Published in J Virol on January 01, 1989
Common and unique features of T antigens encoded by the polyomavirus group. J Virol (1992) 3.31
Simian virus 40 T-antigen DNA helicase is a hexamer which forms a binary complex during bidirectional unwinding from the viral origin of DNA replication. J Virol (1992) 2.96
Transformation of a continuous rat embryo fibroblast cell line requires three separate domains of simian virus 40 large T antigen. J Virol (1992) 1.51
Four major sequence elements of simian virus 40 large T antigen coordinate its specific and nonspecific DNA binding. J Virol (1990) 1.48
Mapping the transcriptional transactivation function of simian virus 40 large T antigen. J Virol (1991) 1.47
Identification of simian virus 40 T-antigen residues important for specific and nonspecific binding to DNA and for helicase activity. J Virol (1990) 1.35
The SPT10 and SPT21 genes of Saccharomyces cerevisiae. Genetics (1994) 1.25
The DNA-binding domain of simian virus 40 tumor antigen has multiple functions. J Virol (1993) 1.22
Mapping of helicase and helicase substrate-binding domains on simian virus 40 large T antigen. J Virol (1990) 1.22
The zinc finger region of simian virus 40 large T antigen is needed for hexamer assembly and origin melting. J Virol (1991) 1.16
Role of single-stranded DNA binding activity of T antigen in simian virus 40 DNA replication. J Virol (2001) 1.13
The ability of large T antigen to complex with p53 is necessary for the increased life span and partial transformation of human cells by simian virus 40. J Virol (1991) 1.11
Temperature-sensitive mutants identify crucial structural regions of simian virus 40 large T antigen. J Virol (1989) 1.09
Properties of the DNA-binding domain of the simian virus 40 large T antigen. Mol Cell Biol (1989) 1.08
Mechanisms of simian virus 40 T-antigen activation by phosphorylation of threonine 124. J Virol (1996) 1.08
Nonspecific DNA binding activity of simian virus 40 large T antigen: evidence for the cooperation of two regions for full activity. J Virol (1992) 1.07
Model for T-antigen-dependent melting of the simian virus 40 core origin based on studies of the interaction of the beta-hairpin with DNA. J Virol (2007) 1.06
Biochemical analysis of mutants with changes in the origin-binding domain of simian virus 40 tumor antigen. J Virol (1993) 1.06
Simian virus 40 small-t antigen binds two zinc ions. J Virol (1993) 1.04
Linker insertion mutants of simian virus 40 large T antigen that show trans-dominant interference with wild-type large T antigen map to multiple sites within the T-antigen gene. J Virol (1989) 1.01
Stable T-p53 complexes are not required for replication of simian virus 40 in culture or for enhanced phosphorylation of T antigen and p53. J Virol (1991) 1.00
The N-terminal side of the origin-binding domain of simian virus 40 large T antigen is involved in A/T untwisting. J Virol (1997) 0.96
Effect of zinc ions on the biochemical behavior of simian virus 40 small-t antigen expressed in bacteria. J Virol (1992) 0.96
Large T-antigen mutants define multiple steps in the initiation of simian virus 40 DNA replication. J Virol (1989) 0.95
Characterization of a novel polyomavirus isolated from a fibroma on the trunk of an African elephant (Loxodonta africana). PLoS One (2013) 0.95
Mutations in a CCHC zinc-binding motif of the reovirus sigma 3 protein decrease its intracellular stability. J Virol (1994) 0.91
Functional characterization of temperature-sensitive mutants of simian virus 40 large T antigen. J Virol (1992) 0.90
Zinc-binding and protein-protein interactions mediated by the polyomavirus large T antigen zinc finger. J Virol (1995) 0.89
The finger domain of simian virus 40 large T antigen controls DNA-binding specificity. J Virol (1990) 0.86
Thermally inactivated simian virus 40 tsA58 mutant T antigen cannot initiate viral DNA replication in vitro. J Virol (1990) 0.85
