Simian virus 40 small-t antigen binds two zinc ions.

PubWeight™: 1.04‹?› | Rank: Top 15%

🔗 View Article (PMC 237723)

Published in J Virol on June 01, 1993

Authors

B Turk1, A Porras, M C Mumby, K Rundell

Author Affiliations

1: Department of Microbiology-Immunology, Northwestern University, Chicago, Illinois 60611-3008.

Articles citing this

The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain. Mol Cell Biol (1997) 2.33

Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation. J Virol (1994) 1.42

A novel simian virus 40 early-region domain mediates transactivation of the cyclin A promoter by small-t antigen and is required for transformation in small-t antigen-dependent assays. J Virol (1996) 1.36

Structural basis of PP2A inhibition by small t antigen. PLoS Biol (2007) 1.32

Simian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptor. Mol Cell Biol (2005) 1.13

Small tumor antigen of polyomaviruses: role in viral life cycle and cell transformation. J Cell Physiol (2008) 1.02

Simian virus 40 small-t antigen stimulates viral DNA replication in permissive monkey cells. J Virol (1994) 0.99

Role of Zn2+ ions in host-virus interactions. J Virol (2008) 0.95

Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens. J Virol (1999) 0.93

Mutations in a CCHC zinc-binding motif of the reovirus sigma 3 protein decrease its intracellular stability. J Virol (1994) 0.91

Zinc-binding and protein-protein interactions mediated by the polyomavirus large T antigen zinc finger. J Virol (1995) 0.89

The Oncogenic Small Tumor Antigen of Merkel Cell Polyomavirus Is an Iron-Sulfur Cluster Protein That Enhances Viral DNA Replication. J Virol (2015) 0.77

SV40 reporter viruses. J Virol Methods (2008) 0.75

Articles cited by this

Calculation of protein extinction coefficients from amino acid sequence data. Anal Biochem (1989) 29.15

Monoclonal antibodies specific for simian virus 40 tumor antigens. J Virol (1981) 15.59

Construction and analysis of viable deletion mutants of simian virus 40. J Virol (1976) 9.11

Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. Cell (1990) 6.12

Mutants of SV40 with an altered small t protein are reduced in their ability to transform cells. Cell (1978) 5.23

New region of the simian virus 40 genome required for efficient viral transformation. Proc Natl Acad Sci U S A (1978) 4.24

Association of protein phosphatase 2A with polyoma virus medium tumor antigen. Proc Natl Acad Sci U S A (1990) 3.76

The roles of the simian virus 40 tumor antigens in transformation of Chinese hamster lung cells. Cell (1979) 3.57

Control of protein phosphatase 2A by simian virus 40 small-t antigen. Mol Cell Biol (1991) 2.80

GAL4 transcription factor is not a "zinc finger" but forms a Zn(II)2Cys6 binuclear cluster. Proc Natl Acad Sci U S A (1990) 2.33

Properties of simian virus 40 small t antigen overproduced in bacteria. J Virol (1981) 2.08

Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen. Mol Cell Biol (1991) 1.99

Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A. EMBO J (1989) 1.83

Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus. Mol Cell Biol (1992) 1.83

Simian virus 40 (SV40) small t antigen inhibits SV40 DNA replication in vitro. J Virol (1992) 1.55

The zinc finger region of simian virus 40 large T antigen. J Virol (1989) 1.47

Purification and functional properties of simian virus 40 large and small T antigens overproduced in insect cells. J Virol (1988) 1.14

Interaction of simian virus 40 small-T antigen produced in bacteria with 56K and 32K proteins of animal cells. J Virol (1985) 1.13

Mutational analysis of simian virus 40 small-t antigen. J Virol (1990) 1.13

Effect of zinc ions on the biochemical behavior of simian virus 40 small-t antigen expressed in bacteria. J Virol (1992) 0.96

Zinc release from Xenopus transcription factor IIIA induced by chemical modifications. Biochemistry (1989) 0.95

Articles by these authors

Regulation of tumor antigen synthesis by simain virus 40 gene A. J Virol (1975) 9.93

Organization and expression of early genes of simian virus 40. Proc Natl Acad Sci U S A (1978) 7.10

Identification of simian virus 40 protein A. J Virol (1977) 4.93

Modification of simian virus 40 protein A. J Virol (1977) 3.79

Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. Neuron (1999) 3.70

Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol Cell (2000) 3.54

p38 MAP kinases: beyond the stress response. Trends Biochem Sci (2000) 3.20

Control of protein phosphatase 2A by simian virus 40 small-t antigen. Mol Cell Biol (1991) 2.80

Ceramide activates heterotrimeric protein phosphatase 2A. J Biol Chem (1993) 2.77

INH, a negative regulator of MPF, is a form of protein phosphatase 2A. Cell (1991) 2.73

Cellular proteins associated with simian virus 40 early gene products in newly infected cells. J Virol (1979) 2.44

The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain. Mol Cell Biol (1997) 2.33

Purification and characterization of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from bovine tissues. J Biol Chem (1982) 2.12

A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle. J Cell Biol (1995) 2.02

Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen. Mol Cell Biol (1991) 1.99

Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A. Neuron (1996) 1.93

Induction of cyclin D1 by simian virus 40 small tumor antigen. Proc Natl Acad Sci U S A (1996) 1.86

Comparison of heterotrimeric protein phosphatase 2A containing different B subunits. J Biol Chem (1994) 1.73

Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid. J Biol Chem (1999) 1.63

Association of cellular 56,000- and 32,000-molecular-weight protein with BK virus and polyoma virus t-antigens. J Virol (1981) 1.63

Complete interaction of cellular 56,000- and 32,000-Mr proteins with simian virus 40 small-t antigen in productively infected cells. J Virol (1987) 1.63

Simian virus 40 (SV40) small t antigen inhibits SV40 DNA replication in vitro. J Virol (1992) 1.55

Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies. J Biol Chem (1999) 1.54

Regulation of endosome sorting by a specific PP2A isoform. J Cell Biol (1998) 1.51

Critical role for SV40 small-t antigen in human cell transformation. Virology (2001) 1.46

Simian virus 40 t antigen affects the sensitivity of cellular DNA synthesis to theophylline. J Virol (1979) 1.43

Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation. J Virol (1994) 1.42

Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle. J Biol Chem (1996) 1.41

Identification and properties of cyclic nucleotide phosphodiesterases. Mol Cell Endocrinol (1983) 1.41

Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases. Proc Natl Acad Sci U S A (1993) 1.38

Cardiac contractile protein phosphatases. Purification of two enzyme forms and their characterization with subunit-specific antibodies. J Biol Chem (1987) 1.37

A novel simian virus 40 early-region domain mediates transactivation of the cyclin A promoter by small-t antigen and is required for transformation in small-t antigen-dependent assays. J Virol (1996) 1.36

PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. Mol Cell Biol (2000) 1.36

Diversity in the regulatory B-subunits of protein phosphatase 2A: identification of a novel isoform highly expressed in brain. Biochemistry (1994) 1.35

Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocytic differentiation. Mol Cell Biol (1997) 1.35

Molecular cloning and sequence analysis of the catalytic subunit of bovine type 2A protein phosphatase. Proc Natl Acad Sci U S A (1987) 1.32

GTP gamma S-dependent regulation of smooth muscle contractile elements. Am J Physiol (1992) 1.29

Simian virus 40 small t antigen cooperates with mitogen-activated kinases to stimulate AP-1 activity. Mol Cell Biol (1994) 1.27

Proteolysis at the 2A/2B junction in Theiler's murine encephalomyelitis virus. Virology (1991) 1.26

Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A. Mol Cell Biol (1998) 1.24

Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes. Science (1991) 1.22

Glutamatergic neurotransmission in aging: a critical perspective. Mech Ageing Dev (2001) 1.22

Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model. Clin Pharmacol Ther (1999) 1.22

Homologous cellular proteins associated with simian virus 40 small T antigen and polyomavirus medium T antigen. J Virol (1988) 1.21

Structural characterization of cardiac protein phosphatase with a monoclonal antibody. Evidence that the Mr = 38,000 phosphatase is the catalytic subunit of the native enzyme(s). J Biol Chem (1985) 1.21

The ras signaling pathway mimics insulin action on glucose transporter translocation. Proc Natl Acad Sci U S A (1993) 1.20

Failure of simian virus 40 small t antigen to disorganize actin cables in nonpermissive cell lines. J Virol (1988) 1.20

Distinct roles for PP1 and PP2A in phosphorylation of the retinoblastoma protein. PP2a regulates the activities of G(1) cyclin-dependent kinases. J Biol Chem (1999) 1.19

Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits. J Biol Chem (1992) 1.19

Subunit interactions control protein phosphatase 2A. Effects of limited proteolysis, N-ethylmaleimide, and heparin on the interaction of the B subunit. J Biol Chem (1991) 1.17

Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation. J Biol Chem (1997) 1.16

Brain protein serine/threonine phosphatases. Curr Opin Neurobiol (1999) 1.15

Interaction of simian virus 40 small-T antigen produced in bacteria with 56K and 32K proteins of animal cells. J Virol (1985) 1.13

Mutational analysis of simian virus 40 small-t antigen. J Virol (1990) 1.13

Effects of regulatory subunits on the kinetics of protein phosphatase 2A. Biochemistry (2000) 1.12

NH2-terminal modification of the phosphatase 2A catalytic subunit allows functional expression in mammalian cells. J Biol Chem (1992) 1.12

Association of simian virus 40 small-t antigen with the 61-kilodalton component of a cellular protein complex. J Virol (1990) 1.11

Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response. Oncogene (2010) 1.09

Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements. Mol Cell Biol (1993) 1.09

Identification of an activity that interacts with the 3'-untranslated region of c-myc mRNA and the role of its target sequence in mediating rapid mRNA degradation. J Biol Chem (1994) 1.08

p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A. Mol Cell Biol (1996) 1.08

Frequency of sexual dysfunction and other reproductive side-effects in patients with schizophrenia treated with risperidone, olanzapine, quetiapine, or haloperidol: the results of the EIRE study. J Sex Marital Ther (2003) 1.07

