Published in J Bacteriol on April 01, 1993
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc Natl Acad Sci U S A (2001) 4.56
Genomic basis for natural product biosynthetic diversity in the actinomycetes. Nat Prod Rep (2009) 3.74
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis. Proc Natl Acad Sci U S A (1999) 1.98
Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae. J Bacteriol (2001) 1.44
Genomewide insertional mutagenesis in Streptomyces coelicolor reveals additional genes involved in morphological differentiation. Proc Natl Acad Sci U S A (2000) 1.28
Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters. J Ind Microbiol Biotechnol (2013) 1.07
Antibiotic overproduction by rpsL and rsmG mutants of various actinomycetes. Appl Environ Microbiol (2009) 1.05
Recombinant organisms for production of industrial products. Bioeng Bugs (2009) 1.04
Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone. Biochemistry (2011) 0.97
The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis. Mol Genet Genomics (2009) 0.96
Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis. J Antibiot (Tokyo) (2010) 0.85
A novel TetR family transcriptional regulator, SAV576, negatively controls avermectin biosynthesis in Streptomyces avermitilis. PLoS One (2013) 0.83
Production and Screening of High Yield Avermectin B1b Mutant of Streptomyces avermitilis 41445 Through Mutagenesis. Jundishapur J Microbiol (2014) 0.75
Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene (1985) 213.67
Genetic engineering in vivo using translocatable drug-resistance elements. New methods in bacterial genetics. J Mol Biol (1977) 20.29
Physical and genetic characterization of symbiotic and auxotrophic mutants of Rhizobium meliloti induced by transposon Tn5 mutagenesis. J Bacteriol (1982) 14.27
Factors affecting the isolation of CCC DNA from Streptomyces lividans and Escherichia coli. Plasmid (1984) 10.92
Avermectins, new family of potent anthelmintic agents: producing organism and fermentation. Antimicrob Agents Chemother (1979) 5.88
Genetic transposition and insertional mutagenesis in Bacillus subtilis with Streptococcus faecalis transposon Tn917. Proc Natl Acad Sci U S A (1983) 5.57
Genetic analysis of Bacillus subtilis spo mutations generated by Tn917-mediated insertional mutagenesis. Genetics (1987) 3.04
Plasmid pIJ699, a multi-copy positive-selection vector for Streptomyces. Gene (1988) 2.53
Isolation of temperature-sensitive mutants of R plasmid by in vitro mutagenesis with hydroxylamine. J Bacteriol (1976) 1.86
Regional specificity of illegitimate recombination by the translocatable ampicillin-resistance element Tn1 in the genome of phage P22. Genetics (1979) 1.57
Genetic studies of avermectin biosynthesis in Streptomyces avermitilis. J Bacteriol (1987) 1.31
Tn501 insertion mutagenesis in Pseudomonas aeruginosa PAO. Mol Gen Genet (1984) 1.17
Transposition of Tn5096 and other IS493 derivatives in Streptomyces griseofuscus. J Bacteriol (1991) 1.17
Tn1 insertion mutagenesis in Escherichia coli K-12 using a temperature-sensitive mutant of plasmid RP4. Mol Gen Genet (1981) 1.12
Tn4556, a 6.8-kilobase-pair transposable element of Streptomyces fradiae. J Bacteriol (1987) 1.11
Method for selection of transposable DNA and characterization of a new insertion sequence, IS493, from Streptomyces lividans. J Bacteriol (1989) 1.09
Involvement of glucose catabolism in avermectin production by Streptomyces avermitilis. Antimicrob Agents Chemother (1988) 1.00
Nucleotide sequence of Streptomyces fradiae transposable element Tn4556: a class-II transposon related to Tn3. Gene (1990) 0.97
Selective production of specific components of avermectins in Streptomyces avermitilis. J Antibiot (Tokyo) (1991) 0.93
Transposition of Tn4560 in Streptomyces avermitilis. J Antibiot (Tokyo) (1990) 0.85
Read-through transcription from a derepressed Tn3 promoter affects ColE1 functions on a ColE1::Tn3 composite plasmid. Mol Gen Genet (1982) 0.84
Effect of oligomycin and succinate on mitochondrial metabolism of adenine nucleotides. Biochim Biophys Acta (1967) 0.79
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell (1998) 12.66
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett (1997) 11.19
VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell (1990) 8.87
A highly sensitive method to assay FK-506 levels in plasma. Transplant Proc (1987) 8.45
Degradation of CFTR by the ubiquitin-proteasome pathway. Cell (1995) 7.88
Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature (2000) 6.70
Avermectins, new family of potent anthelmintic agents: producing organism and fermentation. Antimicrob Agents Chemother (1979) 5.88
Nrl is required for rod photoreceptor development. Nat Genet (2001) 5.68
Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small-cell lung cancer. J Clin Oncol (1999) 5.65
Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature (1988) 5.60
Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci U S A (1990) 4.40
X-ray diffraction evidence for the extensibility of actin and myosin filaments during muscle contraction. Biophys J (1994) 4.37
Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA). Nat Genet (1994) 4.36
Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation (2000) 4.32
The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis. Bacteriol Rev (1976) 4.11
Simultaneous observation of individual ATPase and mechanical events by a single myosin molecule during interaction with actin. Cell (1998) 3.79
Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med (2001) 3.69
The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution. Neuron (2001) 3.68
Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J (1998) 3.63
Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J (1994) 3.60
Rapid detection and evaluation of clinical characteristics of emerging multiple-drug-resistant gram-negative rods carrying the metallo-beta-lactamase gene blaIMP. Antimicrob Agents Chemother (1998) 3.57
Diagnostic criteria for primary osteoporosis: year 2000 revision. J Bone Miner Metab (2001) 3.43
Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene. Nat Genet (1994) 3.39
Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway. Cancer Res (1996) 3.37
Prostaglandin D2 as a mediator of allergic asthma. Science (2000) 3.19
Electric and magnetic phenomena observed before the volcano-seismic activity in 2000 in the Izu Island Region, Japan. Proc Natl Acad Sci U S A (2002) 3.18
Inhibition of fatty acid synthesis by the antibiotic cerulenin. Specific inactivation of beta-ketoacyl-acyl carrier protein synthetase. Biochim Biophys Acta (1973) 3.10
Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT. Nat Genet (1996) 3.07
Characterization of the cell surface heterodimer VLA-4 and related peptides. J Biol Chem (1987) 2.94
Retracted Comparison of ramosetron and granisetron for preventing postoperative nausea and vomiting after gynecologic surgery. Anesth Analg (1999) 2.85
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature (2001) 2.83
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene. Nat Genet (2001) 2.79
In vitro activities of a new lipopeptide antifungal agent, FK463, against a variety of clinically important fungi. Antimicrob Agents Chemother (2000) 2.73
Activated conformations of very late activation integrins detected by a group of antibodies (HUTS) specific for a novel regulatory region (355-425) of the common beta 1 chain. J Biol Chem (1996) 2.72
Visualization of dystrophic muscle fibers in mdx mouse by vital staining with Evans blue: evidence of apoptosis in dystrophin-deficient muscle. J Biochem (1995) 2.69
Programmable matter by folding. Proc Natl Acad Sci U S A (2010) 2.65
Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha. Mol Cell Biol (2000) 2.61
Fibronectin receptor structures in the VLA family of heterodimers. Nature (1987) 2.54
Flow-cytometric separation and enrichment of hepatic progenitor cells in the developing mouse liver. Hepatology (2000) 2.43
Overtime work, insufficient sleep, and risk of non-fatal acute myocardial infarction in Japanese men. Occup Environ Med (2002) 2.43
Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway. Mol Cell Biol (1997) 2.43
Limb blood flow and vascular conductance are reduced with age in healthy humans: relation to elevations in sympathetic nerve activity and declines in oxygen demand. Circulation (1999) 2.40
Gene cloning of chitinase A1 from Bacillus circulans WL-12 revealed its evolutionary relationship to Serratia chitinase and to the type III homology units of fibronectin. J Biol Chem (1990) 2.38
Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells. J Virol (1996) 2.38
Brachial-ankle pulse wave velocity: an index of central arterial stiffness? J Hum Hypertens (2005) 2.36
Uveal effusion syndrome: clinical features, surgical treatment, histologic examination of the sclera, and pathophysiology. Ophthalmology (2000) 2.36
Phenotypic difference of normal plasma cells from mature myeloma cells. Blood (1993) 2.35
Control of cell pattern in the developing nervous system: polarizing activity of the floor plate and notochord. Cell (1991) 2.31
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors. J Med Chem (1996) 2.29
Identification of glutamic acid 204 and aspartic acid 200 in chitinase A1 of Bacillus circulans WL-12 as essential residues for chitinase activity. J Biol Chem (1993) 2.28
1 alpha,25-Dihydroxyvitamin D3 induces differentiation of human myeloid leukemia cells. Biochem Biophys Res Commun (1981) 2.21
Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures. J Biol Chem (1988) 2.20