Loss of DNA-binding and new transcriptional trans-activation function in polyomavirus large T-antigen with mutation of zinc finger motif. Nucleic Acids Res (1990) 0.85
Simian virus 40 DNA replication is dependent on an interaction between topoisomerase I and the C-terminal end of T antigen. J Virol (2007) 0.82
Necdin, a p53-target gene, is an inhibitor of p53-mediated growth arrest. PLoS One (2012) 0.81
Role of the hydrophilic channels of simian virus 40 T-antigen helicase in DNA replication. J Virol (2007) 0.79
A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology (1973) 127.36
Selective extraction of polyoma DNA from infected mouse cell cultures. J Mol Biol (1967) 106.91
New M13 vectors for cloning. Methods Enzymol (1983) 90.74
Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc Natl Acad Sci U S A (1985) 68.48
SV40-transformed simian cells support the replication of early SV40 mutants. Cell (1981) 34.67
Enchancement of the infectivity of simian virus 40 deoxyribonucleic acid with diethylaminoethyl-dextran. J Natl Cancer Inst (1968) 21.44
Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J (1985) 20.39
T antigen is bound to a host protein in SV40-transformed cells. Nature (1979) 17.78
Simian virus 40 deoxyribonucleic acid synthesis: the viral replicon. J Virol (1972) 16.59
An interactive graphics program for comparing and aligning nucleic acid and amino acid sequences. Nucleic Acids Res (1982) 12.58
Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell (1987) 12.30
The binding site on SV40 DNA for a T antigen-related protein. Cell (1978) 10.58
Regulation of tumor antigen synthesis by simain virus 40 gene A. J Virol (1975) 9.93
Autoregulation of simian virus 40 gene A by T antigen. Proc Natl Acad Sci U S A (1976) 6.38
DNA helicase activity of SV40 large tumor antigen. EMBO J (1986) 6.08
Human polyomavirus JC virus genome. J Virol (1984) 5.87
DNA infectivity and the induction of host DNA synthesis with temperature-sensitive mutants of simian virus 40. J Virol (1975) 5.22
Topography of simian virus 40 A protein-DNA complexes: arrangement of pentanucleotide interaction sites at the origin of replication. J Virol (1983) 5.00
Simian virus 40 (SV40) DNA replication: SV40 large T antigen unwinds DNA containing the SV40 origin of replication. Proc Natl Acad Sci U S A (1987) 4.79
Relationship of replication and transcription of Simian Virus 40 DNA. Proc Natl Acad Sci U S A (1973) 4.35
Initiation of simian virus 40 DNA replication in vitro: large-tumor-antigen- and origin-dependent unwinding of the template. Proc Natl Acad Sci U S A (1987) 4.23
Enzymatic activities associated with a purified simian virus 40 T antigen-related protein. Proc Natl Acad Sci U S A (1979) 3.82
Stimulation of simian virus 40 late gene expression by simian virus 40 tumor antigen. Proc Natl Acad Sci U S A (1984) 3.80
Functional domains of adenovirus type 5 E1a proteins. Cell (1987) 3.79
In vitro mutagenesis of a putative DNA binding domain of SV40 large-T. Virology (1984) 3.50
p53 and DNA polymerase alpha compete for binding to SV40 T antigen. Nature (1987) 3.34
T-antigen-DNA polymerase alpha complex implicated in simian virus 40 DNA replication. Mol Cell Biol (1986) 3.22
Functional interactions of the simian virus 40 core origin of replication with flanking regulatory sequences. J Virol (1986) 3.15
A multigene family encoding several "finger" structures is present and differentially active in mammalian genomes. Cell (1987) 3.09
Specific mutator effects of ung (uracil-DNA glycosylase) mutations in Escherichia coli. J Bacteriol (1982) 2.92
Complete DNA sequence of lymphotropic papovavirus: prototype of a new species of the polyomavirus genus. Virology (1985) 2.53
Consensus topography in the ATP binding site of the simian virus 40 and polyomavirus large tumor antigens. Proc Natl Acad Sci U S A (1987) 2.15
Distinct binding sites for zinc and double-stranded RNA in the reovirus outer capsid protein sigma 3. Mol Cell Biol (1988) 1.96
