc Natl Acad Sci U S A on January 15, 1993
Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells. Mol Cell Biol (1995) 4.60
Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am J Pathol (1999) 4.04
CD44 is required for two consecutive steps in HGF/c-Met signaling. Genes Dev (2002) 3.07
Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation. Proc Natl Acad Sci U S A (1994) 2.36
Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network. Mol Cell Biol (1996) 2.05
RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. EMBO J (1994) 2.04
Hepatocyte growth factor and its receptor (c-MET) in prostatic carcinoma. Am J Pathol (1995) 1.94
Cell movement elicited by epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis. J Cell Biol (1994) 1.75
Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain. Mol Cell Biol (1995) 1.73
Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes. EMBO J (1997) 1.60
Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin. Mol Biol Cell (2006) 1.43
The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro. Mol Biol Cell (1996) 1.42
Plexin-B3 is a functional receptor for semaphorin 5A. EMBO Rep (2004) 1.39
Three-dimensional multispecies nonlinear tumor growth-II: Tumor invasion and angiogenesis. J Theor Biol (2010) 1.37
Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro. Proc Natl Acad Sci U S A (1996) 1.37
Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas. Br J Cancer (1996) 1.35
Hepatocyte growth factor/scatter factor-induced intracellular signalling. Int J Exp Pathol (2000) 1.22
c-MET expression in myofibroblasts: role in autocrine activation and prognostic significance in lung adenocarcinoma. Am J Pathol (2001) 1.16
Constitutive activation of the RON gene promotes invasive growth but not transformation. Mol Cell Biol (1996) 1.13
Paracrine regulation of germinal center B cell adhesion through the c-met-hepatocyte growth factor/scatter factor pathway. J Exp Med (1997) 1.13
Hepatocyte growth factor induces proliferation and differentiation of multipotent and erythroid hemopoietic progenitors. J Cell Biol (1994) 1.12
Overexpression of the hepatocyte growth factor (HGF) receptor (Met) and presence of a truncated and activated intracellular HGF receptor fragment in locally aggressive/malignant human musculoskeletal tumors. Am J Pathol (2000) 1.04
Detection of hepatocyte growth factor/scatter factor receptor (c-Met) in axillary drainage after operations for breast cancer using reverse transcriptase-polymerase chain reaction. Breast Cancer Res (2003) 1.02
Influence of the host microenvironment on the clonal selection of human colon carcinoma cells during primary tumor growth and metastasis. Clin Exp Metastasis (1997) 1.00
HGF/SF activates glycolysis and oxidative phosphorylation in DA3 murine mammary cancer cells. Neoplasia (2001) 0.97
Expression of Met/hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors. Am J Pathol (1996) 0.97
Regulation of cytokine signaling by B cell antigen receptor and CD40-controlled expression of heparan sulfate proteoglycans. J Exp Med (2000) 0.89
Progression of familial adenomatous polyposis (FAP) colonic cells after transfer of the src or polyoma middle T oncogenes: cooperation between src and HGF/Met in invasion. Br J Cancer (1997) 0.86
Hepatocyte growth factor and invasion-stimulatory activity are induced in pleural fluid by surgery in lung cancer patients. Br J Cancer (1999) 0.82
Hepatocyte growth factor levels in bone marrow plasma of patients with leukaemia and its gene expression in leukaemic blast cells. Br J Cancer (1996) 0.81
Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers. Br J Cancer (2000) 0.81
C-met activation is necessary but not sufficient for liver colonization by B16 murine melanoma cells. Clin Exp Metastasis (1998) 0.80
Chromosomal localization of rat hepatocyte growth factor (Hgf) and HGF receptor (Met) and characterization of HGF receptor cDNA. Mamm Genome (1997) 0.77
HGF/SF and its receptor c-MET play a minor role in the dissemination of human B-lymphoma cells in SCID mice. Br J Cancer (1999) 0.76
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A (1979) 365.71
Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science (1991) 8.68
A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res (1987) 7.43
Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature (1987) 6.26
Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol (1992) 5.04
Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell (1991) 4.98
Mechanism of met oncogene activation. Cell (1986) 4.20
Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells. J Cell Biol (1990) 4.05
Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors. Proc Natl Acad Sci U S A (1987) 3.99
Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET. Oncogene (1991) 3.41
Evidence for the identity of human scatter factor and human hepatocyte growth factor. Proc Natl Acad Sci U S A (1991) 3.27
Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J (1991) 3.20
Tyrosine kinase receptor indistinguishable from the c-met protein. Nature (1989) 3.00
A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor. Proc Natl Acad Sci U S A (1991) 2.93
Quantification of cells cultured on 96-well plates. Anal Biochem (1989) 2.66
Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement. Proc Natl Acad Sci U S A (1989) 2.61
Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes. Cancer Res (1989) 2.59
Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures. Proc Natl Acad Sci U S A (1986) 2.37
Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure. J Clin Invest (1988) 2.22
Hepatocyte growth factor--scatter factor: mitogen, motogen, and met. Cancer Cells (1991) 1.99
Detection of phosphotyrosine-containing proteins in the detergent-insoluble fraction of RSV-transformed fibroblasts by azobenzene phosphonate antibodies. EMBO J (1984) 1.98
Hepatocyte growth factor/hepatopoietin A stimulates the growth of rat kidney proximal tubule epithelial cells (RPTE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes and stimulates anchorage-independent growth of SV-40 transformed RPTE. Biochem Biophys Res Commun (1991) 1.95
Biosynthesis of the protein encoded by the c-met proto-oncogene. Oncogene (1989) 1.92
Alternative splicing generates isoforms of the met receptor tyrosine kinase which undergo differential processing. Mol Cell Biol (1991) 1.90
The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation. Mol Cell Biol (1991) 1.90
The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase. J Biol Chem (1991) 1.71
c-met is amplified but not mutated in a cell line with an activated met tyrosine kinase. Oncogene (1991) 1.58
Scatter factor and hepatocyte growth factor: activities, properties, and mechanism. Cell Growth Differ (1992) 1.56
C-terminal truncated forms of Met, the hepatocyte growth factor receptor. Mol Cell Biol (1991) 1.53
Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells. Proc Natl Acad Sci U S A (1992) 1.48
Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase. J Biol Chem (1991) 1.48
Hepatocyte growth factor is a potent mitogen for cultured rabbit renal tubular epithelial cells. Biochem Biophys Res Commun (1991) 1.45
Hepatocyte growth factor is a potent stimulator of human melanocyte DNA synthesis and growth. Biochem Biophys Res Commun (1991) 1.42
Identity of a tumor cytotoxic factor from human fibroblasts and hepatocyte growth factor. Biochem Biophys Res Commun (1990) 1.37
Marked stimulation of growth and motility of human keratinocytes by hepatocyte growth factor. Exp Cell Res (1991) 1.28
p145, a protein with associated tyrosine kinase activity in a human gastric carcinoma cell line. Mol Cell Biol (1988) 1.22
Hepatocyte growth factor has potent anti-proliferative activity in various tumor cell lines. FEBS Lett (1991) 1.16
Hepatocyte growth factor modulates migration and proliferation of human microvascular endothelial cells in culture. Biochem Biophys Res Commun (1991) 1.10
Autophosphorylation promotes complex formation of recombinant hepatocyte growth factor receptor with cytoplasmic effectors containing SH2 domains. Oncogene (1992) 1.08
Protein kinase-c activation inhibits tyrosine phosphorylation of the c-met protein. Oncogene (1990) 1.04
Intracellular calcium regulates the tyrosine kinase receptor encoded by the MET oncogene. J Biol Chem (1991) 1.00
Quantitation of cytokine-stimulated migration of endothelium and epithelium by a new assay using microcarrier beads. Exp Cell Res (1990) 1.00
Expression of a human hepatocyte growth factor/scatter factor cDNA in MDCK epithelial cells influences cell morphology, motility, and anchorage-independent growth. J Cell Biol (1992) 0.96
Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell (1999) 5.07
Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol (1992) 5.04
Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells. Mol Cell Biol (1995) 4.60
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell (1994) 4.10
Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes. Exp Cell Res (1985) 3.41
Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET. Oncogene (1991) 3.41
Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J (1991) 3.20
Tyrosine kinase receptor indistinguishable from the c-met protein. Nature (1989) 3.00
Induction of epithelial tubules by growth factor HGF depends on the STAT pathway. Nature (1998) 2.83
Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. EMBO J (1992) 2.65
A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth. Cell (2001) 2.62
Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells. J Cell Biol (1997) 2.51
Expression of the Met/HGF receptor in normal and neoplastic human tissues. Oncogene (1991) 2.44
Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell (1998) 2.39
Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas. Oncogene (2000) 2.27
Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development. Cell (1996) 2.14
HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. EMBO J (1996) 2.09
Biological activation of pro-HGF (hepatocyte growth factor) by urokinase is controlled by a stoichiometric reaction. J Biol Chem (1995) 2.06
RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. EMBO J (1994) 2.04
Detection of phosphotyrosine-containing proteins in the detergent-insoluble fraction of RSV-transformed fibroblasts by azobenzene phosphonate antibodies. EMBO J (1984) 1.98
Monoclonal antibodies against murine gamma interferon. Proc Natl Acad Sci U S A (1984) 1.95
The receptor encoded by the human c-MET oncogene is expressed in hepatocytes, epithelial cells and solid tumors. Int J Cancer (1991) 1.95
Biosynthesis of the protein encoded by the c-met proto-oncogene. Oncogene (1989) 1.92
Cell surface molecules and fibronectin-mediated cell adhesion: effect of proteolytic digestion of membrane proteins. J Cell Biol (1982) 1.90
The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation. Mol Cell Biol (1991) 1.90
Signalling by semaphorin receptors: cell guidance and beyond. Trends Cell Biol (2000) 1.89
Cleavage of a 135 kD cell surface glycoprotein correlates with loss of fibroblast adhesion to fibronectin. Exp Cell Res (1985) 1.86
Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor). Oncogene (1994) 1.81
Agonistic monoclonal antibodies against the Met receptor dissect the biological responses to HGF. J Cell Sci (1998) 1.75
Overexpression of the RON gene in human breast carcinoma. Oncogene (1998) 1.73
Cross-talk between the proto-oncogenes Met and Ron. Oncogene (2000) 1.71
The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase. J Biol Chem (1991) 1.71
A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis. Proc Natl Acad Sci U S A (1992) 1.70
The transmembrane protein Off-track associates with Plexins and functions downstream of Semaphorin signaling during axon guidance. Neuron (2001) 1.68
The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit. Oncogene (1995) 1.66
A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype. Mol Cell Biol (1996) 1.65
Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes. EMBO J (1997) 1.60
c-met is amplified but not mutated in a cell line with an activated met tyrosine kinase. Oncogene (1991) 1.58
A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth. Oncogene (2006) 1.56
Expression of the c-Met/HGF receptor in human melanocytic neoplasms: demonstration of the relationship to malignant melanoma tumour progression. Br J Cancer (1993) 1.55
Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger. J Biol Chem (1993) 1.51
A 135,000 molecular weight plasma membrane glycoprotein involved in fibronectin-mediated cell adhesion. Immunofluorescence localization in normal and RSV-transformed fibroblasts. Exp Cell Res (1986) 1.48
Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase. J Biol Chem (1991) 1.48
Plexin signaling hampers integrin-based adhesion, leading to Rho-kinase independent cell rounding, and inhibiting lamellipodia extension and cell motility. FASEB J (2004) 1.46
A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor. Mol Cell Biol (1993) 1.44
Silencing the MET oncogene leads to regression of experimental tumors and metastases. Oncogene (2007) 1.42