Degradation of a mutant secretory protein, alpha1-antitrypsin Z, in the endoplasmic reticulum requires proteasome activity. J Biol Chem (1996) 2.19
Evaluation of topical pharyngeal anesthesia for upper endoscopy including factors associated with patient tolerance. Gastrointest Endosc (2001) 2.19
The gene for Machado-Joseph disease maps to human chromosome 14q. Nat Genet (1993) 2.18
Cardiac involvement in mitochondrial diseases. A study on 17 patients with documented mitochondrial DNA defects. Circulation (1995) 2.15
New and reliable MRI diagnosis for progressive supranuclear palsy. Neurology (2005) 2.14
The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis. Proc Natl Acad Sci U S A (1987) 2.11
Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells. EMBO J (1999) 2.10
Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions. J Cell Biol (1993) 2.08
Potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by 5-ethyl-6-phenylthiouracil derivatives through their interaction with the HIV-1 reverse transcriptase. Proc Natl Acad Sci U S A (1991) 2.08
Increasing numbers of synaptic puncta during late-phase LTP: N-cadherin is synthesized, recruited to synaptic sites, and required for potentiation. Neuron (2000) 2.07
Proteasome inhibitors block development of Plasmodium spp. Antimicrob Agents Chemother (1998) 2.07
Production of 'hybrid' antibiotics by genetic engineering. Nature (1985) 2.04
Studies on penicillinase inhibitors produced by microorganisms. J Antibiot (Tokyo) (1972) 2.04
Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation. J Biol Chem (2000) 2.04
Adenylate cyclases in yeast: a comparison of the genes from Schizosaccharomyces pombe and Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1989) 2.01
Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism. J Neurochem (1991) 2.01
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis. Proc Natl Acad Sci U S A (1999) 1.98
Binding site of cerulenin in fatty acid synthetase. J Biochem (1989) 1.98
Modulation of EphA receptor function by coexpressed ephrinA ligands on retinal ganglion cell axons. Neuron (1999) 1.97
Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury. Kidney Int (2008) 1.97
Laparoscopic removal of a large gastric trichobezoar. J Pediatr Surg (1998) 1.96
A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization. J Antibiot (Tokyo) (1977) 1.92
Cerulenin. Methods Enzymol (1981) 1.92
Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch. Nat Genet (1998) 1.91
The roles of the C-terminal domain and type III domains of chitinase A1 from Bacillus circulans WL-12 in chitin degradation. J Bacteriol (1994) 1.91
Deficiency of osteoclasts in osteopetrotic mice is due to a defect in the local microenvironment provided by osteoblastic cells. Endocrinology (1991) 1.90
Central arterial compliance is associated with age- and habitual exercise-related differences in cardiovagal baroreflex sensitivity. Circulation (2001) 1.89
Three distinct types of Ca(2+) waves in Langendorff-perfused rat heart revealed by real-time confocal microscopy. Circ Res (2000) 1.88
Treatment of gallbladder cancer by radical resection. Br J Surg (1999) 1.88
The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2. Biochem Biophys Res Commun (1990) 1.88
The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70. J Biol Chem (1997) 1.87
Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells. J Antibiot (Tokyo) (1991) 1.86
A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells. Blood (2000) 1.86
Expression of a gibberellin 2-oxidase gene around the shoot apex is related to phase transition in rice. Plant Physiol (2001) 1.86
Multitissue circadian expression of rat period homolog (rPer2) mRNA is governed by the mammalian circadian clock, the suprachiasmatic nucleus in the brain. J Biol Chem (1998) 1.86
Decreased 1,25-dihydroxyvitamin D3 receptor density is associated with a more severe form of parathyroid hyperplasia in chronic uremic patients. J Clin Invest (1993) 1.85
In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells. Science (1991) 1.85
Suppression of DNA replication via Mos function during meiotic divisions in Xenopus oocytes. EMBO J (1994) 1.84
N-cadherin redistribution during synaptogenesis in hippocampal neurons. J Neurosci (1998) 1.84
Structure of the integrin VLA-4 and its cell-cell and cell-matrix adhesion functions. Immunol Rev (1990) 1.83
Heme oxygenase-1 protects against radiocontrast-induced acute kidney injury by regulating anti-apoptotic proteins. Kidney Int (2007) 1.80
Structure of the gene encoding beta-1,3-glucanase A1 of Bacillus circulans WL-12. Gene (1990) 1.79
Age-related declines in maximal aerobic capacity in regularly exercising vs. sedentary women: a meta-analysis. J Appl Physiol (1985) (1997) 1.79