Gene 32 protein, the single-stranded DNA binding protein from bacteriophage T4, is a zinc metalloprotein. Proc Natl Acad Sci U S A (1986) 1.86
Mutations in the phosphorylation sites of simian virus 40 (SV40) T antigen alter its origin DNA-binding specificity for sites I or II and affect SV40 DNA replication activity. J Virol (1988) 1.85
Simian virus 40 origin DNA-binding domain on large T antigen. J Virol (1986) 1.80
Expression of simian virus 40 T antigen in Escherichia coli: localization of T-antigen origin DNA-binding domain to within 129 amino acids. J Virol (1988) 1.77
Monoclonal antibodies as probes for a function of large T antigen during the elongation process of simian virus 40 DNA replication. J Virol (1987) 1.67
DNA-binding region of the simian virus 40 tumor antigen. J Virol (1986) 1.62
Studies on the origin-specific DNA-binding domain of simian virus 40 large T antigen. J Virol (1987) 1.56
Characterization of the in vitro interaction between SV40 T antigen and p53: mapping the p53 binding site. Virology (1988) 1.56
Fingering too many proteins. Cell (1988) 1.47
Simian virus 40 large tumor antigen on replicating viral chromatin: tight binding and localization on the viral genome. J Virol (1983) 1.29
Immortalization of primary mouse embryo fibroblasts with SV40 virions, viral DNA, and a subgenomic DNA fragment in a quantitative assay. Virology (1984) 1.24
Simian virus 40 and polyoma virus stimulate overall cellular RNA and protein synthesis. Proc Natl Acad Sci U S A (1980) 1.21
Mechanism of carboxypeptidase A: hydration of a ketonic substrate analogue. Proc Natl Acad Sci U S A (1987) 1.08
Metal ions in proteins: structural and functional roles. Cold Spring Harb Symp Quant Biol (1987) 0.90
WAF1, a potential mediator of p53 tumor suppression. Cell (1993) 38.72
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (1997) 29.34
Simian virus 40 deoxyribonucleic acid synthesis: the viral replicon. J Virol (1972) 16.59
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science (1995) 13.15
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet (1997) 10.71
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell (1993) 9.93
Regulation of tumor antigen synthesis by simain virus 40 gene A. J Virol (1975) 9.93
Function of simian virus 40 gene A in transforming infection. J Virol (1975) 8.09
Temperature-sensitive mutants of simian virus 40: infection of permissive cells. J Virol (1971) 7.95
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci U S A (1999) 7.88
Organization and expression of early genes of simian virus 40. Proc Natl Acad Sci U S A (1978) 7.10
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science (1998) 6.62
Inactivating and mutagenic effects of nitrosoguanidine on simian virus 40. Proc Natl Acad Sci U S A (1970) 5.46
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci U S A (1997) 5.32
Topography of simian virus 40 A protein-DNA complexes: arrangement of pentanucleotide interaction sites at the origin of replication. J Virol (1983) 5.00
Identification of simian virus 40 protein A. J Virol (1977) 4.93
Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nat Med (1996) 4.87
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proc Natl Acad Sci U S A (2001) 4.62
Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat Genet (1997) 4.39
Relationship of replication and transcription of Simian Virus 40 DNA. Proc Natl Acad Sci U S A (1973) 4.35
Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res (1997) 4.32
Altered patterns of protein synthesis in infection by SV40 mutants. Cold Spring Harb Symp Quant Biol (1975) 4.30
Modification of simian virus 40 protein A. J Virol (1977) 3.79
Suicide within 12 months of contact with mental health services: national clinical survey. BMJ (1999) 3.61
PTEN: life as a tumor suppressor. Exp Cell Res (2001) 3.41
Mutations of GTBP in genetically unstable cells. Science (1995) 3.23
Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res (1997) 3.17
PTEN gene mutations are seen in high-grade but not in low-grade gliomas. Cancer Res (1997) 3.15
Functional interactions of the simian virus 40 core origin of replication with flanking regulatory sequences. J Virol (1986) 3.15
Genetic instability occurs in the majority of young patients with colorectal cancer. Nat Med (1995) 3.07
An altered DNA conformation in origin region I is a determinant for the binding of SV40 large T antigen. Cell (1986) 2.88
Topography of simian virus 40 A protein-DNA complexes: arrangement of protein bound to the origin of replication. J Virol (1983) 2.79
p53 domains: identification and characterization of two autonomous DNA-binding regions. Genes Dev (1993) 2.74
Domain structure of the simian virus 40 core origin of replication. Mol Cell Biol (1986) 2.72
The role of PTEN signaling perturbations in cancer and in targeted therapy. Oncogene (2008) 2.66
Proposal for a uniform nomenclature for simian virus 40 mutants. J Virol (1972) 2.55
Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression. Proc Natl Acad Sci U S A (2001) 2.50
ATP enhances the binding of simian virus 40 large T antigen to the origin of replication. J Virol (1987) 2.43
The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene. Cancer Res (1998) 2.32
The adenine-thymine domain of the simian virus 40 core origin directs DNA bending and coordinately regulates DNA replication. Mol Cell Biol (1986) 2.31
Simian virus 40 deoxyribonucleic acid synthesis: analysis by gel electrophoresis. J Virol (1972) 2.31
DNA binding properties of simian virus 40 temperature-sensitive A proteins. J Virol (1982) 2.31
Three domains in the simian virus 40 core origin orchestrate the binding, melting, and DNA helicase activities of T antigen. J Virol (1990) 2.24
A phase 1/2 clinical trial of enzyme replacement in fabry disease: pharmacokinetic, substrate clearance, and safety studies. Am J Hum Genet (2001) 2.13
Alternative interactions of the SV40 A protein with DNA. Virology (1981) 2.09
The T-antigen-binding domain of the simian virus 40 core origin of replication. J Virol (1987) 2.08
Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors. Cancer Res (1997) 2.06
Anaemia in housed newborn lambs. Vet Rec (1995) 2.02
PTEN mutations in gliomas and glioneuronal tumors. Oncogene (1998) 2.01
Synthesis and assembly of simian virus 40. II. Synthesis of the major capsid protein and its incorporation into viral particles. J Virol (1972) 2.01
Altered protein metabolism in infection by the late tsB11 mutant of simian virus 40. J Virol (1974) 1.94
Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer. Oncogene (1995) 1.91
Role of cysteine residues in regulation of p53 function. Mol Cell Biol (1995) 1.91
Simian virus 40 large tumor antigen requires three core replication origin domains for DNA unwinding and replication in vitro. Proc Natl Acad Sci U S A (1987) 1.89
The pathogenic properties of Fusobacterium and Bacteroides species from wallabies and other sources. J Hyg (Lond) (1984) 1.89
A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res (1995) 1.86
Homozygous deletion of the PTEN tumor suppressor gene in a subset of prostate adenocarcinomas. Clin Cancer Res (1998) 1.83
Cooperative assembly of simian virus 40 T-antigen hexamers on functional halves of the replication origin. J Virol (1991) 1.78
Deletion of PTEN in a patient with Bannayan-Riley-Ruvalcaba syndrome suggests allelism with Cowden disease. Am J Med Genet (1997) 1.74
Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity. Diabetologia (2006) 1.72
Mental disorder and clinical care in people convicted of homicide: national clinical survey. BMJ (1999) 1.71
Sequence-specific binding of simian virus 40 A protein to nonorigin and cellular DNA. Mol Cell Biol (1984) 1.68
p53 domains: structure, oligomerization, and transformation. Mol Cell Biol (1994) 1.68