The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro. Mol Biol Cell (1996) 1.42
HGF: a multifunctional growth factor controlling cell scattering. Int J Biochem Cell Biol (1999) 1.41
Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer. Cancer Res (1995) 1.40
The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein. Oncogene (1995) 1.38
Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro. Proc Natl Acad Sci U S A (1996) 1.37
Overexpression of the Met/HGF receptor in ovarian cancer. Int J Cancer (1994) 1.36
Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas. Br J Cancer (1996) 1.35
A randomized, placebo-controlled phase 2 study of ganitumab (AMG 479) or conatumumab (AMG 655) in combination with gemcitabine in patients with metastatic pancreatic cancer. Ann Oncol (2012) 1.34
Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential. Oncogene (1997) 1.34
SV40 replication in human mesothelial cells induces HGF/Met receptor activation: a model for viral-related carcinogenesis of human malignant mesothelioma. Proc Natl Acad Sci U S A (2001) 1.29
Fibronectin-plasma membrane interaction in the adhesion of hemopoietic cells. J Cell Biol (1986) 1.29
Hepatocyte growth factor (HGF) receptor expression is inducible and is part of the delayed-early response to HGF. J Biol Chem (1994) 1.26
Retrogenic expression of the MET proto-oncogene correlates with the invasive phenotype of human rhabdomyosarcomas. Oncogene (1996) 1.25
Creation of an hepatocyte growth factor/scatter factor autocrine loop in carcinoma cells induces invasive properties associated with increased tumorigenicity. Oncogene (1994) 1.24
The hyaluronate receptor is identical to a glycoprotein of Mr 85,000 (gp85) as shown by a monoclonal antibody that interferes with binding activity. J Biol Chem (1987) 1.24
p145, a protein with associated tyrosine kinase activity in a human gastric carcinoma cell line. Mol Cell Biol (1988) 1.22
Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility. J Biol Chem (1996) 1.22
Targeting of the SF/HGF receptor to the basolateral domain of polarized epithelial cells. J Cell Biol (1994) 1.22
Pathway specificity for Met signalling. Nat Cell Biol (2001) 1.19
Overexpression of the met/HGF receptor in renal cell carcinomas. Int J Cancer (1996) 1.18
Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth. Cancer Res (2001) 1.18
Phosphotyrosine antibodies identify the p210c-abl tyrosine kinase and proteins phosphorylated on tyrosine in human chronic myelogenous leukemia cells. Mol Cell Biol (1986) 1.17
Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis. Oncogene (2000) 1.15
Hepatocyte growth factor and its receptor, the tyrosine kinase encoded by the c-MET proto-oncogene. Cell Mol Biol (Noisy-le-grand) (1994) 1.15
Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase. J Biol Chem (1994) 1.15
Karyotypic analysis of gastric carcinoma cell lines carrying an amplified c-met oncogene. Cancer Genet Cytogenet (1992) 1.14
Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists. Oncogene (1999) 1.14
A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor. Proc Natl Acad Sci U S A (1996) 1.14
HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity. FASEB J (2000) 1.13
Constitutive activation of the RON gene promotes invasive growth but not transformation. Mol Cell Biol (1996) 1.13
Hepatocyte growth factor induces proliferation and differentiation of multipotent and erythroid hemopoietic progenitors. J Cell Biol (1994) 1.12
Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells. Oncogene (1997) 1.12
The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1. J Biol Chem (1996) 1.11
Molecular characteristics of HGF-SF and its role in cell motility and invasion. EXS (1993) 1.10
Plexins, semaphorins, and scatter factor receptors: a common root for cell guidance signals? IUBMB Life (1999) 1.10
Immunological detection of proteins phosphorylated at tyrosine in cells stimulated by growth factors or transformed by retroviral-oncogene-coded tyrosine kinases. Eur J Biochem (1986) 1.09
Structural and functional domains critical for constitutive activation of the HGF-receptor (Met). Oncogene (1994) 1.09
Src-mediated activation of alpha-diacylglycerol kinase is required for hepatocyte growth factor-induced cell motility. EMBO J (2000) 1.09
Receptor for bombesin with associated tyrosine kinase activity. Mol Cell Biol (1986) 1.08