The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution.

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🔗 View Article (PMID 11604139)

Published in Neuron on October 11, 2001

Authors

G R Phillips1, J K Huang, Y Wang, H Tanaka, L Shapiro, W Zhang, W S Shan, K Arndt, M Frank, R E Gordon, M A Gawinowicz, Y Zhao, D R Colman

Author Affiliations

1: The Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Department of Neurology and The Fishberg Research Center for Neurobiology, New York, NY 10029, USA.

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Bacterial differentiation. Science (1971) 3.65

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Facilitation and depression at single central synapses. Neuron (1995) 2.95