Formation of stable p53 homotetramers and multiples of tetramers. Mol Carcinog (1992) 1.68
Seventeen base pairs of region I encode a novel tripartite binding signal for SV40 T antigen. Cell (1985) 1.64
Induction of ventricular fibrillation to facilitate endovascular stent graft repair of thoracic aortic aneurysms. Anesthesiology (1998) 1.63
Herpes simplex virus origin-binding protein (UL9) loops and distorts the viral replication origin. J Virol (1991) 1.62
Monomers through trimers of large tumor antigen bind in region I and monomers through tetramers bind in region II of simian virus 40 origin of replication DNA as stable structures in solution. Proc Natl Acad Sci U S A (1985) 1.59
p53 oligomerization and DNA looping are linked with transcriptional activation. EMBO J (1994) 1.57
PCDH8, the human homolog of PAPC, is a candidate tumor suppressor of breast cancer. Oncogene (2008) 1.54
Feline herpesvirus infection in fused cultures of naturally resistant human cells. J Virol (1969) 1.52
The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation. Proc Natl Acad Sci U S A (1995) 1.52
Partial purification of SV40 A protein and a related cellular protein from permissive cells. Virology (1981) 1.51
Critical spatial requirement within the origin of simian virus 40 DNA replication. J Virol (1984) 1.49
Four major sequence elements of simian virus 40 large T antigen coordinate its specific and nonspecific DNA binding. J Virol (1990) 1.48
Replication but not transcription of simian virus 40 DNA is dependent on nuclear domain 10. J Virol (2000) 1.46
Identification of alanine dehydrogenase and its role in mixed secretion of ammonium and alanine by pea bacteroids. Mol Microbiol (2000) 1.41
Interaction of p53 with its consensus DNA-binding site. Mol Cell Biol (1995) 1.40
Characterization of major recognition sequences for a herpes simplex virus type 1 origin-binding protein. J Virol (1988) 1.39
Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas. Oncogene (1998) 1.38
Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers. Oncogene (1998) 1.36
Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice. BMC Mol Biol (2001) 1.36
APC truncation and increased beta-catenin levels in a human breast cancer cell line. Carcinogenesis (2000) 1.32
Binding of dephosphorylated A protein to SV40 DNA. Virology (1981) 1.30
Binding of simian virus 40 a protein to DNA with deletions at the origin of replication. J Virol (1984) 1.26
p53 domains: suppression, transformation, and transactivation. Gene Expr (1993) 1.24
Antigenic phenotypes and complementation groups of temperature-sensitive mutants of simian virus 40. J Virol (1974) 1.24
Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation. Cancer Res (1995) 1.24
Reciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: implications for regulation. Mol Cell Biol (1997) 1.23
Differential subtraction chain, a method for identifying differences in genomic DNA and mRNA. Nucleic Acids Res (1999) 1.18
Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage. Am J Hum Genet (1994) 1.18
The zinc finger region of simian virus 40 large T antigen is needed for hexamer assembly and origin melting. J Virol (1991) 1.16
Mutational analysis of the PTEN gene in head and neck squamous cell carcinoma. Int J Cancer (1998) 1.16
Mixed bacterial infection of the pericardium. South Med J (1983) 1.15
cdc2 phosphorylation of threonine 124 activates the origin-unwinding functions of simian virus 40 T antigen. J Virol (1993) 1.15
Binding of SV40 a protein to the BK virus origin of DNA replication. Virology (1983) 1.14
Temperature-sensitive mutants identify crucial structural regions of simian virus 40 large T antigen. J Virol (1989) 1.09
p53 alterations are associated with improved prognosis in distal colonic carcinomas. Clin Cancer Res (1997) 1.09
Mechanisms of simian virus 40 T-antigen activation by phosphorylation of threonine 124. J Virol (1996) 1.08