Pharmacokinetics, COX-2 specificity, and tolerability of supratherapeutic doses of rofecoxib in humans. Eur J Clin Pharmacol (2000) 1.02

Differential activities of protein phosphatase types 1 and 2A in cytosolic and particulate fractions from rat forebrain. J Neurochem (1994) 1.01

The simian virus 40 small-t and large-T antigens jointly regulate cell cycle reentry in human fibroblasts. J Virol (1999) 1.00

Identification of structural elements involved in the interaction of simian virus 40 small tumor antigen with protein phosphatase 2A. J Biol Chem (1998) 1.00

Simian virus 40 small-t antigen stimulates viral DNA replication in permissive monkey cells. J Virol (1994) 0.99

Purification and characterization of ceramide-activated protein phosphatases. Biochemistry (1998) 0.98

Cell cycle progression in monkey cells expressing simian virus 40 small t antigen from adenovirus vectors. J Virol (1998) 0.98

[Validation of the Spanish version of PRIME-MD: a procedure for diagnosing mental disorders in primary care]. Actas Esp Psiquiatr (2000) 0.97

Resistance of Salmonella typhimurium mutants to galactose death. J Bacteriol (1969) 0.97

Simian virus 40 small-t antigen-induced theophylline resistance is not mediated by cyclic AMP. J Virol (1985) 0.96

Effect of zinc ions on the biochemical behavior of simian virus 40 small-t antigen expressed in bacteria. J Virol (1992) 0.96

p21ras-induced meiotic maturation of Xenopus oocytes in the absence of protein synthesis: MPF activation is preceded by activation of MAP and S6 kinases. Oncogene (1993) 0.95

The interconversion of protein phosphatase 2A between PP2A1 and PP2A0 during retinoic acid-induced granulocytic differentiation and a modification on the catalytic subunit in S phase of HL-60 cells. Arch Biochem Biophys (1997) 0.94

Identification of the human papovavirus T antigen and comparison with the simian virus 40 protein a. Virology (1977) 0.93

TNF-alpha inhibits UCP-1 expression in brown adipocytes via ERKs. Opposite effect of p38MAPK. FEBS Lett (2001) 0.93

SV40 antitumor sera that directly immunoprecipitate small-t-associated cellular proteins. Virology (1981) 0.93

Dopamine receptor blockade inhibits the amphetamine-induced release of diadenosine polyphosphates, diadenosine tetraphosphate and diadenosine pentaphosphate, from neostriatum of the conscious rat. J Neurochem (1995) 0.92

Simian virus 40 small-t does not transactivate RNA polymerase II promoters in virus infections. J Virol (1991) 0.92

The regulatory subunit of neural cAMP-dependent protein kinase II represents a unique gene product. J Biol Chem (1985) 0.90

Activation of p38MAPK by TGF-beta in fetal rat hepatocytes requires radical oxygen production, but is dispensable for cell death. FEBS Lett (2001) 0.90

p38 mitogen-activated protein kinase mediates tumor necrosis factor-alpha-induced apoptosis in rat fetal brown adipocytes. Endocrinology (2000) 0.90

SV40 17K protein is associated with two cellular proteins. Cold Spring Harb Symp Quant Biol (1980) 0.89

Presence in growth-arrested cells of cellular proteins that interact with simian virus 40 small-t antigen. J Virol (1982) 0.89

Overexpression of simian virus 40 small-T antigen blocks centrosome function and mitotic progression in human fibroblasts. J Virol (2001) 0.88

Effect of aspirin and sulindac on methotrexate clearance. J Pharm Sci (1990) 0.87

Insulin stimulates the generation of an adipocyte phosphoprotein that is isolated with a monoclonal antibody against the regulatory subunit of bovine heart cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1986) 0.87

Triiodothyronine induces the transcription of the uncoupling protein gene and stabilizes its mRNA in fetal rat brown adipocyte primary cultures. J Biol Chem (1996) 0.87

Establishment of permanent brown adipocyte cell lines achieved by transfection with SV40 large T antigen and ras genes. Exp Cell Res (1993) 0.87

Structural studies of rabbit skeletal muscle myosin light chain kinase with monoclonal antibodies. J Biol Chem (1987) 0.87

Effects of a nitric oxide donor on glutamate and GABA release in striatum and hippocampus of the conscious rat. Neuroreport (1994) 0.87

Amphetamine-induced release of diadenosine polyphosphates--Ap4A and Ap5A--from caudate putamen of conscious rat. Neurosci Lett (1993) 0.86

The leader polypeptide of Theiler's murine encephalomyelitis virus is required for the assembly of virions in mouse L cells. J Virol (2000) 0.84

Site-specific dephosphorylation of smooth muscle myosin light chain kinase by protein phosphatases 1 and 2A. Biochemistry (1992) 0.84

Antibiotic susceptibility and molecular epidemiology of nasopharyngeal pneumococci from Spanish children. Clin Microbiol Infect (2008) 0.84

Membrane-associated nucleotide sugar reactions: influence of mutations affecting lipopolysaccharide on the first enzyme of O-antigen synthesis. J Bacteriol (1975) 0.84